Motif ID: DRGX_PROP1
Z-value: 1.582
Transcription factors associated with DRGX_PROP1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| DRGX | ENSG00000165606.4 | DRGX |
| PROP1 | ENSG00000175325.2 | PROP1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.6 | GO:0010430 | ethanol catabolic process(GO:0006068) fatty acid omega-oxidation(GO:0010430) |
| 0.8 | 2.5 | GO:0060318 | definitive erythrocyte differentiation(GO:0060318) |
| 0.3 | 1.4 | GO:0031936 | negative regulation of chromatin silencing(GO:0031936) |
| 0.3 | 1.3 | GO:0060259 | regulation of feeding behavior(GO:0060259) |
| 0.2 | 0.6 | GO:0010273 | regulation of oxidative phosphorylation(GO:0002082) detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169) |
| 0.2 | 0.6 | GO:0046292 | formaldehyde metabolic process(GO:0046292) |
| 0.2 | 0.8 | GO:0021759 | globus pallidus development(GO:0021759) menarche(GO:0042696) |
| 0.2 | 1.5 | GO:0051895 | negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392) |
| 0.2 | 0.7 | GO:0060743 | epithelial cell maturation involved in prostate gland development(GO:0060743) |
| 0.2 | 0.8 | GO:0007182 | common-partner SMAD protein phosphorylation(GO:0007182) |
| 0.2 | 1.0 | GO:0043316 | natural killer cell activation involved in immune response(GO:0002323) cytotoxic T cell degranulation(GO:0043316) natural killer cell degranulation(GO:0043320) |
| 0.1 | 3.5 | GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504) |
| 0.1 | 0.5 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
| 0.1 | 0.5 | GO:0046952 | ketone body catabolic process(GO:0046952) |
| 0.1 | 0.2 | GO:0007207 | phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
| 0.1 | 0.2 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.1 | 0.4 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.1 | 1.3 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
| 0.1 | 0.4 | GO:0007549 | dosage compensation(GO:0007549) |
| 0.1 | 0.3 | GO:0021527 | spinal cord association neuron differentiation(GO:0021527) neuron fate determination(GO:0048664) |
| 0.0 | 0.1 | GO:0045603 | positive regulation of endothelial cell differentiation(GO:0045603) |
| 0.0 | 0.2 | GO:0043438 | acetoacetic acid metabolic process(GO:0043438) ketone body metabolic process(GO:1902224) |
| 0.0 | 0.5 | GO:0006570 | tyrosine metabolic process(GO:0006570) |
| 0.0 | 0.6 | GO:0060736 | prostate gland growth(GO:0060736) |
| 0.0 | 0.1 | GO:0042415 | norepinephrine metabolic process(GO:0042415) |
| 0.0 | 0.7 | GO:0090399 | replicative senescence(GO:0090399) |
| 0.0 | 0.2 | GO:1902913 | positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942) positive regulation of neuroepithelial cell differentiation(GO:1902913) |
| 0.0 | 1.4 | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124) |
| 0.0 | 0.1 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.0 | 0.8 | GO:0042462 | eye photoreceptor cell development(GO:0042462) |
| 0.0 | 0.3 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.0 | 0.5 | GO:0034453 | microtubule nucleation(GO:0007020) microtubule anchoring(GO:0034453) |
| 0.0 | 0.2 | GO:0019985 | translesion synthesis(GO:0019985) |
| 0.0 | 0.1 | GO:0070172 | positive regulation of tooth mineralization(GO:0070172) |
| 0.0 | 0.2 | GO:0034695 | response to prostaglandin E(GO:0034695) |
| 0.0 | 0.2 | GO:0000244 | spliceosomal tri-snRNP complex assembly(GO:0000244) |
| 0.0 | 0.8 | GO:0046847 | filopodium assembly(GO:0046847) |
| 0.0 | 0.1 | GO:0007210 | serotonin receptor signaling pathway(GO:0007210) |
| 0.0 | 0.3 | GO:0042255 | ribosome assembly(GO:0042255) |
| 0.0 | 0.7 | GO:0001708 | cell fate specification(GO:0001708) |
| 0.0 | 0.6 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.0 | 1.7 | GO:0051592 | response to calcium ion(GO:0051592) |
| 0.0 | 0.5 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
| 0.0 | 0.4 | GO:0019933 | cAMP-mediated signaling(GO:0019933) |
| 0.0 | 3.5 | GO:0007601 | visual perception(GO:0007601) |
| 0.0 | 0.5 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.0 | 0.3 | GO:0007398 | ectoderm development(GO:0007398) |
| 0.0 | 0.3 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.0 | 1.0 | GO:0030833 | regulation of actin filament polymerization(GO:0030833) |
| 0.0 | 0.1 | GO:0015824 | proline transport(GO:0015824) |
| 0.0 | 0.1 | GO:0007500 | mesodermal cell fate determination(GO:0007500) |
| 0.0 | 0.1 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
| 0.0 | 5.4 | GO:0006954 | inflammatory response(GO:0006954) |
| 0.0 | 0.8 | GO:0061025 | membrane fusion(GO:0061025) |
| 0.0 | 0.7 | GO:0030902 | hindbrain development(GO:0030902) |
| 0.0 | 0.5 | GO:0019233 | sensory perception of pain(GO:0019233) |
| 0.0 | 0.7 | GO:0006334 | nucleosome assembly(GO:0006334) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 2.5 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
| 0.2 | 3.5 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.2 | 1.8 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.1 | 0.7 | GO:0033162 | melanosome membrane(GO:0033162) chitosome(GO:0045009) |
| 0.1 | 0.4 | GO:0001740 | Barr body(GO:0001740) |
| 0.1 | 0.8 | GO:0008091 | spectrin(GO:0008091) |
| 0.1 | 0.5 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.1 | 0.7 | GO:0071778 | obsolete WINAC complex(GO:0071778) |
| 0.0 | 0.2 | GO:0005687 | U4 snRNP(GO:0005687) U4/U6 x U5 tri-snRNP complex(GO:0046540) spliceosomal tri-snRNP complex(GO:0097526) |
| 0.0 | 1.3 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 0.3 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 0.5 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.0 | 0.6 | GO:0030140 | trans-Golgi network transport vesicle(GO:0030140) |
| 0.0 | 1.5 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 0.1 | GO:0042584 | chromaffin granule(GO:0042583) chromaffin granule membrane(GO:0042584) |
| 0.0 | 0.2 | GO:0042575 | DNA polymerase complex(GO:0042575) |
| 0.0 | 0.8 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 0.2 | GO:0017119 | Golgi transport complex(GO:0017119) |
| 0.0 | 0.1 | GO:0002102 | podosome(GO:0002102) |
| 0.0 | 0.2 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.0 | 1.5 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 0.8 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 1.0 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.0 | 0.1 | GO:0070081 | clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083) |
| 0.0 | 0.7 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 0.7 | GO:0000781 | chromosome, telomeric region(GO:0000781) |
| 0.0 | 4.1 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 0.3 | GO:0005891 | voltage-gated calcium channel complex(GO:0005891) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.6 | GO:0035276 | ethanol binding(GO:0035276) |
| 0.4 | 1.6 | GO:0043024 | ribosomal small subunit binding(GO:0043024) |
| 0.3 | 1.4 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.2 | 2.5 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
| 0.2 | 0.5 | GO:0003858 | 3-hydroxybutyrate dehydrogenase activity(GO:0003858) |
| 0.2 | 1.5 | GO:0016004 | phospholipase activator activity(GO:0016004) |
| 0.2 | 0.6 | GO:0016531 | copper chaperone activity(GO:0016531) |
| 0.2 | 0.6 | GO:0004663 | Rab geranylgeranyltransferase activity(GO:0004663) |
| 0.1 | 2.0 | GO:0017091 | AU-rich element binding(GO:0017091) |
| 0.1 | 1.0 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.1 | 2.6 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.1 | 0.5 | GO:0004167 | dopachrome isomerase activity(GO:0004167) |
| 0.1 | 0.4 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.1 | 0.5 | GO:0008107 | galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127) |
| 0.1 | 1.4 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.1 | 0.5 | GO:0005237 | inhibitory extracellular ligand-gated ion channel activity(GO:0005237) |
| 0.1 | 0.6 | GO:0070215 | obsolete MDM2 binding(GO:0070215) |
| 0.1 | 1.3 | GO:0043499 | obsolete eukaryotic cell surface binding(GO:0043499) |
| 0.0 | 0.3 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.0 | 1.3 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
| 0.0 | 0.4 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.0 | 0.2 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
| 0.0 | 0.2 | GO:0004060 | arylamine N-acetyltransferase activity(GO:0004060) |
| 0.0 | 0.4 | GO:0031013 | troponin I binding(GO:0031013) |
| 0.0 | 0.4 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 0.5 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 0.1 | GO:0016715 | oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced ascorbate as one donor, and incorporation of one atom of oxygen(GO:0016715) |
| 0.0 | 0.9 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 0.1 | GO:0046848 | hydroxyapatite binding(GO:0046848) |
| 0.0 | 1.9 | GO:0003704 | obsolete specific RNA polymerase II transcription factor activity(GO:0003704) |
| 0.0 | 0.5 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 0.8 | GO:0008601 | protein phosphatase type 2A regulator activity(GO:0008601) |
| 0.0 | 0.3 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.0 | 1.2 | GO:0005262 | calcium channel activity(GO:0005262) |
| 0.0 | 0.3 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 6.0 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
| 0.0 | 0.4 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
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