Motif ID: DDIT3

Z-value: 0.883


Transcription factors associated with DDIT3:

Gene SymbolEntrez IDGene Name
DDIT3 ENSG00000175197.6 DDIT3



Activity profile for motif DDIT3.

activity profile for motif DDIT3


Sorted Z-values histogram for motif DDIT3

Sorted Z-values for motif DDIT3



Network of associatons between targets according to the STRING database.



First level regulatory network of DDIT3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_216300784 3.216 ENST00000421182.1
ENST00000432072.2
ENST00000323926.6
ENST00000336916.4
ENST00000357867.4
ENST00000359671.1
ENST00000346544.3
ENST00000345488.5
ENST00000357009.2
ENST00000446046.1
ENST00000356005.4
ENST00000443816.1
ENST00000426059.1
ENST00000354785.4
 FN1













fibronectin 1













chr3_+_157154578 2.905 ENST00000295927.3
 PTX3
pentraxin 3, long
chr10_-_17659357 1.883 ENST00000326961.6
ENST00000361271.3
 PTPLA

protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A

chr2_-_161350305 1.874 ENST00000348849.3
 RBMS1
RNA binding motif, single stranded interacting protein 1
chr10_-_92681033 1.748 ENST00000371697.3
 ANKRD1
ankyrin repeat domain 1 (cardiac muscle)
chr4_-_99578789 1.530 ENST00000511651.1
ENST00000505184.1
 TSPAN5

tetraspanin 5

chr2_+_192141611 1.438 ENST00000392316.1
 MYO1B
myosin IB
chr10_-_17659234 1.359 ENST00000466335.1
 PTPLA
protein tyrosine phosphatase-like (proline instead of catalytic arginine), member A
chr8_-_18744528 1.262 ENST00000523619.1
 PSD3
pleckstrin and Sec7 domain containing 3
chr9_+_112542591 0.959 ENST00000413420.1
ENST00000302798.7
ENST00000555236.1
ENST00000510514.5
ENST00000483909.1
ENST00000314527.4
 PALM2-AKAP2

AKAP2

PALM2

PALM2-AKAP2 readthrough

A kinase (PRKA) anchor protein 2

paralemmin 2

chr2_-_179672142 0.942 ENST00000342992.6
ENST00000360870.5
ENST00000460472.2
ENST00000589042.1
ENST00000591111.1
ENST00000342175.6
ENST00000359218.5
 TTN






titin






chr9_+_112542572 0.928 ENST00000374530.3
 PALM2-AKAP2
PALM2-AKAP2 readthrough
chr3_+_38017264 0.809 ENST00000436654.1
 CTDSPL
CTD (carboxy-terminal domain, RNA polymerase II, polypeptide A) small phosphatase-like
chr12_-_52867569 0.793 ENST00000252250.6
 KRT6C
keratin 6C
chr5_-_54281407 0.753 ENST00000381403.4
 ESM1
endothelial cell-specific molecule 1
chr16_+_56965960 0.699 ENST00000439977.2
ENST00000344114.4
ENST00000300302.5
ENST00000379792.2
 HERPUD1



homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1



chr15_+_85923797 0.686 ENST00000559362.1
 AKAP13
A kinase (PRKA) anchor protein 13
chr1_+_169079823 0.614 ENST00000367813.3
 ATP1B1
ATPase, Na+/K+ transporting, beta 1 polypeptide
chr2_-_208030647 0.573 ENST00000309446.6
 KLF7
Kruppel-like factor 7 (ubiquitous)
chr4_+_157997273 0.538 ENST00000541722.1
ENST00000512619.1
 GLRB

glycine receptor, beta

chr16_+_56970567 0.532 ENST00000563911.1
 HERPUD1
homocysteine-inducible, endoplasmic reticulum stress-inducible, ubiquitin-like domain member 1
chr10_-_116444371 0.526 ENST00000533213.2
ENST00000369252.4
 ABLIM1

actin binding LIM protein 1

chr4_+_157997209 0.481 ENST00000264428.4
 GLRB
glycine receptor, beta
chr17_+_4855053 0.429 ENST00000518175.1
 ENO3
enolase 3 (beta, muscle)
chr7_-_56101826 0.412 ENST00000421626.1
 PSPH
phosphoserine phosphatase
chr3_-_45883558 0.383 ENST00000445698.1
ENST00000296135.6
 LZTFL1

leucine zipper transcription factor-like 1

chr15_+_41245160 0.366 ENST00000444189.2
ENST00000446533.3
 CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr8_-_93029865 0.362 ENST00000422361.2
 RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr17_+_56315936 0.355 ENST00000543544.1
 LPO
lactoperoxidase
chr17_+_56315787 0.268 ENST00000262290.4
ENST00000421678.2
 LPO

lactoperoxidase

chr7_-_44530479 0.252 ENST00000355451.7
 NUDCD3
NudC domain containing 3
chr20_+_24929866 0.233 ENST00000480798.1
ENST00000376835.2
 CST7

cystatin F (leukocystatin)

chr5_-_137878887 0.224 ENST00000507939.1
ENST00000572514.1
ENST00000499810.2
ENST00000360541.5
 ETF1



eukaryotic translation termination factor 1



chr12_-_53074182 0.222 ENST00000252244.3
 KRT1
keratin 1
chr11_+_62495541 0.198 ENST00000530625.1
ENST00000513247.2
 TTC9C

tetratricopeptide repeat domain 9C

chr2_-_32390801 0.194 ENST00000608489.1
 RP11-563N4.1
RP11-563N4.1
chr20_+_48807351 0.190 ENST00000303004.3
 CEBPB
CCAAT/enhancer binding protein (C/EBP), beta
chr13_-_24007815 0.173 ENST00000382298.3
 SACS
spastic ataxia of Charlevoix-Saguenay (sacsin)
chr16_-_68269971 0.167 ENST00000565858.1
 ESRP2
epithelial splicing regulatory protein 2
chr14_-_92413727 0.162 ENST00000267620.10
 FBLN5
fibulin 5
chr14_-_92413353 0.161 ENST00000556154.1
 FBLN5
fibulin 5
chr3_+_15643476 0.160 ENST00000436193.1
ENST00000383778.4
 BTD

biotinidase

chr6_+_31895254 0.152 ENST00000299367.5
ENST00000442278.2
 C2

complement component 2

chr15_+_85923856 0.124 ENST00000560302.1
ENST00000394518.2
ENST00000361243.2
ENST00000560256.1
 AKAP13



A kinase (PRKA) anchor protein 13



chr3_+_186330712 0.118 ENST00000411641.2
ENST00000273784.5
 AHSG

alpha-2-HS-glycoprotein

chr10_+_86004802 0.095 ENST00000359452.4
ENST00000358110.5
ENST00000372092.3
 RGR


retinal G protein coupled receptor


chr1_+_150954493 0.081 ENST00000368947.4
 ANXA9
annexin A9
chr14_+_21387508 0.079 ENST00000555624.1
 RP11-84C10.2
RP11-84C10.2
chr5_+_72143988 0.069 ENST00000506351.2
 TNPO1
transportin 1
chrX_-_40506766 0.066 ENST00000378421.1
ENST00000440784.2
ENST00000327877.5
ENST00000378426.1
ENST00000378418.2
 CXorf38




chromosome X open reading frame 38




chr3_+_130569429 0.062 ENST00000505330.1
ENST00000504381.1
ENST00000507488.2
ENST00000393221.4
 ATP2C1



ATPase, Ca++ transporting, type 2C, member 1



chr17_-_34257731 0.059 ENST00000431884.2
ENST00000425909.3
ENST00000394528.3
ENST00000430160.2
 RDM1



RAD52 motif 1



chr6_-_157744531 0.054 ENST00000400788.4
ENST00000367144.4
 TMEM242

transmembrane protein 242

chr1_-_161277210 0.052 ENST00000491222.2
 MPZ
myelin protein zero
chr9_-_95056010 0.048 ENST00000443024.2
 IARS
isoleucyl-tRNA synthetase
chr6_+_168399772 0.041 ENST00000443060.2
 KIF25
kinesin family member 25
chr22_-_30901637 0.041 ENST00000381982.3
ENST00000255858.7
ENST00000540456.1
ENST00000392772.2
 SEC14L4



SEC14-like 4 (S. cerevisiae)



chr17_-_46691990 0.038 ENST00000576562.1
 HOXB8
homeobox B8
chr4_-_2935674 0.035 ENST00000514800.1
 MFSD10
major facilitator superfamily domain containing 10
chr11_+_61976137 0.029 ENST00000244930.4
 SCGB2A1
secretoglobin, family 2A, member 1
chr12_-_25102252 0.029 ENST00000261192.7
 BCAT1
branched chain amino-acid transaminase 1, cytosolic
chr4_-_119274121 0.024 ENST00000296498.3
 PRSS12
protease, serine, 12 (neurotrypsin, motopsin)
chr2_-_63815628 0.010 ENST00000409562.3
 WDPCP
WD repeat containing planar cell polarity effector
chrX_-_100129128 0.009 ENST00000372960.4
ENST00000372964.1
ENST00000217885.5
 NOX1


NADPH oxidase 1


chr8_-_21669826 0.008 ENST00000517328.1
 GFRA2
GDNF family receptor alpha 2
chr7_-_99006443 0.004 ENST00000350498.3
 PDAP1
PDGFA associated protein 1

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.9 GO:0008228 opsonization(GO:0008228)
0.3 1.0 GO:0060012 synaptic transmission, glycinergic(GO:0060012)
0.3 0.9 GO:0031034 skeletal muscle myosin thick filament assembly(GO:0030241) myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688)
0.2 3.2 GO:0034446 substrate adhesion-dependent cell spreading(GO:0034446)
0.1 0.3 GO:2000121 regulation of removal of superoxide radicals(GO:2000121)
0.1 1.3 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.2 GO:0090084 negative regulation of inclusion body assembly(GO:0090084)
0.0 0.2 GO:0001867 complement activation, lectin pathway(GO:0001867)
0.0 0.4 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)
0.0 0.6 GO:0042744 hydrogen peroxide catabolic process(GO:0042744)
0.0 3.0 GO:0006633 fatty acid biosynthetic process(GO:0006633)
0.0 0.4 GO:0043403 skeletal muscle tissue regeneration(GO:0043403)
0.0 0.1 GO:0045780 positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852)
0.0 0.2 GO:0006449 regulation of translational termination(GO:0006449)
0.0 0.2 GO:0045408 regulation of interleukin-6 biosynthetic process(GO:0045408)
0.0 0.1 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.0 0.1 GO:0032472 cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) Golgi calcium ion transport(GO:0032472) manganese ion homeostasis(GO:0055071)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.2 GO:0005577 fibrinogen complex(GO:0005577)
0.1 0.3 GO:0071953 elastic fiber(GO:0071953)
0.1 0.9 GO:0031430 M band(GO:0031430)
0.1 0.4 GO:0000015 phosphopyruvate hydratase complex(GO:0000015)
0.0 0.6 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.0 0.2 GO:0070852 cell body fiber(GO:0070852)
0.0 1.0 GO:0045095 keratin filament(GO:0045095)
0.0 0.0 GO:0043083 synaptic cleft(GO:0043083)
0.0 1.1 GO:0031674 I band(GO:0031674)
0.0 1.4 GO:0016459 myosin complex(GO:0016459)
0.0 0.0 GO:0005871 kinesin complex(GO:0005871)
0.0 1.0 GO:0034707 chloride channel complex(GO:0034707)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 2.9 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.2 1.0 GO:0016933 extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934)
0.1 0.9 GO:0051393 alpha-actinin binding(GO:0051393)
0.1 0.4 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.1 0.4 GO:0004634 phosphopyruvate hydratase activity(GO:0004634)
0.1 3.2 GO:0005518 collagen binding(GO:0005518)
0.1 0.2 GO:0047708 biotinidase activity(GO:0047708)
0.1 0.8 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 1.0 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.6 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.0 0.2 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.0 0.1 GO:0030292 protein tyrosine kinase inhibitor activity(GO:0030292)
0.0 0.8 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.0 3.2 GO:0004725 protein tyrosine phosphatase activity(GO:0004725)
0.0 1.3 GO:0003697 single-stranded DNA binding(GO:0003697)
0.0 0.2 GO:0070628 proteasome binding(GO:0070628)
0.0 0.6 GO:0016684 peroxidase activity(GO:0004601) oxidoreductase activity, acting on peroxide as acceptor(GO:0016684)
0.0 0.1 GO:0015410 manganese-transporting ATPase activity(GO:0015410)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.6 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.