Motif ID: CUX2
Z-value: 1.565
Transcription factors associated with CUX2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
CUX2 | ENSG00000111249.9 | CUX2 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 3.2 | GO:0001907 | cytolysis by symbiont of host cells(GO:0001897) killing by symbiont of host cells(GO:0001907) hemolysis by symbiont of host erythrocytes(GO:0019836) disruption by symbiont of host cell(GO:0044004) hemolysis in other organism(GO:0044179) positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010) cytolysis in other organism(GO:0051715) cytolysis in other organism involved in symbiotic interaction(GO:0051801) hemolysis in other organism involved in symbiotic interaction(GO:0052331) |
0.9 | 8.7 | GO:0051918 | negative regulation of fibrinolysis(GO:0051918) |
0.8 | 2.3 | GO:2000644 | low-density lipoprotein particle receptor catabolic process(GO:0032802) regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206) regulation of receptor catabolic process(GO:2000644) |
0.4 | 1.6 | GO:0071400 | cellular response to oleic acid(GO:0071400) |
0.4 | 1.2 | GO:1903961 | positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) positive regulation of anion transmembrane transport(GO:1903961) |
0.3 | 1.3 | GO:0001705 | ectoderm formation(GO:0001705) central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
0.3 | 1.4 | GO:0032509 | endosome transport via multivesicular body sorting pathway(GO:0032509) plasma membrane to endosome transport(GO:0048227) |
0.2 | 1.7 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
0.2 | 0.6 | GO:0002378 | immunoglobulin biosynthetic process(GO:0002378) |
0.2 | 0.5 | GO:0043095 | regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105) |
0.2 | 0.5 | GO:0051919 | positive regulation of fibrinolysis(GO:0051919) |
0.2 | 0.6 | GO:0047484 | regulation of response to osmotic stress(GO:0047484) |
0.2 | 1.1 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
0.1 | 0.9 | GO:0006537 | glutamate biosynthetic process(GO:0006537) proline catabolic process(GO:0006562) |
0.1 | 0.4 | GO:0072205 | collecting duct development(GO:0072044) metanephric collecting duct development(GO:0072205) |
0.1 | 0.7 | GO:0030210 | heparin biosynthetic process(GO:0030210) |
0.1 | 0.9 | GO:0051895 | negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392) |
0.1 | 5.8 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
0.1 | 0.5 | GO:0009235 | cobalamin metabolic process(GO:0009235) |
0.1 | 0.3 | GO:0006432 | phenylalanyl-tRNA aminoacylation(GO:0006432) |
0.1 | 1.7 | GO:0006700 | C21-steroid hormone biosynthetic process(GO:0006700) |
0.1 | 0.3 | GO:0021836 | chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923) |
0.1 | 1.9 | GO:0000380 | alternative mRNA splicing, via spliceosome(GO:0000380) |
0.1 | 0.5 | GO:0051790 | short-chain fatty acid biosynthetic process(GO:0051790) |
0.1 | 2.3 | GO:0034035 | purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) |
0.1 | 0.5 | GO:0007500 | mesodermal cell fate determination(GO:0007500) |
0.1 | 0.2 | GO:0072201 | negative regulation of mesenchymal cell proliferation(GO:0072201) |
0.1 | 0.5 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
0.1 | 0.4 | GO:0060242 | contact inhibition(GO:0060242) |
0.1 | 1.0 | GO:0030388 | fructose 1,6-bisphosphate metabolic process(GO:0030388) |
0.1 | 0.3 | GO:0042519 | tyrosine phosphorylation of Stat4 protein(GO:0042504) regulation of tyrosine phosphorylation of Stat4 protein(GO:0042519) positive regulation of tyrosine phosphorylation of Stat4 protein(GO:0042520) |
0.1 | 0.2 | GO:0048852 | diencephalon morphogenesis(GO:0048852) |
0.1 | 0.4 | GO:0015742 | alpha-ketoglutarate transport(GO:0015742) |
0.1 | 1.9 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
0.1 | 0.4 | GO:0048296 | isotype switching to IgA isotypes(GO:0048290) regulation of isotype switching to IgA isotypes(GO:0048296) positive regulation of isotype switching to IgA isotypes(GO:0048298) |
0.0 | 0.1 | GO:0010430 | ethanol catabolic process(GO:0006068) fatty acid omega-oxidation(GO:0010430) |
0.0 | 1.0 | GO:0015804 | neutral amino acid transport(GO:0015804) |
0.0 | 0.3 | GO:0048853 | forebrain morphogenesis(GO:0048853) |
0.0 | 0.1 | GO:0034723 | DNA replication-dependent nucleosome organization(GO:0034723) |
0.0 | 0.4 | GO:0034382 | chylomicron remnant clearance(GO:0034382) triglyceride-rich lipoprotein particle clearance(GO:0071830) |
0.0 | 0.1 | GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion(GO:0010881) |
0.0 | 0.1 | GO:0044240 | multicellular organism lipid catabolic process(GO:0044240) |
0.0 | 0.2 | GO:0048537 | mucosal-associated lymphoid tissue development(GO:0048537) |
0.0 | 0.1 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
0.0 | 0.4 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
0.0 | 0.2 | GO:0045896 | regulation of transcription during mitosis(GO:0045896) positive regulation of transcription during mitosis(GO:0045897) |
0.0 | 0.4 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
0.0 | 0.1 | GO:0045475 | locomotor rhythm(GO:0045475) |
0.0 | 0.1 | GO:0010046 | response to mycotoxin(GO:0010046) |
0.0 | 0.5 | GO:0008210 | estrogen metabolic process(GO:0008210) |
0.0 | 0.1 | GO:0006422 | aspartyl-tRNA aminoacylation(GO:0006422) |
0.0 | 0.2 | GO:0046051 | GTP biosynthetic process(GO:0006183) UTP biosynthetic process(GO:0006228) CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036) UTP metabolic process(GO:0046051) |
0.0 | 0.3 | GO:0016226 | iron-sulfur cluster assembly(GO:0016226) metallo-sulfur cluster assembly(GO:0031163) |
0.0 | 0.2 | GO:0007598 | blood coagulation, extrinsic pathway(GO:0007598) |
0.0 | 0.5 | GO:0008209 | androgen metabolic process(GO:0008209) |
0.0 | 0.1 | GO:0030490 | maturation of SSU-rRNA(GO:0030490) |
0.0 | 0.1 | GO:0070245 | positive regulation of thymocyte apoptotic process(GO:0070245) |
0.0 | 0.3 | GO:0007128 | meiotic prophase I(GO:0007128) |
0.0 | 0.1 | GO:0002860 | natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860) |
0.0 | 0.2 | GO:0019321 | pentose metabolic process(GO:0019321) |
0.0 | 0.7 | GO:0060338 | regulation of type I interferon-mediated signaling pathway(GO:0060338) |
0.0 | 0.4 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
0.0 | 0.1 | GO:0048147 | negative regulation of fibroblast proliferation(GO:0048147) |
0.0 | 0.3 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
0.0 | 0.1 | GO:0061025 | membrane fusion(GO:0061025) |
0.0 | 0.4 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
0.0 | 0.7 | GO:0002286 | T cell activation involved in immune response(GO:0002286) |
0.0 | 0.1 | GO:0060992 | response to fungicide(GO:0060992) |
0.0 | 0.1 | GO:0019934 | cGMP-mediated signaling(GO:0019934) |
0.0 | 0.5 | GO:0030866 | cortical cytoskeleton organization(GO:0030865) cortical actin cytoskeleton organization(GO:0030866) |
0.0 | 0.2 | GO:0006400 | tRNA modification(GO:0006400) |
0.0 | 1.1 | GO:0006968 | cellular defense response(GO:0006968) |
0.0 | 0.1 | GO:0002888 | positive regulation of myeloid leukocyte mediated immunity(GO:0002888) positive regulation of mast cell activation(GO:0033005) positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306) |
0.0 | 0.4 | GO:0051925 | obsolete regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051925) |
0.0 | 0.4 | GO:0051930 | regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931) |
0.0 | 0.4 | GO:0051865 | protein autoubiquitination(GO:0051865) |
0.0 | 0.2 | GO:0035338 | long-chain fatty-acyl-CoA metabolic process(GO:0035336) long-chain fatty-acyl-CoA biosynthetic process(GO:0035338) |
0.0 | 1.0 | GO:0008360 | regulation of cell shape(GO:0008360) |
0.0 | 0.3 | GO:0007172 | signal complex assembly(GO:0007172) |
0.0 | 0.3 | GO:0033209 | tumor necrosis factor-mediated signaling pathway(GO:0033209) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 2.3 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
0.2 | 5.2 | GO:0042627 | chylomicron(GO:0042627) |
0.1 | 1.7 | GO:0030673 | axolemma(GO:0030673) |
0.1 | 0.7 | GO:0001891 | phagocytic cup(GO:0001891) |
0.1 | 1.0 | GO:1903561 | extracellular exosome(GO:0070062) extracellular vesicle(GO:1903561) |
0.1 | 0.3 | GO:0072536 | interleukin-23 receptor complex(GO:0072536) |
0.1 | 0.3 | GO:0042272 | nuclear RNA export factor complex(GO:0042272) |
0.1 | 0.5 | GO:0005579 | membrane attack complex(GO:0005579) |
0.1 | 1.4 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
0.0 | 0.4 | GO:0005587 | collagen type IV trimer(GO:0005587) |
0.0 | 2.6 | GO:0005884 | actin filament(GO:0005884) |
0.0 | 0.4 | GO:0000796 | condensin complex(GO:0000796) |
0.0 | 3.2 | GO:0005604 | basement membrane(GO:0005604) |
0.0 | 1.6 | GO:0042645 | mitochondrial nucleoid(GO:0042645) |
0.0 | 2.0 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
0.0 | 0.1 | GO:0032585 | multivesicular body membrane(GO:0032585) |
0.0 | 0.5 | GO:0031528 | microvillus membrane(GO:0031528) |
0.0 | 0.1 | GO:0033011 | perinuclear theca(GO:0033011) cytoskeletal calyx(GO:0033150) |
0.0 | 0.2 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
0.0 | 0.4 | GO:0030914 | STAGA complex(GO:0030914) |
0.0 | 0.1 | GO:0031512 | motile primary cilium(GO:0031512) |
0.0 | 0.6 | GO:0005811 | lipid particle(GO:0005811) |
0.0 | 1.0 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
0.0 | 5.9 | GO:0005792 | obsolete microsome(GO:0005792) |
0.0 | 0.1 | GO:0042589 | zymogen granule membrane(GO:0042589) |
0.0 | 0.5 | GO:0044452 | nucleolar part(GO:0044452) |
0.0 | 2.6 | GO:0016607 | nuclear speck(GO:0016607) |
0.0 | 0.5 | GO:0005839 | proteasome core complex(GO:0005839) |
0.0 | 0.2 | GO:0008091 | spectrin(GO:0008091) |
0.0 | 0.4 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
0.0 | 0.1 | GO:0005678 | obsolete chromatin assembly complex(GO:0005678) |
0.0 | 0.1 | GO:0001950 | obsolete plasma membrane enriched fraction(GO:0001950) |
0.0 | 0.4 | GO:0009898 | cytoplasmic side of plasma membrane(GO:0009898) cytoplasmic side of membrane(GO:0098562) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.0 | 5.2 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
0.3 | 2.3 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
0.3 | 3.2 | GO:0015643 | toxic substance binding(GO:0015643) |
0.3 | 2.3 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
0.3 | 1.7 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
0.3 | 9.7 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
0.2 | 1.4 | GO:0048406 | nerve growth factor binding(GO:0048406) |
0.2 | 0.9 | GO:0004657 | proline dehydrogenase activity(GO:0004657) |
0.2 | 1.6 | GO:0016595 | glutamate binding(GO:0016595) |
0.2 | 0.5 | GO:0044549 | GTP cyclohydrolase binding(GO:0044549) |
0.2 | 0.5 | GO:0047042 | androsterone dehydrogenase (B-specific) activity(GO:0047042) |
0.2 | 0.9 | GO:0016004 | phospholipase activator activity(GO:0016004) |
0.1 | 3.4 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
0.1 | 1.1 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
0.1 | 1.7 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
0.1 | 1.0 | GO:0004332 | fructose-bisphosphate aldolase activity(GO:0004332) |
0.1 | 0.2 | GO:0017099 | very-long-chain-acyl-CoA dehydrogenase activity(GO:0017099) |
0.1 | 0.2 | GO:0050051 | leukotriene-B4 20-monooxygenase activity(GO:0050051) |
0.1 | 0.9 | GO:0016405 | CoA-ligase activity(GO:0016405) |
0.1 | 0.3 | GO:0042020 | interleukin-23 binding(GO:0042019) interleukin-23 receptor activity(GO:0042020) |
0.1 | 0.3 | GO:0004826 | phenylalanine-tRNA ligase activity(GO:0004826) |
0.1 | 0.5 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
0.1 | 0.1 | GO:0031177 | phosphopantetheine binding(GO:0031177) |
0.1 | 0.9 | GO:0017153 | sodium:dicarboxylate symporter activity(GO:0017153) |
0.1 | 0.2 | GO:0035198 | miRNA binding(GO:0035198) |
0.1 | 0.4 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
0.1 | 0.3 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
0.1 | 1.2 | GO:0004467 | long-chain fatty acid-CoA ligase activity(GO:0004467) fatty acid ligase activity(GO:0015645) |
0.1 | 0.5 | GO:0031419 | cobalamin binding(GO:0031419) |
0.1 | 0.4 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) |
0.0 | 0.2 | GO:0004727 | prenylated protein tyrosine phosphatase activity(GO:0004727) |
0.0 | 0.5 | GO:0004312 | fatty acid synthase activity(GO:0004312) |
0.0 | 0.6 | GO:0047617 | acyl-CoA hydrolase activity(GO:0047617) |
0.0 | 0.8 | GO:0043499 | obsolete eukaryotic cell surface binding(GO:0043499) |
0.0 | 0.3 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
0.0 | 1.1 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
0.0 | 0.1 | GO:0004853 | uroporphyrinogen decarboxylase activity(GO:0004853) |
0.0 | 0.5 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
0.0 | 0.1 | GO:0035276 | ethanol binding(GO:0035276) |
0.0 | 0.3 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
0.0 | 0.4 | GO:0034185 | apolipoprotein binding(GO:0034185) |
0.0 | 0.1 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
0.0 | 0.2 | GO:0042731 | PH domain binding(GO:0042731) |
0.0 | 0.2 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
0.0 | 0.3 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
0.0 | 0.1 | GO:0004815 | aspartate-tRNA ligase activity(GO:0004815) |
0.0 | 0.2 | GO:0004396 | hexokinase activity(GO:0004396) |
0.0 | 0.4 | GO:0005310 | dicarboxylic acid transmembrane transporter activity(GO:0005310) |
0.0 | 0.2 | GO:0004550 | nucleoside diphosphate kinase activity(GO:0004550) |
0.0 | 0.1 | GO:0008907 | integrase activity(GO:0008907) |
0.0 | 0.6 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
0.0 | 0.1 | GO:0018685 | alkane 1-monooxygenase activity(GO:0018685) |
0.0 | 1.3 | GO:0008301 | DNA binding, bending(GO:0008301) |
0.0 | 0.4 | GO:0070064 | proline-rich region binding(GO:0070064) |
0.0 | 0.3 | GO:0017091 | AU-rich element binding(GO:0017091) |
0.0 | 1.5 | GO:0042562 | hormone binding(GO:0042562) |
0.0 | 0.1 | GO:0008327 | methyl-CpG binding(GO:0008327) |
0.0 | 0.1 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
0.0 | 0.4 | GO:0042393 | histone binding(GO:0042393) |
0.0 | 0.1 | GO:0004749 | ribose phosphate diphosphokinase activity(GO:0004749) |
0.0 | 0.1 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
0.0 | 0.3 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
0.0 | 0.2 | GO:0030346 | protein phosphatase 2B binding(GO:0030346) |
0.0 | 0.1 | GO:0032052 | bile acid binding(GO:0032052) |
0.0 | 0.2 | GO:0003924 | GTPase activity(GO:0003924) |
0.0 | 0.3 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) |
0.0 | 0.2 | GO:0009982 | pseudouridine synthase activity(GO:0009982) snoRNA binding(GO:0030515) |
0.0 | 0.0 | GO:0070260 | 5'-tyrosyl-DNA phosphodiesterase activity(GO:0070260) |
0.0 | 0.2 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
0.0 | 0.3 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
0.0 | 0.4 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
0.0 | 0.5 | GO:0036459 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
0.0 | 0.1 | GO:0003917 | DNA topoisomerase type I activity(GO:0003917) |
0.0 | 0.1 | GO:0050780 | dopamine receptor binding(GO:0050780) |
0.0 | 0.1 | GO:0034875 | oxidoreductase activity, acting on CH or CH2 groups, quinone or similar compound as acceptor(GO:0033695) caffeine oxidase activity(GO:0034875) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 0.6 | SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |