Motif ID: DUXA
Z-value: 1.188
Transcription factors associated with DUXA:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| DUXA | ENSG00000258873.2 | DUXA |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.2 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
| 0.3 | 2.0 | GO:0007499 | ectoderm and mesoderm interaction(GO:0007499) |
| 0.2 | 2.0 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.2 | 1.0 | GO:0035630 | glycolate metabolic process(GO:0009441) bone mineralization involved in bone maturation(GO:0035630) |
| 0.1 | 0.5 | GO:0051902 | negative regulation of mitochondrial depolarization(GO:0051902) negative regulation of membrane depolarization(GO:1904180) |
| 0.1 | 0.8 | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185) |
| 0.1 | 0.3 | GO:0072677 | eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677) |
| 0.1 | 0.3 | GO:0033262 | regulation of nuclear cell cycle DNA replication(GO:0033262) replication fork protection(GO:0048478) |
| 0.1 | 0.2 | GO:0003056 | regulation of vascular smooth muscle contraction(GO:0003056) |
| 0.1 | 0.5 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.1 | 0.3 | GO:0015670 | carbon dioxide transport(GO:0015670) |
| 0.1 | 0.6 | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037) |
| 0.1 | 0.2 | GO:0048003 | antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) |
| 0.0 | 0.2 | GO:0014742 | positive regulation of cardiac muscle hypertrophy(GO:0010613) positive regulation of muscle hypertrophy(GO:0014742) |
| 0.0 | 0.2 | GO:0072205 | collecting duct development(GO:0072044) metanephric tubule development(GO:0072170) metanephric collecting duct development(GO:0072205) metanephric epithelium development(GO:0072207) metanephric nephron tubule development(GO:0072234) metanephric nephron epithelium development(GO:0072243) |
| 0.0 | 0.2 | GO:0001514 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.0 | 0.1 | GO:0010273 | regulation of oxidative phosphorylation(GO:0002082) detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169) |
| 0.0 | 0.3 | GO:0006069 | ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069) |
| 0.0 | 0.2 | GO:0044245 | polysaccharide digestion(GO:0044245) |
| 0.0 | 0.1 | GO:0009698 | phenylpropanoid metabolic process(GO:0009698) coumarin metabolic process(GO:0009804) |
| 0.0 | 0.8 | GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504) |
| 0.0 | 0.3 | GO:0098927 | early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927) |
| 0.0 | 0.1 | GO:0002887 | negative regulation of myeloid leukocyte mediated immunity(GO:0002887) negative regulation of leukocyte degranulation(GO:0043301) |
| 0.0 | 0.2 | GO:0015889 | cobalamin transport(GO:0015889) |
| 0.0 | 0.3 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.0 | 0.5 | GO:0006596 | polyamine biosynthetic process(GO:0006596) |
| 0.0 | 0.3 | GO:0042447 | hormone catabolic process(GO:0042447) |
| 0.0 | 0.1 | GO:0032581 | ER-dependent peroxisome organization(GO:0032581) |
| 0.0 | 0.1 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 0.0 | 0.2 | GO:0051290 | protein heterotetramerization(GO:0051290) |
| 0.0 | 0.2 | GO:0045056 | transcytosis(GO:0045056) |
| 0.0 | 0.1 | GO:0034371 | positive regulation of sequestering of triglyceride(GO:0010890) chylomicron remodeling(GO:0034371) |
| 0.0 | 2.4 | GO:0006754 | ATP biosynthetic process(GO:0006754) |
| 0.0 | 0.3 | GO:0033523 | histone monoubiquitination(GO:0010390) histone H2B ubiquitination(GO:0033523) |
| 0.0 | 0.1 | GO:0090400 | stress-induced premature senescence(GO:0090400) |
| 0.0 | 0.7 | GO:0050931 | melanocyte differentiation(GO:0030318) pigment cell differentiation(GO:0050931) |
| 0.0 | 0.3 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.0 | 0.2 | GO:0048268 | clathrin coat assembly(GO:0048268) |
| 0.0 | 0.6 | GO:0046329 | negative regulation of JNK cascade(GO:0046329) |
| 0.0 | 0.4 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.0 | 0.2 | GO:0006657 | CDP-choline pathway(GO:0006657) |
| 0.0 | 0.0 | GO:0032416 | negative regulation of sodium:proton antiporter activity(GO:0032416) negative regulation of sodium ion transmembrane transport(GO:1902306) negative regulation of sodium ion transmembrane transporter activity(GO:2000650) |
| 0.0 | 0.1 | GO:0051085 | chaperone mediated protein folding requiring cofactor(GO:0051085) |
| 0.0 | 0.0 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
| 0.0 | 0.7 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.0 | 0.1 | GO:0048702 | embryonic neurocranium morphogenesis(GO:0048702) |
| 0.0 | 0.2 | GO:0050930 | induction of positive chemotaxis(GO:0050930) |
| 0.0 | 0.1 | GO:0007603 | phototransduction, visible light(GO:0007603) |
| 0.0 | 0.1 | GO:0016540 | protein autoprocessing(GO:0016540) |
| 0.0 | 0.1 | GO:0005984 | disaccharide metabolic process(GO:0005984) |
| 0.0 | 0.3 | GO:0045730 | respiratory burst(GO:0045730) |
| 0.0 | 0.3 | GO:0042730 | fibrinolysis(GO:0042730) |
| 0.0 | 0.0 | GO:0007206 | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) |
| 0.0 | 0.4 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.0 | 0.3 | GO:0050909 | sensory perception of taste(GO:0050909) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 1.0 | GO:0016942 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 0.1 | 2.2 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.1 | 0.5 | GO:0019815 | immunoglobulin complex(GO:0019814) B cell receptor complex(GO:0019815) |
| 0.1 | 0.4 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 0.3 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.0 | 0.3 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.0 | 0.8 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 0.2 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.0 | 0.3 | GO:0016272 | prefoldin complex(GO:0016272) |
| 0.0 | 0.5 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.0 | 0.3 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 0.2 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.0 | 0.5 | GO:0001527 | microfibril(GO:0001527) |
| 0.0 | 0.2 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.0 | 0.2 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 0.3 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
| 0.0 | 0.3 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 0.2 | GO:0032389 | MutLalpha complex(GO:0032389) |
| 0.0 | 0.2 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 0.2 | GO:0030122 | AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) |
| 0.0 | 0.5 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 0.9 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 0.2 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 1.0 | GO:0016363 | nuclear matrix(GO:0016363) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.0 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) |
| 0.2 | 0.9 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.1 | 2.2 | GO:0042166 | acetylcholine binding(GO:0042166) |
| 0.1 | 0.4 | GO:0070052 | collagen V binding(GO:0070052) |
| 0.1 | 0.5 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.1 | 2.1 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.1 | 0.3 | GO:0004024 | alcohol dehydrogenase activity, zinc-dependent(GO:0004024) |
| 0.1 | 2.0 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 1.1 | GO:0008484 | sulfuric ester hydrolase activity(GO:0008484) |
| 0.1 | 0.2 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.0 | 0.3 | GO:0030506 | ankyrin binding(GO:0030506) |
| 0.0 | 0.2 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
| 0.0 | 0.2 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.0 | 0.8 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.0 | 0.5 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.0 | 0.2 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
| 0.0 | 0.1 | GO:0017129 | triglyceride binding(GO:0017129) |
| 0.0 | 0.2 | GO:0031404 | chloride ion binding(GO:0031404) |
| 0.0 | 0.3 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
| 0.0 | 1.0 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.0 | 0.2 | GO:0004703 | G-protein coupled receptor kinase activity(GO:0004703) |
| 0.0 | 0.2 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.0 | 0.3 | GO:0008527 | taste receptor activity(GO:0008527) |
| 0.0 | 0.2 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.0 | 0.1 | GO:0016531 | copper chaperone activity(GO:0016531) |
| 0.0 | 0.3 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093) |
| 0.0 | 0.1 | GO:0004083 | bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619) |
| 0.0 | 0.1 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.0 | 0.8 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 0.3 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
| 0.0 | 0.6 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 0.2 | GO:0047035 | testosterone dehydrogenase (NAD+) activity(GO:0047035) |
| 0.0 | 0.2 | GO:0033612 | receptor serine/threonine kinase binding(GO:0033612) |
| 0.0 | 0.1 | GO:0004447 | iodide peroxidase activity(GO:0004447) |
| 0.0 | 0.0 | GO:0004535 | poly(A)-specific ribonuclease activity(GO:0004535) |
| 0.0 | 0.1 | GO:0004461 | lactose synthase activity(GO:0004461) |
| 0.0 | 0.1 | GO:0034190 | apolipoprotein receptor binding(GO:0034190) |
| 0.0 | 0.2 | GO:0016421 | CoA carboxylase activity(GO:0016421) |
| 0.0 | 0.1 | GO:0004955 | prostaglandin receptor activity(GO:0004955) |
| 0.0 | 0.1 | GO:0070568 | guanylyltransferase activity(GO:0070568) |
| 0.0 | 0.2 | GO:0016565 | obsolete general transcriptional repressor activity(GO:0016565) |
| 0.0 | 0.0 | GO:0003829 | beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829) |
| 0.0 | 0.6 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.0 | 0.4 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.1 | GO:0019863 | IgE binding(GO:0019863) |
| 0.0 | 0.1 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.0 | 0.0 | GO:0046848 | hydroxyapatite binding(GO:0046848) |
| 0.0 | 0.2 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 0.2 | GO:0031593 | polyubiquitin binding(GO:0031593) |
| 0.0 | 0.6 | GO:0004860 | protein kinase inhibitor activity(GO:0004860) |
| 0.0 | 1.2 | GO:0016566 | obsolete specific transcriptional repressor activity(GO:0016566) |
| 0.0 | 1.1 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.5 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 0.3 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
