Motif ID: FOXF2_FOXJ1
Z-value: 1.265
Transcription factors associated with FOXF2_FOXJ1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| FOXF2 | ENSG00000137273.3 | FOXF2 |
| FOXJ1 | ENSG00000129654.7 | FOXJ1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.4 | 7.2 | GO:2000910 | regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910) |
| 0.6 | 2.6 | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
| 0.5 | 1.9 | GO:0001705 | ectoderm formation(GO:0001705) central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 0.4 | 1.2 | GO:0052805 | histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805) |
| 0.3 | 1.0 | GO:0055005 | optic placode formation involved in camera-type eye formation(GO:0046619) ventricular cardiac myofibril assembly(GO:0055005) regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251) |
| 0.3 | 0.8 | GO:0019482 | beta-alanine metabolic process(GO:0019482) |
| 0.3 | 1.5 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
| 0.2 | 3.0 | GO:0018214 | peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214) |
| 0.1 | 0.5 | GO:0045299 | otolith mineralization(GO:0045299) |
| 0.1 | 0.4 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 0.1 | 0.5 | GO:0006975 | DNA damage induced protein phosphorylation(GO:0006975) |
| 0.1 | 0.7 | GO:0009249 | protein lipoylation(GO:0009249) |
| 0.1 | 0.6 | GO:0060762 | regulation of branching involved in mammary gland duct morphogenesis(GO:0060762) |
| 0.1 | 0.4 | GO:0042797 | 5S class rRNA transcription from RNA polymerase III type 1 promoter(GO:0042791) tRNA transcription from RNA polymerase III promoter(GO:0042797) |
| 0.1 | 1.3 | GO:0008210 | estrogen metabolic process(GO:0008210) |
| 0.1 | 0.4 | GO:0016265 | obsolete death(GO:0016265) dopamine biosynthetic process(GO:0042416) dopaminergic neuron differentiation(GO:0071542) |
| 0.0 | 1.1 | GO:0031000 | response to caffeine(GO:0031000) |
| 0.0 | 0.2 | GO:0045938 | regulation of circadian sleep/wake cycle, REM sleep(GO:0042320) positive regulation of circadian sleep/wake cycle, sleep(GO:0045938) |
| 0.0 | 2.2 | GO:0045576 | mast cell activation(GO:0045576) |
| 0.0 | 0.4 | GO:0006553 | lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554) |
| 0.0 | 0.5 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
| 0.0 | 0.1 | GO:0045338 | farnesyl diphosphate metabolic process(GO:0045338) |
| 0.0 | 0.2 | GO:0032959 | inositol trisphosphate biosynthetic process(GO:0032959) |
| 0.0 | 0.1 | GO:0071428 | rRNA-containing ribonucleoprotein complex export from nucleus(GO:0071428) |
| 0.0 | 0.8 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.0 | 0.7 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
| 0.0 | 2.3 | GO:0031668 | cellular response to extracellular stimulus(GO:0031668) |
| 0.0 | 0.2 | GO:0043045 | DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538) |
| 0.0 | 0.2 | GO:0097352 | autophagosome maturation(GO:0097352) |
| 0.0 | 3.0 | GO:0042157 | lipoprotein metabolic process(GO:0042157) |
| 0.0 | 0.2 | GO:0044341 | sodium-dependent phosphate transport(GO:0044341) |
| 0.0 | 0.3 | GO:0001843 | neural tube closure(GO:0001843) primary neural tube formation(GO:0014020) tube closure(GO:0060606) |
| 0.0 | 0.7 | GO:0042994 | cytoplasmic sequestering of transcription factor(GO:0042994) |
| 0.0 | 1.3 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 0.5 | GO:0007158 | neuron cell-cell adhesion(GO:0007158) |
| 0.0 | 1.7 | GO:0006821 | chloride transport(GO:0006821) |
| 0.0 | 0.8 | GO:1900047 | negative regulation of blood coagulation(GO:0030195) negative regulation of wound healing(GO:0061045) negative regulation of hemostasis(GO:1900047) |
| 0.0 | 0.5 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation(GO:0033138) |
| 0.0 | 0.8 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 6.0 | GO:0006979 | response to oxidative stress(GO:0006979) |
| 0.0 | 0.2 | GO:0006474 | N-terminal protein amino acid acetylation(GO:0006474) |
| 0.0 | 0.3 | GO:0046627 | negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077) |
| 0.0 | 0.0 | GO:0045852 | regulation of integrin biosynthetic process(GO:0045113) positive regulation of integrin biosynthetic process(GO:0045726) pH elevation(GO:0045852) intracellular pH elevation(GO:0051454) |
| 0.0 | 0.0 | GO:0061117 | cardiac chamber formation(GO:0003207) cardiac ventricle formation(GO:0003211) cardiac left ventricle formation(GO:0003218) negative regulation of cardiac muscle tissue growth(GO:0055022) negative regulation of cardiac muscle tissue development(GO:0055026) negative regulation of cardiac muscle cell proliferation(GO:0060044) negative regulation of heart growth(GO:0061117) |
| 0.0 | 0.1 | GO:0048853 | forebrain morphogenesis(GO:0048853) |
| 0.0 | 0.0 | GO:1904396 | regulation of synaptic growth at neuromuscular junction(GO:0008582) regulation of neuromuscular junction development(GO:1904396) |
| 0.0 | 1.2 | GO:0007605 | sensory perception of sound(GO:0007605) |
| 0.0 | 0.1 | GO:0031641 | regulation of myelination(GO:0031641) |
| 0.0 | 0.3 | GO:0000380 | alternative mRNA splicing, via spliceosome(GO:0000380) |
| 0.0 | 0.2 | GO:0032438 | melanosome organization(GO:0032438) pigment granule organization(GO:0048753) |
| 0.0 | 0.3 | GO:0001508 | action potential(GO:0001508) |
| 0.0 | 0.3 | GO:0032570 | response to progesterone(GO:0032570) |
| 0.0 | 7.4 | GO:0007186 | G-protein coupled receptor signaling pathway(GO:0007186) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 7.2 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.1 | 0.9 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.1 | 2.9 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.1 | 0.5 | GO:0000796 | condensin complex(GO:0000796) |
| 0.1 | 0.2 | GO:0035032 | phosphatidylinositol 3-kinase complex, class III(GO:0035032) PAS complex(GO:0070772) |
| 0.1 | 0.4 | GO:0000127 | transcription factor TFIIIC complex(GO:0000127) |
| 0.0 | 0.8 | GO:0008091 | spectrin(GO:0008091) |
| 0.0 | 0.2 | GO:0032585 | multivesicular body membrane(GO:0032585) |
| 0.0 | 1.4 | GO:0045095 | keratin filament(GO:0045095) |
| 0.0 | 0.1 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 0.0 | 3.8 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 0.2 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 0.5 | GO:0043073 | germ cell nucleus(GO:0043073) |
| 0.0 | 4.2 | GO:0019717 | obsolete synaptosome(GO:0019717) |
| 0.0 | 1.3 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 0.1 | GO:0016342 | catenin complex(GO:0016342) |
| 0.0 | 0.1 | GO:0033269 | internode region of axon(GO:0033269) |
| 0.0 | 1.0 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 0.1 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.0 | 0.2 | GO:0000791 | euchromatin(GO:0000791) |
| 0.0 | 0.2 | GO:0005762 | organellar large ribosomal subunit(GO:0000315) mitochondrial large ribosomal subunit(GO:0005762) |
| 0.0 | 0.7 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 5.0 | GO:0030659 | cytoplasmic vesicle membrane(GO:0030659) |
| 0.0 | 0.4 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 1.7 | GO:0030424 | axon(GO:0030424) |
| 0.0 | 0.4 | GO:0030530 | obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 7.2 | GO:0034190 | apolipoprotein receptor binding(GO:0034190) high-density lipoprotein particle receptor binding(GO:0070653) |
| 0.3 | 1.0 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.3 | 2.8 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 0.3 | 1.2 | GO:0016841 | ammonia-lyase activity(GO:0016841) |
| 0.3 | 6.8 | GO:0008430 | selenium binding(GO:0008430) |
| 0.2 | 0.7 | GO:0016402 | pristanoyl-CoA oxidase activity(GO:0016402) |
| 0.2 | 1.7 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) |
| 0.2 | 1.1 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.1 | 0.4 | GO:0019962 | type I interferon binding(GO:0019962) |
| 0.1 | 0.9 | GO:0004904 | interferon receptor activity(GO:0004904) |
| 0.1 | 0.8 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.1 | 0.4 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) |
| 0.1 | 0.4 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.1 | 0.3 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.1 | 0.5 | GO:0031434 | mitogen-activated protein kinase kinase binding(GO:0031434) |
| 0.1 | 0.2 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.1 | 3.4 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.1 | 4.3 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 0.2 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.0 | 0.1 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.0 | 0.1 | GO:0004917 | interleukin-4 receptor activity(GO:0004913) interleukin-7 receptor activity(GO:0004917) interleukin-2 binding(GO:0019976) |
| 0.0 | 0.4 | GO:0005402 | sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) D-glucose transmembrane transporter activity(GO:0055056) |
| 0.0 | 0.3 | GO:0004703 | G-protein coupled receptor kinase activity(GO:0004703) |
| 0.0 | 0.1 | GO:0051996 | farnesyl-diphosphate farnesyltransferase activity(GO:0004310) squalene synthase activity(GO:0051996) |
| 0.0 | 0.2 | GO:0004992 | platelet activating factor receptor activity(GO:0004992) |
| 0.0 | 0.5 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.0 | 1.3 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 3.4 | GO:0005319 | lipid transporter activity(GO:0005319) |
| 0.0 | 0.2 | GO:0015321 | sodium-dependent phosphate transmembrane transporter activity(GO:0015321) |
| 0.0 | 0.4 | GO:0003709 | obsolete RNA polymerase III transcription factor activity(GO:0003709) |
| 0.0 | 0.3 | GO:0005021 | vascular endothelial growth factor-activated receptor activity(GO:0005021) |
| 0.0 | 0.2 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.0 | 1.3 | GO:0050136 | NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.2 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.0 | 0.1 | GO:0003870 | 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749) |
| 0.0 | 0.2 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.0 | 0.5 | GO:0004708 | MAP kinase kinase activity(GO:0004708) |
| 0.0 | 0.5 | GO:0008373 | sialyltransferase activity(GO:0008373) |
| 0.0 | 0.7 | GO:0016620 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620) |
| 0.0 | 7.5 | GO:0004930 | G-protein coupled receptor activity(GO:0004930) |
| 0.0 | 1.2 | GO:0008013 | beta-catenin binding(GO:0008013) |
| 0.0 | 0.1 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.0 | 0.1 | GO:0031013 | troponin I binding(GO:0031013) |
| 0.0 | 2.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.0 | GO:0003938 | IMP dehydrogenase activity(GO:0003938) |
| 0.0 | 0.5 | GO:0005080 | protein kinase C binding(GO:0005080) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.4 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.0 | 0.5 | ST_P38_MAPK_PATHWAY | p38 MAPK Pathway |
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