Motif ID: FOXO4
Z-value: 2.419
Transcription factors associated with FOXO4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| FOXO4 | ENSG00000184481.12 | FOXO4 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.8 | 7.3 | GO:0050928 | negative regulation of positive chemotaxis(GO:0050928) |
| 0.8 | 2.5 | GO:0010982 | regulation of high-density lipoprotein particle clearance(GO:0010982) |
| 0.5 | 2.6 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 0.3 | 1.4 | GO:0009109 | coenzyme catabolic process(GO:0009109) |
| 0.3 | 1.0 | GO:0042759 | fatty acid elongation, saturated fatty acid(GO:0019367) long-chain fatty acid biosynthetic process(GO:0042759) |
| 0.2 | 2.7 | GO:0051497 | negative regulation of stress fiber assembly(GO:0051497) |
| 0.2 | 0.7 | GO:0043006 | activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006) |
| 0.2 | 2.7 | GO:0010658 | striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667) |
| 0.2 | 2.0 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.2 | 1.3 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.2 | 1.2 | GO:0051387 | negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387) |
| 0.2 | 3.6 | GO:0042403 | thyroid hormone metabolic process(GO:0042403) |
| 0.1 | 0.9 | GO:0016080 | synaptic vesicle targeting(GO:0016080) |
| 0.1 | 0.3 | GO:0001514 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.1 | 1.1 | GO:0006553 | lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554) |
| 0.1 | 4.0 | GO:0042554 | superoxide anion generation(GO:0042554) |
| 0.1 | 0.7 | GO:0045074 | interleukin-10 biosynthetic process(GO:0042091) regulation of interleukin-10 biosynthetic process(GO:0045074) |
| 0.1 | 1.2 | GO:0032528 | microvillus assembly(GO:0030033) microvillus organization(GO:0032528) |
| 0.1 | 0.7 | GO:0010508 | positive regulation of autophagy(GO:0010508) |
| 0.1 | 0.8 | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037) |
| 0.1 | 1.2 | GO:0008354 | germ cell migration(GO:0008354) |
| 0.1 | 0.8 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.1 | 3.8 | GO:0031532 | actin cytoskeleton reorganization(GO:0031532) |
| 0.1 | 2.3 | GO:0007172 | signal complex assembly(GO:0007172) |
| 0.1 | 0.3 | GO:0010966 | regulation of phosphate transport(GO:0010966) |
| 0.1 | 0.6 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.1 | 0.3 | GO:0046984 | regulation of hemoglobin biosynthetic process(GO:0046984) |
| 0.1 | 0.8 | GO:0006622 | protein targeting to lysosome(GO:0006622) protein targeting to vacuole(GO:0006623) protein localization to lysosome(GO:0061462) protein localization to vacuole(GO:0072665) establishment of protein localization to vacuole(GO:0072666) |
| 0.1 | 1.2 | GO:0048261 | negative regulation of receptor-mediated endocytosis(GO:0048261) |
| 0.1 | 0.3 | GO:0006542 | glutamine biosynthetic process(GO:0006542) |
| 0.1 | 0.2 | GO:1903960 | negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192) |
| 0.1 | 1.5 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
| 0.1 | 2.9 | GO:0008633 | obsolete activation of pro-apoptotic gene products(GO:0008633) |
| 0.1 | 2.2 | GO:0051897 | positive regulation of protein kinase B signaling(GO:0051897) |
| 0.1 | 0.6 | GO:0060762 | regulation of branching involved in mammary gland duct morphogenesis(GO:0060762) |
| 0.1 | 1.5 | GO:0046627 | negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077) |
| 0.1 | 1.0 | GO:0018298 | detection of visible light(GO:0009584) protein-chromophore linkage(GO:0018298) |
| 0.1 | 2.5 | GO:0030837 | negative regulation of actin filament polymerization(GO:0030837) |
| 0.1 | 1.1 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.1 | 0.6 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.1 | 0.2 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.1 | 0.2 | GO:0051088 | PMA-inducible membrane protein ectodomain proteolysis(GO:0051088) |
| 0.0 | 1.1 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.0 | 0.6 | GO:1904031 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031) |
| 0.0 | 0.7 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.0 | 1.1 | GO:0006378 | mRNA polyadenylation(GO:0006378) |
| 0.0 | 2.0 | GO:0045576 | mast cell activation(GO:0045576) |
| 0.0 | 0.2 | GO:0050912 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) detection of chemical stimulus involved in sensory perception of taste(GO:0050912) |
| 0.0 | 0.2 | GO:0045722 | positive regulation of gluconeogenesis(GO:0045722) |
| 0.0 | 2.4 | GO:0007569 | cell aging(GO:0007569) |
| 0.0 | 0.1 | GO:0032747 | positive regulation of interleukin-23 production(GO:0032747) |
| 0.0 | 0.3 | GO:0071425 | hematopoietic stem cell proliferation(GO:0071425) |
| 0.0 | 0.2 | GO:0021520 | spinal cord motor neuron cell fate specification(GO:0021520) |
| 0.0 | 1.3 | GO:0051297 | centrosome organization(GO:0051297) |
| 0.0 | 0.3 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
| 0.0 | 1.6 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
| 0.0 | 0.7 | GO:0042130 | negative regulation of T cell proliferation(GO:0042130) |
| 0.0 | 0.1 | GO:0006420 | arginyl-tRNA aminoacylation(GO:0006420) |
| 0.0 | 5.6 | GO:0001525 | angiogenesis(GO:0001525) |
| 0.0 | 0.2 | GO:0000301 | retrograde transport, vesicle recycling within Golgi(GO:0000301) |
| 0.0 | 6.3 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.0 | 0.5 | GO:0015813 | L-glutamate transport(GO:0015813) |
| 0.0 | 0.2 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
| 0.0 | 0.3 | GO:0043154 | negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154) |
| 0.0 | 2.8 | GO:0006979 | response to oxidative stress(GO:0006979) |
| 0.0 | 0.2 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.0 | 1.4 | GO:0006469 | negative regulation of protein kinase activity(GO:0006469) |
| 0.0 | 0.2 | GO:0034035 | purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.6 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.1 | 1.9 | GO:0030122 | AP-2 adaptor complex(GO:0030122) clathrin coat of endocytic vesicle(GO:0030128) |
| 0.1 | 0.7 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.1 | 0.5 | GO:0005955 | calcineurin complex(GO:0005955) |
| 0.1 | 18.6 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.1 | 3.2 | GO:0030018 | Z disc(GO:0030018) |
| 0.1 | 3.2 | GO:0005902 | microvillus(GO:0005902) |
| 0.1 | 0.8 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.1 | 1.2 | GO:0005942 | phosphatidylinositol 3-kinase complex(GO:0005942) |
| 0.1 | 1.2 | GO:0070161 | anchoring junction(GO:0070161) |
| 0.1 | 0.1 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
| 0.1 | 0.2 | GO:0032593 | insulin-responsive compartment(GO:0032593) |
| 0.1 | 0.6 | GO:0043202 | lysosomal lumen(GO:0043202) |
| 0.1 | 0.5 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.0 | 0.2 | GO:0000407 | pre-autophagosomal structure(GO:0000407) |
| 0.0 | 0.4 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.0 | 1.2 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 1.6 | GO:0098636 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.0 | 0.1 | GO:0000221 | vacuolar proton-transporting V-type ATPase, V1 domain(GO:0000221) |
| 0.0 | 1.3 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 6.1 | GO:0005911 | cell-cell junction(GO:0005911) |
| 0.0 | 0.7 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 0.3 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.0 | 1.4 | GO:0031901 | early endosome membrane(GO:0031901) |
| 0.0 | 0.3 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.0 | 3.4 | GO:0009986 | cell surface(GO:0009986) |
| 0.0 | 1.4 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 1.3 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 1.1 | GO:0044853 | caveola(GO:0005901) plasma membrane raft(GO:0044853) |
| 0.0 | 1.2 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 4.2 | GO:0005792 | obsolete microsome(GO:0005792) |
| 0.0 | 5.9 | GO:0005815 | microtubule organizing center(GO:0005815) |
| 0.0 | 0.2 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.0 | 12.6 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 0.1 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.0 | 0.2 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.4 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.8 | 2.5 | GO:0008970 | phosphatidylcholine 1-acylhydrolase activity(GO:0008970) |
| 0.7 | 3.7 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.5 | 2.6 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.4 | 4.0 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.3 | 2.7 | GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity(GO:0030297) |
| 0.3 | 1.2 | GO:0032050 | clathrin heavy chain binding(GO:0032050) |
| 0.3 | 1.4 | GO:0004090 | carbonyl reductase (NADPH) activity(GO:0004090) |
| 0.3 | 3.7 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.3 | 1.3 | GO:0008474 | palmitoyl-(protein) hydrolase activity(GO:0008474) palmitoyl hydrolase activity(GO:0098599) |
| 0.2 | 7.2 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.2 | 2.0 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.2 | 1.2 | GO:0046934 | phosphatidylinositol-4,5-bisphosphate 3-kinase activity(GO:0046934) phosphatidylinositol bisphosphate kinase activity(GO:0052813) |
| 0.2 | 1.0 | GO:0009922 | fatty acid elongase activity(GO:0009922) |
| 0.2 | 1.2 | GO:0042577 | lipid phosphatase activity(GO:0042577) |
| 0.2 | 7.3 | GO:1990782 | receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782) |
| 0.2 | 2.7 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.2 | 1.1 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.2 | 0.9 | GO:0042043 | neurexin family protein binding(GO:0042043) |
| 0.2 | 0.3 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.2 | 0.8 | GO:0005294 | neutral L-amino acid secondary active transmembrane transporter activity(GO:0005294) |
| 0.2 | 0.6 | GO:0016997 | exo-alpha-sialidase activity(GO:0004308) alpha-sialidase activity(GO:0016997) |
| 0.2 | 2.1 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.1 | 0.7 | GO:0004597 | peptide-aspartate beta-dioxygenase activity(GO:0004597) |
| 0.1 | 1.0 | GO:0008020 | G-protein coupled photoreceptor activity(GO:0008020) |
| 0.1 | 3.2 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.1 | 1.2 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093) |
| 0.1 | 0.5 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.1 | 0.8 | GO:0005402 | sugar:proton symporter activity(GO:0005351) cation:sugar symporter activity(GO:0005402) D-glucose transmembrane transporter activity(GO:0055056) |
| 0.1 | 0.3 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.1 | 1.1 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
| 0.1 | 0.5 | GO:0015410 | manganese-transporting ATPase activity(GO:0015410) |
| 0.1 | 0.7 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.1 | 0.3 | GO:0016211 | glutamate-ammonia ligase activity(GO:0004356) ammonia ligase activity(GO:0016211) acid-ammonia (or amide) ligase activity(GO:0016880) |
| 0.1 | 1.1 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 0.1 | 3.2 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.1 | 0.8 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.1 | 0.5 | GO:0004849 | uridine kinase activity(GO:0004849) |
| 0.1 | 1.3 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.1 | 2.3 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.1 | 0.7 | GO:0055103 | ligase regulator activity(GO:0055103) ubiquitin-protein transferase regulator activity(GO:0055106) |
| 0.1 | 0.3 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
| 0.1 | 0.8 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.0 | 0.5 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.0 | 0.3 | GO:0004430 | 1-phosphatidylinositol 4-kinase activity(GO:0004430) |
| 0.0 | 0.8 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 1.5 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.0 | 1.2 | GO:0001104 | transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076) RNA polymerase II transcription cofactor activity(GO:0001104) |
| 0.0 | 0.5 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
| 0.0 | 0.3 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
| 0.0 | 0.6 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.0 | 3.5 | GO:0004714 | transmembrane receptor protein tyrosine kinase activity(GO:0004714) |
| 0.0 | 5.1 | GO:0035257 | nuclear hormone receptor binding(GO:0035257) |
| 0.0 | 0.1 | GO:0005223 | intracellular cGMP activated cation channel activity(GO:0005223) |
| 0.0 | 0.6 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 0.2 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) |
| 0.0 | 6.4 | GO:0030246 | carbohydrate binding(GO:0030246) |
| 0.0 | 4.4 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 0.2 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
| 0.0 | 0.1 | GO:0004814 | arginine-tRNA ligase activity(GO:0004814) |
| 0.0 | 0.4 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.0 | 0.1 | GO:0004980 | melanocyte-stimulating hormone receptor activity(GO:0004980) |
| 0.0 | 0.0 | GO:0033858 | galactokinase activity(GO:0004335) N-acetylgalactosamine kinase activity(GO:0033858) |
| 0.0 | 0.1 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.0 | 0.1 | GO:0004904 | interferon receptor activity(GO:0004904) |
| 0.0 | 0.2 | GO:0004435 | phosphatidylinositol phospholipase C activity(GO:0004435) |
| 0.0 | 0.6 | GO:0005518 | collagen binding(GO:0005518) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.3 | ST_GA12_PATHWAY | G alpha 12 Pathway |
| 0.0 | 0.9 | ST_G_ALPHA_I_PATHWAY | G alpha i Pathway |
| 0.0 | 1.2 | SIG_CHEMOTAXIS | Genes related to chemotaxis |
| 0.0 | 3.2 | ST_INTEGRIN_SIGNALING_PATHWAY | Integrin Signaling Pathway |
| 0.0 | 1.5 | SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 0.3 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
