Motif ID: E2F8
Z-value: 1.589
Transcription factors associated with E2F8:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| E2F8 | ENSG00000129173.8 | E2F8 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.6 | GO:0033364 | mast cell secretory granule organization(GO:0033364) |
| 0.8 | 3.2 | GO:0071313 | cellular response to caffeine(GO:0071313) |
| 0.7 | 1.4 | GO:0006269 | DNA replication, synthesis of RNA primer(GO:0006269) |
| 0.7 | 2.1 | GO:0007079 | mitotic chromosome movement towards spindle pole(GO:0007079) chromosome movement towards spindle pole(GO:0051305) |
| 0.5 | 1.5 | GO:0006273 | lagging strand elongation(GO:0006273) |
| 0.5 | 1.4 | GO:0021570 | rhombomere 4 development(GO:0021570) |
| 0.5 | 1.4 | GO:1901724 | positive regulation of cell proliferation involved in kidney development(GO:1901724) |
| 0.4 | 1.2 | GO:0000059 | protein import into nucleus, docking(GO:0000059) |
| 0.4 | 12.7 | GO:0006271 | DNA strand elongation involved in DNA replication(GO:0006271) |
| 0.4 | 1.4 | GO:0034086 | maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088) |
| 0.3 | 1.4 | GO:0032075 | positive regulation of nuclease activity(GO:0032075) |
| 0.3 | 1.1 | GO:0018352 | protein-pyridoxal-5-phosphate linkage(GO:0018352) |
| 0.2 | 0.7 | GO:0006167 | AMP biosynthetic process(GO:0006167) |
| 0.2 | 0.7 | GO:0046604 | regulation of mitotic centrosome separation(GO:0046602) positive regulation of mitotic centrosome separation(GO:0046604) |
| 0.2 | 0.6 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.2 | 1.3 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 0.2 | 0.6 | GO:0000354 | cis assembly of pre-catalytic spliceosome(GO:0000354) |
| 0.2 | 0.6 | GO:0046826 | negative regulation of protein export from nucleus(GO:0046826) |
| 0.2 | 0.6 | GO:0090267 | positive regulation of spindle checkpoint(GO:0090232) regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090266) positive regulation of mitotic cell cycle spindle assembly checkpoint(GO:0090267) positive regulation of cell cycle checkpoint(GO:1901978) regulation of mitotic spindle checkpoint(GO:1903504) |
| 0.1 | 0.6 | GO:0009186 | deoxyribonucleoside diphosphate metabolic process(GO:0009186) |
| 0.1 | 0.4 | GO:0021919 | BMP signaling pathway involved in spinal cord dorsal/ventral patterning(GO:0021919) |
| 0.1 | 0.9 | GO:0051383 | kinetochore assembly(GO:0051382) kinetochore organization(GO:0051383) |
| 0.1 | 0.6 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 0.1 | 0.5 | GO:0019985 | translesion synthesis(GO:0019985) |
| 0.1 | 1.1 | GO:0006516 | glycoprotein catabolic process(GO:0006516) |
| 0.1 | 1.0 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.1 | 1.3 | GO:0007096 | regulation of exit from mitosis(GO:0007096) |
| 0.1 | 0.9 | GO:0046653 | tetrahydrofolate metabolic process(GO:0046653) |
| 0.1 | 0.4 | GO:0034723 | DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.1 | 0.2 | GO:0071848 | regulation of fever generation by regulation of prostaglandin secretion(GO:0071810) positive regulation of fever generation by positive regulation of prostaglandin secretion(GO:0071812) TNFSF11-mediated signaling pathway(GO:0071847) positive regulation of ERK1 and ERK2 cascade via TNFSF11-mediated signaling(GO:0071848) regulation of fever generation by prostaglandin secretion(GO:0100009) |
| 0.1 | 0.7 | GO:0031498 | nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986) negative regulation of histone acetylation(GO:0035067) negative regulation of protein acetylation(GO:1901984) negative regulation of peptidyl-lysine acetylation(GO:2000757) |
| 0.1 | 0.6 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.1 | 0.4 | GO:0021513 | spinal cord dorsal/ventral patterning(GO:0021513) |
| 0.1 | 0.6 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.1 | 0.5 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 0.1 | 0.2 | GO:0001830 | trophectodermal cell fate commitment(GO:0001830) |
| 0.1 | 0.8 | GO:0006910 | phagocytosis, recognition(GO:0006910) |
| 0.1 | 0.1 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) negative regulation of histone modification(GO:0031057) |
| 0.1 | 0.4 | GO:0006102 | isocitrate metabolic process(GO:0006102) |
| 0.0 | 0.5 | GO:0046498 | S-adenosylhomocysteine metabolic process(GO:0046498) |
| 0.0 | 0.5 | GO:0033683 | nucleotide-excision repair, DNA incision(GO:0033683) |
| 0.0 | 0.3 | GO:0010642 | negative regulation of platelet-derived growth factor receptor signaling pathway(GO:0010642) |
| 0.0 | 0.1 | GO:0048852 | diencephalon morphogenesis(GO:0048852) |
| 0.0 | 0.5 | GO:0045749 | obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749) |
| 0.0 | 0.3 | GO:0044818 | mitotic G2/M transition checkpoint(GO:0044818) protein neddylation(GO:0045116) |
| 0.0 | 0.6 | GO:0070059 | intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059) |
| 0.0 | 0.4 | GO:0008612 | peptidyl-lysine modification to peptidyl-hypusine(GO:0008612) |
| 0.0 | 0.9 | GO:0006283 | transcription-coupled nucleotide-excision repair(GO:0006283) |
| 0.0 | 1.2 | GO:0030239 | myofibril assembly(GO:0030239) |
| 0.0 | 17.0 | GO:0000122 | negative regulation of transcription from RNA polymerase II promoter(GO:0000122) |
| 0.0 | 0.3 | GO:0055091 | phospholipid homeostasis(GO:0055091) |
| 0.0 | 1.0 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.0 | 0.3 | GO:0006734 | NADH metabolic process(GO:0006734) |
| 0.0 | 0.2 | GO:0045652 | regulation of megakaryocyte differentiation(GO:0045652) regulation of hematopoietic progenitor cell differentiation(GO:1901532) |
| 0.0 | 0.6 | GO:0007032 | endosome organization(GO:0007032) |
| 0.0 | 0.6 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 0.6 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
| 0.0 | 0.6 | GO:0006270 | DNA replication initiation(GO:0006270) |
| 0.0 | 1.5 | GO:0006383 | transcription from RNA polymerase III promoter(GO:0006383) |
| 0.0 | 0.5 | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) extrinsic apoptotic signaling pathway(GO:0097191) |
| 0.0 | 0.2 | GO:0032288 | myelin assembly(GO:0032288) |
| 0.0 | 0.3 | GO:0000083 | regulation of transcription involved in G1/S transition of mitotic cell cycle(GO:0000083) |
| 0.0 | 0.1 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
| 0.0 | 0.6 | GO:0006986 | response to unfolded protein(GO:0006986) |
| 0.0 | 0.3 | GO:0001522 | pseudouridine synthesis(GO:0001522) |
| 0.0 | 0.4 | GO:0006596 | polyamine biosynthetic process(GO:0006596) |
| 0.0 | 0.3 | GO:0060736 | prostate gland growth(GO:0060736) |
| 0.0 | 0.5 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
| 0.0 | 1.7 | GO:0031497 | chromatin assembly(GO:0031497) |
| 0.0 | 0.2 | GO:0034644 | cellular response to UV(GO:0034644) |
| 0.0 | 0.3 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.0 | 0.1 | GO:0009174 | UMP biosynthetic process(GO:0006222) pyrimidine nucleoside monophosphate biosynthetic process(GO:0009130) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049) |
| 0.0 | 0.4 | GO:0014823 | response to activity(GO:0014823) |
| 0.0 | 0.7 | GO:0043484 | regulation of RNA splicing(GO:0043484) |
| 0.0 | 0.1 | GO:0070189 | kynurenine metabolic process(GO:0070189) |
| 0.0 | 1.1 | GO:0097696 | JAK-STAT cascade(GO:0007259) STAT cascade(GO:0097696) |
| 0.0 | 0.2 | GO:0048169 | regulation of long-term neuronal synaptic plasticity(GO:0048169) |
| 0.0 | 0.7 | GO:0007517 | muscle organ development(GO:0007517) |
| 0.0 | 0.0 | GO:0001832 | blastocyst growth(GO:0001832) inner cell mass cell proliferation(GO:0001833) |
| 0.0 | 0.6 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 0.0 | GO:0031635 | adenylate cyclase-inhibiting opioid receptor signaling pathway(GO:0031635) opioid receptor signaling pathway(GO:0038003) |
| 0.0 | 0.2 | GO:0031570 | DNA integrity checkpoint(GO:0031570) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.2 | 3.6 | GO:0042629 | mast cell granule(GO:0042629) |
| 0.6 | 6.9 | GO:0042555 | MCM complex(GO:0042555) |
| 0.4 | 2.2 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 0.3 | 3.7 | GO:0030894 | replisome(GO:0030894) nuclear replisome(GO:0043601) |
| 0.2 | 2.1 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.2 | 1.0 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.2 | 17.7 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.2 | 1.5 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.2 | 0.9 | GO:0000444 | MIS12/MIND type complex(GO:0000444) |
| 0.2 | 1.3 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 0.2 | 0.5 | GO:0000439 | core TFIIH complex(GO:0000439) |
| 0.2 | 0.6 | GO:0031436 | BRCA1-BARD1 complex(GO:0031436) |
| 0.2 | 0.6 | GO:0000306 | extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313) |
| 0.1 | 3.3 | GO:0005657 | replication fork(GO:0005657) |
| 0.1 | 0.4 | GO:0005873 | plus-end kinesin complex(GO:0005873) |
| 0.1 | 0.5 | GO:0042575 | DNA polymerase complex(GO:0042575) |
| 0.1 | 0.8 | GO:0005828 | kinetochore microtubule(GO:0005828) |
| 0.1 | 0.6 | GO:0005682 | U5 snRNP(GO:0005682) |
| 0.1 | 0.6 | GO:0032039 | integrator complex(GO:0032039) |
| 0.1 | 0.5 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.1 | 0.6 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.0 | 1.0 | GO:0045263 | proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263) |
| 0.0 | 0.2 | GO:0031428 | box C/D snoRNP complex(GO:0031428) |
| 0.0 | 2.4 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 0.9 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 1.8 | GO:0030863 | cortical cytoskeleton(GO:0030863) |
| 0.0 | 0.4 | GO:0005678 | obsolete chromatin assembly complex(GO:0005678) |
| 0.0 | 1.5 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 0.3 | GO:0005732 | small nucleolar ribonucleoprotein complex(GO:0005732) |
| 0.0 | 0.2 | GO:0043218 | compact myelin(GO:0043218) |
| 0.0 | 0.2 | GO:0031465 | Cul4B-RING E3 ubiquitin ligase complex(GO:0031465) |
| 0.0 | 0.7 | GO:0030530 | obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530) |
| 0.0 | 1.2 | GO:0000775 | chromosome, centromeric region(GO:0000775) |
| 0.0 | 0.1 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 0.0 | 0.3 | GO:0005689 | U12-type spliceosomal complex(GO:0005689) |
| 0.0 | 0.2 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 0.7 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 1.8 | GO:0000793 | condensed chromosome(GO:0000793) |
| 0.0 | 0.1 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.0 | 1.3 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 2.9 | GO:0005813 | centrosome(GO:0005813) |
| 0.0 | 0.2 | GO:0005763 | organellar small ribosomal subunit(GO:0000314) mitochondrial small ribosomal subunit(GO:0005763) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.4 | GO:0003896 | DNA primase activity(GO:0003896) |
| 0.4 | 1.3 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.3 | 0.9 | GO:0004146 | dihydrofolate reductase activity(GO:0004146) |
| 0.2 | 1.0 | GO:0004140 | dephospho-CoA kinase activity(GO:0004140) |
| 0.2 | 1.5 | GO:0008296 | 3'-5'-exodeoxyribonuclease activity(GO:0008296) |
| 0.2 | 0.5 | GO:0032558 | purine deoxyribonucleotide binding(GO:0032554) adenyl deoxyribonucleotide binding(GO:0032558) dATP binding(GO:0032564) |
| 0.2 | 1.9 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.2 | 18.0 | GO:0016566 | obsolete specific transcriptional repressor activity(GO:0016566) |
| 0.1 | 0.6 | GO:0061731 | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor(GO:0004748) oxidoreductase activity, acting on CH or CH2 groups, disulfide as acceptor(GO:0016728) ribonucleoside-diphosphate reductase activity(GO:0061731) |
| 0.1 | 1.4 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.1 | 0.6 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 0.1 | 0.8 | GO:0008429 | phosphatidylethanolamine binding(GO:0008429) |
| 0.1 | 0.6 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.1 | 0.3 | GO:0017129 | triglyceride binding(GO:0017129) |
| 0.1 | 1.4 | GO:0016565 | obsolete general transcriptional repressor activity(GO:0016565) |
| 0.1 | 0.3 | GO:0030611 | arsenate reductase activity(GO:0030611) |
| 0.1 | 3.7 | GO:0004003 | ATP-dependent DNA helicase activity(GO:0004003) |
| 0.1 | 0.7 | GO:0016842 | amidine-lyase activity(GO:0016842) |
| 0.1 | 2.0 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.1 | 0.4 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
| 0.1 | 0.2 | GO:0003707 | steroid hormone receptor activity(GO:0003707) |
| 0.1 | 1.2 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.1 | 0.3 | GO:0030060 | L-malate dehydrogenase activity(GO:0030060) |
| 0.1 | 0.4 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.1 | 0.3 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.1 | 1.2 | GO:0004004 | ATP-dependent RNA helicase activity(GO:0004004) |
| 0.1 | 0.4 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 0.1 | 0.4 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
| 0.1 | 0.2 | GO:0033743 | peptide-methionine (R)-S-oxide reductase activity(GO:0033743) |
| 0.1 | 1.6 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.0 | 0.7 | GO:0017025 | TBP-class protein binding(GO:0017025) |
| 0.0 | 2.3 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062) |
| 0.0 | 1.4 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 1.3 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 0.7 | GO:0005092 | GDP-dissociation inhibitor activity(GO:0005092) |
| 0.0 | 2.3 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.1 | GO:0035198 | miRNA binding(GO:0035198) |
| 0.0 | 0.3 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.0 | 2.3 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 0.3 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.0 | 0.1 | GO:0016531 | copper chaperone activity(GO:0016531) |
| 0.0 | 0.2 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.0 | 0.6 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 0.2 | GO:0050733 | RS domain binding(GO:0050733) |
| 0.0 | 0.4 | GO:0070403 | 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857) NAD+ binding(GO:0070403) |
| 0.0 | 0.1 | GO:0019103 | pyrimidine nucleotide binding(GO:0019103) |
| 0.0 | 0.6 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 0.3 | GO:0008641 | small protein activating enzyme activity(GO:0008641) |
| 0.0 | 0.4 | GO:0031418 | L-ascorbic acid binding(GO:0031418) |
| 0.0 | 0.2 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.0 | 0.7 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 0.8 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 0.0 | 0.2 | GO:0030515 | snoRNA binding(GO:0030515) |
| 0.0 | 0.9 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
| 0.0 | 0.3 | GO:0004437 | obsolete inositol or phosphatidylinositol phosphatase activity(GO:0004437) |
| 0.0 | 0.4 | GO:0008173 | RNA methyltransferase activity(GO:0008173) |
| 0.0 | 0.3 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.0 | 0.1 | GO:0046404 | ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734) |
| 0.0 | 0.5 | GO:0008601 | protein phosphatase type 2A regulator activity(GO:0008601) |
| 0.0 | 0.1 | GO:0004996 | thyroid-stimulating hormone receptor activity(GO:0004996) |
| 0.0 | 0.2 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) |
| 0.0 | 0.9 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 0.1 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.0 | 0.1 | GO:0004791 | thioredoxin-disulfide reductase activity(GO:0004791) |
| 0.0 | 0.6 | GO:0050136 | NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.0 | GO:0004988 | obsolete mu-opioid receptor activity(GO:0004988) |
| 0.0 | 0.5 | GO:0002039 | p53 binding(GO:0002039) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.1 | SA_G2_AND_M_PHASES | Cdc25 activates the cdc2/cyclin B complex to induce the G2/M transition. |
| 0.0 | 0.8 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 1.7 | SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 0.3 | SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES | Genes related to the insulin receptor pathway |
