Motif ID: GATA6

Z-value: 1.404


Transcription factors associated with GATA6:

Gene SymbolEntrez IDGene Name
GATA6 ENSG00000141448.4 GATA6



Activity profile for motif GATA6.

activity profile for motif GATA6


Sorted Z-values histogram for motif GATA6

Sorted Z-values for motif GATA6



Network of associatons between targets according to the STRING database.



First level regulatory network of GATA6

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr17_-_62084241 4.010 ENST00000449662.2
 ICAM2
intercellular adhesion molecule 2
chr16_+_202686 3.338 ENST00000252951.2
 HBZ
hemoglobin, zeta
chr12_-_54689532 3.202 ENST00000540264.2
ENST00000312156.4
 NFE2

nuclear factor, erythroid 2

chr19_-_13213662 2.621 ENST00000264824.4
 LYL1
lymphoblastic leukemia derived sequence 1
chr19_+_10397621 2.172 ENST00000380770.3
 ICAM4
intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)
chr19_+_10397648 2.149 ENST00000340992.4
ENST00000393717.2
 ICAM4

intercellular adhesion molecule 4 (Landsteiner-Wiener blood group)

chr7_-_100239132 2.043 ENST00000223051.3
ENST00000431692.1
 TFR2

transferrin receptor 2

chr11_-_116708302 1.602 ENST00000375320.1
ENST00000359492.2
ENST00000375329.2
ENST00000375323.1
 APOA1



apolipoprotein A-I



chr11_+_118958689 1.515 ENST00000535253.1
ENST00000392841.1
 HMBS

hydroxymethylbilane synthase

chr2_+_102928009 1.434 ENST00000404917.2
ENST00000447231.1
 IL1RL1

interleukin 1 receptor-like 1

chr13_-_46716969 1.397 ENST00000435666.2
 LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chr8_-_38008783 1.376 ENST00000276449.4
 STAR
steroidogenic acute regulatory protein
chr12_-_6233828 1.199 ENST00000572068.1
ENST00000261405.5
 VWF

von Willebrand factor

chr1_-_158656488 1.196 ENST00000368147.4
 SPTA1
spectrin, alpha, erythrocytic 1 (elliptocytosis 2)
chr15_-_64126084 1.171 ENST00000560316.1
ENST00000443617.2
ENST00000560462.1
ENST00000558532.1
ENST00000561400.1
 HERC1




HECT and RLD domain containing E3 ubiquitin protein ligase family member 1




chr8_+_21823726 1.159 ENST00000433566.4
 XPO7
exportin 7
chr11_-_66206260 1.111 ENST00000329819.4
ENST00000310999.7
ENST00000430466.2
 MRPL11


mitochondrial ribosomal protein L11


chr3_+_69812877 1.042 ENST00000457080.1
ENST00000328528.6
 MITF

microphthalmia-associated transcription factor

chr1_+_25598989 1.039 ENST00000454452.2
 RHD
Rh blood group, D antigen
chr17_+_74381343 1.030 ENST00000392496.3
 SPHK1
sphingosine kinase 1
chr2_+_3642545 0.970 ENST00000382062.2
ENST00000236693.7
ENST00000349077.4
 COLEC11


collectin sub-family member 11


chr1_+_161136180 0.945 ENST00000352210.5
ENST00000367999.4
ENST00000544598.1
ENST00000535223.1
ENST00000432542.2
 PPOX




protoporphyrinogen oxidase




chr2_+_138722028 0.935 ENST00000280096.5
 HNMT
histamine N-methyltransferase
chr1_-_27240455 0.756 ENST00000254227.3
 NR0B2
nuclear receptor subfamily 0, group B, member 2
chr4_+_100495864 0.688 ENST00000265517.5
ENST00000422897.2
 MTTP

microsomal triglyceride transfer protein

chr18_+_19749386 0.688 ENST00000269216.3
 GATA6
GATA binding protein 6
chr21_-_39870339 0.667 ENST00000429727.2
ENST00000398905.1
ENST00000398907.1
ENST00000453032.2
ENST00000288319.7
 ERG




v-ets avian erythroblastosis virus E26 oncogene homolog




chr1_+_25598872 0.612 ENST00000328664.4
 RHD
Rh blood group, D antigen
chr1_-_24469602 0.612 ENST00000270800.1
 IL22RA1
interleukin 22 receptor, alpha 1
chr3_+_148583043 0.550 ENST00000296046.3
 CPA3
carboxypeptidase A3 (mast cell)
chr8_-_95449155 0.549 ENST00000481490.2
 FSBP
fibrinogen silencer binding protein
chr1_+_25599018 0.541 ENST00000417538.2
ENST00000357542.4
ENST00000568195.1
ENST00000342055.5
ENST00000423810.2
 RHD




Rh blood group, D antigen




chr2_-_44065889 0.530 ENST00000543989.1
ENST00000405322.1
 ABCG5

ATP-binding cassette, sub-family G (WHITE), member 5

chr17_+_4675175 0.527 ENST00000270560.3
 TM4SF5
transmembrane 4 L six family member 5
chr4_-_103266355 0.525 ENST00000424970.2
 SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr2_-_44065946 0.514 ENST00000260645.1
 ABCG5
ATP-binding cassette, sub-family G (WHITE), member 5
chr1_+_12524965 0.502 ENST00000471923.1
 VPS13D
vacuolar protein sorting 13 homolog D (S. cerevisiae)
chr20_-_30795511 0.460 ENST00000246229.4
 PLAGL2
pleiomorphic adenoma gene-like 2
chr18_-_28742813 0.452 ENST00000257197.3
ENST00000257198.5
 DSC1

desmocollin 1

chr6_+_12290586 0.377 ENST00000379375.5
 EDN1
endothelin 1
chr19_-_11494975 0.375 ENST00000222139.6
ENST00000592375.2
 EPOR

erythropoietin receptor

chr20_-_54967187 0.326 ENST00000422322.1
ENST00000371356.2
ENST00000451915.1
ENST00000347343.2
ENST00000395911.1
ENST00000395907.1
ENST00000441357.1
ENST00000456249.1
ENST00000420474.1
ENST00000395909.4
ENST00000395914.1
ENST00000312783.6
ENST00000395915.3
ENST00000395913.3
 AURKA













aurora kinase A













chr5_+_159848807 0.323 ENST00000352433.5
 PTTG1
pituitary tumor-transforming 1
chr19_-_55549624 0.302 ENST00000417454.1
ENST00000310373.3
ENST00000333884.2
 GP6


glycoprotein VI (platelet)


chr14_+_75988851 0.286 ENST00000555504.1
 BATF
basic leucine zipper transcription factor, ATF-like
chr6_-_30128657 0.284 ENST00000449742.2
ENST00000376704.3
 TRIM10

tripartite motif containing 10

chr12_+_53818855 0.257 ENST00000550839.1
 AMHR2
anti-Mullerian hormone receptor, type II
chr12_+_111843749 0.246 ENST00000341259.2
 SH2B3
SH2B adaptor protein 3
chr7_+_155090271 0.242 ENST00000476756.1
 INSIG1
insulin induced gene 1
chr2_-_219850277 0.227 ENST00000295727.1
 FEV
FEV (ETS oncogene family)
chr4_-_103266219 0.214 ENST00000394833.2
 SLC39A8
solute carrier family 39 (zinc transporter), member 8
chr17_-_4806369 0.208 ENST00000293780.4
 CHRNE
cholinergic receptor, nicotinic, epsilon (muscle)
chr2_+_169757750 0.199 ENST00000375363.3
ENST00000429379.2
ENST00000421979.1
 G6PC2


glucose-6-phosphatase, catalytic, 2


chr10_+_118350468 0.193 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
 PNLIPRP1


pancreatic lipase-related protein 1


chr3_+_69812701 0.191 ENST00000472437.1
 MITF
microphthalmia-associated transcription factor
chr6_-_86099898 0.185 ENST00000455071.1
 RP11-30P6.6
RP11-30P6.6
chr4_-_186697044 0.181 ENST00000437304.2
 SORBS2
sorbin and SH3 domain containing 2
chr9_-_117692697 0.167 ENST00000223795.2
 TNFSF8
tumor necrosis factor (ligand) superfamily, member 8
chr2_+_220436917 0.163 ENST00000243786.2
 INHA
inhibin, alpha
chr14_+_53173910 0.161 ENST00000606149.1
ENST00000555339.1
ENST00000556813.1
 PSMC6


proteasome (prosome, macropain) 26S subunit, ATPase, 6


chr1_+_171217677 0.159 ENST00000402921.2
 FMO1
flavin containing monooxygenase 1
chr15_-_43513187 0.149 ENST00000540029.1
ENST00000441366.2
 EPB42

erythrocyte membrane protein band 4.2

chr16_+_71560154 0.147 ENST00000539698.3
 CHST4
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
chr10_+_118350522 0.145 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
 PNLIPRP1



pancreatic lipase-related protein 1



chr14_+_53173890 0.129 ENST00000445930.2
 PSMC6
proteasome (prosome, macropain) 26S subunit, ATPase, 6
chr11_-_47374246 0.126 ENST00000545968.1
ENST00000399249.2
ENST00000256993.4
 MYBPC3


myosin binding protein C, cardiac


chr5_-_33984741 0.119 ENST00000382102.3
ENST00000509381.1
ENST00000342059.3
ENST00000345083.5
 SLC45A2



solute carrier family 45, member 2



chr1_+_50574585 0.102 ENST00000371824.1
ENST00000371823.4
 ELAVL4

ELAV like neuron-specific RNA binding protein 4

chr18_-_45663666 0.089 ENST00000535628.2
 ZBTB7C
zinc finger and BTB domain containing 7C
chr20_+_43029911 0.079 ENST00000443598.2
ENST00000316099.4
ENST00000415691.2
 HNF4A


hepatocyte nuclear factor 4, alpha


chr2_-_214014959 0.074 ENST00000442445.1
ENST00000457361.1
ENST00000342002.2
 IKZF2


IKAROS family zinc finger 2 (Helios)


chr5_-_33984786 0.073 ENST00000296589.4
 SLC45A2
solute carrier family 45, member 2
chr7_-_107880508 0.061 ENST00000425651.2
 NRCAM
neuronal cell adhesion molecule
chr1_+_171217622 0.053 ENST00000433267.1
ENST00000367750.3
 FMO1

flavin containing monooxygenase 1

chr16_+_71560023 0.039 ENST00000572450.1
 CHST4
carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 4
chr8_-_20040638 0.033 ENST00000519026.1
ENST00000276373.5
ENST00000440926.1
ENST00000437980.1
 SLC18A1



solute carrier family 18 (vesicular monoamine transporter), member 1



chr14_+_21945335 0.027 ENST00000262709.3
ENST00000457430.2
ENST00000448790.2
 TOX4


TOX high mobility group box family member 4


chr8_-_93107443 0.022 ENST00000360348.2
ENST00000520428.1
ENST00000518992.1
ENST00000520556.1
ENST00000518317.1
ENST00000521319.1
ENST00000521375.1
ENST00000518449.1
 RUNX1T1







runt-related transcription factor 1; translocated to, 1 (cyclin D-related)







chr14_+_75988768 0.012 ENST00000286639.6
 BATF
basic leucine zipper transcription factor, ATF-like
chr14_-_21945057 0.009 ENST00000397762.1
 RAB2B
RAB2B, member RAS oncogene family
chr2_+_87565634 0.008 ENST00000421835.2
 IGKV3OR2-268
immunoglobulin kappa variable 3/OR2-268 (non-functional)
chr2_-_90538397 0.004 ENST00000443397.3
 RP11-685N3.1
Uncharacterized protein
chr9_+_125796806 0.001 ENST00000373642.1
 GPR21
G protein-coupled receptor 21

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.6 GO:0001955 blood vessel maturation(GO:0001955)
0.5 1.5 GO:0097237 response to cobalt ion(GO:0032025) cellular response to antibiotic(GO:0071236) cellular response to toxic substance(GO:0097237)
0.5 3.5 GO:0043249 erythrocyte maturation(GO:0043249)
0.4 2.6 GO:1904729 regulation of intestinal cholesterol absorption(GO:0030300) regulation of intestinal absorption(GO:1904478) regulation of intestinal lipid absorption(GO:1904729)
0.3 1.0 GO:0046521 sphingoid catabolic process(GO:0046521)
0.2 3.2 GO:0031498 nucleosome disassembly(GO:0006337) chromatin disassembly(GO:0031498) protein-DNA complex disassembly(GO:0032986)
0.2 0.7 GO:0071635 negative regulation of transforming growth factor beta production(GO:0071635)
0.1 0.4 GO:0060024 rhythmic synaptic transmission(GO:0060024) positive regulation of sarcomere organization(GO:0060298) regulation of prostaglandin-endoperoxide synthase activity(GO:0060584) positive regulation of prostaglandin-endoperoxide synthase activity(GO:0060585)
0.1 0.9 GO:0002347 response to tumor cell(GO:0002347)
0.1 0.2 GO:0070995 NADPH oxidation(GO:0070995)
0.1 1.2 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.1 0.3 GO:0001880 Mullerian duct regression(GO:0001880)
0.0 0.2 GO:0032933 SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.0 0.1 GO:1903115 regulation of muscle filament sliding(GO:0032971) regulation of actin filament-based movement(GO:1903115)
0.0 0.2 GO:0045578 negative regulation of B cell differentiation(GO:0045578)
0.0 0.1 GO:0060398 regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0 1.2 GO:0051693 actin filament capping(GO:0051693)
0.0 0.7 GO:0071577 zinc II ion transmembrane transport(GO:0071577)
0.0 1.4 GO:0002286 T cell activation involved in immune response(GO:0002286)
0.0 1.2 GO:0050931 melanocyte differentiation(GO:0030318) pigment cell differentiation(GO:0050931)
0.0 2.0 GO:0006826 iron ion transport(GO:0006826)
0.0 0.2 GO:0035162 embryonic hemopoiesis(GO:0035162)
0.0 0.2 GO:0006477 protein sulfation(GO:0006477)
0.0 0.8 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.0 0.4 GO:0046697 decidualization(GO:0046697)
0.0 0.2 GO:0048066 developmental pigmentation(GO:0048066)
0.0 1.2 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.7 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 8.3 GO:0016337 single organismal cell-cell adhesion(GO:0016337)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 4.0 GO:0031254 uropod(GO:0001931) cell trailing edge(GO:0031254)
0.2 1.2 GO:0033093 Weibel-Palade body(GO:0033093)
0.2 1.2 GO:0031235 intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235)
0.2 3.3 GO:0005833 hemoglobin complex(GO:0005833)
0.2 1.4 GO:0001891 phagocytic cup(GO:0001891)
0.1 0.9 GO:0031304 intrinsic component of mitochondrial inner membrane(GO:0031304)
0.1 1.6 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.1 0.2 GO:0043512 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.0 0.3 GO:0031616 spindle pole centrosome(GO:0031616)
0.0 3.2 GO:0016605 PML body(GO:0016605)
0.0 0.1 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.0 1.1 GO:0005761 organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761)
0.0 0.2 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 1.4 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.0 0.5 GO:0005921 gap junction(GO:0005921)
0.0 1.2 GO:0005643 nuclear pore(GO:0005643)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 2.0 GO:0004998 transferrin receptor activity(GO:0004998)
0.4 1.6 GO:0034190 apolipoprotein receptor binding(GO:0034190) high-density lipoprotein particle receptor binding(GO:0070653)
0.3 0.9 GO:0002114 interleukin-33 receptor activity(GO:0002114)
0.3 3.3 GO:0005344 oxygen transporter activity(GO:0005344)
0.2 1.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.2 2.4 GO:0017127 cholesterol transporter activity(GO:0017127)
0.2 1.0 GO:0017050 sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050)
0.1 1.5 GO:0043176 amine binding(GO:0043176)
0.1 3.2 GO:0050699 WW domain binding(GO:0050699)
0.1 2.2 GO:0008519 ammonium transmembrane transporter activity(GO:0008519)
0.1 0.8 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.1 9.5 GO:0005178 integrin binding(GO:0005178)
0.1 0.9 GO:0016634 oxidoreductase activity, acting on the CH-CH group of donors, oxygen as acceptor(GO:0016634)
0.1 0.4 GO:0031708 bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708)
0.1 0.3 GO:0005026 transforming growth factor beta receptor activity, type II(GO:0005026)
0.1 0.6 GO:0004904 interferon receptor activity(GO:0004904)
0.1 1.0 GO:0005537 mannose binding(GO:0005537)
0.1 1.2 GO:0005086 ARF guanyl-nucleotide exchange factor activity(GO:0005086)
0.0 0.2 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
0.0 0.2 GO:0001517 N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517)
0.0 2.6 GO:0051015 actin filament binding(GO:0051015)
0.0 0.2 GO:0034711 inhibin binding(GO:0034711)
0.0 0.7 GO:0005385 zinc ion transmembrane transporter activity(GO:0005385)
0.0 0.1 GO:0032036 myosin heavy chain binding(GO:0032036)
0.0 0.2 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.1 GO:0030506 ankyrin binding(GO:0030506)
0.0 0.9 GO:0008170 N-methyltransferase activity(GO:0008170)
0.0 0.3 GO:0004806 triglyceride lipase activity(GO:0004806)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.8 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway