Motif ID: FOXL1
Z-value: 1.508
Transcription factors associated with FOXL1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| FOXL1 | ENSG00000176678.4 | FOXL1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 4.0 | 11.9 | GO:0070886 | positive regulation of calcineurin-NFAT signaling cascade(GO:0070886) |
| 1.1 | 11.7 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.9 | 5.3 | GO:0008228 | opsonization(GO:0008228) |
| 0.9 | 4.4 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 0.4 | 1.3 | GO:0071529 | cementum mineralization(GO:0071529) |
| 0.4 | 1.2 | GO:0019695 | choline metabolic process(GO:0019695) |
| 0.4 | 1.1 | GO:0071380 | cellular response to prostaglandin E stimulus(GO:0071380) |
| 0.4 | 2.1 | GO:2000124 | cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926) regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.3 | 1.0 | GO:0010716 | regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054) |
| 0.3 | 0.9 | GO:0003350 | pulmonary myocardium development(GO:0003350) |
| 0.3 | 2.5 | GO:0060100 | regulation of phagocytosis, engulfment(GO:0060099) positive regulation of phagocytosis, engulfment(GO:0060100) regulation of membrane invagination(GO:1905153) positive regulation of membrane invagination(GO:1905155) |
| 0.3 | 1.5 | GO:0045989 | positive regulation of striated muscle contraction(GO:0045989) |
| 0.3 | 3.0 | GO:0097435 | extracellular fibril organization(GO:0043206) fibril organization(GO:0097435) |
| 0.3 | 1.2 | GO:0051503 | purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503) |
| 0.2 | 0.7 | GO:0021836 | chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923) |
| 0.2 | 0.8 | GO:0031340 | positive regulation of vesicle fusion(GO:0031340) |
| 0.2 | 0.6 | GO:0045578 | progesterone secretion(GO:0042701) negative regulation of B cell differentiation(GO:0045578) regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279) |
| 0.2 | 1.6 | GO:0007598 | blood coagulation, extrinsic pathway(GO:0007598) |
| 0.2 | 0.6 | GO:0043006 | activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006) |
| 0.2 | 0.8 | GO:0050965 | detection of temperature stimulus involved in sensory perception(GO:0050961) detection of temperature stimulus involved in sensory perception of pain(GO:0050965) |
| 0.2 | 0.6 | GO:0070171 | negative regulation of tooth mineralization(GO:0070171) |
| 0.2 | 1.7 | GO:0032528 | microvillus assembly(GO:0030033) microvillus organization(GO:0032528) |
| 0.2 | 1.2 | GO:2000111 | positive regulation of macrophage apoptotic process(GO:2000111) |
| 0.2 | 2.4 | GO:1901797 | negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797) |
| 0.2 | 1.0 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
| 0.2 | 0.6 | GO:0006848 | pyruvate transport(GO:0006848) |
| 0.1 | 0.6 | GO:0046121 | deoxyribonucleoside catabolic process(GO:0046121) |
| 0.1 | 0.4 | GO:0035120 | post-embryonic appendage morphogenesis(GO:0035120) |
| 0.1 | 0.6 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.1 | 0.5 | GO:0055098 | response to low-density lipoprotein particle(GO:0055098) |
| 0.1 | 0.3 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 0.1 | 1.2 | GO:0048873 | homeostasis of number of cells within a tissue(GO:0048873) |
| 0.1 | 0.2 | GO:0090005 | negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376) |
| 0.1 | 0.4 | GO:0033033 | negative regulation of myeloid cell apoptotic process(GO:0033033) |
| 0.1 | 0.7 | GO:0002726 | positive regulation of T cell cytokine production(GO:0002726) |
| 0.1 | 0.4 | GO:0006154 | adenosine catabolic process(GO:0006154) |
| 0.1 | 0.3 | GO:0019731 | antibacterial humoral response(GO:0019731) |
| 0.1 | 1.5 | GO:0060638 | mesenchymal-epithelial cell signaling(GO:0060638) |
| 0.1 | 1.0 | GO:0006621 | protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437) |
| 0.1 | 0.5 | GO:0001553 | luteinization(GO:0001553) |
| 0.1 | 0.3 | GO:0071679 | commissural neuron axon guidance(GO:0071679) |
| 0.1 | 1.7 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.1 | 0.3 | GO:0009822 | alkaloid catabolic process(GO:0009822) |
| 0.1 | 1.6 | GO:0031000 | response to caffeine(GO:0031000) |
| 0.1 | 0.8 | GO:0090292 | nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292) |
| 0.1 | 0.2 | GO:0051102 | DNA ligation involved in DNA recombination(GO:0051102) |
| 0.1 | 0.6 | GO:0050435 | beta-amyloid metabolic process(GO:0050435) |
| 0.1 | 1.2 | GO:0060390 | regulation of SMAD protein import into nucleus(GO:0060390) positive regulation of SMAD protein import into nucleus(GO:0060391) |
| 0.1 | 0.2 | GO:0070857 | regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251) |
| 0.1 | 0.3 | GO:0060209 | estrus(GO:0060209) |
| 0.1 | 0.1 | GO:0010936 | negative regulation of macrophage cytokine production(GO:0010936) |
| 0.1 | 0.1 | GO:0099515 | nuclear migration along microfilament(GO:0031022) actin filament-based transport(GO:0099515) |
| 0.1 | 2.6 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.1 | 0.4 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.1 | 1.1 | GO:0008634 | obsolete negative regulation of survival gene product expression(GO:0008634) |
| 0.1 | 0.2 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.1 | 0.2 | GO:0048861 | leukemia inhibitory factor signaling pathway(GO:0048861) |
| 0.1 | 0.1 | GO:0051659 | maintenance of mitochondrion location(GO:0051659) |
| 0.1 | 0.3 | GO:0019046 | release from viral latency(GO:0019046) |
| 0.1 | 1.7 | GO:0034199 | activation of protein kinase A activity(GO:0034199) |
| 0.1 | 0.4 | GO:0006552 | leucine catabolic process(GO:0006552) |
| 0.1 | 2.4 | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124) |
| 0.1 | 0.2 | GO:0007500 | mesodermal cell fate determination(GO:0007500) |
| 0.1 | 0.5 | GO:0015014 | heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014) |
| 0.1 | 0.3 | GO:0090084 | negative regulation of inclusion body assembly(GO:0090084) |
| 0.1 | 0.4 | GO:0034465 | cellular potassium ion homeostasis(GO:0030007) response to carbon monoxide(GO:0034465) negative regulation of cell volume(GO:0045794) |
| 0.1 | 0.2 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.1 | 0.3 | GO:2000172 | regulation of branching morphogenesis of a nerve(GO:2000172) |
| 0.1 | 0.2 | GO:0071318 | cellular response to ATP(GO:0071318) |
| 0.0 | 5.0 | GO:0030198 | extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062) |
| 0.0 | 0.2 | GO:0008628 | hormone-mediated apoptotic signaling pathway(GO:0008628) |
| 0.0 | 0.2 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.0 | 0.8 | GO:0070206 | protein trimerization(GO:0070206) |
| 0.0 | 0.1 | GO:0006691 | leukotriene metabolic process(GO:0006691) |
| 0.0 | 0.9 | GO:0003407 | neural retina development(GO:0003407) |
| 0.0 | 0.2 | GO:0010624 | regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626) |
| 0.0 | 0.1 | GO:0032071 | regulation of endodeoxyribonuclease activity(GO:0032071) |
| 0.0 | 0.5 | GO:0006030 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) |
| 0.0 | 0.2 | GO:0090343 | positive regulation of cell aging(GO:0090343) |
| 0.0 | 0.2 | GO:0045948 | positive regulation of translational initiation(GO:0045948) |
| 0.0 | 0.2 | GO:1903301 | regulation of glucokinase activity(GO:0033131) positive regulation of glucokinase activity(GO:0033133) regulation of hexokinase activity(GO:1903299) positive regulation of hexokinase activity(GO:1903301) |
| 0.0 | 0.1 | GO:0090042 | tubulin deacetylation(GO:0090042) |
| 0.0 | 0.8 | GO:0035329 | hippo signaling(GO:0035329) |
| 0.0 | 0.3 | GO:0033089 | positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400) |
| 0.0 | 1.5 | GO:0043462 | regulation of ATPase activity(GO:0043462) |
| 0.0 | 0.7 | GO:0007128 | meiotic prophase I(GO:0007128) |
| 0.0 | 0.5 | GO:0031529 | ruffle organization(GO:0031529) |
| 0.0 | 0.1 | GO:0072677 | eosinophil chemotaxis(GO:0048245) eosinophil migration(GO:0072677) |
| 0.0 | 0.1 | GO:0009698 | phenylpropanoid metabolic process(GO:0009698) coumarin metabolic process(GO:0009804) |
| 0.0 | 0.1 | GO:0052805 | histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805) |
| 0.0 | 0.4 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 0.0 | 0.1 | GO:0007635 | chemosensory behavior(GO:0007635) |
| 0.0 | 0.0 | GO:0019627 | urea metabolic process(GO:0019627) |
| 0.0 | 0.2 | GO:0042989 | sequestering of actin monomers(GO:0042989) |
| 0.0 | 0.1 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
| 0.0 | 4.8 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 0.1 | GO:0098762 | meiotic cell cycle phase(GO:0098762) |
| 0.0 | 0.3 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 0.0 | 0.2 | GO:0035587 | purinergic receptor signaling pathway(GO:0035587) purinergic nucleotide receptor signaling pathway(GO:0035590) |
| 0.0 | 0.5 | GO:0014003 | oligodendrocyte development(GO:0014003) |
| 0.0 | 1.0 | GO:0031532 | actin cytoskeleton reorganization(GO:0031532) |
| 0.0 | 0.1 | GO:0002885 | positive regulation of hypersensitivity(GO:0002885) |
| 0.0 | 0.1 | GO:0050951 | sensory perception of temperature stimulus(GO:0050951) |
| 0.0 | 0.5 | GO:0042730 | fibrinolysis(GO:0042730) |
| 0.0 | 0.2 | GO:0055015 | ventricular cardiac muscle cell development(GO:0055015) |
| 0.0 | 0.3 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.0 | 0.6 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.0 | 2.3 | GO:0000910 | cytokinesis(GO:0000910) |
| 0.0 | 1.1 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) regulation of microtubule depolymerization(GO:0031114) |
| 0.0 | 0.3 | GO:0019054 | modulation by virus of host process(GO:0019054) modulation by symbiont of host cellular process(GO:0044068) |
| 0.0 | 5.0 | GO:0006184 | obsolete GTP catabolic process(GO:0006184) |
| 0.0 | 0.2 | GO:0009396 | folic acid-containing compound biosynthetic process(GO:0009396) |
| 0.0 | 0.1 | GO:0018874 | benzoate metabolic process(GO:0018874) |
| 0.0 | 0.2 | GO:0006703 | estrogen biosynthetic process(GO:0006703) |
| 0.0 | 7.7 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.0 | 0.1 | GO:0001514 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.0 | 0.2 | GO:0046835 | carbohydrate phosphorylation(GO:0046835) |
| 0.0 | 0.2 | GO:0035964 | COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205) |
| 0.0 | 0.2 | GO:0045329 | amino-acid betaine biosynthetic process(GO:0006578) carnitine biosynthetic process(GO:0045329) |
| 0.0 | 0.6 | GO:0017158 | regulation of calcium ion-dependent exocytosis(GO:0017158) |
| 0.0 | 0.2 | GO:0043415 | positive regulation of skeletal muscle tissue regeneration(GO:0043415) regulation of skeletal muscle tissue regeneration(GO:0043416) |
| 0.0 | 0.5 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.0 | 0.1 | GO:0006011 | UDP-glucose metabolic process(GO:0006011) |
| 0.0 | 0.5 | GO:0007030 | Golgi organization(GO:0007030) |
| 0.0 | 0.1 | GO:0043371 | negative regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043371) negative regulation of T-helper cell differentiation(GO:0045623) negative regulation of CD4-positive, alpha-beta T cell activation(GO:2000515) |
| 0.0 | 0.1 | GO:0006896 | Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896) |
| 0.0 | 0.1 | GO:0046541 | saliva secretion(GO:0046541) |
| 0.0 | 0.0 | GO:0097061 | dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061) |
| 0.0 | 0.2 | GO:0071285 | cellular response to lithium ion(GO:0071285) |
| 0.0 | 0.1 | GO:0035461 | vitamin transmembrane transport(GO:0035461) |
| 0.0 | 0.1 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.0 | 0.1 | GO:0006264 | mitochondrial DNA replication(GO:0006264) |
| 0.0 | 0.3 | GO:1902591 | vesicle coating(GO:0006901) vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114) single-organism membrane budding(GO:1902591) |
| 0.0 | 0.1 | GO:0010898 | positive regulation of triglyceride catabolic process(GO:0010898) |
| 0.0 | 0.4 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
| 0.0 | 0.1 | GO:0006013 | mannose metabolic process(GO:0006013) |
| 0.0 | 0.2 | GO:0045104 | intermediate filament cytoskeleton organization(GO:0045104) |
| 0.0 | 1.0 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.0 | 0.4 | GO:0043631 | RNA polyadenylation(GO:0043631) |
| 0.0 | 0.1 | GO:0007341 | penetration of zona pellucida(GO:0007341) |
| 0.0 | 0.6 | GO:0009408 | response to heat(GO:0009408) |
| 0.0 | 0.4 | GO:0050909 | sensory perception of taste(GO:0050909) |
| 0.0 | 1.3 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
| 0.0 | 0.4 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.0 | 0.2 | GO:0006699 | bile acid biosynthetic process(GO:0006699) |
| 0.0 | 0.1 | GO:0070301 | cellular response to hydrogen peroxide(GO:0070301) |
| 0.0 | 0.3 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.0 | 2.9 | GO:0050900 | leukocyte migration(GO:0050900) |
| 0.0 | 0.1 | GO:0019852 | L-ascorbic acid metabolic process(GO:0019852) |
| 0.0 | 0.0 | GO:0009414 | response to water deprivation(GO:0009414) |
| 0.0 | 0.0 | GO:1901160 | serotonin metabolic process(GO:0042428) primary amino compound metabolic process(GO:1901160) |
| 0.0 | 0.2 | GO:0006098 | pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682) |
| 0.0 | 0.5 | GO:0006636 | unsaturated fatty acid biosynthetic process(GO:0006636) |
| 0.0 | 0.0 | GO:0048670 | regulation of collateral sprouting(GO:0048670) |
| 0.0 | 0.1 | GO:0015781 | pyrimidine nucleotide-sugar transport(GO:0015781) |
| 0.0 | 0.0 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
| 0.0 | 0.3 | GO:0018208 | peptidyl-proline modification(GO:0018208) |
| 0.0 | 0.1 | GO:0006108 | malate metabolic process(GO:0006108) |
| 0.0 | 0.1 | GO:0034643 | establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497) |
| 0.0 | 0.4 | GO:0008633 | obsolete activation of pro-apoptotic gene products(GO:0008633) |
| 0.0 | 0.2 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.0 | 0.4 | GO:0071260 | cellular response to mechanical stimulus(GO:0071260) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 11.7 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.3 | 1.2 | GO:0005641 | nuclear envelope lumen(GO:0005641) |
| 0.3 | 3.0 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.2 | 1.0 | GO:0000153 | cytoplasmic ubiquitin ligase complex(GO:0000153) |
| 0.2 | 0.6 | GO:0043512 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 0.2 | 1.0 | GO:0071438 | invadopodium membrane(GO:0071438) |
| 0.2 | 2.4 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 0.6 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.1 | 2.1 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 1.1 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.1 | 0.6 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 0.1 | 0.9 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.1 | 0.4 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 1.1 | GO:0000421 | autophagosome membrane(GO:0000421) smooth endoplasmic reticulum(GO:0005790) |
| 0.1 | 0.3 | GO:0043219 | lateral loop(GO:0043219) |
| 0.1 | 1.0 | GO:0071203 | WASH complex(GO:0071203) |
| 0.1 | 1.3 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.1 | 12.6 | GO:0030016 | myofibril(GO:0030016) |
| 0.1 | 0.7 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.1 | 0.2 | GO:0005712 | chiasma(GO:0005712) MutLbeta complex(GO:0032390) |
| 0.1 | 24.8 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.1 | 0.6 | GO:0043235 | receptor complex(GO:0043235) |
| 0.1 | 2.5 | GO:0030286 | dynein complex(GO:0030286) |
| 0.1 | 5.1 | GO:0044853 | caveola(GO:0005901) plasma membrane raft(GO:0044853) |
| 0.1 | 1.0 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.0 | 1.4 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 0.5 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.0 | 0.2 | GO:0032807 | DNA ligase IV complex(GO:0032807) |
| 0.0 | 0.2 | GO:0042599 | lamellar body(GO:0042599) |
| 0.0 | 0.3 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.0 | 0.2 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.0 | 0.4 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 0.4 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 0.6 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 0.3 | GO:0042589 | zymogen granule membrane(GO:0042589) |
| 0.0 | 0.3 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 0.7 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 0.2 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.0 | 0.2 | GO:0005638 | lamin filament(GO:0005638) |
| 0.0 | 1.7 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 0.2 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.0 | 0.2 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.0 | 0.3 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 0.2 | GO:0031233 | intrinsic component of external side of plasma membrane(GO:0031233) |
| 0.0 | 0.9 | GO:0098636 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.0 | 0.1 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 0.2 | GO:0001950 | obsolete plasma membrane enriched fraction(GO:0001950) |
| 0.0 | 0.2 | GO:0030663 | COPI vesicle coat(GO:0030126) COPI-coated vesicle membrane(GO:0030663) |
| 0.0 | 0.1 | GO:0032281 | AMPA glutamate receptor complex(GO:0032281) |
| 0.0 | 0.3 | GO:0032421 | stereocilium bundle(GO:0032421) |
| 0.0 | 0.2 | GO:0005625 | obsolete soluble fraction(GO:0005625) |
| 0.0 | 0.1 | GO:0000125 | PCAF complex(GO:0000125) |
| 0.0 | 0.1 | GO:0071546 | pi-body(GO:0071546) |
| 0.0 | 0.2 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
| 0.0 | 0.4 | GO:0090568 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568) |
| 0.0 | 0.1 | GO:0016589 | NURF complex(GO:0016589) |
| 0.0 | 1.8 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.0 | 0.6 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 0.5 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 1.8 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 0.1 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.0 | 0.3 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.0 | 0.1 | GO:0008290 | F-actin capping protein complex(GO:0008290) |
| 0.0 | 0.1 | GO:0016442 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 0.0 | 0.6 | GO:0022627 | cytosolic small ribosomal subunit(GO:0022627) |
| 0.0 | 1.7 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 0.4 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.4 | GO:0002114 | interleukin-33 receptor activity(GO:0002114) |
| 0.7 | 4.4 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.5 | 1.5 | GO:0004771 | sterol esterase activity(GO:0004771) |
| 0.5 | 1.8 | GO:0008112 | nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760) |
| 0.4 | 5.4 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.4 | 2.5 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.4 | 0.4 | GO:0070052 | collagen V binding(GO:0070052) |
| 0.3 | 3.5 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.3 | 11.6 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.3 | 1.2 | GO:0003990 | acetylcholinesterase activity(GO:0003990) |
| 0.3 | 1.5 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.3 | 0.8 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.2 | 1.4 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.2 | 6.9 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.2 | 0.8 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.2 | 0.6 | GO:0048184 | obsolete follistatin binding(GO:0048184) |
| 0.2 | 0.6 | GO:0004139 | deoxyribose-phosphate aldolase activity(GO:0004139) |
| 0.2 | 1.3 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
| 0.2 | 2.1 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.2 | 1.2 | GO:0055105 | ubiquitin-protein transferase inhibitor activity(GO:0055105) |
| 0.2 | 0.5 | GO:0047718 | indanol dehydrogenase activity(GO:0047718) |
| 0.2 | 0.9 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.2 | 0.6 | GO:0050833 | pyruvate secondary active transmembrane transporter activity(GO:0005477) pyruvate transmembrane transporter activity(GO:0050833) |
| 0.1 | 3.5 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 0.5 | GO:0042328 | heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328) N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509) |
| 0.1 | 1.4 | GO:0016725 | oxidoreductase activity, acting on CH or CH2 groups(GO:0016725) |
| 0.1 | 1.1 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.1 | 1.2 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.1 | 0.5 | GO:0034597 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) |
| 0.1 | 1.6 | GO:0005521 | lamin binding(GO:0005521) |
| 0.1 | 0.9 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.1 | 0.3 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.1 | 0.6 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.1 | 0.7 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.1 | 1.4 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 1.8 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 0.4 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.1 | 1.0 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093) |
| 0.1 | 0.2 | GO:0019215 | intermediate filament binding(GO:0019215) |
| 0.1 | 0.3 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.1 | 1.5 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.1 | 0.2 | GO:0004924 | oncostatin-M receptor activity(GO:0004924) |
| 0.1 | 0.3 | GO:0000739 | obsolete DNA strand annealing activity(GO:0000739) |
| 0.1 | 13.2 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.1 | 0.2 | GO:0003863 | alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863) |
| 0.1 | 0.3 | GO:0004982 | N-formyl peptide receptor activity(GO:0004982) |
| 0.1 | 0.3 | GO:0004690 | cyclic nucleotide-dependent protein kinase activity(GO:0004690) |
| 0.1 | 0.5 | GO:1901567 | icosanoid binding(GO:0050542) arachidonic acid binding(GO:0050544) fatty acid derivative binding(GO:1901567) |
| 0.1 | 0.5 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.1 | 0.7 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.1 | 1.0 | GO:0008239 | dipeptidyl-peptidase activity(GO:0008239) |
| 0.1 | 1.4 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.1 | 0.4 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.1 | 0.2 | GO:0016882 | cyclo-ligase activity(GO:0016882) |
| 0.1 | 0.3 | GO:0034235 | GPI anchor binding(GO:0034235) |
| 0.1 | 0.2 | GO:0019797 | procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544) |
| 0.0 | 0.4 | GO:0031685 | adenosine receptor binding(GO:0031685) |
| 0.0 | 0.2 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.0 | 0.5 | GO:0008527 | taste receptor activity(GO:0008527) |
| 0.0 | 0.2 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 0.0 | 0.6 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.0 | 0.5 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.0 | 0.1 | GO:0004523 | RNA-DNA hybrid ribonuclease activity(GO:0004523) |
| 0.0 | 0.5 | GO:0004568 | chitinase activity(GO:0004568) |
| 0.0 | 5.3 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 0.1 | GO:0047150 | betaine-homocysteine S-methyltransferase activity(GO:0047150) |
| 0.0 | 0.6 | GO:0000339 | RNA cap binding(GO:0000339) |
| 0.0 | 1.0 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 4.2 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 0.7 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.0 | 4.4 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.2 | GO:0003696 | satellite DNA binding(GO:0003696) |
| 0.0 | 0.3 | GO:0016717 | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717) |
| 0.0 | 0.3 | GO:0051636 | obsolete Gram-negative bacterial cell surface binding(GO:0051636) |
| 0.0 | 0.1 | GO:0019862 | IgA binding(GO:0019862) |
| 0.0 | 0.4 | GO:0030976 | thiamine pyrophosphate binding(GO:0030976) |
| 0.0 | 0.2 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
| 0.0 | 0.2 | GO:0052650 | NADP-retinol dehydrogenase activity(GO:0052650) |
| 0.0 | 1.3 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 0.1 | GO:0003983 | UTP:glucose-1-phosphate uridylyltransferase activity(GO:0003983) UTP-monosaccharide-1-phosphate uridylyltransferase activity(GO:0051748) |
| 0.0 | 0.2 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) |
| 0.0 | 1.0 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 0.1 | GO:0070053 | thrombospondin receptor activity(GO:0070053) |
| 0.0 | 0.1 | GO:0046848 | hydroxyapatite binding(GO:0046848) |
| 0.0 | 0.7 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.2 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.0 | 0.1 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.0 | 0.3 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) bicarbonate transmembrane transporter activity(GO:0015106) |
| 0.0 | 0.5 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.0 | 0.2 | GO:0004185 | serine-type carboxypeptidase activity(GO:0004185) |
| 0.0 | 2.6 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.0 | 0.1 | GO:0019763 | immunoglobulin receptor activity(GO:0019763) |
| 0.0 | 0.5 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 0.3 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.0 | 0.5 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 0.1 | GO:0004662 | CAAX-protein geranylgeranyltransferase activity(GO:0004662) |
| 0.0 | 0.1 | GO:0016841 | ammonia-lyase activity(GO:0016841) |
| 0.0 | 0.2 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.0 | 0.1 | GO:0090482 | vitamin transmembrane transporter activity(GO:0090482) |
| 0.0 | 0.1 | GO:0003996 | acyl-CoA ligase activity(GO:0003996) |
| 0.0 | 0.6 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 0.1 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
| 0.0 | 0.1 | GO:0004525 | ribonuclease III activity(GO:0004525) double-stranded RNA-specific ribonuclease activity(GO:0032296) |
| 0.0 | 0.9 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
| 0.0 | 0.1 | GO:0018685 | alkane 1-monooxygenase activity(GO:0018685) |
| 0.0 | 0.1 | GO:0004559 | alpha-mannosidase activity(GO:0004559) |
| 0.0 | 0.3 | GO:0043176 | amine binding(GO:0043176) |
| 0.0 | 0.4 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.0 | 1.0 | GO:0001948 | glycoprotein binding(GO:0001948) |
| 0.0 | 0.4 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.0 | 0.1 | GO:0047045 | testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045) |
| 0.0 | 0.5 | GO:0045182 | translation regulator activity(GO:0045182) |
| 0.0 | 0.3 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 0.1 | GO:0043499 | obsolete eukaryotic cell surface binding(GO:0043499) |
| 0.0 | 0.9 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.0 | 0.1 | GO:0016019 | peptidoglycan receptor activity(GO:0016019) |
| 0.0 | 0.2 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.0 | 0.1 | GO:0034584 | piRNA binding(GO:0034584) |
| 0.0 | 0.1 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 0.1 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.0 | 1.0 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 1.5 | GO:0003777 | microtubule motor activity(GO:0003777) |
| 0.0 | 0.1 | GO:0097642 | calcitonin family receptor activity(GO:0097642) |
| 0.0 | 0.4 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.0 | 0.1 | GO:0004914 | interleukin-5 receptor activity(GO:0004914) |
| 0.0 | 0.1 | GO:0005152 | interleukin-1 receptor antagonist activity(GO:0005152) |
| 0.0 | 0.1 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
| 0.0 | 0.6 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.0 | 0.3 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 0.3 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.0 | 0.2 | GO:0016857 | racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857) |
| 0.0 | 0.0 | GO:0004833 | tryptophan 2,3-dioxygenase activity(GO:0004833) |
| 0.0 | 0.2 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
| 0.0 | 4.3 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 0.3 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.0 | 3.2 | GO:0005543 | phospholipid binding(GO:0005543) |
| 0.0 | 0.2 | GO:0035381 | extracellular ATP-gated cation channel activity(GO:0004931) ATP-gated ion channel activity(GO:0035381) |
| 0.0 | 0.4 | GO:0003730 | mRNA 3'-UTR binding(GO:0003730) |
| 0.0 | 0.9 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.0 | GO:0015204 | urea transmembrane transporter activity(GO:0015204) |
| 0.0 | 1.2 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389) |
| 0.0 | 0.1 | GO:0015165 | pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165) |
| 0.0 | 0.1 | GO:0061659 | ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
| 0.0 | 0.0 | GO:0042805 | actinin binding(GO:0042805) |
| 0.0 | 0.3 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
| 0.0 | 0.2 | GO:0005484 | SNAP receptor activity(GO:0005484) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 5.4 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.1 | 2.0 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 1.2 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 0.3 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.0 | 1.3 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
| 0.0 | 0.8 | ST_G_ALPHA_I_PATHWAY | G alpha i Pathway |
| 0.0 | 0.1 | ST_GAQ_PATHWAY | G alpha q Pathway |
| 0.0 | 1.0 | ST_INTEGRIN_SIGNALING_PATHWAY | Integrin Signaling Pathway |
