Motif ID: DLX3_EVX1_MEOX1
Z-value: 1.407
Transcription factors associated with DLX3_EVX1_MEOX1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| DLX3 | ENSG00000064195.7 | DLX3 |
| EVX1 | ENSG00000106038.8 | EVX1 |
| MEOX1 | ENSG00000005102.8 | MEOX1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.0 | 12.2 | GO:0043316 | natural killer cell activation involved in immune response(GO:0002323) cytotoxic T cell degranulation(GO:0043316) natural killer cell degranulation(GO:0043320) |
| 0.3 | 2.3 | GO:0045647 | negative regulation of erythrocyte differentiation(GO:0045647) |
| 0.3 | 0.8 | GO:0055005 | optic placode formation involved in camera-type eye formation(GO:0046619) ventricular cardiac myofibril assembly(GO:0055005) regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251) |
| 0.2 | 0.6 | GO:0001907 | cytolysis by symbiont of host cells(GO:0001897) killing by symbiont of host cells(GO:0001907) hemolysis by symbiont of host erythrocytes(GO:0019836) disruption by symbiont of host cell(GO:0044004) hemolysis in other organism(GO:0044179) positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010) cytolysis in other organism(GO:0051715) cytolysis in other organism involved in symbiotic interaction(GO:0051801) hemolysis in other organism involved in symbiotic interaction(GO:0052331) |
| 0.2 | 0.5 | GO:0002082 | regulation of oxidative phosphorylation(GO:0002082) |
| 0.1 | 0.4 | GO:0002378 | immunoglobulin biosynthetic process(GO:0002378) |
| 0.1 | 2.9 | GO:0007597 | blood coagulation, intrinsic pathway(GO:0007597) |
| 0.1 | 0.3 | GO:0060839 | lymphatic endothelial cell fate commitment(GO:0060838) endothelial cell fate commitment(GO:0060839) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849) |
| 0.1 | 0.3 | GO:0051661 | maintenance of centrosome location(GO:0051661) |
| 0.1 | 0.3 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.1 | 0.8 | GO:0048013 | ephrin receptor signaling pathway(GO:0048013) |
| 0.1 | 0.3 | GO:0048619 | embryonic hindgut morphogenesis(GO:0048619) |
| 0.1 | 0.8 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.1 | 0.3 | GO:0017055 | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055) |
| 0.1 | 0.5 | GO:0033160 | positive regulation of protein import into nucleus, translocation(GO:0033160) |
| 0.1 | 0.2 | GO:0003099 | positive regulation of the force of heart contraction by chemical signal(GO:0003099) |
| 0.1 | 0.4 | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) |
| 0.1 | 0.3 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
| 0.1 | 0.2 | GO:0021759 | globus pallidus development(GO:0021759) menarche(GO:0042696) |
| 0.1 | 0.5 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.1 | 0.2 | GO:0060023 | soft palate development(GO:0060023) |
| 0.1 | 0.3 | GO:0007352 | zygotic specification of dorsal/ventral axis(GO:0007352) |
| 0.1 | 0.3 | GO:0019985 | translesion synthesis(GO:0019985) |
| 0.0 | 1.5 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
| 0.0 | 0.5 | GO:0006107 | oxaloacetate metabolic process(GO:0006107) |
| 0.0 | 0.4 | GO:0007064 | mitotic sister chromatid cohesion(GO:0007064) kinetochore assembly(GO:0051382) kinetochore organization(GO:0051383) |
| 0.0 | 0.3 | GO:0006883 | cellular sodium ion homeostasis(GO:0006883) |
| 0.0 | 0.4 | GO:0021516 | dorsal spinal cord development(GO:0021516) |
| 0.0 | 0.2 | GO:0046621 | negative regulation of organ growth(GO:0046621) |
| 0.0 | 0.5 | GO:0007512 | adult heart development(GO:0007512) |
| 0.0 | 0.6 | GO:0050872 | white fat cell differentiation(GO:0050872) |
| 0.0 | 0.1 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.0 | 1.3 | GO:0002286 | T cell activation involved in immune response(GO:0002286) |
| 0.0 | 0.4 | GO:0032148 | activation of protein kinase B activity(GO:0032148) |
| 0.0 | 0.3 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 0.0 | 0.2 | GO:0060992 | response to fungicide(GO:0060992) |
| 0.0 | 0.2 | GO:0031536 | positive regulation of exit from mitosis(GO:0031536) |
| 0.0 | 0.4 | GO:0007020 | microtubule nucleation(GO:0007020) |
| 0.0 | 0.1 | GO:0060259 | regulation of feeding behavior(GO:0060259) |
| 0.0 | 0.1 | GO:0032416 | negative regulation of sodium:proton antiporter activity(GO:0032416) negative regulation of sodium ion transmembrane transport(GO:1902306) negative regulation of sodium ion transmembrane transporter activity(GO:2000650) |
| 0.0 | 0.3 | GO:0019228 | neuronal action potential(GO:0019228) |
| 0.0 | 0.1 | GO:0007181 | transforming growth factor beta receptor complex assembly(GO:0007181) |
| 0.0 | 0.5 | GO:0042493 | response to drug(GO:0042493) |
| 0.0 | 1.0 | GO:0048477 | oogenesis(GO:0048477) |
| 0.0 | 0.2 | GO:0046653 | tetrahydrofolate metabolic process(GO:0046653) |
| 0.0 | 0.1 | GO:0017183 | peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) |
| 0.0 | 0.3 | GO:0050858 | negative regulation of antigen receptor-mediated signaling pathway(GO:0050858) negative regulation of T cell receptor signaling pathway(GO:0050860) |
| 0.0 | 0.2 | GO:0030539 | male genitalia development(GO:0030539) |
| 0.0 | 0.1 | GO:0044818 | mitotic G2/M transition checkpoint(GO:0044818) protein neddylation(GO:0045116) |
| 0.0 | 0.1 | GO:0048853 | forebrain morphogenesis(GO:0048853) |
| 0.0 | 0.1 | GO:0090080 | positive regulation of MAPKKK cascade by fibroblast growth factor receptor signaling pathway(GO:0090080) |
| 0.0 | 0.1 | GO:1904037 | positive regulation of epithelial cell apoptotic process(GO:1904037) positive regulation of endothelial cell apoptotic process(GO:2000353) |
| 0.0 | 0.0 | GO:0060398 | regulation of growth hormone receptor signaling pathway(GO:0060398) |
| 0.0 | 0.1 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.0 | 0.2 | GO:0006570 | tyrosine metabolic process(GO:0006570) |
| 0.0 | 0.5 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.0 | 1.3 | GO:0031295 | lymphocyte costimulation(GO:0031294) T cell costimulation(GO:0031295) |
| 0.0 | 0.3 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
| 0.0 | 0.2 | GO:0007342 | fusion of sperm to egg plasma membrane(GO:0007342) |
| 0.0 | 0.0 | GO:0000239 | pachytene(GO:0000239) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 2.3 | GO:0033093 | Weibel-Palade body(GO:0033093) |
| 0.3 | 0.8 | GO:0005873 | plus-end kinesin complex(GO:0005873) |
| 0.2 | 1.3 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.2 | 12.2 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.1 | 0.2 | GO:0036452 | ESCRT III complex(GO:0000815) ESCRT complex(GO:0036452) |
| 0.1 | 0.5 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.0 | 1.0 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
| 0.0 | 0.2 | GO:0016600 | flotillin complex(GO:0016600) synaptic cleft(GO:0043083) |
| 0.0 | 0.4 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.0 | 0.3 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) beta-catenin-TCF complex(GO:1990907) |
| 0.0 | 0.4 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.0 | 0.3 | GO:0042575 | DNA polymerase complex(GO:0042575) |
| 0.0 | 0.4 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 1.2 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.0 | 0.5 | GO:0042627 | chylomicron(GO:0042627) |
| 0.0 | 0.1 | GO:0005863 | striated muscle myosin thick filament(GO:0005863) |
| 0.0 | 0.2 | GO:0033162 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.0 | 0.2 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.0 | 0.1 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.0 | 0.5 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 0.1 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 0.2 | GO:0045120 | pronucleus(GO:0045120) |
| 0.0 | 0.1 | GO:0031305 | integral component of mitochondrial inner membrane(GO:0031305) |
| 0.0 | 1.0 | GO:0034774 | platelet alpha granule lumen(GO:0031093) secretory granule lumen(GO:0034774) |
| 0.0 | 0.3 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 0.1 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.0 | 3.8 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 0.0 | GO:0032584 | growth cone membrane(GO:0032584) |
| 0.0 | 0.3 | GO:0000922 | spindle pole(GO:0000922) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 12.2 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.3 | 0.8 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.1 | 1.0 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.1 | 0.4 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) |
| 0.1 | 0.5 | GO:0042910 | xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910) |
| 0.1 | 0.8 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.1 | 0.5 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.1 | 2.4 | GO:0019865 | immunoglobulin binding(GO:0019865) |
| 0.1 | 0.5 | GO:0046912 | transferase activity, transferring acyl groups, acyl groups converted into alkyl on transfer(GO:0046912) |
| 0.1 | 0.3 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 0.1 | 0.4 | GO:0005294 | neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) |
| 0.1 | 0.4 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.1 | 0.5 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.1 | 0.3 | GO:0004346 | glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309) |
| 0.1 | 0.2 | GO:0004937 | alpha1-adrenergic receptor activity(GO:0004937) |
| 0.1 | 0.3 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.1 | 0.4 | GO:0008107 | galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127) |
| 0.1 | 0.4 | GO:0043422 | protein kinase B binding(GO:0043422) |
| 0.1 | 0.6 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.1 | 0.3 | GO:0019871 | sodium channel inhibitor activity(GO:0019871) |
| 0.0 | 0.2 | GO:0008898 | S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898) |
| 0.0 | 0.5 | GO:0061659 | ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
| 0.0 | 0.1 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.0 | 0.1 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.0 | 0.2 | GO:0032190 | acrosin binding(GO:0032190) |
| 0.0 | 1.0 | GO:0016986 | obsolete transcription initiation factor activity(GO:0016986) |
| 0.0 | 0.2 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.0 | 0.2 | GO:0030020 | extracellular matrix structural constituent conferring tensile strength(GO:0030020) |
| 0.0 | 0.2 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 0.2 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.0 | 0.2 | GO:0004167 | dopachrome isomerase activity(GO:0004167) |
| 0.0 | 2.8 | GO:0003704 | obsolete specific RNA polymerase II transcription factor activity(GO:0003704) |
| 0.0 | 0.3 | GO:0003706 | obsolete ligand-regulated transcription factor activity(GO:0003706) |
| 0.0 | 0.3 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.1 | GO:0004566 | beta-glucuronidase activity(GO:0004566) |
| 0.0 | 0.3 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 0.5 | GO:0033613 | activating transcription factor binding(GO:0033613) |
| 0.0 | 0.1 | GO:0030197 | extracellular matrix constituent, lubricant activity(GO:0030197) |
| 0.0 | 0.3 | GO:0034185 | apolipoprotein binding(GO:0034185) |
| 0.0 | 0.1 | GO:0001733 | galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694) |
| 0.0 | 0.1 | GO:0005174 | CD40 receptor binding(GO:0005174) |
| 0.0 | 0.4 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.0 | 0.4 | GO:0043499 | obsolete eukaryotic cell surface binding(GO:0043499) |
| 0.0 | 0.3 | GO:0050786 | DNA binding, bending(GO:0008301) RAGE receptor binding(GO:0050786) |
| 0.0 | 0.1 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.0 | 1.3 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 1.3 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 0.5 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.0 | 0.3 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.0 | 0.4 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.0 | 0.8 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 0.3 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 0.2 | GO:0051018 | protein kinase A binding(GO:0051018) |
| 0.0 | 0.9 | GO:0008017 | microtubule binding(GO:0008017) |
| 0.0 | 2.5 | GO:0003682 | chromatin binding(GO:0003682) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.5 | ST_B_CELL_ANTIGEN_RECEPTOR | B Cell Antigen Receptor |
| 0.0 | 0.6 | SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
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