Motif ID: ESR1
Z-value: 1.556
Transcription factors associated with ESR1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| ESR1 | ENSG00000091831.17 | ESR1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 5.3 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.4 | 1.1 | GO:0051712 | positive regulation of killing of cells of other organism(GO:0051712) |
| 0.3 | 0.9 | GO:1903961 | positive regulation of plasma membrane long-chain fatty acid transport(GO:0010747) positive regulation of anion transmembrane transport(GO:1903961) |
| 0.3 | 0.9 | GO:0072677 | eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677) |
| 0.3 | 0.9 | GO:0034135 | innate immune response in mucosa(GO:0002227) mucosal immune response(GO:0002385) antibacterial humoral response(GO:0019731) regulation of toll-like receptor 2 signaling pathway(GO:0034135) activation of MAPK activity involved in innate immune response(GO:0035419) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585) |
| 0.3 | 0.9 | GO:0001757 | somite specification(GO:0001757) |
| 0.2 | 0.7 | GO:0071539 | protein localization to centrosome(GO:0071539) |
| 0.2 | 0.7 | GO:0042097 | lymphotoxin A production(GO:0032641) interleukin-4 biosynthetic process(GO:0042097) lymphotoxin A biosynthetic process(GO:0042109) regulation of interleukin-4 biosynthetic process(GO:0045402) positive regulation of interleukin-4 biosynthetic process(GO:0045404) |
| 0.2 | 0.7 | GO:0016554 | cytidine to uridine editing(GO:0016554) |
| 0.2 | 0.7 | GO:0006307 | DNA dealkylation involved in DNA repair(GO:0006307) DNA dealkylation(GO:0035510) |
| 0.2 | 1.2 | GO:0030186 | melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187) |
| 0.2 | 1.0 | GO:0010993 | ubiquitin homeostasis(GO:0010992) regulation of ubiquitin homeostasis(GO:0010993) free ubiquitin chain polymerization(GO:0010994) |
| 0.2 | 0.5 | GO:0045198 | establishment of epithelial cell apical/basal polarity(GO:0045198) |
| 0.2 | 0.5 | GO:0048496 | maintenance of organ identity(GO:0048496) |
| 0.2 | 0.5 | GO:0045656 | negative regulation of monocyte differentiation(GO:0045656) |
| 0.1 | 1.0 | GO:0002726 | positive regulation of T cell cytokine production(GO:0002726) |
| 0.1 | 0.5 | GO:0071364 | cellular response to epidermal growth factor stimulus(GO:0071364) |
| 0.1 | 0.6 | GO:0072526 | pyridine-containing compound catabolic process(GO:0072526) |
| 0.1 | 0.5 | GO:0001969 | activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969) positive regulation of activation of membrane attack complex(GO:0001970) positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259) |
| 0.1 | 0.5 | GO:0043441 | acetoacetic acid biosynthetic process(GO:0043441) |
| 0.1 | 0.5 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 0.1 | 0.4 | GO:0015910 | peroxisomal long-chain fatty acid import(GO:0015910) |
| 0.1 | 1.0 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.1 | 0.3 | GO:0046015 | carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015) positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522) |
| 0.1 | 0.6 | GO:0046121 | deoxyribonucleoside catabolic process(GO:0046121) |
| 0.1 | 0.3 | GO:0006051 | mannosamine metabolic process(GO:0006050) N-acetylmannosamine metabolic process(GO:0006051) |
| 0.1 | 0.2 | GO:0060297 | regulation of sarcomere organization(GO:0060297) |
| 0.1 | 1.8 | GO:0008635 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635) |
| 0.1 | 0.6 | GO:0009450 | gamma-aminobutyric acid catabolic process(GO:0009450) |
| 0.1 | 0.9 | GO:0009404 | toxin metabolic process(GO:0009404) |
| 0.1 | 1.4 | GO:0071230 | cellular response to amino acid stimulus(GO:0071230) |
| 0.1 | 0.3 | GO:0007262 | STAT protein import into nucleus(GO:0007262) |
| 0.1 | 0.5 | GO:0000089 | mitotic metaphase(GO:0000089) |
| 0.1 | 0.5 | GO:0021520 | spinal cord motor neuron cell fate specification(GO:0021520) |
| 0.1 | 4.0 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.1 | 0.7 | GO:0001706 | endoderm formation(GO:0001706) |
| 0.1 | 0.5 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.1 | 0.2 | GO:1903115 | regulation of muscle filament sliding(GO:0032971) regulation of actin filament-based movement(GO:1903115) |
| 0.1 | 0.5 | GO:0072073 | ureteric bud development(GO:0001657) mesonephros development(GO:0001823) kidney epithelium development(GO:0072073) mesonephric epithelium development(GO:0072163) mesonephric tubule development(GO:0072164) |
| 0.1 | 0.3 | GO:0051534 | negative regulation of NFAT protein import into nucleus(GO:0051534) |
| 0.1 | 1.0 | GO:0002920 | regulation of humoral immune response(GO:0002920) |
| 0.1 | 0.3 | GO:0060677 | ureteric bud elongation(GO:0060677) renal vesicle formation(GO:0072033) |
| 0.1 | 2.1 | GO:0032024 | positive regulation of insulin secretion(GO:0032024) |
| 0.1 | 0.3 | GO:2001259 | positive regulation of calcium ion transmembrane transporter activity(GO:1901021) positive regulation of cation channel activity(GO:2001259) |
| 0.1 | 0.5 | GO:0045071 | negative regulation of viral genome replication(GO:0045071) |
| 0.1 | 0.4 | GO:0051957 | positive regulation of glutamate secretion(GO:0014049) positive regulation of amino acid transport(GO:0051957) |
| 0.1 | 0.3 | GO:0006789 | bilirubin conjugation(GO:0006789) biphenyl metabolic process(GO:0018879) biphenyl catabolic process(GO:0070980) |
| 0.1 | 1.6 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.1 | 0.2 | GO:0014063 | regulation of serotonin secretion(GO:0014062) negative regulation of serotonin secretion(GO:0014063) |
| 0.0 | 0.2 | GO:0032959 | inositol trisphosphate biosynthetic process(GO:0032959) |
| 0.0 | 0.1 | GO:0030488 | tRNA methylation(GO:0030488) |
| 0.0 | 0.2 | GO:0010759 | regulation of macrophage chemotaxis(GO:0010758) positive regulation of macrophage chemotaxis(GO:0010759) |
| 0.0 | 0.2 | GO:0010629 | negative regulation of gene expression(GO:0010629) |
| 0.0 | 0.3 | GO:0070779 | D-aspartate transport(GO:0070777) D-aspartate import(GO:0070779) |
| 0.0 | 0.2 | GO:0002331 | immature B cell differentiation(GO:0002327) pre-B cell differentiation(GO:0002329) pre-B cell allelic exclusion(GO:0002331) |
| 0.0 | 0.3 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
| 0.0 | 0.3 | GO:0000012 | single strand break repair(GO:0000012) |
| 0.0 | 0.4 | GO:0060438 | trachea development(GO:0060438) |
| 0.0 | 0.3 | GO:0046618 | drug transmembrane transport(GO:0006855) tetracycline transport(GO:0015904) drug export(GO:0046618) |
| 0.0 | 0.1 | GO:0010836 | negative regulation of protein ADP-ribosylation(GO:0010836) negative regulation of protein glycosylation(GO:0060051) |
| 0.0 | 0.1 | GO:0090257 | regulation of muscle system process(GO:0090257) |
| 0.0 | 0.3 | GO:0032647 | interferon-alpha production(GO:0032607) regulation of interferon-alpha production(GO:0032647) positive regulation of interferon-alpha production(GO:0032727) |
| 0.0 | 0.4 | GO:0046415 | urate metabolic process(GO:0046415) |
| 0.0 | 0.3 | GO:0010452 | histone H3-K36 methylation(GO:0010452) |
| 0.0 | 0.3 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.0 | 0.1 | GO:0033590 | response to cobalamin(GO:0033590) |
| 0.0 | 0.7 | GO:0031648 | protein destabilization(GO:0031648) |
| 0.0 | 0.2 | GO:0030277 | epithelial structure maintenance(GO:0010669) maintenance of gastrointestinal epithelium(GO:0030277) |
| 0.0 | 1.0 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 0.0 | 0.4 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
| 0.0 | 0.2 | GO:0061099 | negative regulation of protein tyrosine kinase activity(GO:0061099) |
| 0.0 | 0.2 | GO:0055091 | phospholipid homeostasis(GO:0055091) |
| 0.0 | 0.2 | GO:0006477 | protein sulfation(GO:0006477) |
| 0.0 | 0.1 | GO:0032223 | negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212) |
| 0.0 | 0.4 | GO:0050930 | induction of positive chemotaxis(GO:0050930) |
| 0.0 | 0.3 | GO:0006030 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) |
| 0.0 | 0.1 | GO:0032527 | retrograde protein transport, ER to cytosol(GO:0030970) protein exit from endoplasmic reticulum(GO:0032527) |
| 0.0 | 0.2 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.0 | 0.2 | GO:0015937 | coenzyme A biosynthetic process(GO:0015937) |
| 0.0 | 0.1 | GO:0071542 | dopaminergic neuron differentiation(GO:0071542) |
| 0.0 | 1.9 | GO:0051291 | protein heterooligomerization(GO:0051291) |
| 0.0 | 0.1 | GO:0010820 | T cell chemotaxis(GO:0010818) regulation of T cell chemotaxis(GO:0010819) positive regulation of T cell chemotaxis(GO:0010820) regulation of lymphocyte chemotaxis(GO:1901623) regulation of lymphocyte migration(GO:2000401) positive regulation of lymphocyte migration(GO:2000403) regulation of T cell migration(GO:2000404) positive regulation of T cell migration(GO:2000406) |
| 0.0 | 0.5 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
| 0.0 | 0.3 | GO:0048207 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114) |
| 0.0 | 0.1 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.0 | 1.5 | GO:0006968 | cellular defense response(GO:0006968) |
| 0.0 | 0.2 | GO:0032836 | glomerular basement membrane development(GO:0032836) |
| 0.0 | 0.6 | GO:0031424 | keratinization(GO:0031424) |
| 0.0 | 0.5 | GO:0035338 | long-chain fatty-acyl-CoA metabolic process(GO:0035336) long-chain fatty-acyl-CoA biosynthetic process(GO:0035338) |
| 0.0 | 0.2 | GO:0002209 | behavioral fear response(GO:0001662) behavioral defense response(GO:0002209) |
| 0.0 | 0.2 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.0 | 0.1 | GO:0045299 | otolith mineralization(GO:0045299) |
| 0.0 | 0.7 | GO:0046847 | filopodium assembly(GO:0046847) |
| 0.0 | 0.1 | GO:0000729 | DNA double-strand break processing(GO:0000729) |
| 0.0 | 0.5 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.0 | 0.2 | GO:0030512 | negative regulation of transforming growth factor beta receptor signaling pathway(GO:0030512) negative regulation of cellular response to transforming growth factor beta stimulus(GO:1903845) |
| 0.0 | 0.2 | GO:2000273 | positive regulation of receptor activity(GO:2000273) |
| 0.0 | 0.3 | GO:0006750 | glutathione biosynthetic process(GO:0006750) |
| 0.0 | 1.3 | GO:0007270 | neuron-neuron synaptic transmission(GO:0007270) |
| 0.0 | 0.0 | GO:0031047 | gene silencing by RNA(GO:0031047) |
| 0.0 | 0.1 | GO:0019852 | L-ascorbic acid metabolic process(GO:0019852) |
| 0.0 | 0.3 | GO:0008633 | obsolete activation of pro-apoptotic gene products(GO:0008633) |
| 0.0 | 0.1 | GO:0034219 | carbohydrate transmembrane transport(GO:0034219) |
| 0.0 | 0.1 | GO:0006516 | glycoprotein catabolic process(GO:0006516) |
| 0.0 | 0.2 | GO:0042104 | positive regulation of activated T cell proliferation(GO:0042104) |
| 0.0 | 0.2 | GO:1902603 | carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603) |
| 0.0 | 0.1 | GO:0006646 | phosphatidylethanolamine biosynthetic process(GO:0006646) phosphatidylethanolamine metabolic process(GO:0046337) |
| 0.0 | 0.1 | GO:0039703 | positive regulation of transcription elongation from RNA polymerase II promoter(GO:0032968) single stranded viral RNA replication via double stranded DNA intermediate(GO:0039692) viral RNA genome replication(GO:0039694) RNA replication(GO:0039703) |
| 0.0 | 0.1 | GO:0030163 | protein catabolic process(GO:0030163) |
| 0.0 | 0.7 | GO:0001892 | embryonic placenta development(GO:0001892) |
| 0.0 | 0.3 | GO:0045214 | sarcomere organization(GO:0045214) |
| 0.0 | 0.2 | GO:0071479 | cellular response to ionizing radiation(GO:0071479) |
| 0.0 | 0.1 | GO:0006013 | mannose metabolic process(GO:0006013) |
| 0.0 | 0.0 | GO:0034126 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) positive regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034126) |
| 0.0 | 0.1 | GO:0046902 | regulation of mitochondrial membrane permeability(GO:0046902) regulation of membrane permeability(GO:0090559) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.7 | GO:0005610 | laminin-5 complex(GO:0005610) |
| 0.2 | 0.7 | GO:0030895 | apolipoprotein B mRNA editing enzyme complex(GO:0030895) |
| 0.2 | 1.0 | GO:0032449 | CBM complex(GO:0032449) |
| 0.2 | 1.1 | GO:0019815 | immunoglobulin complex(GO:0019814) B cell receptor complex(GO:0019815) |
| 0.2 | 0.5 | GO:0005608 | laminin-3 complex(GO:0005608) |
| 0.1 | 0.3 | GO:0072669 | tRNA-splicing ligase complex(GO:0072669) |
| 0.1 | 0.3 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 0.5 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.1 | 0.9 | GO:0005606 | laminin-1 complex(GO:0005606) |
| 0.1 | 5.3 | GO:0016605 | PML body(GO:0016605) |
| 0.1 | 0.7 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 0.9 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.1 | 0.8 | GO:0030130 | clathrin coat of trans-Golgi network vesicle(GO:0030130) |
| 0.1 | 0.3 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.0 | 0.4 | GO:0010369 | chromocenter(GO:0010369) |
| 0.0 | 0.4 | GO:0000796 | condensin complex(GO:0000796) |
| 0.0 | 0.4 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 0.3 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 0.1 | GO:0031372 | UBC13-MMS2 complex(GO:0031372) |
| 0.0 | 1.0 | GO:0005680 | anaphase-promoting complex(GO:0005680) |
| 0.0 | 0.1 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.0 | 0.3 | GO:0030673 | axolemma(GO:0030673) |
| 0.0 | 0.1 | GO:0031205 | endoplasmic reticulum Sec complex(GO:0031205) |
| 0.0 | 0.2 | GO:0033391 | chromatoid body(GO:0033391) |
| 0.0 | 0.3 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 0.3 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.0 | 0.3 | GO:0005625 | obsolete soluble fraction(GO:0005625) |
| 0.0 | 0.3 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 0.2 | GO:0042598 | obsolete vesicular fraction(GO:0042598) |
| 0.0 | 0.6 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 0.1 | GO:0005854 | nascent polypeptide-associated complex(GO:0005854) |
| 0.0 | 0.2 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 0.1 | GO:0031305 | integral component of mitochondrial inner membrane(GO:0031305) |
| 0.0 | 0.4 | GO:0031231 | integral component of peroxisomal membrane(GO:0005779) intrinsic component of peroxisomal membrane(GO:0031231) |
| 0.0 | 0.4 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.0 | 0.1 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 0.2 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.0 | 0.2 | GO:0034518 | mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518) |
| 0.0 | 1.6 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 0.2 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 0.1 | GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276) |
| 0.0 | 0.8 | GO:0005626 | obsolete insoluble fraction(GO:0005626) |
| 0.0 | 0.1 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 0.3 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 0.4 | GO:0043195 | terminal bouton(GO:0043195) |
| 0.0 | 0.2 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
| 0.0 | 0.3 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 0.2 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 2.2 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.0 | 0.4 | GO:0030530 | obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 5.3 | GO:0008310 | single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) exoribonuclease II activity(GO:0008859) |
| 0.2 | 1.2 | GO:0017096 | acetylserotonin O-methyltransferase activity(GO:0017096) |
| 0.2 | 0.9 | GO:0048020 | CCR chemokine receptor binding(GO:0048020) |
| 0.2 | 0.6 | GO:0004514 | nicotinate-nucleotide diphosphorylase (carboxylating) activity(GO:0004514) |
| 0.2 | 1.1 | GO:0019863 | IgE binding(GO:0019863) |
| 0.2 | 0.5 | GO:0004139 | deoxyribose-phosphate aldolase activity(GO:0004139) |
| 0.2 | 0.5 | GO:0016314 | phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity(GO:0016314) |
| 0.1 | 8.3 | GO:0003823 | antigen binding(GO:0003823) |
| 0.1 | 0.6 | GO:0070324 | thyroid hormone binding(GO:0070324) |
| 0.1 | 0.9 | GO:0042834 | peptidoglycan binding(GO:0042834) CARD domain binding(GO:0050700) |
| 0.1 | 0.4 | GO:0010861 | thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375) |
| 0.1 | 0.4 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.1 | 2.4 | GO:0043621 | protein self-association(GO:0043621) |
| 0.1 | 0.4 | GO:0005229 | intracellular calcium activated chloride channel activity(GO:0005229) |
| 0.1 | 0.3 | GO:0045127 | N-acetylglucosamine kinase activity(GO:0045127) |
| 0.1 | 0.7 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
| 0.1 | 0.5 | GO:0016833 | oxo-acid-lyase activity(GO:0016833) |
| 0.1 | 0.3 | GO:0019215 | intermediate filament binding(GO:0019215) |
| 0.1 | 0.9 | GO:0008526 | phosphatidylinositol transporter activity(GO:0008526) |
| 0.1 | 0.3 | GO:0003863 | alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863) |
| 0.1 | 1.6 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.1 | 0.2 | GO:0017129 | triglyceride binding(GO:0017129) |
| 0.1 | 0.3 | GO:0016286 | small conductance calcium-activated potassium channel activity(GO:0016286) |
| 0.1 | 0.3 | GO:0004723 | calcium-dependent protein serine/threonine phosphatase activity(GO:0004723) |
| 0.1 | 0.7 | GO:0005402 | sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) |
| 0.1 | 0.3 | GO:0070259 | tyrosyl-DNA phosphodiesterase activity(GO:0070259) |
| 0.1 | 0.2 | GO:0015386 | potassium:proton antiporter activity(GO:0015386) |
| 0.1 | 0.5 | GO:0046934 | obsolete inositol or phosphatidylinositol kinase activity(GO:0004428) phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
| 0.1 | 0.3 | GO:0004095 | carnitine O-palmitoyltransferase activity(GO:0004095) O-palmitoyltransferase activity(GO:0016416) |
| 0.1 | 0.2 | GO:0004768 | stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) |
| 0.1 | 0.4 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 0.1 | 0.3 | GO:0015520 | tetracycline:proton antiporter activity(GO:0015520) |
| 0.0 | 0.5 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.0 | 0.3 | GO:0015501 | glutamate:sodium symporter activity(GO:0015501) |
| 0.0 | 1.0 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.0 | 0.7 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 0.1 | GO:0016429 | tRNA (adenine) methyltransferase activity(GO:0016426) tRNA (adenine-N1-)-methyltransferase activity(GO:0016429) |
| 0.0 | 0.4 | GO:0016671 | oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) |
| 0.0 | 0.2 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.0 | 2.6 | GO:0004715 | non-membrane spanning protein tyrosine kinase activity(GO:0004715) |
| 0.0 | 0.2 | GO:0004111 | creatine kinase activity(GO:0004111) |
| 0.0 | 0.3 | GO:0034237 | protein kinase A regulatory subunit binding(GO:0034237) |
| 0.0 | 0.2 | GO:0016635 | oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635) |
| 0.0 | 0.2 | GO:0004992 | platelet activating factor receptor activity(GO:0004992) |
| 0.0 | 0.5 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.0 | 0.4 | GO:0050780 | dopamine receptor binding(GO:0050780) |
| 0.0 | 0.1 | GO:0005105 | type 1 fibroblast growth factor receptor binding(GO:0005105) type 2 fibroblast growth factor receptor binding(GO:0005111) |
| 0.0 | 0.2 | GO:0017089 | glycolipid transporter activity(GO:0017089) |
| 0.0 | 0.3 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
| 0.0 | 0.1 | GO:0008523 | sodium-dependent multivitamin transmembrane transporter activity(GO:0008523) |
| 0.0 | 0.2 | GO:0004741 | magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724) [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.0 | 0.1 | GO:0004476 | mannose-6-phosphate isomerase activity(GO:0004476) |
| 0.0 | 0.9 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 0.3 | GO:0046983 | protein dimerization activity(GO:0046983) |
| 0.0 | 0.7 | GO:0035254 | glutamate receptor binding(GO:0035254) |
| 0.0 | 0.1 | GO:0050051 | leukotriene-B4 20-monooxygenase activity(GO:0050051) |
| 0.0 | 0.2 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) |
| 0.0 | 0.3 | GO:0004568 | chitinase activity(GO:0004568) |
| 0.0 | 0.2 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.0 | 0.1 | GO:0080030 | methyl indole-3-acetate esterase activity(GO:0080030) methyl salicylate esterase activity(GO:0080031) methyl jasmonate esterase activity(GO:0080032) |
| 0.0 | 0.7 | GO:0019239 | deaminase activity(GO:0019239) |
| 0.0 | 0.1 | GO:0008148 | obsolete negative transcription elongation factor activity(GO:0008148) |
| 0.0 | 2.0 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 0.4 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.0 | 0.5 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.0 | 0.1 | GO:0001641 | group II metabotropic glutamate receptor activity(GO:0001641) |
| 0.0 | 0.1 | GO:0031177 | phosphopantetheine binding(GO:0031177) |
| 0.0 | 0.3 | GO:0017153 | sodium:dicarboxylate symporter activity(GO:0017153) |
| 0.0 | 0.3 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.0 | 0.2 | GO:0031013 | troponin I binding(GO:0031013) |
| 0.0 | 0.0 | GO:0070095 | fructose-6-phosphate binding(GO:0070095) |
| 0.0 | 0.1 | GO:0050508 | glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity(GO:0050508) |
| 0.0 | 0.1 | GO:0004103 | choline kinase activity(GO:0004103) |
| 0.0 | 0.2 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.0 | 0.5 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.0 | 0.3 | GO:0003840 | gamma-glutamyltransferase activity(GO:0003840) |
| 0.0 | 0.2 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.0 | 0.2 | GO:0050682 | AF-2 domain binding(GO:0050682) |
| 0.0 | 0.2 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.0 | 0.1 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.0 | 0.2 | GO:0043560 | insulin receptor substrate binding(GO:0043560) |
| 0.0 | 0.2 | GO:0003688 | DNA replication origin binding(GO:0003688) |
| 0.0 | 0.2 | GO:0017080 | sodium channel regulator activity(GO:0017080) |
| 0.0 | 0.0 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.0 | 0.0 | GO:0052593 | tryptamine:oxygen oxidoreductase (deaminating) activity(GO:0052593) aminoacetone:oxygen oxidoreductase(deaminating) activity(GO:0052594) aliphatic-amine oxidase activity(GO:0052595) phenethylamine:oxygen oxidoreductase (deaminating) activity(GO:0052596) |
| 0.0 | 0.3 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.0 | 0.3 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 0.1 | GO:0001517 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) |
| 0.0 | 0.3 | GO:0004407 | histone deacetylase activity(GO:0004407) |
| 0.0 | 0.3 | GO:0008320 | protein transmembrane transporter activity(GO:0008320) |
| 0.0 | 0.2 | GO:0000339 | RNA cap binding(GO:0000339) |
| 0.0 | 0.2 | GO:0005522 | profilin binding(GO:0005522) |
| 0.0 | 0.1 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
| 0.0 | 0.0 | GO:0004609 | phosphatidylserine decarboxylase activity(GO:0004609) |
| 0.0 | 0.1 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.0 | 3.0 | GO:0004842 | ubiquitin-protein transferase activity(GO:0004842) |
| 0.0 | 0.1 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.0 | 0.1 | GO:0015467 | G-protein activated inward rectifier potassium channel activity(GO:0015467) |
| 0.0 | 0.1 | GO:0045029 | UDP-activated nucleotide receptor activity(GO:0045029) |
| 0.0 | 0.2 | GO:0043499 | obsolete eukaryotic cell surface binding(GO:0043499) |
| 0.0 | 0.1 | GO:0070063 | RNA polymerase binding(GO:0070063) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 3.8 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.8 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 0.2 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 0.3 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.3 | ST_INTERLEUKIN_4_PATHWAY | Interleukin 4 (IL-4) Pathway |
