Motif ID: DMC1

Z-value: 0.857


Transcription factors associated with DMC1:

Gene SymbolEntrez IDGene Name
DMC1 ENSG00000100206.5 DMC1



Activity profile for motif DMC1.

activity profile for motif DMC1


Sorted Z-values histogram for motif DMC1

Sorted Z-values for motif DMC1



Network of associatons between targets according to the STRING database.



First level regulatory network of DMC1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_-_134305322 1.541 ENST00000276241.6
ENST00000344129.2
 CXorf48

cancer/testis antigen 55

chrX_+_65382433 1.436 ENST00000374727.3
 HEPH
hephaestin
chr12_-_8803128 1.022 ENST00000543467.1
 MFAP5
microfibrillar associated protein 5
chr3_-_141747950 0.973 ENST00000497579.1
 TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr11_-_85779971 0.851 ENST00000393346.3
 PICALM
phosphatidylinositol binding clathrin assembly protein
chr11_-_85780086 0.735 ENST00000532317.1
ENST00000528256.1
ENST00000526033.1
 PICALM


phosphatidylinositol binding clathrin assembly protein


chr14_-_21491477 0.695 ENST00000298684.5
ENST00000557169.1
ENST00000553563.1
 NDRG2


NDRG family member 2


chr10_+_11047259 0.577 ENST00000379261.4
ENST00000416382.2
 CELF2

CUGBP, Elav-like family member 2

chr14_-_21492113 0.574 ENST00000554094.1
 NDRG2
NDRG family member 2
chr5_-_82969405 0.532 ENST00000510978.1
 HAPLN1
hyaluronan and proteoglycan link protein 1
chr14_-_21492251 0.530 ENST00000554398.1
 NDRG2
NDRG family member 2
chr3_-_141747459 0.504 ENST00000477292.1
ENST00000478006.1
ENST00000495310.1
ENST00000486111.1
 TFDP2



transcription factor Dp-2 (E2F dimerization partner 2)



chr7_+_150758304 0.409 ENST00000482950.1
ENST00000463414.1
ENST00000310317.5
 SLC4A2


solute carrier family 4 (anion exchanger), member 2


chr21_-_35281399 0.402 ENST00000418933.1
 ATP5O
ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit
chr2_+_233497931 0.380 ENST00000264059.3
 EFHD1
EF-hand domain family, member D1
chr7_-_22539771 0.366 ENST00000406890.2
ENST00000424363.1
 STEAP1B

STEAP family member 1B

chr19_-_3600549 0.293 ENST00000589966.1
 TBXA2R
thromboxane A2 receptor
chr2_+_219247021 0.286 ENST00000539932.1
 SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
chr2_-_21022818 0.266 ENST00000440866.2
ENST00000541941.1
ENST00000402479.2
ENST00000435420.2
ENST00000432947.1
ENST00000403006.2
ENST00000419825.2
ENST00000381090.3
ENST00000237822.3
ENST00000412261.1
 C2orf43









chromosome 2 open reading frame 43









chr10_-_62332357 0.265 ENST00000503366.1
 ANK3
ankyrin 3, node of Ranvier (ankyrin G)
chr18_+_56892724 0.261 ENST00000456142.3
ENST00000530323.1
 GRP

gastrin-releasing peptide

chrX_+_65382381 0.254 ENST00000519389.1
 HEPH
hephaestin
chr6_-_150067632 0.251 ENST00000460354.2
ENST00000367404.4
ENST00000543637.1
 NUP43


nucleoporin 43kDa


chr3_+_101546827 0.236 ENST00000461724.1
ENST00000483180.1
ENST00000394054.2
 NFKBIZ


nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta


chr5_-_135231516 0.233 ENST00000274520.1
 IL9
interleukin 9
chr1_-_190446759 0.229 ENST00000367462.3
 BRINP3
bone morphogenetic protein/retinoic acid inducible neural-specific 3
chr8_+_145438870 0.223 ENST00000527931.1
 FAM203B
family with sequence similarity 203, member B
chr1_+_12290121 0.207 ENST00000358136.3
ENST00000356315.4
 VPS13D

vacuolar protein sorting 13 homolog D (S. cerevisiae)

chr1_-_11863571 0.202 ENST00000376583.3
 MTHFR
methylenetetrahydrofolate reductase (NAD(P)H)
chr16_+_2255710 0.201 ENST00000397124.1
ENST00000565250.1
 MLST8

MTOR associated protein, LST8 homolog (S. cerevisiae)

chr6_-_150067696 0.186 ENST00000340413.2
ENST00000367403.3
 NUP43

nucleoporin 43kDa

chr3_+_148457585 0.177 ENST00000402260.1
 AGTR1
angiotensin II receptor, type 1
chr2_+_219246746 0.169 ENST00000233202.6
 SLC11A1
solute carrier family 11 (proton-coupled divalent metal ion transporter), member 1
chr10_+_17851362 0.166 ENST00000331429.2
ENST00000457317.1
 MRC1L1

cDNA FLJ56855, highly similar to Macrophage mannose receptor 1

chrX_-_49965663 0.164 ENST00000376056.2
ENST00000376058.2
ENST00000358526.2
 AKAP4


A kinase (PRKA) anchor protein 4


chr17_-_60142609 0.158 ENST00000397786.2
 MED13
mediator complex subunit 13
chr19_+_1041212 0.137 ENST00000433129.1
 ABCA7
ATP-binding cassette, sub-family A (ABC1), member 7
chr11_+_71846748 0.121 ENST00000445078.2
 FOLR3
folate receptor 3 (gamma)
chr2_-_48982857 0.115 ENST00000403273.1
ENST00000401907.1
ENST00000344775.3
 LHCGR


luteinizing hormone/choriogonadotropin receptor


chr11_+_71846764 0.104 ENST00000456237.1
ENST00000442948.2
ENST00000546166.1
 FOLR3


folate receptor 3 (gamma)


chr10_+_74870206 0.090 ENST00000357321.4
ENST00000349051.5
 NUDT13

nudix (nucleoside diphosphate linked moiety X)-type motif 13

chr10_+_62538248 0.082 ENST00000448257.2
 CDK1
cyclin-dependent kinase 1
chr2_+_136343820 0.080 ENST00000410054.1
 R3HDM1
R3H domain containing 1
chr12_-_109025849 0.080 ENST00000228463.6
 SELPLG
selectin P ligand
chr16_-_30122717 0.076 ENST00000566613.1
 GDPD3
glycerophosphodiester phosphodiesterase domain containing 3
chr10_+_62538089 0.065 ENST00000519078.2
ENST00000395284.3
ENST00000316629.4
 CDK1


cyclin-dependent kinase 1


chr7_-_15601595 0.063 ENST00000342526.3
 AGMO
alkylglycerol monooxygenase
chr10_+_74870253 0.062 ENST00000544879.1
ENST00000537969.1
ENST00000372997.3
 NUDT13


nudix (nucleoside diphosphate linked moiety X)-type motif 13


chr11_+_101785727 0.060 ENST00000263468.8
 KIAA1377
KIAA1377
chr2_-_163008903 0.055 ENST00000418842.2
ENST00000375497.3
 GCG

glucagon

chrX_-_49965009 0.053 ENST00000437370.1
ENST00000376064.3
ENST00000448865.1
 AKAP4


A kinase (PRKA) anchor protein 4


chr2_-_48982708 0.053 ENST00000428232.1
ENST00000405626.1
ENST00000294954.7
 LHCGR


luteinizing hormone/choriogonadotropin receptor


chr11_+_71238313 0.043 ENST00000398536.4
 KRTAP5-7
keratin associated protein 5-7
chr18_-_5396271 0.039 ENST00000579951.1
 EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr10_-_135187193 0.038 ENST00000368547.3
 ECHS1
enoyl CoA hydratase, short chain, 1, mitochondrial
chr7_+_47694842 0.030 ENST00000408988.2
 C7orf65
chromosome 7 open reading frame 65
chr6_-_62996066 0.024 ENST00000281156.4
 KHDRBS2
KH domain containing, RNA binding, signal transduction associated 2
chr11_-_73720122 0.006 ENST00000426995.2
 UCP3
uncoupling protein 3 (mitochondrial, proton carrier)

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0090467 L-arginine import(GO:0043091) arginine import(GO:0090467) L-arginine transport(GO:1902023)
0.1 1.6 GO:0048268 negative regulation of receptor-mediated endocytosis(GO:0048261) clathrin coat assembly(GO:0048268)
0.1 1.7 GO:0006825 copper ion transport(GO:0006825)
0.0 0.2 GO:0032754 positive regulation of interleukin-5 production(GO:0032754)
0.0 0.2 GO:2000858 renin-angiotensin regulation of aldosterone production(GO:0002018) regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) positive regulation of NAD(P)H oxidase activity(GO:0033864) mineralocorticoid secretion(GO:0035931) aldosterone secretion(GO:0035932) regulation of mineralocorticoid secretion(GO:2000855) regulation of aldosterone secretion(GO:2000858)
0.0 0.1 GO:0034501 protein localization to kinetochore(GO:0034501)
0.0 0.2 GO:0046886 positive regulation of hormone metabolic process(GO:0032352) positive regulation of hormone biosynthetic process(GO:0046886)
0.0 0.4 GO:0015701 bicarbonate transport(GO:0015701)
0.0 0.4 GO:0042776 mitochondrial ATP synthesis coupled proton transport(GO:0042776)
0.0 0.2 GO:0046655 folic acid metabolic process(GO:0046655)
0.0 0.2 GO:0015884 folic acid transport(GO:0015884)
0.0 0.2 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.0 0.2 GO:0030317 sperm motility(GO:0030317)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0009279 cell outer membrane(GO:0009279)
0.1 1.6 GO:0030122 AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128)
0.1 1.0 GO:0001527 microfibril(GO:0001527)
0.0 0.4 GO:0045261 proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261)
0.0 0.4 GO:0031080 nuclear pore outer ring(GO:0031080)
0.0 0.2 GO:0031233 intrinsic component of external side of plasma membrane(GO:0031233)
0.0 0.1 GO:0043190 ATP-binding cassette (ABC) transporter complex(GO:0043190)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.6 GO:0032050 clathrin heavy chain binding(GO:0032050)
0.1 0.3 GO:0004960 thromboxane receptor activity(GO:0004960) thromboxane A2 receptor activity(GO:0004961)
0.1 0.2 GO:0001596 angiotensin type I receptor activity(GO:0001596)
0.0 0.2 GO:0004489 methylenetetrahydrofolate reductase (NAD(P)H) activity(GO:0004489)
0.0 0.5 GO:0005384 manganese ion transmembrane transporter activity(GO:0005384)
0.0 1.7 GO:0005507 copper ion binding(GO:0005507)
0.0 0.5 GO:0005540 hyaluronic acid binding(GO:0005540)
0.0 0.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.4 GO:0005452 inorganic anion exchanger activity(GO:0005452)
0.0 0.2 GO:0005542 folic acid binding(GO:0005542)