Motif ID: GATA2
Z-value: 2.008
Transcription factors associated with GATA2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| GATA2 | ENSG00000179348.7 | GATA2 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.3 | GO:0019747 | regulation of isoprenoid metabolic process(GO:0019747) |
| 0.5 | 5.5 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.5 | 1.9 | GO:0070208 | protein heterotrimerization(GO:0070208) |
| 0.4 | 2.0 | GO:0048682 | axon extension involved in regeneration(GO:0048677) sprouting of injured axon(GO:0048682) |
| 0.4 | 1.6 | GO:2001258 | negative regulation of ryanodine-sensitive calcium-release channel activity(GO:0060315) negative regulation of calcium ion transmembrane transporter activity(GO:1901020) negative regulation of cation channel activity(GO:2001258) |
| 0.3 | 1.0 | GO:0043006 | activation of phospholipase A2 activity by calcium-mediated signaling(GO:0043006) |
| 0.3 | 1.0 | GO:0021836 | chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923) |
| 0.3 | 1.3 | GO:0010566 | regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347) |
| 0.3 | 1.9 | GO:0032460 | negative regulation of protein oligomerization(GO:0032460) negative regulation of protein homooligomerization(GO:0032463) |
| 0.3 | 4.6 | GO:0034446 | substrate adhesion-dependent cell spreading(GO:0034446) |
| 0.3 | 1.2 | GO:0033197 | response to vitamin E(GO:0033197) |
| 0.2 | 1.7 | GO:0030007 | cellular potassium ion homeostasis(GO:0030007) negative regulation of cell volume(GO:0045794) |
| 0.2 | 0.7 | GO:0001907 | cytolysis by symbiont of host cells(GO:0001897) killing by symbiont of host cells(GO:0001907) hemolysis by symbiont of host erythrocytes(GO:0019836) disruption by symbiont of host cell(GO:0044004) hemolysis in other organism(GO:0044179) positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010) cytolysis in other organism(GO:0051715) cytolysis in other organism involved in symbiotic interaction(GO:0051801) hemolysis in other organism involved in symbiotic interaction(GO:0052331) |
| 0.2 | 1.3 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 0.2 | 2.7 | GO:0048488 | synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583) |
| 0.2 | 0.6 | GO:0019367 | fatty acid elongation, saturated fatty acid(GO:0019367) |
| 0.2 | 1.3 | GO:0046121 | deoxyribonucleoside catabolic process(GO:0046121) |
| 0.2 | 0.6 | GO:0014889 | muscle atrophy(GO:0014889) regulation of skeletal muscle tissue growth(GO:0048631) |
| 0.2 | 0.8 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.2 | 0.2 | GO:0031223 | auditory behavior(GO:0031223) |
| 0.2 | 1.4 | GO:1904893 | negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893) |
| 0.2 | 0.6 | GO:0070672 | response to interleukin-15(GO:0070672) |
| 0.2 | 0.6 | GO:0060831 | smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831) |
| 0.2 | 0.7 | GO:0050928 | negative regulation of positive chemotaxis(GO:0050928) |
| 0.2 | 0.7 | GO:0060457 | negative regulation of digestive system process(GO:0060457) |
| 0.2 | 1.1 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.2 | 0.6 | GO:0002523 | leukocyte migration involved in inflammatory response(GO:0002523) |
| 0.2 | 0.2 | GO:0070857 | regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251) |
| 0.1 | 0.4 | GO:0060689 | cell differentiation involved in salivary gland development(GO:0060689) |
| 0.1 | 0.7 | GO:0032497 | detection of lipopolysaccharide(GO:0032497) |
| 0.1 | 1.9 | GO:1901797 | negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797) |
| 0.1 | 0.8 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.1 | 0.3 | GO:0010833 | telomere maintenance via telomere lengthening(GO:0010833) |
| 0.1 | 0.4 | GO:0014831 | intestine smooth muscle contraction(GO:0014827) gastro-intestinal system smooth muscle contraction(GO:0014831) |
| 0.1 | 0.5 | GO:0032431 | activation of phospholipase A2 activity(GO:0032431) |
| 0.1 | 1.0 | GO:0032288 | myelin assembly(GO:0032288) |
| 0.1 | 0.6 | GO:0090084 | negative regulation of inclusion body assembly(GO:0090084) |
| 0.1 | 4.5 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.1 | 0.3 | GO:0031034 | skeletal muscle myosin thick filament assembly(GO:0030241) myosin filament assembly(GO:0031034) striated muscle myosin thick filament assembly(GO:0071688) |
| 0.1 | 0.6 | GO:1901503 | ether lipid biosynthetic process(GO:0008611) glycerol ether biosynthetic process(GO:0046504) ether biosynthetic process(GO:1901503) |
| 0.1 | 1.2 | GO:0042447 | hormone catabolic process(GO:0042447) |
| 0.1 | 0.8 | GO:0006013 | mannose metabolic process(GO:0006013) |
| 0.1 | 1.3 | GO:0008631 | intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) cell death in response to oxidative stress(GO:0036473) |
| 0.1 | 0.4 | GO:0045872 | positive regulation of rhodopsin gene expression(GO:0045872) |
| 0.1 | 0.4 | GO:0006780 | uroporphyrinogen III biosynthetic process(GO:0006780) |
| 0.1 | 0.3 | GO:0048619 | embryonic hindgut morphogenesis(GO:0048619) |
| 0.1 | 0.3 | GO:0071679 | commissural neuron axon guidance(GO:0071679) |
| 0.1 | 0.8 | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037) |
| 0.1 | 0.5 | GO:0045916 | negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258) |
| 0.1 | 0.5 | GO:0007499 | ectoderm and mesoderm interaction(GO:0007499) |
| 0.1 | 0.3 | GO:0019276 | UDP-N-acetylgalactosamine metabolic process(GO:0019276) |
| 0.1 | 2.2 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.1 | 1.1 | GO:0032456 | endocytic recycling(GO:0032456) |
| 0.1 | 1.5 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.1 | 1.0 | GO:0007567 | parturition(GO:0007567) |
| 0.1 | 1.9 | GO:0034199 | activation of protein kinase A activity(GO:0034199) |
| 0.1 | 0.8 | GO:0050435 | beta-amyloid metabolic process(GO:0050435) |
| 0.1 | 0.2 | GO:0006427 | histidyl-tRNA aminoacylation(GO:0006427) |
| 0.1 | 0.2 | GO:0045603 | positive regulation of endothelial cell differentiation(GO:0045603) |
| 0.1 | 0.1 | GO:0034650 | cortisol metabolic process(GO:0034650) cortisol biosynthetic process(GO:0034651) |
| 0.1 | 0.6 | GO:0090292 | nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292) |
| 0.1 | 1.3 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.1 | 0.3 | GO:0014012 | peripheral nervous system axon regeneration(GO:0014012) |
| 0.1 | 0.8 | GO:0051482 | positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway(GO:0051482) |
| 0.1 | 0.2 | GO:0060152 | peroxisome localization(GO:0060151) microtubule-based peroxisome localization(GO:0060152) |
| 0.1 | 0.7 | GO:0001945 | lymph vessel development(GO:0001945) |
| 0.1 | 0.1 | GO:0042754 | negative regulation of circadian sleep/wake cycle, sleep(GO:0042321) negative regulation of circadian rhythm(GO:0042754) regulation of mucus secretion(GO:0070255) negative regulation of mucus secretion(GO:0070256) |
| 0.0 | 1.3 | GO:0017158 | regulation of calcium ion-dependent exocytosis(GO:0017158) |
| 0.0 | 0.2 | GO:0007341 | penetration of zona pellucida(GO:0007341) male courtship behavior(GO:0008049) male mating behavior(GO:0060179) |
| 0.0 | 0.6 | GO:0006027 | glycosaminoglycan catabolic process(GO:0006027) |
| 0.0 | 0.6 | GO:0051654 | establishment of mitochondrion localization(GO:0051654) |
| 0.0 | 0.4 | GO:0032528 | microvillus assembly(GO:0030033) microvillus organization(GO:0032528) |
| 0.0 | 0.8 | GO:0045749 | obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749) |
| 0.0 | 0.2 | GO:0002220 | innate immune response activating cell surface receptor signaling pathway(GO:0002220) |
| 0.0 | 0.1 | GO:0070172 | positive regulation of tooth mineralization(GO:0070172) |
| 0.0 | 0.6 | GO:0051131 | chaperone-mediated protein complex assembly(GO:0051131) |
| 0.0 | 0.2 | GO:0010447 | response to acidic pH(GO:0010447) |
| 0.0 | 0.0 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 0.0 | GO:0050918 | positive chemotaxis(GO:0050918) |
| 0.0 | 1.0 | GO:0007263 | nitric oxide mediated signal transduction(GO:0007263) |
| 0.0 | 0.1 | GO:0002428 | antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428) antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481) |
| 0.0 | 0.4 | GO:0034453 | microtubule anchoring(GO:0034453) |
| 0.0 | 0.1 | GO:0060732 | positive regulation of inositol phosphate biosynthetic process(GO:0060732) |
| 0.0 | 0.2 | GO:0033033 | negative regulation of myeloid cell apoptotic process(GO:0033033) |
| 0.0 | 0.5 | GO:0043627 | response to estrogen(GO:0043627) |
| 0.0 | 0.5 | GO:0007220 | Notch receptor processing(GO:0007220) membrane protein intracellular domain proteolysis(GO:0031293) |
| 0.0 | 0.1 | GO:0061072 | iris morphogenesis(GO:0061072) |
| 0.0 | 1.4 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
| 0.0 | 0.7 | GO:0007413 | axonal fasciculation(GO:0007413) |
| 0.0 | 0.9 | GO:0042554 | superoxide anion generation(GO:0042554) |
| 0.0 | 0.1 | GO:0061099 | negative regulation of protein tyrosine kinase activity(GO:0061099) |
| 0.0 | 0.1 | GO:0006848 | pyruvate transport(GO:0006848) |
| 0.0 | 0.6 | GO:0042403 | thyroid hormone metabolic process(GO:0042403) |
| 0.0 | 0.1 | GO:0006880 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
| 0.0 | 0.9 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 0.2 | GO:0015811 | sulfur amino acid transport(GO:0000101) L-cystine transport(GO:0015811) |
| 0.0 | 0.1 | GO:0060014 | granulosa cell differentiation(GO:0060014) |
| 0.0 | 4.4 | GO:0007160 | cell-matrix adhesion(GO:0007160) |
| 0.0 | 0.2 | GO:0021548 | pons development(GO:0021548) |
| 0.0 | 1.8 | GO:0032387 | negative regulation of intracellular transport(GO:0032387) |
| 0.0 | 2.0 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.0 | 0.0 | GO:0009441 | glycolate metabolic process(GO:0009441) |
| 0.0 | 2.5 | GO:0008064 | regulation of actin polymerization or depolymerization(GO:0008064) |
| 0.0 | 0.1 | GO:0006089 | lactate metabolic process(GO:0006089) |
| 0.0 | 0.4 | GO:0071230 | cellular response to amino acid stimulus(GO:0071230) |
| 0.0 | 0.3 | GO:0045329 | amino-acid betaine biosynthetic process(GO:0006578) carnitine biosynthetic process(GO:0045329) |
| 0.0 | 0.7 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 0.5 | GO:0006693 | prostaglandin metabolic process(GO:0006693) |
| 0.0 | 0.1 | GO:0009296 | obsolete flagellum assembly(GO:0009296) |
| 0.0 | 0.2 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
| 0.0 | 0.6 | GO:0009409 | response to cold(GO:0009409) |
| 0.0 | 2.7 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 1.3 | GO:0048704 | embryonic skeletal system morphogenesis(GO:0048704) |
| 0.0 | 1.0 | GO:0051101 | regulation of DNA binding(GO:0051101) |
| 0.0 | 0.1 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 0.0 | 0.4 | GO:1901224 | activation of NF-kappaB-inducing kinase activity(GO:0007250) NIK/NF-kappaB signaling(GO:0038061) regulation of NIK/NF-kappaB signaling(GO:1901222) positive regulation of NIK/NF-kappaB signaling(GO:1901224) |
| 0.0 | 0.7 | GO:0007190 | activation of adenylate cyclase activity(GO:0007190) |
| 0.0 | 1.8 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 6.4 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.0 | 0.1 | GO:0046520 | diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520) |
| 0.0 | 0.5 | GO:0042733 | embryonic digit morphogenesis(GO:0042733) |
| 0.0 | 0.2 | GO:0006465 | signal peptide processing(GO:0006465) |
| 0.0 | 0.3 | GO:1901661 | quinone metabolic process(GO:1901661) |
| 0.0 | 0.1 | GO:0000271 | polysaccharide biosynthetic process(GO:0000271) cellular polysaccharide biosynthetic process(GO:0033692) |
| 0.0 | 0.1 | GO:0009396 | folic acid-containing compound biosynthetic process(GO:0009396) |
| 0.0 | 0.2 | GO:0051319 | mitotic G2 phase(GO:0000085) G2 phase(GO:0051319) |
| 0.0 | 1.0 | GO:1902652 | cholesterol metabolic process(GO:0008203) secondary alcohol metabolic process(GO:1902652) |
| 0.0 | 0.1 | GO:0008212 | mineralocorticoid biosynthetic process(GO:0006705) mineralocorticoid metabolic process(GO:0008212) |
| 0.0 | 0.6 | GO:0001837 | epithelial to mesenchymal transition(GO:0001837) |
| 0.0 | 0.4 | GO:0007528 | neuromuscular junction development(GO:0007528) |
| 0.0 | 0.1 | GO:0046340 | diacylglycerol catabolic process(GO:0046340) |
| 0.0 | 1.1 | GO:0008277 | regulation of G-protein coupled receptor protein signaling pathway(GO:0008277) |
| 0.0 | 0.1 | GO:0046174 | polyol catabolic process(GO:0046174) |
| 0.0 | 0.0 | GO:0061298 | retina vasculature development in camera-type eye(GO:0061298) retina vasculature morphogenesis in camera-type eye(GO:0061299) |
| 0.0 | 0.3 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.0 | 0.2 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 0.0 | 0.1 | GO:0032410 | negative regulation of transporter activity(GO:0032410) |
| 0.0 | 0.5 | GO:0051318 | G1 phase(GO:0051318) |
| 0.0 | 0.4 | GO:0070830 | bicellular tight junction assembly(GO:0070830) |
| 0.0 | 0.1 | GO:0050852 | T cell receptor signaling pathway(GO:0050852) |
| 0.0 | 3.9 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 0.0 | 0.1 | GO:0048295 | positive regulation of isotype switching to IgE isotypes(GO:0048295) |
| 0.0 | 0.2 | GO:0033280 | response to vitamin D(GO:0033280) |
| 0.0 | 0.3 | GO:0045768 | obsolete positive regulation of anti-apoptosis(GO:0045768) |
| 0.0 | 0.1 | GO:0007172 | signal complex assembly(GO:0007172) |
| 0.0 | 0.0 | GO:0070171 | negative regulation of tooth mineralization(GO:0070171) |
| 0.0 | 0.1 | GO:0016098 | monoterpenoid metabolic process(GO:0016098) |
| 0.0 | 0.0 | GO:0014050 | negative regulation of glutamate secretion(GO:0014050) |
| 0.0 | 0.2 | GO:0045670 | regulation of osteoclast differentiation(GO:0045670) |
| 0.0 | 1.2 | GO:0007281 | germ cell development(GO:0007281) |
| 0.0 | 0.1 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) glycerophospholipid catabolic process(GO:0046475) |
| 0.0 | 0.0 | GO:0035405 | histone-threonine phosphorylation(GO:0035405) |
| 0.0 | 1.3 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.1 | GO:0005607 | laminin-2 complex(GO:0005607) |
| 0.7 | 2.0 | GO:0005608 | laminin-3 complex(GO:0005608) |
| 0.5 | 4.1 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.4 | 1.3 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.4 | 5.5 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.3 | 1.6 | GO:0031512 | motile primary cilium(GO:0031512) |
| 0.2 | 1.2 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.2 | 2.6 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.2 | 1.9 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.2 | 0.4 | GO:0016011 | dystroglycan complex(GO:0016011) |
| 0.2 | 1.0 | GO:0070435 | Shc-EGFR complex(GO:0070435) |
| 0.2 | 0.8 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.1 | 0.7 | GO:0046696 | lipopolysaccharide receptor complex(GO:0046696) |
| 0.1 | 0.4 | GO:0071986 | Ragulator complex(GO:0071986) |
| 0.1 | 1.0 | GO:0043218 | compact myelin(GO:0043218) |
| 0.1 | 1.0 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 1.8 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
| 0.1 | 1.7 | GO:0030867 | rough endoplasmic reticulum membrane(GO:0030867) |
| 0.1 | 0.6 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.1 | 1.3 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.1 | 0.5 | GO:0032311 | angiogenin-PRI complex(GO:0032311) |
| 0.1 | 1.8 | GO:0043205 | fibril(GO:0043205) |
| 0.1 | 0.3 | GO:0071546 | pi-body(GO:0071546) |
| 0.1 | 0.2 | GO:0005787 | signal peptidase complex(GO:0005787) |
| 0.1 | 0.3 | GO:0070188 | obsolete Stn1-Ten1 complex(GO:0070188) |
| 0.1 | 0.3 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) beta-catenin-TCF complex(GO:1990907) |
| 0.1 | 0.6 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.1 | 1.6 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 0.6 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 0.3 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.0 | 0.6 | GO:0005790 | smooth endoplasmic reticulum(GO:0005790) |
| 0.0 | 2.4 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.4 | GO:0000145 | exocyst(GO:0000145) |
| 0.0 | 6.8 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 1.3 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 0.1 | GO:0031310 | intrinsic component of endosome membrane(GO:0031302) intrinsic component of vacuolar membrane(GO:0031310) |
| 0.0 | 0.7 | GO:0043204 | perikaryon(GO:0043204) |
| 0.0 | 1.5 | GO:0043679 | axon terminus(GO:0043679) |
| 0.0 | 0.9 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 0.9 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 0.2 | GO:0071437 | invadopodium(GO:0071437) |
| 0.0 | 2.3 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 0.7 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 0.1 | GO:0070288 | intracellular ferritin complex(GO:0008043) ferritin complex(GO:0070288) |
| 0.0 | 2.0 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 0.8 | GO:0005902 | microvillus(GO:0005902) |
| 0.0 | 0.2 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.0 | 1.7 | GO:0044853 | caveola(GO:0005901) plasma membrane raft(GO:0044853) |
| 0.0 | 2.3 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
| 0.0 | 0.5 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 0.4 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 0.7 | GO:0005637 | nuclear inner membrane(GO:0005637) |
| 0.0 | 0.8 | GO:0098636 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.0 | 0.1 | GO:0071204 | histone pre-mRNA 3'end processing complex(GO:0071204) |
| 0.0 | 0.2 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.0 | 1.5 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 0.0 | GO:0098984 | asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984) |
| 0.0 | 1.0 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 0.5 | GO:0031526 | brush border membrane(GO:0031526) |
| 0.0 | 3.8 | GO:0009986 | cell surface(GO:0009986) |
| 0.0 | 0.2 | GO:0008091 | spectrin(GO:0008091) |
| 0.0 | 0.3 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 0.2 | GO:0042627 | chylomicron(GO:0042627) |
| 0.0 | 0.4 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.0 | 0.1 | GO:0019861 | obsolete flagellum(GO:0019861) |
| 0.0 | 0.4 | GO:0005912 | adherens junction(GO:0005912) |
| 0.0 | 0.3 | GO:0005871 | kinesin complex(GO:0005871) |
| 0.0 | 2.5 | GO:0015629 | actin cytoskeleton(GO:0015629) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 3.0 | GO:0004504 | peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598) |
| 0.6 | 2.5 | GO:0008112 | nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760) |
| 0.6 | 1.8 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.6 | 1.7 | GO:0008475 | procollagen-lysine 5-dioxygenase activity(GO:0008475) |
| 0.5 | 2.0 | GO:0016972 | thiol oxidase activity(GO:0016972) |
| 0.5 | 2.4 | GO:0034597 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) |
| 0.4 | 1.3 | GO:0016670 | oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) |
| 0.4 | 1.3 | GO:0004139 | deoxyribose-phosphate aldolase activity(GO:0004139) |
| 0.3 | 1.4 | GO:0003680 | AT DNA binding(GO:0003680) |
| 0.3 | 1.6 | GO:0003960 | NADPH:quinone reductase activity(GO:0003960) |
| 0.3 | 0.8 | GO:0003863 | alpha-ketoacid dehydrogenase activity(GO:0003826) 3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring) activity(GO:0003863) |
| 0.2 | 1.7 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.2 | 0.6 | GO:0050062 | long-chain-fatty-acyl-CoA reductase activity(GO:0050062) |
| 0.2 | 0.6 | GO:0019797 | procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544) |
| 0.2 | 1.3 | GO:0008321 | Ral guanyl-nucleotide exchange factor activity(GO:0008321) |
| 0.2 | 0.6 | GO:0043023 | ribosomal large subunit binding(GO:0043023) |
| 0.2 | 5.7 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.2 | 1.9 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.2 | 0.5 | GO:0047718 | indanol dehydrogenase activity(GO:0047718) |
| 0.2 | 9.4 | GO:0005518 | collagen binding(GO:0005518) |
| 0.2 | 1.7 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.2 | 1.3 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.2 | 0.6 | GO:0070492 | oligosaccharide binding(GO:0070492) |
| 0.1 | 0.6 | GO:0043237 | laminin-1 binding(GO:0043237) |
| 0.1 | 1.0 | GO:0008020 | G-protein coupled photoreceptor activity(GO:0008020) |
| 0.1 | 0.5 | GO:0004031 | aldehyde oxidase activity(GO:0004031) |
| 0.1 | 0.7 | GO:0005000 | vasopressin receptor activity(GO:0005000) |
| 0.1 | 0.7 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.1 | 3.2 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.1 | 1.6 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093) |
| 0.1 | 1.9 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 0.8 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.1 | 1.9 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.1 | 1.0 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
| 0.1 | 0.9 | GO:0019826 | oxygen sensor activity(GO:0019826) |
| 0.1 | 1.2 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.1 | 3.2 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.1 | 0.3 | GO:0019958 | C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959) |
| 0.1 | 0.5 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.1 | 0.5 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.1 | 0.7 | GO:0001875 | lipopolysaccharide receptor activity(GO:0001875) |
| 0.1 | 0.3 | GO:0047288 | monosialoganglioside sialyltransferase activity(GO:0047288) |
| 0.1 | 0.2 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 0.7 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.1 | 0.6 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.1 | 0.2 | GO:0004821 | histidine-tRNA ligase activity(GO:0004821) |
| 0.1 | 0.3 | GO:0098847 | single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847) |
| 0.1 | 1.5 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 1.8 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 1.2 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 0.9 | GO:0030618 | transforming growth factor beta receptor, pathway-specific cytoplasmic mediator activity(GO:0030618) |
| 0.1 | 0.3 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.1 | 1.1 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.1 | 0.8 | GO:0004559 | alpha-mannosidase activity(GO:0004559) |
| 0.1 | 0.3 | GO:0008330 | protein tyrosine/threonine phosphatase activity(GO:0008330) |
| 0.1 | 0.6 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.1 | 0.8 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.1 | 0.6 | GO:0004415 | hyalurononglucosaminidase activity(GO:0004415) |
| 0.1 | 0.8 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.1 | 0.7 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.1 | 0.4 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 1.2 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 0.6 | GO:0046625 | sphingolipid binding(GO:0046625) |
| 0.0 | 0.2 | GO:0001595 | angiotensin receptor activity(GO:0001595) angiotensin type II receptor activity(GO:0004945) |
| 0.0 | 0.6 | GO:0030544 | Hsp70 protein binding(GO:0030544) |
| 0.0 | 0.4 | GO:0042153 | obsolete RPTP-like protein binding(GO:0042153) |
| 0.0 | 0.6 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.0 | 0.7 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.0 | 4.2 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.4 | GO:0051393 | alpha-actinin binding(GO:0051393) |
| 0.0 | 0.2 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.0 | 0.8 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 0.3 | GO:0004551 | nucleotide diphosphatase activity(GO:0004551) |
| 0.0 | 0.8 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 0.5 | GO:0050780 | dopamine receptor binding(GO:0050780) |
| 0.0 | 0.6 | GO:0005521 | lamin binding(GO:0005521) |
| 0.0 | 0.2 | GO:0043236 | laminin binding(GO:0043236) |
| 0.0 | 0.2 | GO:0051766 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766) |
| 0.0 | 0.1 | GO:0016882 | cyclo-ligase activity(GO:0016882) |
| 0.0 | 0.1 | GO:0032795 | heterotrimeric G-protein binding(GO:0032795) |
| 0.0 | 0.3 | GO:0004522 | ribonuclease A activity(GO:0004522) |
| 0.0 | 1.0 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.0 | 0.1 | GO:0050528 | acyloxyacyl hydrolase activity(GO:0050528) |
| 0.0 | 0.5 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.0 | 0.1 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.0 | 0.2 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.0 | 0.1 | GO:0050833 | pyruvate secondary active transmembrane transporter activity(GO:0005477) pyruvate transmembrane transporter activity(GO:0050833) |
| 0.0 | 0.2 | GO:0004563 | beta-N-acetylhexosaminidase activity(GO:0004563) |
| 0.0 | 0.1 | GO:0047315 | kynurenine-glyoxylate transaminase activity(GO:0047315) |
| 0.0 | 0.2 | GO:0015184 | L-cystine transmembrane transporter activity(GO:0015184) |
| 0.0 | 0.4 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.0 | 0.0 | GO:0016623 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623) |
| 0.0 | 0.1 | GO:0036002 | pre-mRNA binding(GO:0036002) |
| 0.0 | 2.3 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 2.6 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.2 | GO:0016595 | glutamate binding(GO:0016595) |
| 0.0 | 0.3 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.1 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.0 | 0.3 | GO:0005123 | death receptor binding(GO:0005123) |
| 0.0 | 0.3 | GO:0043014 | alpha-tubulin binding(GO:0043014) |
| 0.0 | 0.1 | GO:0033878 | hormone-sensitive lipase activity(GO:0033878) |
| 0.0 | 0.3 | GO:0008395 | steroid hydroxylase activity(GO:0008395) |
| 0.0 | 0.8 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 0.1 | GO:0004591 | oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591) |
| 0.0 | 0.1 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 0.0 | 0.4 | GO:0017134 | fibroblast growth factor binding(GO:0017134) |
| 0.0 | 0.2 | GO:0030306 | ADP-ribosylation factor binding(GO:0030306) |
| 0.0 | 0.1 | GO:0016724 | ferroxidase activity(GO:0004322) oxidoreductase activity, oxidizing metal ions, oxygen as acceptor(GO:0016724) |
| 0.0 | 0.2 | GO:0004835 | tubulin-tyrosine ligase activity(GO:0004835) |
| 0.0 | 0.1 | GO:0004447 | iodide peroxidase activity(GO:0004447) |
| 0.0 | 0.2 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
| 0.0 | 0.2 | GO:0030346 | protein phosphatase 2B binding(GO:0030346) |
| 0.0 | 0.1 | GO:0031997 | N-terminal myristoylation domain binding(GO:0031997) |
| 0.0 | 0.1 | GO:0034185 | apolipoprotein binding(GO:0034185) |
| 0.0 | 5.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 0.4 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
| 0.0 | 0.1 | GO:0004886 | 9-cis retinoic acid receptor activity(GO:0004886) |
| 0.0 | 7.0 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 0.1 | GO:0005110 | frizzled-2 binding(GO:0005110) |
| 0.0 | 0.4 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
| 0.0 | 0.1 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.2 | GO:0015271 | outward rectifier potassium channel activity(GO:0015271) |
| 0.0 | 0.2 | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812) |
| 0.0 | 0.2 | GO:0008527 | taste receptor activity(GO:0008527) |
| 0.0 | 0.5 | GO:0008028 | monocarboxylic acid transmembrane transporter activity(GO:0008028) |
| 0.0 | 0.1 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.0 | 0.4 | GO:0003746 | translation elongation factor activity(GO:0003746) |
| 0.0 | 0.1 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
| 0.0 | 0.2 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.0 | 0.3 | GO:0008376 | acetylgalactosaminyltransferase activity(GO:0008376) |
| 0.0 | 0.6 | GO:1990782 | receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782) |
| 0.0 | 8.4 | GO:0005509 | calcium ion binding(GO:0005509) |
| 0.0 | 0.1 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) |
| 0.0 | 2.7 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 0.1 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 0.0 | GO:0002162 | dystroglycan binding(GO:0002162) |
| 0.0 | 0.3 | GO:0005452 | inorganic anion exchanger activity(GO:0005452) |
| 0.0 | 0.1 | GO:0043855 | intracellular cyclic nucleotide activated cation channel activity(GO:0005221) cyclic nucleotide-gated ion channel activity(GO:0043855) |
| 0.0 | 0.1 | GO:0030276 | clathrin binding(GO:0030276) |
| 0.0 | 0.2 | GO:0042288 | MHC class I protein binding(GO:0042288) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 1.3 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 1.2 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 2.5 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
| 0.0 | 1.3 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 1.8 | ST_G_ALPHA_I_PATHWAY | G alpha i Pathway |
| 0.0 | 0.8 | SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.0 | 0.9 | SIG_CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 0.3 | ST_DIFFERENTIATION_PATHWAY_IN_PC12_CELLS | Differentiation Pathway in PC12 Cells; this is a specific case of PAC1 Receptor Pathway. |
