Motif ID: DLX5

Z-value: 0.787


Transcription factors associated with DLX5:

Gene SymbolEntrez IDGene Name
DLX5 ENSG00000105880.4 DLX5



Activity profile for motif DLX5.

activity profile for motif DLX5


Sorted Z-values histogram for motif DLX5

Sorted Z-values for motif DLX5



Network of associatons between targets according to the STRING database.



First level regulatory network of DLX5

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr12_+_81110684 1.999 ENST00000228644.3
 MYF5
myogenic factor 5
chr4_-_143767428 1.399 ENST00000513000.1
ENST00000509777.1
ENST00000503927.1
 INPP4B


inositol polyphosphate-4-phosphatase, type II, 105kDa


chr7_+_100770328 1.123 ENST00000223095.4
ENST00000445463.2
 SERPINE1

serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 1

chr12_+_54378923 1.095 ENST00000303460.4
 HOXC10
homeobox C10
chr12_-_50616382 0.818 ENST00000552783.1
 LIMA1
LIM domain and actin binding 1
chr8_+_32579341 0.720 ENST00000519240.1
ENST00000539990.1
 NRG1

neuregulin 1

chr6_-_112194484 0.483 ENST00000518295.1
ENST00000484067.2
ENST00000229470.5
ENST00000356013.2
ENST00000368678.4
ENST00000523238.1
ENST00000354650.3
 FYN






FYN oncogene related to SRC, FGR, YES






chr2_+_30369859 0.476 ENST00000402003.3
 YPEL5
yippee-like 5 (Drosophila)
chr2_+_30369807 0.472 ENST00000379520.3
ENST00000379519.3
ENST00000261353.4
 YPEL5


yippee-like 5 (Drosophila)


chr11_-_102651343 0.418 ENST00000279441.4
ENST00000539681.1
 MMP10

matrix metallopeptidase 10 (stromelysin 2)

chr1_-_28969517 0.394 ENST00000263974.4
ENST00000373824.4
 TAF12

TAF12 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 20kDa

chr18_-_33709268 0.390 ENST00000269187.5
ENST00000590986.1
ENST00000440549.2
 SLC39A6


solute carrier family 39 (zinc transporter), member 6


chr2_-_220118631 0.381 ENST00000248437.4
 TUBA4A
tubulin, alpha 4a
chr19_+_36606354 0.319 ENST00000589996.1
ENST00000591296.1
 TBCB

tubulin folding cofactor B

chr19_+_36605850 0.313 ENST00000221855.3
 TBCB
tubulin folding cofactor B
chr15_+_89631381 0.292 ENST00000352732.5
 ABHD2
abhydrolase domain containing 2
chr11_-_26743546 0.278 ENST00000280467.6
ENST00000396005.3
 SLC5A12

solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12

chr14_-_68283291 0.258 ENST00000555452.1
ENST00000347230.4
 ZFYVE26

zinc finger, FYVE domain containing 26

chr14_-_24711470 0.230 ENST00000559969.1
 TINF2
TERF1 (TRF1)-interacting nuclear factor 2
chr12_+_7014126 0.198 ENST00000415834.1
ENST00000436789.1
 LRRC23

leucine rich repeat containing 23

chr3_-_105588231 0.194 ENST00000545639.1
ENST00000394027.3
ENST00000438603.1
ENST00000447441.1
ENST00000443752.1
 CBLB




Cbl proto-oncogene B, E3 ubiquitin protein ligase




chr12_+_7013897 0.189 ENST00000007969.8
ENST00000323702.5
 LRRC23

leucine rich repeat containing 23

chr12_-_10151773 0.188 ENST00000298527.6
ENST00000348658.4
 CLEC1B

C-type lectin domain family 1, member B

chr14_-_24711865 0.186 ENST00000399423.4
ENST00000267415.7
 TINF2

TERF1 (TRF1)-interacting nuclear factor 2

chr14_-_24711806 0.185 ENST00000540705.1
ENST00000538777.1
ENST00000558566.1
ENST00000559019.1
 TINF2



TERF1 (TRF1)-interacting nuclear factor 2



chr1_+_202317815 0.181 ENST00000608999.1
ENST00000336894.4
ENST00000480184.1
 PPP1R12B


protein phosphatase 1, regulatory subunit 12B


chr11_-_71823715 0.167 ENST00000545944.1
ENST00000502597.2
 ANAPC15

anaphase promoting complex subunit 15

chr11_-_71823266 0.159 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
 ANAPC15


anaphase promoting complex subunit 15


chr12_+_7014064 0.158 ENST00000443597.2
 LRRC23
leucine rich repeat containing 23
chr1_-_23670817 0.129 ENST00000478691.1
 HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr1_-_23670813 0.108 ENST00000374612.1
 HNRNPR
heterogeneous nuclear ribonucleoprotein R
chr19_-_14785674 0.104 ENST00000253673.5
 EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr19_+_58570605 0.098 ENST00000359978.6
ENST00000401053.4
ENST00000439855.2
ENST00000313434.5
ENST00000511556.1
ENST00000506786.1
 ZNF135





zinc finger protein 135





chr3_-_105587879 0.096 ENST00000264122.4
ENST00000403724.1
ENST00000405772.1
 CBLB


Cbl proto-oncogene B, E3 ubiquitin protein ligase


chr19_-_14785622 0.094 ENST00000443157.2
 EMR3
egf-like module containing, mucin-like, hormone receptor-like 3
chr19_-_14785698 0.089 ENST00000344373.4
ENST00000595472.1
 EMR3

egf-like module containing, mucin-like, hormone receptor-like 3

chr2_-_183387064 0.086 ENST00000536095.1
ENST00000331935.6
ENST00000358139.2
ENST00000456212.1
 PDE1A



phosphodiesterase 1A, calmodulin-dependent



chr4_-_8873531 0.085 ENST00000400677.3
 HMX1
H6 family homeobox 1
chr1_-_23670752 0.079 ENST00000302271.6
ENST00000426846.2
ENST00000427764.2
ENST00000606561.1
ENST00000374616.3
 HNRNPR




heterogeneous nuclear ribonucleoprotein R




chr20_+_43849941 0.079 ENST00000372769.3
 SEMG2
semenogelin II
chr8_-_22526597 0.079 ENST00000519513.1
ENST00000276416.6
ENST00000520292.1
ENST00000522268.1
 BIN3



bridging integrator 3



chr6_-_38670897 0.078 ENST00000373365.4
 GLO1
glyoxalase I
chr7_+_97736197 0.076 ENST00000297293.5
 LMTK2
lemur tyrosine kinase 2
chr12_-_57039739 0.066 ENST00000552959.1
ENST00000551020.1
ENST00000553007.2
ENST00000552919.1
ENST00000552104.1
ENST00000262030.3
 ATP5B





ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide





chr17_-_37009882 0.063 ENST00000378096.3
ENST00000394332.1
ENST00000394333.1
ENST00000577407.1
ENST00000479035.2
 RPL23




ribosomal protein L23




chr9_+_34646651 0.054 ENST00000378842.3
 GALT
galactose-1-phosphate uridylyltransferase
chr1_+_101003687 0.043 ENST00000315033.4
 GPR88
G protein-coupled receptor 88
chr12_-_53171128 0.042 ENST00000332411.2
 KRT76
keratin 76
chr7_-_86849883 0.038 ENST00000433078.1
 TMEM243
transmembrane protein 243, mitochondrial
chr9_+_34646624 0.038 ENST00000450095.2
ENST00000556278.1
 GALT
GALT
galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr14_+_24540046 0.037 ENST00000397016.2
ENST00000537691.1
ENST00000560356.1
ENST00000558450.1
 CPNE6



copine VI (neuronal)



chr2_-_183387283 0.035 ENST00000435564.1
 PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr4_-_7069760 0.033 ENST00000264954.4
 GRPEL1
GrpE-like 1, mitochondrial (E. coli)
chr4_+_151503077 0.030 ENST00000317605.4
 MAB21L2
mab-21-like 2 (C. elegans)
chr3_+_11178779 0.027 ENST00000438284.2
 HRH1
histamine receptor H1
chr1_-_78444738 0.023 ENST00000436586.2
ENST00000370768.2
 FUBP1

far upstream element (FUSE) binding protein 1

chr17_-_47785504 0.023 ENST00000514907.1
ENST00000503334.1
ENST00000508520.1
 SLC35B1


solute carrier family 35, member B1


chr1_+_50569575 0.021 ENST00000371827.1
 ELAVL4
ELAV like neuron-specific RNA binding protein 4
chr1_+_160160283 0.020 ENST00000368079.3
 CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr7_-_99716952 0.018 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
 TAF6










TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa










chr3_+_158519654 0.017 ENST00000415822.2
ENST00000392813.4
ENST00000264266.8
 MFSD1


major facilitator superfamily domain containing 1


chr14_+_96000930 0.013 ENST00000331334.4
 GLRX5
glutaredoxin 5
chr13_-_36050819 0.013 ENST00000379919.4
 MAB21L1
mab-21-like 1 (C. elegans)
chr1_+_160160346 0.007 ENST00000368078.3
 CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr1_+_54569968 0.005 ENST00000391366.1
 AL161915.1
Uncharacterized protein
chr2_+_169757750 0.005 ENST00000375363.3
ENST00000429379.2
ENST00000421979.1
 G6PC2


glucose-6-phosphatase, catalytic, 2


chr5_-_160279207 0.003 ENST00000327245.5
 ATP10B
ATPase, class V, type 10B
chr19_+_54641444 0.002 ENST00000221232.5
ENST00000358389.3
 CNOT3

CCR4-NOT transcription complex, subunit 3


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0010757 chronological cell aging(GO:0001300) arachidonic acid metabolite production involved in inflammatory response(GO:0002538) leukotriene production involved in inflammatory response(GO:0002540) negative regulation of plasminogen activation(GO:0010757) negative regulation of cell adhesion mediated by integrin(GO:0033629)
0.2 2.0 GO:0042693 muscle cell fate commitment(GO:0042693)
0.2 0.6 GO:0010836 negative regulation of protein ADP-ribosylation(GO:0010836) negative regulation of protein glycosylation(GO:0060051)
0.2 1.1 GO:0021520 spinal cord motor neuron cell fate specification(GO:0021520)
0.1 0.7 GO:0010658 striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.1 0.3 GO:0046642 negative regulation of alpha-beta T cell proliferation(GO:0046642)
0.0 0.8 GO:0031529 ruffle organization(GO:0031529)
0.0 0.1 GO:0000917 barrier septum assembly(GO:0000917) cell septum assembly(GO:0090529) mitotic cytokinetic process(GO:1902410)
0.0 0.1 GO:0009438 methylglyoxal metabolic process(GO:0009438)
0.0 0.4 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 1.0 GO:0051084 'de novo' posttranslational protein folding(GO:0051084)
0.0 0.4 GO:0030574 collagen catabolic process(GO:0030574)
0.0 0.1 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.1 GO:0009136 ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188)
0.0 0.5 GO:0050690 regulation of defense response to virus by virus(GO:0050690)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.6 GO:0010370 perinucleolar chromocenter(GO:0010370)
0.2 1.1 GO:0019907 cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907)
0.0 0.4 GO:0000125 PCAF complex(GO:0000125)
0.0 0.4 GO:0031258 lamellipodium membrane(GO:0031258)
0.0 1.1 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.0 0.8 GO:0001725 stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.4 GO:0034597 phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597)
0.1 0.9 GO:0008113 peptide-methionine (S)-S-oxide reductase activity(GO:0008113)
0.1 0.7 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.1 2.0 GO:0070888 E-box binding(GO:0070888)
0.0 0.8 GO:0003785 actin monomer binding(GO:0003785)
0.0 0.3 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.6 GO:0042162 telomeric DNA binding(GO:0042162)
0.0 1.1 GO:0002020 protease binding(GO:0002020)
0.0 0.4 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.2 GO:0016986 obsolete transcription initiation factor activity(GO:0016986)