Motif ID: GCUGGUG
Z-value: 1.267
Mature miRNA associated with seed GCUGGUG:
| Name | miRBase Accession |
|---|---|
| hsa-miR-138-5p | MIMAT0000430 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.4 | GO:0046619 | optic placode formation involved in camera-type eye formation(GO:0046619) |
| 0.3 | 0.9 | GO:0032927 | positive regulation of activin receptor signaling pathway(GO:0032927) |
| 0.3 | 1.2 | GO:0042271 | susceptibility to natural killer cell mediated cytotoxicity(GO:0042271) |
| 0.3 | 2.9 | GO:0021800 | cerebral cortex tangential migration(GO:0021800) |
| 0.3 | 1.7 | GO:0045722 | response to muscle activity(GO:0014850) positive regulation of gluconeogenesis(GO:0045722) |
| 0.2 | 1.2 | GO:0046607 | positive regulation of centrosome cycle(GO:0046607) |
| 0.2 | 0.4 | GO:0014874 | response to stimulus involved in regulation of muscle adaptation(GO:0014874) |
| 0.2 | 0.7 | GO:0033197 | response to vitamin E(GO:0033197) |
| 0.2 | 0.5 | GO:0032071 | regulation of endodeoxyribonuclease activity(GO:0032071) negative regulation of helicase activity(GO:0051097) |
| 0.2 | 0.6 | GO:0071025 | RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028) |
| 0.1 | 0.4 | GO:0032571 | response to vitamin K(GO:0032571) |
| 0.1 | 0.4 | GO:0007028 | cytoplasm organization(GO:0007028) |
| 0.1 | 0.5 | GO:0048935 | peripheral nervous system neuron development(GO:0048935) |
| 0.1 | 0.4 | GO:0034723 | DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.1 | 2.2 | GO:0031648 | protein destabilization(GO:0031648) |
| 0.1 | 1.8 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.1 | 0.3 | GO:0043371 | negative regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043371) negative regulation of T-helper cell differentiation(GO:0045623) negative regulation of CD4-positive, alpha-beta T cell activation(GO:2000515) |
| 0.1 | 1.0 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.1 | 0.6 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 0.1 | 0.2 | GO:0008050 | female courtship behavior(GO:0008050) |
| 0.1 | 0.3 | GO:0051573 | negative regulation of histone H3-K9 methylation(GO:0051573) |
| 0.1 | 0.3 | GO:0032776 | DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116) |
| 0.1 | 0.4 | GO:0071294 | cellular response to zinc ion(GO:0071294) |
| 0.1 | 0.8 | GO:0007616 | long-term memory(GO:0007616) |
| 0.1 | 0.3 | GO:0035025 | positive regulation of Rho protein signal transduction(GO:0035025) |
| 0.1 | 0.2 | GO:0035330 | regulation of hippo signaling(GO:0035330) |
| 0.1 | 0.3 | GO:0033152 | immunoglobulin V(D)J recombination(GO:0033152) |
| 0.1 | 0.6 | GO:0043306 | positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306) |
| 0.1 | 0.4 | GO:0019852 | L-ascorbic acid metabolic process(GO:0019852) |
| 0.1 | 0.3 | GO:0032754 | positive regulation of interleukin-13 production(GO:0032736) positive regulation of interleukin-5 production(GO:0032754) |
| 0.1 | 0.2 | GO:0033590 | response to cobalamin(GO:0033590) |
| 0.0 | 0.5 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.0 | 0.6 | GO:0035024 | negative regulation of Rho protein signal transduction(GO:0035024) |
| 0.0 | 0.2 | GO:0006930 | substrate-dependent cell migration, cell extension(GO:0006930) |
| 0.0 | 0.9 | GO:0000291 | nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
| 0.0 | 0.1 | GO:0019918 | peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918) |
| 0.0 | 0.3 | GO:0033962 | cytoplasmic mRNA processing body assembly(GO:0033962) |
| 0.0 | 0.2 | GO:0032916 | transforming growth factor beta3 production(GO:0032907) regulation of transforming growth factor beta3 production(GO:0032910) positive regulation of transforming growth factor beta3 production(GO:0032916) |
| 0.0 | 0.6 | GO:0033169 | histone H3-K9 demethylation(GO:0033169) |
| 0.0 | 0.2 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.0 | 0.3 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.0 | 0.2 | GO:0006999 | nuclear pore organization(GO:0006999) |
| 0.0 | 0.1 | GO:0007538 | primary sex determination(GO:0007538) |
| 0.0 | 0.3 | GO:0030903 | notochord development(GO:0030903) |
| 0.0 | 0.2 | GO:0007256 | activation of JNKK activity(GO:0007256) |
| 0.0 | 0.3 | GO:0009249 | protein lipoylation(GO:0009249) |
| 0.0 | 0.2 | GO:0045947 | negative regulation of translational initiation(GO:0045947) |
| 0.0 | 0.2 | GO:0071044 | histone mRNA catabolic process(GO:0071044) |
| 0.0 | 0.1 | GO:0070537 | histone H2A K63-linked deubiquitination(GO:0070537) |
| 0.0 | 0.1 | GO:0014022 | neural plate elongation(GO:0014022) convergent extension involved in neural plate elongation(GO:0022007) |
| 0.0 | 0.2 | GO:0051096 | meiotic mismatch repair(GO:0000710) regulation of helicase activity(GO:0051095) positive regulation of helicase activity(GO:0051096) |
| 0.0 | 0.9 | GO:0042246 | tissue regeneration(GO:0042246) |
| 0.0 | 1.4 | GO:0042552 | myelination(GO:0042552) |
| 0.0 | 2.0 | GO:0007605 | sensory perception of sound(GO:0007605) |
| 0.0 | 0.9 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 0.0 | 0.7 | GO:0048146 | positive regulation of fibroblast proliferation(GO:0048146) |
| 0.0 | 0.5 | GO:0006305 | DNA alkylation(GO:0006305) DNA methylation(GO:0006306) |
| 0.0 | 0.2 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 0.0 | 0.1 | GO:0006020 | inositol metabolic process(GO:0006020) |
| 0.0 | 1.2 | GO:0007588 | excretion(GO:0007588) |
| 0.0 | 0.3 | GO:0007413 | axonal fasciculation(GO:0007413) |
| 0.0 | 0.6 | GO:0006271 | DNA strand elongation involved in DNA replication(GO:0006271) |
| 0.0 | 0.2 | GO:0021533 | cell differentiation in hindbrain(GO:0021533) |
| 0.0 | 0.3 | GO:0031055 | DNA replication-independent nucleosome assembly(GO:0006336) chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) DNA replication-independent nucleosome organization(GO:0034724) CENP-A containing chromatin organization(GO:0061641) |
| 0.0 | 0.0 | GO:0014887 | muscle hypertrophy in response to stress(GO:0003299) cardiac muscle adaptation(GO:0014887) cardiac muscle hypertrophy in response to stress(GO:0014898) |
| 0.0 | 0.2 | GO:0006376 | mRNA splice site selection(GO:0006376) |
| 0.0 | 0.5 | GO:0014047 | glutamate secretion(GO:0014047) |
| 0.0 | 0.2 | GO:0006098 | pentose-phosphate shunt(GO:0006098) glyceraldehyde-3-phosphate metabolic process(GO:0019682) |
| 0.0 | 0.1 | GO:0001573 | ganglioside metabolic process(GO:0001573) |
| 0.0 | 0.0 | GO:0051365 | cellular response to potassium ion starvation(GO:0051365) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 1.4 | GO:0043218 | compact myelin(GO:0043218) |
| 0.1 | 1.2 | GO:0031616 | spindle pole centrosome(GO:0031616) |
| 0.1 | 0.5 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.1 | 0.5 | GO:0033553 | rDNA heterochromatin(GO:0033553) |
| 0.1 | 0.3 | GO:0000788 | nuclear nucleosome(GO:0000788) |
| 0.1 | 0.7 | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex(GO:0019907) |
| 0.1 | 0.2 | GO:0031213 | RSF complex(GO:0031213) |
| 0.1 | 1.7 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.1 | 0.5 | GO:0060199 | clathrin-sculpted glutamate transport vesicle(GO:0060199) clathrin-sculpted glutamate transport vesicle membrane(GO:0060203) |
| 0.0 | 1.6 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
| 0.0 | 0.6 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 0.3 | GO:0000791 | euchromatin(GO:0000791) |
| 0.0 | 0.2 | GO:0032301 | MutSalpha complex(GO:0032301) |
| 0.0 | 0.4 | GO:0005721 | pericentric heterochromatin(GO:0005721) |
| 0.0 | 2.2 | GO:0000118 | histone deacetylase complex(GO:0000118) |
| 0.0 | 0.3 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.0 | 2.0 | GO:0008021 | synaptic vesicle(GO:0008021) |
| 0.0 | 1.0 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.0 | 0.2 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.0 | 0.3 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
| 0.0 | 0.5 | GO:0030530 | obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.3 | GO:0050692 | DBD domain binding(GO:0050692) |
| 0.4 | 1.2 | GO:0030160 | GKAP/Homer scaffold activity(GO:0030160) |
| 0.3 | 0.9 | GO:0016362 | activin receptor activity, type II(GO:0016362) |
| 0.1 | 0.5 | GO:0043398 | HLH domain binding(GO:0043398) |
| 0.1 | 0.4 | GO:0008523 | sodium-dependent multivitamin transmembrane transporter activity(GO:0008523) |
| 0.1 | 0.6 | GO:0004706 | JUN kinase kinase kinase activity(GO:0004706) |
| 0.1 | 0.1 | GO:0042799 | histone methyltransferase activity (H4-K20 specific)(GO:0042799) |
| 0.1 | 2.5 | GO:0004712 | protein serine/threonine/tyrosine kinase activity(GO:0004712) |
| 0.1 | 1.7 | GO:0016922 | ligand-dependent nuclear receptor binding(GO:0016922) |
| 0.1 | 0.6 | GO:0008409 | 5'-3' exonuclease activity(GO:0008409) |
| 0.1 | 1.8 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 0.2 | GO:0017057 | glucose-6-phosphate dehydrogenase activity(GO:0004345) 6-phosphogluconolactonase activity(GO:0017057) |
| 0.1 | 0.3 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
| 0.1 | 0.4 | GO:0030955 | potassium ion binding(GO:0030955) |
| 0.1 | 0.6 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.1 | 0.3 | GO:0070644 | vitamin D response element binding(GO:0070644) |
| 0.1 | 0.2 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.1 | 0.5 | GO:0004835 | tubulin-tyrosine ligase activity(GO:0004835) |
| 0.0 | 1.0 | GO:0051184 | cofactor transporter activity(GO:0051184) |
| 0.0 | 0.5 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.0 | 0.3 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.0 | 0.1 | GO:0035241 | protein-arginine omega-N monomethyltransferase activity(GO:0035241) protein-arginine omega-N symmetric methyltransferase activity(GO:0035243) |
| 0.0 | 0.7 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 0.2 | GO:0032143 | single thymine insertion binding(GO:0032143) |
| 0.0 | 0.0 | GO:0016566 | obsolete specific transcriptional repressor activity(GO:0016566) |
| 0.0 | 0.1 | GO:0070290 | N-acylphosphatidylethanolamine-specific phospholipase D activity(GO:0070290) |
| 0.0 | 0.2 | GO:0003836 | beta-galactoside (CMP) alpha-2,3-sialyltransferase activity(GO:0003836) |
| 0.0 | 0.4 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 0.3 | GO:0031701 | angiotensin receptor binding(GO:0031701) |
| 0.0 | 0.7 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 0.1 | GO:0000827 | inositol-1,3,4,5,6-pentakisphosphate kinase activity(GO:0000827) diphosphoinositol-pentakisphosphate kinase activity(GO:0033857) |
| 0.0 | 0.5 | GO:0005313 | L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172) |
| 0.0 | 0.6 | GO:0051059 | NF-kappaB binding(GO:0051059) |
| 0.0 | 0.1 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.0 | 0.3 | GO:0004707 | MAP kinase activity(GO:0004707) |
| 0.0 | 0.3 | GO:0042605 | peptide antigen binding(GO:0042605) |
| 0.0 | 0.4 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.0 | 0.2 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
| 0.0 | 0.4 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.0 | 1.8 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 1.0 | GO:0008146 | sulfotransferase activity(GO:0008146) |
| 0.0 | 0.1 | GO:0004119 | cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) |
| 0.0 | 0.3 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.6 | GO:0036459 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.0 | 1.4 | GO:0042393 | histone binding(GO:0042393) |
| 0.0 | 0.2 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.0 | 1.2 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 0.1 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.0 | 0.3 | GO:0001071 | nucleic acid binding transcription factor activity(GO:0001071) transcription factor activity, sequence-specific DNA binding(GO:0003700) |
| 0.0 | 0.1 | GO:0050682 | AF-2 domain binding(GO:0050682) |
| 0.0 | 0.2 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.0 | 0.3 | GO:0008188 | neuropeptide receptor activity(GO:0008188) |
| 0.0 | 2.1 | GO:0003702 | obsolete RNA polymerase II transcription factor activity(GO:0003702) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
| 0.0 | 0.5 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.0 | 1.2 | ST_GA13_PATHWAY | G alpha 13 Pathway |
| 0.0 | 0.6 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
