Motif ID: FOXA1
Z-value: 1.535
Transcription factors associated with FOXA1:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
FOXA1 | ENSG00000129514.4 | FOXA1 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.6 | 6.5 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
1.2 | 4.9 | GO:0071379 | cellular response to prostaglandin stimulus(GO:0071379) |
0.7 | 4.6 | GO:0045780 | positive regulation of bone resorption(GO:0045780) positive regulation of bone remodeling(GO:0046852) |
0.4 | 1.3 | GO:0046521 | sphingoid catabolic process(GO:0046521) |
0.4 | 1.6 | GO:0060743 | epithelial cell maturation involved in prostate gland development(GO:0060743) |
0.4 | 1.2 | GO:0055005 | optic placode formation involved in camera-type eye formation(GO:0046619) ventricular cardiac myofibril assembly(GO:0055005) embryonic retina morphogenesis in camera-type eye(GO:0060059) |
0.3 | 1.0 | GO:0035623 | renal glucose absorption(GO:0035623) |
0.3 | 1.9 | GO:0031665 | negative regulation of lipopolysaccharide-mediated signaling pathway(GO:0031665) |
0.2 | 1.1 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
0.2 | 1.0 | GO:0045953 | desensitization of G-protein coupled receptor protein signaling pathway by arrestin(GO:0002032) negative regulation of natural killer cell mediated immunity(GO:0002716) negative regulation of natural killer cell mediated cytotoxicity(GO:0045953) |
0.2 | 1.3 | GO:0060272 | embryonic skeletal joint morphogenesis(GO:0060272) embryonic skeletal joint development(GO:0072498) |
0.2 | 3.9 | GO:0006825 | copper ion transport(GO:0006825) |
0.2 | 0.5 | GO:0045835 | negative regulation of meiotic nuclear division(GO:0045835) |
0.2 | 4.0 | GO:0008211 | glucocorticoid metabolic process(GO:0008211) |
0.2 | 2.2 | GO:0060706 | cell differentiation involved in embryonic placenta development(GO:0060706) |
0.1 | 0.4 | GO:0000114 | obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114) |
0.1 | 0.5 | GO:0051919 | positive regulation of fibrinolysis(GO:0051919) |
0.1 | 0.3 | GO:0007518 | myoblast fate determination(GO:0007518) |
0.1 | 0.4 | GO:1904037 | positive regulation of epithelial cell apoptotic process(GO:1904037) positive regulation of endothelial cell apoptotic process(GO:2000353) |
0.1 | 0.3 | GO:0050917 | sensory perception of umami taste(GO:0050917) |
0.1 | 0.3 | GO:0001544 | initiation of primordial ovarian follicle growth(GO:0001544) |
0.1 | 0.3 | GO:0010430 | ethanol catabolic process(GO:0006068) fatty acid omega-oxidation(GO:0010430) |
0.1 | 4.3 | GO:0046324 | regulation of glucose import(GO:0046324) |
0.1 | 0.2 | GO:0048496 | maintenance of organ identity(GO:0048496) |
0.1 | 0.3 | GO:0048388 | endosomal lumen acidification(GO:0048388) |
0.1 | 1.5 | GO:0008210 | estrogen metabolic process(GO:0008210) |
0.1 | 0.3 | GO:0010157 | response to chlorate(GO:0010157) |
0.1 | 0.2 | GO:0032416 | negative regulation of sodium:proton antiporter activity(GO:0032416) negative regulation of sodium ion transmembrane transport(GO:1902306) negative regulation of sodium ion transmembrane transporter activity(GO:2000650) |
0.1 | 1.4 | GO:0045165 | cell fate commitment(GO:0045165) |
0.1 | 2.9 | GO:0031100 | organ regeneration(GO:0031100) |
0.1 | 0.2 | GO:0035987 | endodermal cell fate commitment(GO:0001711) endodermal cell differentiation(GO:0035987) |
0.1 | 1.8 | GO:1900047 | negative regulation of blood coagulation(GO:0030195) negative regulation of wound healing(GO:0061045) negative regulation of hemostasis(GO:1900047) |
0.0 | 0.2 | GO:2000831 | renin-angiotensin regulation of aldosterone production(GO:0002018) regulation of blood vessel size by renin-angiotensin(GO:0002034) renal control of peripheral vascular resistance involved in regulation of systemic arterial blood pressure(GO:0003072) positive regulation of NAD(P)H oxidase activity(GO:0033864) corticosteroid hormone secretion(GO:0035930) mineralocorticoid secretion(GO:0035931) aldosterone secretion(GO:0035932) regulation of steroid hormone secretion(GO:2000831) regulation of corticosteroid hormone secretion(GO:2000846) regulation of mineralocorticoid secretion(GO:2000855) regulation of aldosterone secretion(GO:2000858) |
0.0 | 0.4 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
0.0 | 0.9 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
0.0 | 0.2 | GO:0090231 | regulation of spindle checkpoint(GO:0090231) |
0.0 | 0.8 | GO:0045730 | respiratory burst(GO:0045730) |
0.0 | 1.6 | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154) negative regulation of cysteine-type endopeptidase activity(GO:2000117) |
0.0 | 0.2 | GO:0060259 | regulation of feeding behavior(GO:0060259) |
0.0 | 0.4 | GO:0031641 | regulation of myelination(GO:0031641) |
0.0 | 0.1 | GO:0042759 | fatty acid elongation, saturated fatty acid(GO:0019367) long-chain fatty acid biosynthetic process(GO:0042759) |
0.0 | 2.9 | GO:0010951 | negative regulation of endopeptidase activity(GO:0010951) |
0.0 | 0.5 | GO:0006657 | CDP-choline pathway(GO:0006657) |
0.0 | 1.1 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
0.0 | 0.5 | GO:0046627 | negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077) |
0.0 | 0.3 | GO:0007379 | segment specification(GO:0007379) |
0.0 | 0.9 | GO:0006024 | glycosaminoglycan biosynthetic process(GO:0006024) |
0.0 | 0.7 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
0.0 | 0.3 | GO:0006621 | protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437) |
0.0 | 0.1 | GO:0050747 | positive regulation of lipoprotein metabolic process(GO:0050747) |
0.0 | 0.4 | GO:0001893 | maternal placenta development(GO:0001893) |
0.0 | 0.1 | GO:0045084 | positive regulation of interleukin-12 biosynthetic process(GO:0045084) |
0.0 | 0.2 | GO:0043171 | peptide catabolic process(GO:0043171) |
0.0 | 0.2 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
0.0 | 0.1 | GO:0046621 | negative regulation of organ growth(GO:0046621) |
0.0 | 0.1 | GO:0046642 | negative regulation of alpha-beta T cell proliferation(GO:0046642) |
0.0 | 1.8 | GO:0007586 | digestion(GO:0007586) |
0.0 | 0.5 | GO:0007214 | gamma-aminobutyric acid signaling pathway(GO:0007214) |
0.0 | 0.1 | GO:0019509 | L-methionine biosynthetic process from methylthioadenosine(GO:0019509) |
0.0 | 1.6 | GO:0048015 | phosphatidylinositol-mediated signaling(GO:0048015) inositol lipid-mediated signaling(GO:0048017) |
0.0 | 0.1 | GO:1900087 | traversing start control point of mitotic cell cycle(GO:0007089) positive regulation of G1/S transition of mitotic cell cycle(GO:1900087) positive regulation of cell cycle G1/S phase transition(GO:1902808) |
0.0 | 0.1 | GO:0045085 | negative regulation of interleukin-2 biosynthetic process(GO:0045085) |
0.0 | 0.1 | GO:0060346 | bone trabecula formation(GO:0060346) bone trabecula morphogenesis(GO:0061430) |
0.0 | 0.7 | GO:0007416 | synapse assembly(GO:0007416) |
0.0 | 1.7 | GO:0007179 | transforming growth factor beta receptor signaling pathway(GO:0007179) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.6 | 6.5 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
1.6 | 4.9 | GO:0031904 | endosome lumen(GO:0031904) |
0.6 | 4.3 | GO:0000300 | obsolete peripheral to membrane of membrane fraction(GO:0000300) |
0.2 | 2.7 | GO:0005577 | fibrinogen complex(GO:0005577) |
0.2 | 0.5 | GO:0032302 | MutSbeta complex(GO:0032302) |
0.2 | 1.1 | GO:0001891 | phagocytic cup(GO:0001891) |
0.1 | 1.3 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
0.1 | 2.2 | GO:0043034 | costamere(GO:0043034) |
0.1 | 0.8 | GO:0005579 | membrane attack complex(GO:0005579) |
0.1 | 0.7 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
0.1 | 0.8 | GO:0043020 | NADPH oxidase complex(GO:0043020) |
0.1 | 1.0 | GO:0045120 | pronucleus(GO:0045120) |
0.0 | 0.2 | GO:0060171 | stereocilium membrane(GO:0060171) |
0.0 | 0.3 | GO:0016342 | catenin complex(GO:0016342) |
0.0 | 0.4 | GO:0048786 | presynaptic active zone(GO:0048786) |
0.0 | 2.3 | GO:0016363 | nuclear matrix(GO:0016363) |
0.0 | 0.3 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
0.0 | 0.4 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
0.0 | 0.1 | GO:0033011 | perinuclear theca(GO:0033011) cytoskeletal calyx(GO:0033150) |
0.0 | 0.1 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
0.0 | 0.2 | GO:0000242 | pericentriolar material(GO:0000242) |
0.0 | 0.9 | GO:0005876 | spindle microtubule(GO:0005876) |
0.0 | 0.1 | GO:0005667 | transcription factor complex(GO:0005667) |
0.0 | 1.0 | GO:0005905 | clathrin-coated pit(GO:0005905) |
0.0 | 3.3 | GO:0005792 | obsolete microsome(GO:0005792) |
0.0 | 0.1 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
0.0 | 9.9 | GO:0005615 | extracellular space(GO:0005615) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.1 | 4.6 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
0.8 | 3.9 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
0.5 | 6.5 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
0.4 | 1.2 | GO:0050692 | DBD domain binding(GO:0050692) |
0.4 | 4.9 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
0.2 | 1.9 | GO:0031434 | mitogen-activated protein kinase kinase binding(GO:0031434) |
0.2 | 1.8 | GO:0042975 | peroxisome proliferator activated receptor binding(GO:0042975) |
0.2 | 1.3 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
0.2 | 1.3 | GO:0030020 | extracellular matrix structural constituent conferring tensile strength(GO:0030020) |
0.2 | 0.5 | GO:0000404 | heteroduplex DNA loop binding(GO:0000404) double-strand/single-strand DNA junction binding(GO:0000406) dinucleotide repeat insertion binding(GO:0032181) |
0.1 | 2.1 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
0.1 | 0.4 | GO:0005174 | CD40 receptor binding(GO:0005174) |
0.1 | 0.9 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
0.1 | 0.4 | GO:0010861 | thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375) |
0.1 | 2.7 | GO:0043499 | obsolete eukaryotic cell surface binding(GO:0043499) |
0.1 | 0.3 | GO:0043533 | inositol 1,3,4,5 tetrakisphosphate binding(GO:0043533) |
0.1 | 0.5 | GO:0004105 | choline-phosphate cytidylyltransferase activity(GO:0004105) |
0.1 | 1.0 | GO:0031701 | angiotensin receptor binding(GO:0031701) |
0.1 | 0.3 | GO:0035276 | ethanol binding(GO:0035276) |
0.1 | 8.3 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
0.1 | 2.9 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
0.1 | 0.3 | GO:0005046 | KDEL sequence binding(GO:0005046) |
0.1 | 1.1 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
0.1 | 0.8 | GO:0016175 | superoxide-generating NADPH oxidase activity(GO:0016175) |
0.1 | 0.2 | GO:0010698 | angiotensin type I receptor activity(GO:0001596) acetyltransferase activator activity(GO:0010698) |
0.1 | 0.2 | GO:0042808 | obsolete neuronal Cdc2-like kinase binding(GO:0042808) |
0.1 | 1.6 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
0.1 | 0.3 | GO:0005113 | patched binding(GO:0005113) |
0.0 | 0.5 | GO:0008106 | alcohol dehydrogenase (NADP+) activity(GO:0008106) |
0.0 | 0.4 | GO:0046934 | obsolete inositol or phosphatidylinositol kinase activity(GO:0004428) phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
0.0 | 3.9 | GO:0016566 | obsolete specific transcriptional repressor activity(GO:0016566) |
0.0 | 0.2 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
0.0 | 0.3 | GO:0042153 | obsolete RPTP-like protein binding(GO:0042153) alpha-catenin binding(GO:0045294) |
0.0 | 3.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
0.0 | 0.3 | GO:0008503 | benzodiazepine receptor activity(GO:0008503) |
0.0 | 0.2 | GO:0001591 | dopamine neurotransmitter receptor activity, coupled via Gi/Go(GO:0001591) |
0.0 | 0.1 | GO:0004608 | phosphatidylethanolamine N-methyltransferase activity(GO:0004608) |
0.0 | 0.1 | GO:0009922 | fatty acid elongase activity(GO:0009922) |
0.0 | 1.2 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
0.0 | 0.2 | GO:0003785 | actin monomer binding(GO:0003785) |
0.0 | 0.9 | GO:0008013 | beta-catenin binding(GO:0008013) |
0.0 | 0.0 | GO:0004967 | glucagon receptor activity(GO:0004967) |
0.0 | 0.3 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
0.0 | 0.1 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
0.0 | 0.9 | GO:0051015 | actin filament binding(GO:0051015) |
0.0 | 0.1 | GO:0031013 | troponin I binding(GO:0031013) |
0.0 | 0.5 | GO:0051219 | phosphoprotein binding(GO:0051219) |
0.0 | 0.1 | GO:0034185 | apolipoprotein binding(GO:0034185) |
0.0 | 0.3 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
0.0 | 0.2 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 3.7 | SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
0.0 | 0.4 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |