Motif ID: GAGAUGA

Z-value: 0.512


Mature miRNA associated with seed GAGAUGA:

NamemiRBase Accession
hsa-miR-143-3p MIMAT0000435
hsa-miR-4770 MIMAT0019924
hsa-miR-6088 MIMAT0023713



Activity profile for motif GAGAUGA.

activity profile for motif GAGAUGA


Sorted Z-values histogram for motif GAGAUGA

Sorted Z-values for motif GAGAUGA



Network of associatons between targets according to the STRING database.



First level regulatory network of GAGAUGA

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_217560248 0.696 ENST00000233813.4
IGFBP5
insulin-like growth factor binding protein 5
chrX_+_73641286 0.472 ENST00000587091.1
SLC16A2
solute carrier family 16, member 2 (thyroid hormone transporter)
chr5_+_32711419 0.467 ENST00000265074.8
NPR3
natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)
chr1_-_57045228 0.440 ENST00000371250.3
PPAP2B
phosphatidic acid phosphatase type 2B
chr6_-_132272504 0.430 ENST00000367976.3
CTGF
connective tissue growth factor
chr7_-_47621736 0.420 ENST00000311160.9
TNS3
tensin 3
chr2_-_190044480 0.408 ENST00000374866.3
COL5A2
collagen, type V, alpha 2
chr15_+_39873268 0.389 ENST00000397591.2
ENST00000260356.5
THBS1

thrombospondin 1

chr17_+_19281034 0.356 ENST00000308406.5
ENST00000299612.7
MAPK7

mitogen-activated protein kinase 7

chr13_+_48807288 0.350 ENST00000378565.5
ITM2B
integral membrane protein 2B
chr12_-_65146636 0.338 ENST00000418919.2
GNS
glucosamine (N-acetyl)-6-sulfatase
chr17_-_48278983 0.325 ENST00000225964.5
COL1A1
collagen, type I, alpha 1
chr4_+_55095264 0.324 ENST00000257290.5
PDGFRA
platelet-derived growth factor receptor, alpha polypeptide
chr10_-_126849068 0.285 ENST00000494626.2
ENST00000337195.5
CTBP2

C-terminal binding protein 2

chr6_-_52441713 0.252 ENST00000182527.3
TRAM2
translocation associated membrane protein 2
chr15_-_49338748 0.245 ENST00000559471.1
SECISBP2L
SECIS binding protein 2-like
chr15_-_26108355 0.237 ENST00000356865.6
ATP10A
ATPase, class V, type 10A
chr17_+_60704762 0.234 ENST00000303375.5
MRC2
mannose receptor, C type 2
chr5_+_71403061 0.222 ENST00000512974.1
ENST00000296755.7
MAP1B

microtubule-associated protein 1B

chr7_-_131241361 0.221 ENST00000378555.3
ENST00000322985.9
ENST00000541194.1
ENST00000537928.1
PODXL



podocalyxin-like



chr8_-_18871159 0.216 ENST00000327040.8
ENST00000440756.2
PSD3

pleckstrin and Sec7 domain containing 3

chr10_+_31608054 0.203 ENST00000320985.10
ENST00000361642.5
ENST00000560721.2
ENST00000558440.1
ENST00000424869.1
ENST00000542815.3
ZEB1





zinc finger E-box binding homeobox 1





chr17_+_28705921 0.201 ENST00000225719.4
CPD
carboxypeptidase D
chr9_+_79074068 0.185 ENST00000444201.2
ENST00000376730.4
GCNT1

glucosaminyl (N-acetyl) transferase 1, core 2

chr16_-_79634595 0.180 ENST00000326043.4
ENST00000393350.1
MAF

v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog

chr20_-_48099182 0.178 ENST00000371741.4
KCNB1
potassium voltage-gated channel, Shab-related subfamily, member 1
chr10_-_30024716 0.178 ENST00000375398.2
ENST00000375400.3
SVIL

supervillin

chr2_+_173292301 0.176 ENST00000264106.6
ENST00000375221.2
ENST00000343713.4
ITGA6


integrin, alpha 6


chr8_-_116681221 0.169 ENST00000395715.3
TRPS1
trichorhinophalangeal syndrome I
chr1_-_205290865 0.166 ENST00000367157.3
NUAK2
NUAK family, SNF1-like kinase, 2
chr6_+_76458909 0.161 ENST00000369981.3
ENST00000369985.4
MYO6

myosin VI

chr6_-_91296602 0.154 ENST00000369325.3
ENST00000369327.3
MAP3K7

mitogen-activated protein kinase kinase kinase 7

chr14_-_96830207 0.154 ENST00000359933.4
ATG2B
autophagy related 2B
chr3_+_9975497 0.139 ENST00000397170.3
ENST00000383811.3
ENST00000452070.1
ENST00000326434.5
CRELD1



cysteine-rich with EGF-like domains 1



chr17_-_46623441 0.137 ENST00000330070.4
HOXB2
homeobox B2
chr6_+_107811162 0.135 ENST00000317357.5
SOBP
sine oculis binding protein homolog (Drosophila)
chr15_+_68871308 0.131 ENST00000261861.5
CORO2B
coronin, actin binding protein, 2B
chr19_-_10121144 0.129 ENST00000264828.3
COL5A3
collagen, type V, alpha 3
chr5_+_141488070 0.126 ENST00000253814.4
NDFIP1
Nedd4 family interacting protein 1
chr14_+_21538429 0.125 ENST00000298694.4
ENST00000555038.1
ARHGEF40

Rho guanine nucleotide exchange factor (GEF) 40

chr15_+_65134088 0.125 ENST00000323544.4
ENST00000437723.1
PLEKHO2
AC069368.3
pleckstrin homology domain containing, family O member 2
Uncharacterized protein
chr1_+_51701924 0.123 ENST00000242719.3
RNF11
ring finger protein 11
chr12_+_8234807 0.119 ENST00000339754.5
NECAP1
NECAP endocytosis associated 1
chr6_+_132129151 0.109 ENST00000360971.2
ENPP1
ectonucleotide pyrophosphatase/phosphodiesterase 1
chr2_+_28615669 0.100 ENST00000379619.1
ENST00000264716.4
FOSL2

FOS-like antigen 2

chr5_-_126366500 0.099 ENST00000308660.5
MARCH3
membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase
chr5_-_38595498 0.092 ENST00000263409.4
LIFR
leukemia inhibitory factor receptor alpha
chr6_+_114178512 0.092 ENST00000368635.4
MARCKS
myristoylated alanine-rich protein kinase C substrate
chrX_-_106959631 0.087 ENST00000486554.1
ENST00000372390.4
TSC22D3

TSC22 domain family, member 3

chr7_-_42276612 0.087 ENST00000395925.3
ENST00000437480.1
GLI3

GLI family zinc finger 3

chr12_-_54673871 0.082 ENST00000209875.4
CBX5
chromobox homolog 5
chrX_+_9983602 0.082 ENST00000380861.4
WWC3
WWC family member 3
chr12_-_46766577 0.081 ENST00000256689.5
SLC38A2
solute carrier family 38, member 2
chr3_-_37034702 0.081 ENST00000322716.5
EPM2AIP1
EPM2A (laforin) interacting protein 1
chr11_+_57520715 0.081 ENST00000524630.1
ENST00000529919.1
ENST00000399039.4
ENST00000533189.1
CTNND1



catenin (cadherin-associated protein), delta 1



chr11_+_113930291 0.079 ENST00000335953.4
ZBTB16
zinc finger and BTB domain containing 16
chr2_-_96931679 0.077 ENST00000258439.3
ENST00000432959.1
TMEM127

transmembrane protein 127

chr9_+_130374537 0.073 ENST00000373302.3
ENST00000373299.1
STXBP1

syntaxin binding protein 1

chr14_+_90863327 0.063 ENST00000356978.4
CALM1
calmodulin 1 (phosphorylase kinase, delta)
chr4_+_77870856 0.063 ENST00000264893.6
ENST00000502584.1
ENST00000510641.1
SEPT11


septin 11


chr2_+_181845298 0.062 ENST00000410062.4
UBE2E3
ubiquitin-conjugating enzyme E2E 3
chr3_-_114790179 0.062 ENST00000462705.1
ZBTB20
zinc finger and BTB domain containing 20
chr12_+_60083118 0.061 ENST00000261187.4
ENST00000543448.1
SLC16A7

solute carrier family 16 (monocarboxylate transporter), member 7

chr15_+_67358163 0.060 ENST00000327367.4
SMAD3
SMAD family member 3
chr1_+_178062855 0.060 ENST00000448150.3
RASAL2
RAS protein activator like 2
chr5_+_141303373 0.058 ENST00000432126.2
ENST00000194118.4
KIAA0141

KIAA0141

chr3_+_171758344 0.058 ENST00000336824.4
ENST00000423424.1
FNDC3B

fibronectin type III domain containing 3B

chr1_+_145611010 0.056 ENST00000369291.5
RNF115
ring finger protein 115
chr9_-_123476719 0.052 ENST00000373930.3
MEGF9
multiple EGF-like-domains 9
chr16_+_66400533 0.051 ENST00000341529.3
CDH5
cadherin 5, type 2 (vascular endothelium)
chr14_+_77228532 0.051 ENST00000167106.4
ENST00000554237.1
VASH1

vasohibin 1

chr3_+_128444965 0.047 ENST00000265062.3
RAB7A
RAB7A, member RAS oncogene family
chr10_+_111767720 0.042 ENST00000356080.4
ENST00000277900.8
ADD3

adducin 3 (gamma)

chr11_-_79151695 0.041 ENST00000278550.7
TENM4
teneurin transmembrane protein 4
chr10_+_11206925 0.040 ENST00000354440.2
ENST00000315874.4
ENST00000427450.1
CELF2


CUGBP, Elav-like family member 2


chr1_-_186649543 0.039 ENST00000367468.5
PTGS2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase)
chr15_+_77287426 0.038 ENST00000558012.1
ENST00000267939.5
ENST00000379595.3
PSTPIP1


proline-serine-threonine phosphatase interacting protein 1


chr1_-_154155595 0.038 ENST00000328159.4
ENST00000368531.2
ENST00000323144.7
ENST00000368533.3
ENST00000341372.3
TPM3




tropomyosin 3




chr19_+_3359561 0.037 ENST00000589123.1
ENST00000346156.5
ENST00000395111.3
ENST00000586919.1
NFIC



nuclear factor I/C (CCAAT-binding transcription factor)



chr2_-_10952922 0.037 ENST00000272227.3
PDIA6
protein disulfide isomerase family A, member 6
chr2_+_220042933 0.037 ENST00000430297.2
FAM134A
family with sequence similarity 134, member A
chr11_+_118477144 0.036 ENST00000361417.2
PHLDB1
pleckstrin homology-like domain, family B, member 1
chr18_-_54305658 0.036 ENST00000586262.1
ENST00000217515.6
TXNL1

thioredoxin-like 1

chr9_-_113342160 0.036 ENST00000401783.2
ENST00000374461.1
SVEP1

sushi, von Willebrand factor type A, EGF and pentraxin domain containing 1

chr15_+_85923856 0.035 ENST00000560302.1
ENST00000394518.2
ENST00000361243.2
ENST00000560256.1
AKAP13



A kinase (PRKA) anchor protein 13



chr2_-_9563319 0.032 ENST00000497105.1
ENST00000360635.3
ENST00000359712.3
ITGB1BP1


integrin beta 1 binding protein 1


chr11_-_26743546 0.031 ENST00000280467.6
ENST00000396005.3
SLC5A12

solute carrier family 5 (sodium/monocarboxylate cotransporter), member 12

chr17_+_57784826 0.028 ENST00000262291.4
VMP1
vacuole membrane protein 1
chr13_+_45563721 0.027 ENST00000361121.2
GPALPP1
GPALPP motifs containing 1
chr17_+_61086917 0.026 ENST00000424789.2
ENST00000389520.4
TANC2

tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2

chr13_+_73632897 0.024 ENST00000377687.4
KLF5
Kruppel-like factor 5 (intestinal)
chr12_+_12764773 0.024 ENST00000228865.2
CREBL2
cAMP responsive element binding protein-like 2
chr19_-_40324255 0.024 ENST00000593685.1
ENST00000600611.1
DYRK1B

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B

chr1_+_2323260 0.020 ENST00000378518.1
ENST00000605895.1
ENST00000378513.3
ENST00000306256.9
ENST00000378512.1
RER1




retention in endoplasmic reticulum sorting receptor 1




chr20_+_30865429 0.018 ENST00000375712.3
KIF3B
kinesin family member 3B
chr11_-_118047376 0.018 ENST00000278947.5
SCN2B
sodium channel, voltage-gated, type II, beta subunit
chr12_-_49449107 0.016 ENST00000301067.7
KMT2D
lysine (K)-specific methyltransferase 2D
chr19_-_47128294 0.014 ENST00000596260.1
ENST00000597185.1
ENST00000598865.1
ENST00000594275.1
ENST00000291294.2
PTGIR




prostaglandin I2 (prostacyclin) receptor (IP)




chr3_+_183873098 0.011 ENST00000313143.3
DVL3
dishevelled segment polarity protein 3
chr3_-_179754706 0.010 ENST00000465751.1
ENST00000467460.1
PEX5L

peroxisomal biogenesis factor 5-like

chr19_-_47735918 0.010 ENST00000449228.1
ENST00000300880.7
ENST00000341983.4
BBC3


BCL2 binding component 3


chr4_-_79860506 0.010 ENST00000295462.3
ENST00000380645.4
ENST00000512733.1
PAQR3


progestin and adipoQ receptor family member III


chr8_-_105601134 0.010 ENST00000276654.5
ENST00000424843.2
LRP12

low density lipoprotein receptor-related protein 12

chr8_+_120079478 0.009 ENST00000332843.2
COLEC10
collectin sub-family member 10 (C-type lectin)
chr11_+_66025167 0.008 ENST00000394067.2
ENST00000316924.5
ENST00000421552.1
ENST00000394078.1
KLC2



kinesin light chain 2



chr3_-_125094093 0.008 ENST00000484491.1
ENST00000492394.1
ENST00000471196.1
ENST00000468369.1
ENST00000544464.1
ENST00000485866.1
ENST00000360647.4
ZNF148






zinc finger protein 148






chrX_-_48824793 0.007 ENST00000376477.1
KCND1
potassium voltage-gated channel, Shal-related subfamily, member 1
chr12_+_103981044 0.007 ENST00000388887.2
STAB2
stabilin 2
chrX_+_133507327 0.006 ENST00000332070.3
ENST00000394292.1
ENST00000370799.1
ENST00000416404.2
PHF6



PHD finger protein 6



chr22_+_40390930 0.006 ENST00000333407.6
FAM83F
family with sequence similarity 83, member F
chr19_-_38806560 0.005 ENST00000591755.1
ENST00000337679.8
ENST00000339413.6
YIF1B


Yip1 interacting factor homolog B (S. cerevisiae)


chr8_-_63998590 0.005 ENST00000260116.4
TTPA
tocopherol (alpha) transfer protein
chr3_+_9834758 0.005 ENST00000485273.1
ENST00000433034.1
ENST00000397256.1
ARPC4

ARPC4-TTLL3
actin related protein 2/3 complex, subunit 4, 20kDa

ARPC4-TTLL3 readthrough
chr11_-_9336234 0.004 ENST00000528080.1
TMEM41B
transmembrane protein 41B
chr17_+_14204389 0.004 ENST00000360954.2
HS3ST3B1
heparan sulfate (glucosamine) 3-O-sulfotransferase 3B1
chr11_-_73309228 0.002 ENST00000356467.4
ENST00000064778.4
FAM168A

family with sequence similarity 168, member A

chr6_+_163835669 0.001 ENST00000453779.2
ENST00000275262.7
ENST00000392127.2
ENST00000361752.3
QKI



QKI, KH domain containing, RNA binding



chr12_-_123011536 0.001 ENST00000331738.7
ENST00000354654.2
RSRC2

arginine/serine-rich coiled-coil 2

chr12_+_112856690 0.000 ENST00000392597.1
ENST00000351677.2
PTPN11

protein tyrosine phosphatase, non-receptor type 11


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0010757 negative regulation of plasminogen activation(GO:0010757)
0.1 0.5 GO:0002158 osteoclast proliferation(GO:0002158)
0.1 0.3 GO:0042339 keratan sulfate metabolic process(GO:0042339)
0.1 0.3 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 0.7 GO:0043569 negative regulation of insulin-like growth factor receptor signaling pathway(GO:0043569)
0.1 0.4 GO:0045989 positive regulation of striated muscle contraction(GO:0045989)
0.0 0.4 GO:0008354 germ cell migration(GO:0008354)
0.0 0.3 GO:0060325 face morphogenesis(GO:0060325)
0.0 0.1 GO:0021570 rhombomere 4 development(GO:0021570)
0.0 0.2 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.0 0.1 GO:0002890 negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890)
0.0 0.2 GO:0070669 response to interleukin-2(GO:0070669)
0.0 0.2 GO:0014012 peripheral nervous system axon regeneration(GO:0014012)
0.0 0.1 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
0.0 0.1 GO:0048861 leukemia inhibitory factor signaling pathway(GO:0048861)
0.0 0.1 GO:0060831 smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831)
0.0 0.1 GO:0060689 cell differentiation involved in salivary gland development(GO:0060689)
0.0 0.1 GO:0070527 axon target recognition(GO:0007412) synaptic vesicle priming(GO:0016082) platelet aggregation(GO:0070527) regulation of synaptic vesicle transport(GO:1902803) regulation of synaptic vesicle exocytosis(GO:2000300)
0.0 0.5 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.2 GO:0002726 positive regulation of T cell cytokine production(GO:0002726)
0.0 0.2 GO:0042149 cellular response to glucose starvation(GO:0042149)
0.0 0.1 GO:0008356 asymmetric cell division(GO:0008356)
0.0 0.1 GO:0003197 endocardial cushion development(GO:0003197)
0.0 0.3 GO:0050872 white fat cell differentiation(GO:0050872)
0.0 0.1 GO:0006848 pyruvate transport(GO:0006848)
0.0 0.3 GO:0032964 collagen biosynthetic process(GO:0032964)
0.0 0.1 GO:2000114 regulation of establishment of cell polarity(GO:2000114)
0.0 0.1 GO:0032007 negative regulation of TOR signaling(GO:0032007)
0.0 0.4 GO:0048286 lung alveolus development(GO:0048286)
0.0 0.2 GO:0032012 regulation of ARF protein signal transduction(GO:0032012)
0.0 0.1 GO:0044413 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0005588 collagen type V trimer(GO:0005588)
0.1 0.7 GO:0016942 insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454)
0.0 0.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 0.4 GO:0005577 fibrinogen complex(GO:0005577)
0.0 0.4 GO:0005801 cis-Golgi network(GO:0005801)
0.0 0.2 GO:0008385 IkappaB kinase complex(GO:0008385)
0.0 0.2 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.0 GO:0005826 actomyosin contractile ring(GO:0005826)
0.0 0.1 GO:0031618 nuclear pericentric heterochromatin(GO:0031618)
0.0 0.2 GO:0031528 microvillus membrane(GO:0031528)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0070052 collagen V binding(GO:0070052)
0.1 0.3 GO:0043199 sulfate binding(GO:0043199)
0.1 0.3 GO:0005017 platelet-derived growth factor-activated receptor activity(GO:0005017)
0.1 0.7 GO:0031994 insulin-like growth factor I binding(GO:0031994)
0.1 0.5 GO:0016941 natriuretic peptide receptor activity(GO:0016941)
0.1 0.4 GO:0042577 lipid phosphatase activity(GO:0042577)
0.1 0.2 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.1 0.5 GO:0015349 thyroid hormone transmembrane transporter activity(GO:0015349)
0.0 0.4 GO:0001968 fibronectin binding(GO:0001968)
0.0 0.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0004924 oncostatin-M receptor activity(GO:0004924) ciliary neurotrophic factor receptor binding(GO:0005127)
0.0 0.2 GO:0004185 serine-type carboxypeptidase activity(GO:0004185)
0.0 0.1 GO:0004528 phosphodiesterase I activity(GO:0004528) 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656)
0.0 0.1 GO:0044325 ion channel binding(GO:0044325)
0.0 0.1 GO:0050833 pyruvate secondary active transmembrane transporter activity(GO:0005477) pyruvate transmembrane transporter activity(GO:0050833)
0.0 0.3 GO:0004707 MAP kinase activity(GO:0004707)
0.0 0.4 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.1 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.0 0.2 GO:0004012 phospholipid-translocating ATPase activity(GO:0004012)
0.0 0.1 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)