Motif ID: GATA5
Z-value: 1.654
Transcription factors associated with GATA5:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| GATA5 | ENSG00000130700.6 | GATA5 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.7 | GO:0019805 | quinolinate biosynthetic process(GO:0019805) |
| 0.3 | 3.1 | GO:0006546 | glycine catabolic process(GO:0006546) |
| 0.3 | 4.7 | GO:0030212 | hyaluronan metabolic process(GO:0030212) |
| 0.3 | 7.1 | GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504) |
| 0.2 | 1.2 | GO:0045916 | negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258) |
| 0.2 | 9.4 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.2 | 2.3 | GO:0019228 | neuronal action potential(GO:0019228) |
| 0.2 | 0.8 | GO:0046952 | ketone body catabolic process(GO:0046952) |
| 0.1 | 0.7 | GO:0042905 | retinal metabolic process(GO:0042574) 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.1 | 1.0 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.1 | 0.4 | GO:0019521 | aldonic acid metabolic process(GO:0019520) D-gluconate metabolic process(GO:0019521) |
| 0.1 | 1.0 | GO:0036037 | maintenance of cell polarity(GO:0030011) positive regulation of cell adhesion mediated by integrin(GO:0033630) CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.1 | 2.6 | GO:0007032 | endosome organization(GO:0007032) |
| 0.1 | 0.5 | GO:0006768 | biotin metabolic process(GO:0006768) |
| 0.1 | 0.5 | GO:0051409 | response to nitrosative stress(GO:0051409) |
| 0.1 | 0.8 | GO:0045647 | negative regulation of erythrocyte differentiation(GO:0045647) |
| 0.1 | 0.3 | GO:0007207 | phospholipase C-activating G-protein coupled acetylcholine receptor signaling pathway(GO:0007207) |
| 0.1 | 1.1 | GO:0006957 | complement activation, alternative pathway(GO:0006957) |
| 0.1 | 0.3 | GO:0046600 | negative regulation of centriole replication(GO:0046600) |
| 0.1 | 0.2 | GO:0010430 | ethanol catabolic process(GO:0006068) fatty acid omega-oxidation(GO:0010430) |
| 0.1 | 0.3 | GO:2000008 | regulation of protein localization to cell surface(GO:2000008) |
| 0.1 | 1.5 | GO:0090399 | replicative senescence(GO:0090399) |
| 0.1 | 3.1 | GO:0002286 | T cell activation involved in immune response(GO:0002286) |
| 0.1 | 0.4 | GO:0010535 | regulation of activation of JAK2 kinase activity(GO:0010534) positive regulation of activation of JAK2 kinase activity(GO:0010535) |
| 0.1 | 0.5 | GO:0050862 | positive regulation of T cell receptor signaling pathway(GO:0050862) |
| 0.1 | 3.2 | GO:0045576 | mast cell activation(GO:0045576) |
| 0.1 | 0.3 | GO:0060662 | tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662) |
| 0.1 | 0.3 | GO:0072207 | metanephric tubule development(GO:0072170) metanephric epithelium development(GO:0072207) metanephric nephron tubule development(GO:0072234) metanephric nephron epithelium development(GO:0072243) |
| 0.1 | 0.2 | GO:0001575 | globoside metabolic process(GO:0001575) |
| 0.0 | 0.6 | GO:0070493 | thrombin receptor signaling pathway(GO:0070493) |
| 0.0 | 0.5 | GO:0030147 | obsolete natriuresis(GO:0030147) |
| 0.0 | 0.2 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
| 0.0 | 0.5 | GO:0030539 | male genitalia development(GO:0030539) |
| 0.0 | 2.0 | GO:0030183 | B cell differentiation(GO:0030183) |
| 0.0 | 0.1 | GO:0060011 | Sertoli cell proliferation(GO:0060011) |
| 0.0 | 1.1 | GO:0000080 | mitotic G1 phase(GO:0000080) |
| 0.0 | 0.5 | GO:0006386 | transcription elongation from RNA polymerase III promoter(GO:0006385) termination of RNA polymerase III transcription(GO:0006386) |
| 0.0 | 2.3 | GO:0051592 | response to calcium ion(GO:0051592) |
| 0.0 | 0.2 | GO:0043982 | histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982) |
| 0.0 | 0.1 | GO:0045872 | regulation of rhodopsin gene expression(GO:0007468) positive regulation of rhodopsin gene expression(GO:0045872) |
| 0.0 | 0.3 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 0.0 | 0.4 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.0 | 0.3 | GO:0045822 | negative regulation of heart contraction(GO:0045822) |
| 0.0 | 0.3 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
| 0.0 | 0.5 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
| 0.0 | 0.1 | GO:0090231 | regulation of spindle checkpoint(GO:0090231) |
| 0.0 | 0.4 | GO:0006493 | protein O-linked glycosylation(GO:0006493) |
| 0.0 | 0.2 | GO:0007128 | meiotic prophase I(GO:0007128) |
| 0.0 | 2.4 | GO:0048511 | rhythmic process(GO:0048511) |
| 0.0 | 1.6 | GO:0006898 | receptor-mediated endocytosis(GO:0006898) |
| 0.0 | 1.2 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 0.6 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 0.2 | GO:0008625 | extrinsic apoptotic signaling pathway via death domain receptors(GO:0008625) extrinsic apoptotic signaling pathway(GO:0097191) |
| 0.0 | 0.1 | GO:0020027 | hemoglobin metabolic process(GO:0020027) |
| 0.0 | 0.1 | GO:0008585 | female gonad development(GO:0008585) |
| 0.0 | 0.1 | GO:0006896 | Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 2.6 | GO:0000306 | extrinsic component of vacuolar membrane(GO:0000306) extrinsic component of endosome membrane(GO:0031313) |
| 0.5 | 3.1 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.3 | 7.1 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.2 | 2.6 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.2 | 3.2 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 2.1 | GO:0034362 | low-density lipoprotein particle(GO:0034362) |
| 0.1 | 0.7 | GO:0005579 | membrane attack complex(GO:0005579) |
| 0.1 | 1.1 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.1 | 0.3 | GO:0031436 | BRCA1-BARD1 complex(GO:0031436) |
| 0.1 | 0.3 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
| 0.0 | 0.3 | GO:0000796 | condensin complex(GO:0000796) |
| 0.0 | 0.5 | GO:0042101 | T cell receptor complex(GO:0042101) |
| 0.0 | 0.5 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 2.3 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 1.7 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 1.3 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 0.1 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
| 0.0 | 0.6 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
| 0.0 | 0.2 | GO:0032982 | myosin filament(GO:0032982) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.7 | GO:0016822 | hydrolase activity, acting on acid carbon-carbon bonds(GO:0016822) hydrolase activity, acting on acid carbon-carbon bonds, in ketonic substances(GO:0016823) |
| 0.4 | 1.2 | GO:0019958 | C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959) |
| 0.3 | 4.9 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.3 | 0.8 | GO:0003858 | 3-hydroxybutyrate dehydrogenase activity(GO:0003858) |
| 0.2 | 1.5 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.2 | 2.5 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.2 | 3.1 | GO:0016638 | oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638) |
| 0.2 | 0.4 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.2 | 0.9 | GO:0004910 | interleukin-1, Type II, blocking receptor activity(GO:0004910) |
| 0.2 | 7.7 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.1 | 0.3 | GO:0005499 | vitamin D binding(GO:0005499) |
| 0.1 | 2.1 | GO:0030169 | low-density lipoprotein particle binding(GO:0030169) |
| 0.1 | 0.4 | GO:0016297 | oleoyl-[acyl-carrier-protein] hydrolase activity(GO:0004320) myristoyl-[acyl-carrier-protein] hydrolase activity(GO:0016295) palmitoyl-[acyl-carrier-protein] hydrolase activity(GO:0016296) acyl-[acyl-carrier-protein] hydrolase activity(GO:0016297) |
| 0.1 | 1.1 | GO:0001848 | complement binding(GO:0001848) |
| 0.1 | 2.6 | GO:0043499 | obsolete eukaryotic cell surface binding(GO:0043499) |
| 0.1 | 2.3 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.1 | 0.5 | GO:0004485 | methylcrotonoyl-CoA carboxylase activity(GO:0004485) |
| 0.1 | 0.6 | GO:0015057 | thrombin receptor activity(GO:0015057) |
| 0.1 | 2.6 | GO:0005545 | 1-phosphatidylinositol binding(GO:0005545) |
| 0.1 | 0.7 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) |
| 0.1 | 0.2 | GO:0035276 | ethanol binding(GO:0035276) |
| 0.1 | 1.0 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.1 | 0.4 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.1 | 0.6 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) |
| 0.1 | 0.4 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 0.1 | 0.5 | GO:0070700 | BMP receptor binding(GO:0070700) |
| 0.1 | 0.3 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
| 0.1 | 3.2 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 0.5 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
| 0.0 | 0.5 | GO:0051428 | peptide hormone receptor binding(GO:0051428) |
| 0.0 | 0.5 | GO:0016595 | glutamate binding(GO:0016595) |
| 0.0 | 0.6 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 0.4 | GO:0005148 | prolactin receptor binding(GO:0005148) |
| 0.0 | 3.5 | GO:0051015 | actin filament binding(GO:0051015) |
| 0.0 | 4.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 0.3 | GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity(GO:0030297) |
| 0.0 | 0.2 | GO:0008853 | exodeoxyribonuclease III activity(GO:0008853) |
| 0.0 | 0.2 | GO:0031432 | titin binding(GO:0031432) |
| 0.0 | 1.0 | GO:0030295 | protein kinase activator activity(GO:0030295) |
| 0.0 | 0.5 | GO:0016289 | CoA hydrolase activity(GO:0016289) |
| 0.0 | 0.7 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 0.1 | GO:0042808 | obsolete neuronal Cdc2-like kinase binding(GO:0042808) |
| 0.0 | 0.3 | GO:0060590 | ATPase regulator activity(GO:0060590) |
| 0.0 | 0.6 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 0.1 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.0 | 0.4 | GO:0008378 | galactosyltransferase activity(GO:0008378) |
| 0.0 | 0.6 | GO:0050136 | NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 1.1 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 0.2 | GO:0008353 | RNA polymerase II carboxy-terminal domain kinase activity(GO:0008353) |
| 0.0 | 0.5 | GO:0003899 | DNA-directed RNA polymerase activity(GO:0003899) RNA polymerase activity(GO:0034062) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.0 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 1.1 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 1.7 | SIG_BCR_SIGNALING_PATHWAY | Members of the BCR signaling pathway |
| 0.0 | 0.6 | SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES | Genes related to the insulin receptor pathway |
