Motif ID: GLI3

Z-value: 1.746


Transcription factors associated with GLI3:

Gene SymbolEntrez IDGene Name
GLI3 ENSG00000106571.8 GLI3



Activity profile for motif GLI3.

activity profile for motif GLI3


Sorted Z-values histogram for motif GLI3

Sorted Z-values for motif GLI3



Network of associatons between targets according to the STRING database.



First level regulatory network of GLI3

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr18_+_21529811 6.620 ENST00000588004.1
LAMA3
laminin, alpha 3
chr1_-_153538292 4.839 ENST00000497140.1
ENST00000368708.3
S100A2

S100 calcium binding protein A2

chr1_-_153538011 4.181 ENST00000368707.4
S100A2
S100 calcium binding protein A2
chr12_-_52887034 3.931 ENST00000330722.6
KRT6A
keratin 6A
chr20_+_62327996 3.864 ENST00000369996.1
TNFRSF6B
tumor necrosis factor receptor superfamily, member 6b, decoy
chr17_-_39928106 3.739 ENST00000540235.1
JUP
junction plakoglobin
chr19_+_35606692 3.278 ENST00000406242.3
ENST00000454903.2
FXYD3

FXYD domain containing ion transport regulator 3

chr12_-_52845910 3.197 ENST00000252252.3
KRT6B
keratin 6B
chr1_+_183155373 3.191 ENST00000493293.1
ENST00000264144.4
LAMC2

laminin, gamma 2

chr12_-_52867569 3.138 ENST00000252250.6
KRT6C
keratin 6C
chr19_-_51456321 3.107 ENST00000391809.2
KLK5
kallikrein-related peptidase 5
chr19_-_51456344 3.019 ENST00000336334.3
ENST00000593428.1
KLK5

kallikrein-related peptidase 5

chr6_+_125540951 2.884 ENST00000524679.1
TPD52L1
tumor protein D52-like 1
chr17_+_15848231 2.674 ENST00000304222.2
ADORA2B
adenosine A2b receptor
chr4_-_90758227 2.328 ENST00000506691.1
ENST00000394986.1
ENST00000506244.1
ENST00000394989.2
ENST00000394991.3
SNCA




synuclein, alpha (non A4 component of amyloid precursor)




chr8_+_31497271 2.049 ENST00000520407.1
NRG1
neuregulin 1
chr1_+_152956549 2.011 ENST00000307122.2
SPRR1A
small proline-rich protein 1A
chr20_-_6104191 1.995 ENST00000217289.4
FERMT1
fermitin family member 1
chr19_-_51456198 1.929 ENST00000594846.1
KLK5
kallikrein-related peptidase 5
chr16_+_68678739 1.814 ENST00000264012.4
CDH3
cadherin 3, type 1, P-cadherin (placental)
chrX_+_152086373 1.794 ENST00000318529.8
ZNF185
zinc finger protein 185 (LIM domain)
chr11_-_12030629 1.733 ENST00000396505.2
DKK3
dickkopf WNT signaling pathway inhibitor 3
chr6_-_46703069 1.700 ENST00000538237.1
ENST00000274793.7
PLA2G7

phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)

chr14_+_94577074 1.672 ENST00000444961.1
ENST00000448882.1
ENST00000557098.1
ENST00000554800.1
ENST00000556544.1
ENST00000298902.5
ENST00000555819.1
ENST00000557634.1
ENST00000555744.1
IFI27








interferon, alpha-inducible protein 27








chr4_-_177713788 1.621 ENST00000280193.2
VEGFC
vascular endothelial growth factor C
chr16_+_68679193 1.585 ENST00000581171.1
CDH3
cadherin 3, type 1, P-cadherin (placental)
chr11_+_2415061 1.554 ENST00000481687.1
CD81
CD81 molecule
chr19_+_48281842 1.528 ENST00000509570.2
SEPW1
selenoprotein W, 1
chr17_+_73750699 1.519 ENST00000584939.1
ITGB4
integrin, beta 4
chr22_+_31489344 1.509 ENST00000404574.1
SMTN
smoothelin
chr8_-_42065187 1.503 ENST00000270189.6
ENST00000352041.3
ENST00000220809.4
PLAT


plasminogen activator, tissue


chr6_-_46703430 1.456 ENST00000537365.1
PLA2G7
phospholipase A2, group VII (platelet-activating factor acetylhydrolase, plasma)
chr11_+_69931519 1.439 ENST00000316296.5
ENST00000530676.1
ANO1

anoctamin 1, calcium activated chloride channel

chr11_-_119991589 1.353 ENST00000526881.1
TRIM29
tripartite motif containing 29
chr16_+_56598961 1.327 ENST00000219162.3
MT4
metallothionein 4
chr10_-_126847276 1.326 ENST00000531469.1
CTBP2
C-terminal binding protein 2
chr19_-_51522955 1.300 ENST00000358789.3
KLK10
kallikrein-related peptidase 10
chr8_+_94929168 1.261 ENST00000518107.1
ENST00000396200.3
PDP1

pyruvate dehyrogenase phosphatase catalytic subunit 1

chr7_-_56119156 1.248 ENST00000421312.1
ENST00000416592.1
PSPH

phosphoserine phosphatase

chr20_+_55204351 1.230 ENST00000201031.2
TFAP2C
transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)
chr12_+_6308881 1.227 ENST00000382518.1
ENST00000536586.1
CD9

CD9 molecule

chr2_+_192109911 1.210 ENST00000418908.1
ENST00000339514.4
ENST00000392318.3
MYO1B


myosin IB


chr19_-_12886327 1.210 ENST00000397668.3
ENST00000587178.1
ENST00000264827.5
HOOK2


hook microtubule-tethering protein 2


chr8_+_94929077 1.206 ENST00000297598.4
ENST00000520614.1
PDP1

pyruvate dehyrogenase phosphatase catalytic subunit 1

chr22_+_31488433 1.202 ENST00000455608.1
SMTN
smoothelin
chr14_-_61748550 1.183 ENST00000555868.1
TMEM30B
transmembrane protein 30B
chr6_-_105627735 1.164 ENST00000254765.3
POPDC3
popeye domain containing 3
chr1_+_152881014 1.155 ENST00000368764.3
ENST00000392667.2
IVL

involucrin

chr8_+_94929110 1.147 ENST00000520728.1
PDP1
pyruvate dehyrogenase phosphatase catalytic subunit 1
chr19_+_48281803 1.143 ENST00000601048.1
SEPW1
selenoprotein W, 1
chr1_+_44399466 1.140 ENST00000498139.2
ENST00000491846.1
ARTN

artemin

chr4_+_74735102 1.137 ENST00000395761.3
CXCL1
chemokine (C-X-C motif) ligand 1 (melanoma growth stimulating activity, alpha)
chr16_+_56691606 1.057 ENST00000334350.6
MT1F
metallothionein 1F
chr7_-_151511911 1.056 ENST00000392801.2
PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr19_+_49713991 1.053 ENST00000597316.1
TRPM4
transient receptor potential cation channel, subfamily M, member 4
chr12_-_8814669 1.050 ENST00000535411.1
ENST00000540087.1
MFAP5

microfibrillar associated protein 5

chr19_+_48281946 1.041 ENST00000595615.1
SEPW1
selenoprotein W, 1
chr19_+_41281416 1.038 ENST00000597140.1
MIA
melanoma inhibitory activity
chr17_-_7307358 0.996 ENST00000535512.1
ENST00000576017.1
ENST00000302422.3
TMEM256-PLSCR3
TMEM256

TMEM256-PLSCR3 readthrough (NMD candidate)
transmembrane protein 256

chr2_+_234637754 0.963 ENST00000609767.1
ENST00000482026.1
UGT1A1
UGT1A3
UDP glucuronosyltransferase 1 family, polypeptide A8
UDP glucuronosyltransferase 1 family, polypeptide A3
chr21_-_45079341 0.961 ENST00000443485.1
ENST00000291560.2
HSF2BP

heat shock transcription factor 2 binding protein

chr2_+_192110199 0.961 ENST00000304164.4
MYO1B
myosin IB
chr2_-_85636928 0.945 ENST00000449030.1
CAPG
capping protein (actin filament), gelsolin-like
chr19_+_48281928 0.942 ENST00000593892.1
SEPW1
selenoprotein W, 1
chr19_-_19051993 0.932 ENST00000594794.1
ENST00000355887.6
ENST00000392351.3
ENST00000596482.1
HOMER3



homer homolog 3 (Drosophila)



chr1_+_35220613 0.911 ENST00000338513.1
GJB5
gap junction protein, beta 5, 31.1kDa
chr16_+_56691838 0.895 ENST00000394501.2
MT1F
metallothionein 1F
chr16_+_68771128 0.878 ENST00000261769.5
ENST00000422392.2
CDH1

cadherin 1, type 1, E-cadherin (epithelial)

chr2_+_235860616 0.872 ENST00000392011.2
SH3BP4
SH3-domain binding protein 4
chr1_-_43833628 0.863 ENST00000413844.2
ENST00000372458.3
ELOVL1

ELOVL fatty acid elongase 1

chr3_+_44626446 0.861 ENST00000441021.1
ENST00000322734.2
ZNF660

zinc finger protein 660

chr3_-_43663519 0.861 ENST00000427171.1
ENST00000292246.3
ANO10

anoctamin 10

chr19_+_41281060 0.860 ENST00000594436.1
ENST00000597784.1
MIA

melanoma inhibitory activity

chr16_+_57653854 0.848 ENST00000568908.1
ENST00000568909.1
ENST00000566778.1
ENST00000561988.1
GPR56



G protein-coupled receptor 56



chr12_-_54813229 0.818 ENST00000293379.4
ITGA5
integrin, alpha 5 (fibronectin receptor, alpha polypeptide)
chr19_+_41281282 0.814 ENST00000263369.3
MIA
melanoma inhibitory activity
chr2_-_24308051 0.803 ENST00000238721.4
ENST00000335934.4
TP53I3

tumor protein p53 inducible protein 3

chr16_+_57653989 0.803 ENST00000567835.1
ENST00000569372.1
ENST00000563548.1
ENST00000562003.1
GPR56



G protein-coupled receptor 56



chr8_-_145013711 0.798 ENST00000345136.3
PLEC
plectin
chr9_-_101017900 0.786 ENST00000375066.5
TBC1D2
TBC1 domain family, member 2
chr11_+_832944 0.781 ENST00000322008.4
ENST00000397421.1
ENST00000529810.1
ENST00000526693.1
ENST00000525333.1
ENST00000524748.1
ENST00000527341.1
CD151






CD151 molecule (Raph blood group)






chr9_-_101017862 0.780 ENST00000375064.1
ENST00000342112.5
TBC1D2

TBC1 domain family, member 2

chr3_-_43663389 0.773 ENST00000444344.1
ENST00000456438.1
ENST00000350459.4
ENST00000396091.3
ENST00000451430.2
ENST00000428472.1
ENST00000414522.2
ANO10






anoctamin 10






chr10_+_124134201 0.764 ENST00000368990.3
ENST00000368988.1
ENST00000368989.2
ENST00000463663.2
PLEKHA1



pleckstrin homology domain containing, family A (phosphoinositide binding specific) member 1



chr1_+_13910194 0.749 ENST00000376057.4
ENST00000510906.1
PDPN

podoplanin

chr18_+_3451646 0.742 ENST00000345133.5
ENST00000330513.5
ENST00000549546.1
TGIF1


TGFB-induced factor homeobox 1


chr8_-_145028013 0.739 ENST00000354958.2
PLEC
plectin
chr1_-_153433120 0.738 ENST00000368723.3
S100A7
S100 calcium binding protein A7
chr11_-_796197 0.738 ENST00000530360.1
ENST00000528606.1
ENST00000320230.5
SLC25A22


solute carrier family 25 (mitochondrial carrier: glutamate), member 22


chr7_-_41742697 0.735 ENST00000242208.4
INHBA
inhibin, beta A
chr1_+_233765353 0.731 ENST00000366620.1
KCNK1
potassium channel, subfamily K, member 1
chr7_-_24797546 0.726 ENST00000414428.1
ENST00000419307.1
ENST00000342947.3
DFNA5


deafness, autosomal dominant 5


chr8_+_15397732 0.725 ENST00000382020.4
ENST00000506802.1
ENST00000509380.1
ENST00000503731.1
TUSC3



tumor suppressor candidate 3



chr9_+_132962843 0.710 ENST00000458469.1
NCS1
neuronal calcium sensor 1
chr7_-_56118981 0.699 ENST00000419984.2
ENST00000413218.1
ENST00000424596.1
PSPH


phosphoserine phosphatase


chr1_+_26869597 0.694 ENST00000530003.1
RPS6KA1
ribosomal protein S6 kinase, 90kDa, polypeptide 1
chr15_+_45422178 0.691 ENST00000389037.3
ENST00000558322.1
DUOX1

dual oxidase 1

chr16_+_56691911 0.682 ENST00000568475.1
MT1F
metallothionein 1F
chr15_+_45422131 0.679 ENST00000321429.4
DUOX1
dual oxidase 1
chr16_-_84538218 0.672 ENST00000562447.1
ENST00000565765.1
ENST00000535580.1
ENST00000343629.6
TLDC1



TBC/LysM-associated domain containing 1



chr11_-_61646054 0.671 ENST00000527379.1
FADS3
fatty acid desaturase 3
chr11_+_2407287 0.667 ENST00000381036.3
ENST00000492252.1
CD81

CD81 molecule

chr10_+_17270214 0.665 ENST00000544301.1
VIM
vimentin
chr16_-_68269971 0.663 ENST00000565858.1
ESRP2
epithelial splicing regulatory protein 2
chr12_-_120687948 0.650 ENST00000458477.2
PXN
paxillin
chr2_-_24307635 0.647 ENST00000313482.4
TP53I3
tumor protein p53 inducible protein 3
chr19_+_676385 0.646 ENST00000166139.4
FSTL3
follistatin-like 3 (secreted glycoprotein)
chr11_+_832804 0.642 ENST00000397420.3
ENST00000525718.1
CD151

CD151 molecule (Raph blood group)

chr1_+_155293702 0.638 ENST00000368347.4
RUSC1
RUN and SH3 domain containing 1
chr1_+_26605618 0.631 ENST00000270792.5
SH3BGRL3
SH3 domain binding glutamic acid-rich protein like 3
chr16_+_27325202 0.625 ENST00000395762.2
ENST00000562142.1
ENST00000561742.1
ENST00000543915.2
ENST00000449195.1
ENST00000380922.3
ENST00000563002.1
IL4R






interleukin 4 receptor






chr16_+_4526341 0.622 ENST00000458134.3
ENST00000219700.6
ENST00000575120.1
ENST00000572812.1
ENST00000574466.1
ENST00000576827.1
ENST00000570445.1
HMOX2






heme oxygenase (decycling) 2






chr11_+_32851487 0.617 ENST00000257836.3
PRRG4
proline rich Gla (G-carboxyglutamic acid) 4 (transmembrane)
chr1_+_36621529 0.616 ENST00000316156.4
MAP7D1
MAP7 domain containing 1
chr4_-_57524061 0.613 ENST00000508121.1
HOPX
HOP homeobox
chr2_-_85637459 0.608 ENST00000409921.1
CAPG
capping protein (actin filament), gelsolin-like
chr11_-_535515 0.608 ENST00000311189.7
ENST00000451590.1
ENST00000417302.1
HRAS


Harvey rat sarcoma viral oncogene homolog


chr9_-_34637718 0.607 ENST00000378892.1
ENST00000277010.4
SIGMAR1

sigma non-opioid intracellular receptor 1

chr10_-_49701686 0.604 ENST00000417247.2
ARHGAP22
Rho GTPase activating protein 22
chr4_+_1283639 0.596 ENST00000303400.4
ENST00000505177.2
ENST00000503653.1
ENST00000264750.6
ENST00000502558.1
ENST00000452175.2
ENST00000514708.1
MAEA






macrophage erythroblast attacher






chrX_+_135229600 0.593 ENST00000370690.3
FHL1
four and a half LIM domains 1
chr9_+_136223414 0.588 ENST00000371964.4
SURF2
surfeit 2
chr12_+_57984965 0.588 ENST00000540759.2
ENST00000551772.1
ENST00000550465.1
ENST00000354947.5
PIP4K2C



phosphatidylinositol-5-phosphate 4-kinase, type II, gamma



chr2_+_234545092 0.584 ENST00000344644.5
UGT1A10
UDP glucuronosyltransferase 1 family, polypeptide A10
chr6_+_116601265 0.572 ENST00000452085.3
DSE
dermatan sulfate epimerase
chr7_-_108096822 0.567 ENST00000379028.3
ENST00000413765.2
ENST00000379022.4
NRCAM


neuronal cell adhesion molecule


chr14_-_107211459 0.557 ENST00000390636.2
IGHV3-73
immunoglobulin heavy variable 3-73
chr11_-_118550346 0.552 ENST00000530256.1
TREH
trehalase (brush-border membrane glycoprotein)
chr1_-_201368707 0.537 ENST00000391967.2
LAD1
ladinin 1
chr5_-_157002775 0.536 ENST00000257527.4
ADAM19
ADAM metallopeptidase domain 19
chr15_+_67430339 0.534 ENST00000439724.3
SMAD3
SMAD family member 3
chr12_-_57522813 0.533 ENST00000556155.1
STAT6
signal transducer and activator of transcription 6, interleukin-4 induced
chr9_-_27529726 0.531 ENST00000262244.5
MOB3B
MOB kinase activator 3B
chr19_-_45926739 0.531 ENST00000589381.1
ENST00000591636.1
ENST00000013807.5
ENST00000592023.1
ERCC1



excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence)



chrX_-_134186144 0.526 ENST00000370775.2
FAM127B
family with sequence similarity 127, member B
chr1_+_167691185 0.525 ENST00000359523.2
MPZL1
myelin protein zero-like 1
chr5_-_79551838 0.524 ENST00000509193.1
ENST00000512972.2
SERINC5

serine incorporator 5

chr5_+_149340282 0.523 ENST00000286298.4
SLC26A2
solute carrier family 26 (anion exchanger), member 2
chr5_-_137878887 0.523 ENST00000507939.1
ENST00000572514.1
ENST00000499810.2
ENST00000360541.5
ETF1



eukaryotic translation termination factor 1



chr1_+_203595903 0.520 ENST00000367218.3
ENST00000367219.3
ENST00000391954.2
ATP2B4


ATPase, Ca++ transporting, plasma membrane 4


chr1_+_154947126 0.514 ENST00000368439.1
CKS1B
CDC28 protein kinase regulatory subunit 1B
chr11_+_44117741 0.512 ENST00000395673.3
ENST00000343631.3
EXT2

exostosin glycosyltransferase 2

chr5_+_65892174 0.510 ENST00000404260.3
ENST00000403625.2
ENST00000406374.1
MAST4


microtubule associated serine/threonine kinase family member 4


chr11_-_8986474 0.509 ENST00000525069.1
TMEM9B
TMEM9 domain family, member B
chr7_-_95064264 0.505 ENST00000536183.1
ENST00000433091.2
ENST00000222572.3
PON2


paraoxonase 2


chr11_+_844067 0.503 ENST00000397406.1
ENST00000409543.2
ENST00000525201.1
TSPAN4


tetraspanin 4


chr6_-_42016385 0.501 ENST00000502771.1
ENST00000508143.1
ENST00000514588.1
ENST00000510503.1
ENST00000415497.2
ENST00000372988.4
CCND3





cyclin D3





chr22_-_28197486 0.500 ENST00000302326.4
MN1
meningioma (disrupted in balanced translocation) 1
chr3_+_101568349 0.495 ENST00000326151.5
ENST00000326172.5
NFKBIZ

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta

chr11_-_65667884 0.492 ENST00000448083.2
ENST00000531493.1
ENST00000532401.1
FOSL1


FOS-like antigen 1


chr11_+_114168085 0.491 ENST00000541754.1
NNMT
nicotinamide N-methyltransferase
chrX_+_135618258 0.489 ENST00000440515.1
ENST00000456412.1
VGLL1

vestigial like 1 (Drosophila)

chr3_+_187871060 0.487 ENST00000448637.1
LPP
LIM domain containing preferred translocation partner in lipoma
chr1_+_47603109 0.486 ENST00000371890.3
ENST00000294337.3
ENST00000371891.3
CYP4A22


cytochrome P450, family 4, subfamily A, polypeptide 22


chr1_-_146040968 0.485 ENST00000401010.3
NBPF11
neuroblastoma breakpoint family, member 11
chr4_-_102268484 0.477 ENST00000394853.4
PPP3CA
protein phosphatase 3, catalytic subunit, alpha isozyme
chr1_+_154947148 0.475 ENST00000368436.1
ENST00000308987.5
CKS1B

CDC28 protein kinase regulatory subunit 1B

chrX_+_134166333 0.473 ENST00000257013.7
FAM127A
family with sequence similarity 127, member A
chrX_+_151999511 0.468 ENST00000370274.3
ENST00000440023.1
ENST00000432467.1
NSDHL


NAD(P) dependent steroid dehydrogenase-like


chr1_+_35544968 0.461 ENST00000359858.4
ENST00000373330.1
ZMYM1

zinc finger, MYM-type 1

chr3_-_127542051 0.457 ENST00000398104.1
MGLL
monoglyceride lipase
chr9_-_113800317 0.457 ENST00000374431.3
LPAR1
lysophosphatidic acid receptor 1
chr17_-_18161870 0.456 ENST00000579294.1
ENST00000545457.2
ENST00000379450.4
ENST00000578558.1
FLII



flightless I homolog (Drosophila)



chrX_+_135229559 0.456 ENST00000394155.2
FHL1
four and a half LIM domains 1
chr7_-_108096765 0.453 ENST00000379024.4
ENST00000351718.4
NRCAM

neuronal cell adhesion molecule

chr5_+_6633456 0.452 ENST00000274192.5
SRD5A1
steroid-5-alpha-reductase, alpha polypeptide 1 (3-oxo-5 alpha-steroid delta 4-dehydrogenase alpha 1)
chr11_-_61658853 0.452 ENST00000525588.1
ENST00000540820.1
FADS3

fatty acid desaturase 3

chr7_-_24797032 0.451 ENST00000409970.1
ENST00000409775.3
DFNA5

deafness, autosomal dominant 5

chr11_+_124735282 0.447 ENST00000397801.1
ROBO3
roundabout, axon guidance receptor, homolog 3 (Drosophila)
chr9_-_139891165 0.445 ENST00000494426.1
CLIC3
chloride intracellular channel 3
chr14_-_74960030 0.445 ENST00000553490.1
ENST00000557510.1
NPC2

Niemann-Pick disease, type C2

chr19_+_18699535 0.436 ENST00000358607.6
C19orf60
chromosome 19 open reading frame 60
chr7_+_69064300 0.429 ENST00000342771.4
AUTS2
autism susceptibility candidate 2
chr19_+_44084696 0.426 ENST00000562255.1
ENST00000569031.2
PINLYP

phospholipase A2 inhibitor and LY6/PLAUR domain containing

chr19_-_54693401 0.421 ENST00000338624.6
MBOAT7
membrane bound O-acyltransferase domain containing 7
chr11_+_64949158 0.421 ENST00000527739.1
ENST00000526966.1
ENST00000533129.1
ENST00000524773.1
CAPN1



calpain 1, (mu/I) large subunit



chr1_-_160990886 0.420 ENST00000537746.1
F11R
F11 receptor
chr6_-_80657292 0.420 ENST00000369816.4
ELOVL4
ELOVL fatty acid elongase 4
chr11_+_64949343 0.418 ENST00000279247.6
ENST00000532285.1
ENST00000534373.1
CAPN1


calpain 1, (mu/I) large subunit


chr14_-_74959994 0.418 ENST00000238633.2
ENST00000434013.2
NPC2

Niemann-Pick disease, type C2

chrX_-_23761317 0.413 ENST00000492081.1
ENST00000379303.5
ENST00000336430.7
ACOT9


acyl-CoA thioesterase 9


chr21_-_33985127 0.404 ENST00000290155.3
C21orf59
chromosome 21 open reading frame 59
chr5_-_180237445 0.401 ENST00000393340.3
MGAT1
mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase
chr1_+_220701740 0.398 ENST00000366917.4
MARK1
MAP/microtubule affinity-regulating kinase 1
chr1_+_40505891 0.396 ENST00000372797.3
ENST00000372802.1
ENST00000449311.1
CAP1


CAP, adenylate cyclase-associated protein 1 (yeast)


chr3_-_127542021 0.394 ENST00000434178.2
MGLL
monoglyceride lipase
chr11_+_64073699 0.391 ENST00000405666.1
ENST00000468670.1
ESRRA

estrogen-related receptor alpha

chr7_+_44240520 0.389 ENST00000496112.1
ENST00000223369.2
YKT6

YKT6 v-SNARE homolog (S. cerevisiae)

chr19_-_51472031 0.388 ENST00000391808.1
KLK6
kallikrein-related peptidase 6
chr2_+_17935119 0.387 ENST00000317402.7
GEN1
GEN1 Holliday junction 5' flap endonuclease
chr7_+_116312411 0.384 ENST00000456159.1
ENST00000397752.3
ENST00000318493.6
MET


met proto-oncogene


chr9_-_113800341 0.383 ENST00000358883.4
LPAR1
lysophosphatidic acid receptor 1
chr18_+_11752040 0.382 ENST00000423027.3
GNAL
guanine nucleotide binding protein (G protein), alpha activating activity polypeptide, olfactory type
chr14_+_29236269 0.380 ENST00000313071.4
FOXG1
forkhead box G1
chr9_-_130639997 0.378 ENST00000373176.1
AK1
adenylate kinase 1
chr1_+_155278539 0.377 ENST00000447866.1
FDPS
farnesyl diphosphate synthase
chr6_+_31371337 0.372 ENST00000449934.2
ENST00000421350.1
MICA

MHC class I polypeptide-related sequence A

chr19_+_37464063 0.371 ENST00000586353.1
ENST00000433993.1
ENST00000592567.1
ZNF568


zinc finger protein 568


chr2_+_17935383 0.371 ENST00000524465.1
ENST00000381254.2
ENST00000532257.1
GEN1


GEN1 Holliday junction 5' flap endonuclease


chr20_-_50808236 0.370 ENST00000361387.2
ZFP64
ZFP64 zinc finger protein

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.7 GO:0071603 negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) endothelial cell-cell adhesion(GO:0071603)
0.9 2.7 GO:0010701 positive regulation of chronic inflammatory response(GO:0002678) positive regulation of norepinephrine secretion(GO:0010701)
0.6 1.7 GO:2000064 regulation of cortisol biosynthetic process(GO:2000064)
0.6 2.2 GO:0043128 regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043126) positive regulation of 1-phosphatidylinositol 4-kinase activity(GO:0043128)
0.5 1.6 GO:0019367 fatty acid elongation, saturated fatty acid(GO:0019367)
0.5 14.3 GO:0031581 hemidesmosome assembly(GO:0031581)
0.5 2.3 GO:0051611 negative regulation of neurotransmitter uptake(GO:0051581) negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495)
0.4 2.2 GO:0090162 establishment of epithelial cell polarity(GO:0090162)
0.4 1.2 GO:0019747 regulation of isoprenoid metabolic process(GO:0019747)
0.3 1.4 GO:0042335 cuticle development(GO:0042335)
0.3 8.2 GO:0045745 positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745)
0.3 1.0 GO:0045162 clustering of voltage-gated sodium channels(GO:0045162)
0.3 2.0 GO:0002052 positive regulation of neuroblast proliferation(GO:0002052)
0.2 1.0 GO:0030913 paranodal junction assembly(GO:0030913)
0.2 0.7 GO:0060279 progesterone secretion(GO:0042701) regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279)
0.2 0.2 GO:0051589 negative regulation of neurotransmitter transport(GO:0051589)
0.2 0.7 GO:0009202 purine deoxyribonucleotide biosynthetic process(GO:0009153) deoxyribonucleoside triphosphate biosynthetic process(GO:0009202)
0.2 0.9 GO:0060662 tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662)
0.2 6.3 GO:0007398 ectoderm development(GO:0007398)
0.2 0.9 GO:0060708 spongiotrophoblast differentiation(GO:0060708)
0.2 0.6 GO:0043371 negative regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043371) negative regulation of T-helper cell differentiation(GO:0045623) negative regulation of CD4-positive, alpha-beta T cell activation(GO:2000515)
0.2 0.6 GO:0006788 heme oxidation(GO:0006788)
0.2 1.8 GO:0051552 flavone metabolic process(GO:0051552)
0.2 1.9 GO:0006564 L-serine biosynthetic process(GO:0006564)
0.2 3.0 GO:0050812 acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812)
0.2 0.2 GO:0050653 chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653)
0.2 2.0 GO:0010658 striated muscle cell apoptotic process(GO:0010658) cardiac muscle cell apoptotic process(GO:0010659) regulation of striated muscle cell apoptotic process(GO:0010662) negative regulation of striated muscle cell apoptotic process(GO:0010664) regulation of cardiac muscle cell apoptotic process(GO:0010665) negative regulation of cardiac muscle cell apoptotic process(GO:0010667)
0.2 0.5 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.2 0.5 GO:0010248 establishment or maintenance of transmembrane electrochemical gradient(GO:0010248) post-embryonic camera-type eye development(GO:0031077)
0.1 0.9 GO:2000124 cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926) regulation of endocannabinoid signaling pathway(GO:2000124)
0.1 0.9 GO:0005984 disaccharide metabolic process(GO:0005984) polysaccharide digestion(GO:0044245)
0.1 0.6 GO:0032926 negative regulation of activin receptor signaling pathway(GO:0032926)
0.1 0.8 GO:0060325 luteinization(GO:0001553) face morphogenesis(GO:0060325)
0.1 0.5 GO:0048295 positive regulation of isotype switching to IgE isotypes(GO:0048295)
0.1 1.5 GO:0060438 trachea development(GO:0060438)
0.1 0.7 GO:0090025 regulation of monocyte chemotaxis(GO:0090025) positive regulation of monocyte chemotaxis(GO:0090026)
0.1 0.5 GO:0046022 regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022)
0.1 0.4 GO:0043461 proton-transporting ATP synthase complex assembly(GO:0043461) proton-transporting ATP synthase complex biogenesis(GO:0070272)
0.1 1.1 GO:0036336 dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336)
0.1 1.5 GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress(GO:0008631) cell death in response to oxidative stress(GO:0036473)
0.1 0.3 GO:0032938 negative regulation of translation in response to oxidative stress(GO:0032938) regulation of translation in response to oxidative stress(GO:0043556)
0.1 0.5 GO:0007386 compartment pattern specification(GO:0007386)
0.1 0.8 GO:0035313 wound healing, spreading of epidermal cells(GO:0035313) wound healing, spreading of cells(GO:0044319) epiboly(GO:0090504) epiboly involved in wound healing(GO:0090505)
0.1 1.6 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.1 3.2 GO:0031424 keratinization(GO:0031424)
0.1 0.5 GO:0002220 innate immune response activating cell surface receptor signaling pathway(GO:0002220)
0.1 0.6 GO:0045071 negative regulation of viral genome replication(GO:0045071)
0.1 1.1 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799) positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.1 1.0 GO:0007216 G-protein coupled glutamate receptor signaling pathway(GO:0007216)
0.1 0.4 GO:0034204 lipid translocation(GO:0034204) phospholipid translocation(GO:0045332)
0.1 0.4 GO:0016199 axon midline choice point recognition(GO:0016199)
0.1 0.5 GO:0044413 evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834)
0.1 0.5 GO:0006295 nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295)
0.1 0.6 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415) regulation of skeletal muscle tissue regeneration(GO:0043416)
0.1 0.5 GO:0006658 phosphatidylserine metabolic process(GO:0006658)
0.1 0.6 GO:0043249 erythrocyte maturation(GO:0043249)
0.1 0.3 GO:0032060 bleb assembly(GO:0032060)
0.1 0.2 GO:0090598 male genitalia morphogenesis(GO:0048808) male anatomical structure morphogenesis(GO:0090598)
0.1 0.7 GO:0001946 lymphangiogenesis(GO:0001946) lymph vessel morphogenesis(GO:0036303)
0.1 0.1 GO:0060298 positive regulation of sarcomere organization(GO:0060298)
0.1 0.1 GO:0033632 regulation of cell-cell adhesion mediated by integrin(GO:0033632)
0.1 5.8 GO:0045454 cell redox homeostasis(GO:0045454)
0.1 0.2 GO:0051547 regulation of keratinocyte migration(GO:0051547) positive regulation of keratinocyte migration(GO:0051549)
0.1 0.1 GO:0030202 heparin metabolic process(GO:0030202) heparin biosynthetic process(GO:0030210)
0.1 0.4 GO:0021869 forebrain ventricular zone progenitor cell division(GO:0021869)
0.1 0.3 GO:0007341 penetration of zona pellucida(GO:0007341)
0.1 0.7 GO:0006702 androgen biosynthetic process(GO:0006702)
0.1 5.8 GO:0043542 endothelial cell migration(GO:0043542)
0.1 0.3 GO:0014820 tonic smooth muscle contraction(GO:0014820) artery smooth muscle contraction(GO:0014824)
0.1 2.3 GO:0006309 DNA catabolic process, endonucleolytic(GO:0000737) apoptotic DNA fragmentation(GO:0006309)
0.1 1.4 GO:0042730 fibrinolysis(GO:0042730)
0.1 0.2 GO:1902803 regulation of synaptic vesicle transport(GO:1902803) regulation of synaptic vesicle exocytosis(GO:2000300)
0.1 1.1 GO:0007405 neuroblast proliferation(GO:0007405)
0.1 0.3 GO:0070682 proteasome regulatory particle assembly(GO:0070682)
0.1 0.2 GO:0033602 negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of dopamine secretion(GO:0033602)
0.1 0.5 GO:0060716 labyrinthine layer blood vessel development(GO:0060716)
0.1 1.2 GO:0007032 endosome organization(GO:0007032)
0.1 0.2 GO:1903960 negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192)
0.1 0.1 GO:0002295 T-helper cell lineage commitment(GO:0002295) positive regulation of cell fate commitment(GO:0010455) CD4-positive, alpha-beta T cell lineage commitment(GO:0043373) memory T cell differentiation(GO:0043379) regulation of memory T cell differentiation(GO:0043380) positive regulation of memory T cell differentiation(GO:0043382) T-helper 17 type immune response(GO:0072538) T-helper 17 cell differentiation(GO:0072539) T-helper 17 cell lineage commitment(GO:0072540) regulation of T-helper 17 type immune response(GO:2000316) positive regulation of T-helper 17 type immune response(GO:2000318) regulation of T-helper 17 cell differentiation(GO:2000319) positive regulation of T-helper 17 cell differentiation(GO:2000321) regulation of T-helper 17 cell lineage commitment(GO:2000328) positive regulation of T-helper 17 cell lineage commitment(GO:2000330)
0.1 0.5 GO:0015014 heparan sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0015014)
0.1 0.7 GO:0051927 obsolete negative regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051927)
0.1 1.8 GO:0008633 obsolete activation of pro-apoptotic gene products(GO:0008633)
0.1 0.9 GO:0032008 positive regulation of TOR signaling(GO:0032008)
0.1 0.3 GO:0002430 complement receptor mediated signaling pathway(GO:0002430)
0.1 0.2 GO:0006530 asparagine catabolic process(GO:0006530) asparagine catabolic process via L-aspartate(GO:0033345)
0.1 3.7 GO:0034332 adherens junction organization(GO:0034332)
0.0 0.2 GO:0002860 natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860)
0.0 0.6 GO:0090398 cellular senescence(GO:0090398)
0.0 0.1 GO:0051102 DNA ligation involved in DNA recombination(GO:0051102)
0.0 0.4 GO:0046835 carbohydrate phosphorylation(GO:0046835)
0.0 0.3 GO:0030007 cellular potassium ion homeostasis(GO:0030007) negative regulation of cell volume(GO:0045794)
0.0 0.5 GO:0010633 negative regulation of epithelial cell migration(GO:0010633)
0.0 0.3 GO:0097384 cellular lipid biosynthetic process(GO:0097384)
0.0 0.2 GO:1903008 organelle disassembly(GO:1903008)
0.0 0.2 GO:0071025 RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028)
0.0 0.3 GO:0046349 UDP-N-acetylglucosamine biosynthetic process(GO:0006048) amino sugar biosynthetic process(GO:0046349)
0.0 0.3 GO:0006561 proline biosynthetic process(GO:0006561)
0.0 0.1 GO:0032621 interleukin-18 production(GO:0032621) regulation of interleukin-18 production(GO:0032661)
0.0 0.5 GO:1904031 positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031)
0.0 0.2 GO:0045948 positive regulation of translational initiation(GO:0045948)
0.0 0.2 GO:0045116 protein neddylation(GO:0045116)
0.0 0.1 GO:0035385 Roundabout signaling pathway(GO:0035385) response to cortisol(GO:0051414) apoptotic process involved in luteolysis(GO:0061364) regulation of chemokine-mediated signaling pathway(GO:0070099) negative regulation of chemokine-mediated signaling pathway(GO:0070100)
0.0 0.2 GO:0006703 estrogen biosynthetic process(GO:0006703)
0.0 2.6 GO:0006939 smooth muscle contraction(GO:0006939)
0.0 0.5 GO:0050872 white fat cell differentiation(GO:0050872)
0.0 0.2 GO:0046676 negative regulation of insulin secretion(GO:0046676) negative regulation of peptide hormone secretion(GO:0090278)
0.0 0.3 GO:0000266 mitochondrial fission(GO:0000266)
0.0 0.1 GO:0050747 positive regulation of lipoprotein metabolic process(GO:0050747)
0.0 0.5 GO:0006449 regulation of translational termination(GO:0006449)
0.0 0.0 GO:0042044 water transport(GO:0006833) fluid transport(GO:0042044)
0.0 0.2 GO:0002063 chondrocyte development(GO:0002063)
0.0 0.1 GO:0042268 regulation of cytolysis(GO:0042268)
0.0 0.2 GO:0050689 negative regulation of defense response to virus by host(GO:0050689)
0.0 2.1 GO:0006821 chloride transport(GO:0006821)
0.0 0.1 GO:0042986 positive regulation of amyloid precursor protein biosynthetic process(GO:0042986)
0.0 0.2 GO:0032472 cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) Golgi calcium ion transport(GO:0032472) manganese ion homeostasis(GO:0055071)
0.0 0.1 GO:0031936 negative regulation of chromatin silencing(GO:0031936)
0.0 0.1 GO:0051958 methotrexate transport(GO:0051958)
0.0 0.3 GO:0000183 chromatin silencing at rDNA(GO:0000183)
0.0 0.7 GO:0045103 intermediate filament-based process(GO:0045103)
0.0 0.7 GO:0008299 isoprenoid biosynthetic process(GO:0008299)
0.0 0.4 GO:0031000 response to caffeine(GO:0031000)
0.0 0.4 GO:0008088 axo-dendritic transport(GO:0008088)
0.0 0.1 GO:0072385 minus-end-directed organelle transport along microtubule(GO:0072385)
0.0 0.1 GO:0006423 cysteinyl-tRNA aminoacylation(GO:0006423)
0.0 0.1 GO:1902414 protein localization to adherens junction(GO:0071896) protein localization to cell junction(GO:1902414)
0.0 0.1 GO:0018352 glutamate decarboxylation to succinate(GO:0006540) protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.0 0.1 GO:0048681 negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571)
0.0 0.3 GO:0015074 DNA integration(GO:0015074)
0.0 0.2 GO:0048630 skeletal muscle tissue growth(GO:0048630)
0.0 0.2 GO:0060479 lung epithelium development(GO:0060428) lung cell differentiation(GO:0060479)
0.0 0.6 GO:0043154 negative regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043154) negative regulation of cysteine-type endopeptidase activity(GO:2000117)
0.0 0.2 GO:0048892 sensory system development(GO:0048880) lateral line nerve development(GO:0048892) lateral line nerve glial cell differentiation(GO:0048895) lateral line system development(GO:0048925) lateral line nerve glial cell development(GO:0048937) iridophore differentiation(GO:0050935)
0.0 0.2 GO:0006177 GMP biosynthetic process(GO:0006177)
0.0 0.0 GO:0002385 innate immune response in mucosa(GO:0002227) mucosal immune response(GO:0002385)
0.0 0.1 GO:0006983 ER overload response(GO:0006983)
0.0 0.3 GO:0008272 sulfate transport(GO:0008272)
0.0 0.1 GO:0015705 iodide transport(GO:0015705)
0.0 1.2 GO:0045839 negative regulation of mitotic nuclear division(GO:0045839)
0.0 0.1 GO:0030186 melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187)
0.0 1.2 GO:0000079 regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029)
0.0 0.3 GO:0030854 positive regulation of granulocyte differentiation(GO:0030854)
0.0 0.1 GO:0090201 negative regulation of mitochondrion organization(GO:0010823) response to cycloheximide(GO:0046898) negative regulation of release of cytochrome c from mitochondria(GO:0090201) negative regulation of apoptotic signaling pathway(GO:2001234)
0.0 0.1 GO:0048537 mucosal-associated lymphoid tissue development(GO:0048537)
0.0 0.1 GO:0015670 carbon dioxide transport(GO:0015670)
0.0 0.7 GO:0033572 ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.0 0.0 GO:0003077 obsolete negative regulation of diuresis(GO:0003077)
0.0 0.3 GO:0014003 oligodendrocyte development(GO:0014003)
0.0 0.3 GO:0018298 protein-chromophore linkage(GO:0018298)
0.0 0.1 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.0 0.3 GO:0060393 regulation of pathway-restricted SMAD protein phosphorylation(GO:0060393)
0.0 0.1 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.2 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.3 GO:0003407 neural retina development(GO:0003407)
0.0 0.4 GO:0016254 preassembly of GPI anchor in ER membrane(GO:0016254)
0.0 0.1 GO:0034260 negative regulation of GTPase activity(GO:0034260)
0.0 0.1 GO:0045008 depyrimidination(GO:0045008)
0.0 0.1 GO:0006707 cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127)
0.0 0.2 GO:0007494 midgut development(GO:0007494)
0.0 0.4 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.2 GO:0007020 microtubule nucleation(GO:0007020)
0.0 0.3 GO:0043968 histone H2A acetylation(GO:0043968)
0.0 0.4 GO:0070830 bicellular tight junction assembly(GO:0070830)
0.0 0.3 GO:0000305 response to superoxide(GO:0000303) response to oxygen radical(GO:0000305)
0.0 0.1 GO:0051965 positive regulation of synapse assembly(GO:0051965)
0.0 0.1 GO:0007168 receptor guanylyl cyclase signaling pathway(GO:0007168)
0.0 1.1 GO:0007605 sensory perception of sound(GO:0007605)
0.0 0.4 GO:0042147 retrograde transport, endosome to Golgi(GO:0042147)
0.0 0.1 GO:0044254 angiotensin catabolic process in blood(GO:0002005) hormone catabolic process(GO:0042447) multicellular organismal protein catabolic process(GO:0044254) protein digestion(GO:0044256) multicellular organismal macromolecule catabolic process(GO:0044266) multicellular organismal protein metabolic process(GO:0044268)
0.0 0.2 GO:0000045 autophagosome assembly(GO:0000045) autophagosome organization(GO:1905037)
0.0 0.1 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.0 0.1 GO:0006506 GPI anchor biosynthetic process(GO:0006506)
0.0 0.1 GO:0043306 positive regulation of mast cell activation(GO:0033005) positive regulation of mast cell activation involved in immune response(GO:0033008) positive regulation of leukocyte degranulation(GO:0043302) positive regulation of mast cell degranulation(GO:0043306)
0.0 0.0 GO:0032506 barrier septum assembly(GO:0000917) cytokinetic process(GO:0032506) cell septum assembly(GO:0090529) mitotic cytokinetic process(GO:1902410)
0.0 0.1 GO:0032096 negative regulation of response to food(GO:0032096)
0.0 0.1 GO:0050435 beta-amyloid metabolic process(GO:0050435)
0.0 0.4 GO:0001667 ameboidal-type cell migration(GO:0001667)
0.0 0.6 GO:0043484 regulation of RNA splicing(GO:0043484)
0.0 0.1 GO:0006338 chromatin remodeling(GO:0006338)
0.0 0.2 GO:0007220 Notch receptor processing(GO:0007220) membrane protein intracellular domain proteolysis(GO:0031293)
0.0 0.1 GO:0032922 circadian regulation of gene expression(GO:0032922)
0.0 0.1 GO:0032516 positive regulation of phosphoprotein phosphatase activity(GO:0032516)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 3.2 GO:0005610 laminin-2 complex(GO:0005607) laminin-5 complex(GO:0005610)
0.5 4.8 GO:0016342 catenin complex(GO:0016342)
0.5 6.6 GO:0005606 laminin-1 complex(GO:0005606)
0.3 1.2 GO:0070695 FHF complex(GO:0070695)
0.3 10.2 GO:0045095 keratin filament(GO:0045095)
0.2 0.7 GO:0043512 inhibin complex(GO:0043511) inhibin A complex(GO:0043512)
0.2 0.6 GO:0005826 actomyosin contractile ring(GO:0005826)
0.2 3.6 GO:0031092 platelet alpha granule membrane(GO:0031092)
0.1 0.4 GO:0071062 alphav-beta3 integrin-vitronectin complex(GO:0071062)
0.1 0.5 GO:0005955 calcineurin complex(GO:0005955)
0.1 3.2 GO:0001533 cornified envelope(GO:0001533)
0.1 1.9 GO:0031941 filamentous actin(GO:0031941)
0.1 0.3 GO:0042406 extrinsic component of endoplasmic reticulum membrane(GO:0042406)
0.1 1.5 GO:0008290 F-actin capping protein complex(GO:0008290)
0.1 1.1 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 3.7 GO:0005913 cell-cell adherens junction(GO:0005913)
0.1 0.7 GO:0008250 oligosaccharyltransferase complex(GO:0008250)
0.1 5.9 GO:0034707 chloride channel complex(GO:0034707)
0.1 0.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.1 1.1 GO:0001527 microfibril(GO:0001527)
0.1 0.3 GO:0008540 proteasome regulatory particle, base subcomplex(GO:0008540)
0.1 0.2 GO:0035327 transcriptionally active chromatin(GO:0035327)
0.1 0.9 GO:0005868 cytoplasmic dynein complex(GO:0005868)
0.1 0.7 GO:0031527 filopodium membrane(GO:0031527)
0.1 0.2 GO:0043159 acrosomal matrix(GO:0043159)
0.1 0.3 GO:0033553 rDNA heterochromatin(GO:0033553)
0.1 0.4 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.0 0.8 GO:0005922 connexon complex(GO:0005922)
0.0 3.2 GO:0008287 protein serine/threonine phosphatase complex(GO:0008287) phosphatase complex(GO:1903293)
0.0 0.5 GO:0000109 nucleotide-excision repair complex(GO:0000109)
0.0 0.1 GO:0032009 early phagosome(GO:0032009)
0.0 0.1 GO:0036452 ESCRT III complex(GO:0000815) ESCRT complex(GO:0036452)
0.0 0.9 GO:0032587 ruffle membrane(GO:0032587)
0.0 0.1 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
0.0 0.3 GO:0005869 dynactin complex(GO:0005869)
0.0 0.3 GO:0002102 podosome(GO:0002102)
0.0 0.5 GO:0035253 ciliary rootlet(GO:0035253)
0.0 0.6 GO:0030315 T-tubule(GO:0030315)
0.0 0.2 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.0 0.3 GO:0005851 eukaryotic translation initiation factor 2B complex(GO:0005851)
0.0 0.1 GO:0001940 male pronucleus(GO:0001940)
0.0 1.3 GO:0005637 nuclear inner membrane(GO:0005637)
0.0 0.1 GO:0032807 DNA ligase IV complex(GO:0032807)
0.0 0.6 GO:0031105 septin complex(GO:0031105) septin cytoskeleton(GO:0032156)
0.0 2.3 GO:0016459 myosin complex(GO:0016459)
0.0 0.3 GO:0019773 proteasome core complex, alpha-subunit complex(GO:0019773)
0.0 0.1 GO:0045257 mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283)
0.0 0.5 GO:0046930 pore complex(GO:0046930)
0.0 0.3 GO:0031307 integral component of mitochondrial outer membrane(GO:0031307)
0.0 0.3 GO:0005885 Arp2/3 protein complex(GO:0005885)
0.0 1.6 GO:0017053 transcriptional repressor complex(GO:0017053)
0.0 0.3 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)
0.0 0.2 GO:0005683 U7 snRNP(GO:0005683)
0.0 0.7 GO:0005680 anaphase-promoting complex(GO:0005680)
0.0 0.2 GO:0001950 obsolete plasma membrane enriched fraction(GO:0001950)
0.0 0.5 GO:0009925 basal plasma membrane(GO:0009925)
0.0 1.8 GO:0042383 sarcolemma(GO:0042383)
0.0 0.4 GO:0031201 SNARE complex(GO:0031201)
0.0 0.2 GO:0098878 ionotropic glutamate receptor complex(GO:0008328) neurotransmitter receptor complex(GO:0098878)
0.0 1.4 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.0 0.1 GO:0031305 integral component of mitochondrial inner membrane(GO:0031305)
0.0 5.2 GO:0005792 obsolete microsome(GO:0005792)
0.0 0.1 GO:0042597 outer membrane-bounded periplasmic space(GO:0030288) periplasmic space(GO:0042597)
0.0 0.4 GO:0042612 MHC class I protein complex(GO:0042612)
0.0 0.2 GO:0097223 acrosomal vesicle(GO:0001669) sperm part(GO:0097223)
0.0 0.9 GO:0031902 late endosome membrane(GO:0031902)
0.0 0.3 GO:0035267 NuA4 histone acetyltransferase complex(GO:0035267)
0.0 0.2 GO:0046658 anchored component of plasma membrane(GO:0046658)
0.0 0.1 GO:0070652 HAUS complex(GO:0070652)
0.0 0.1 GO:0000276 mitochondrial proton-transporting ATP synthase complex, coupling factor F(o)(GO:0000276)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 3.6 GO:0004741 magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724) [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741)
0.5 4.7 GO:0042153 obsolete RPTP-like protein binding(GO:0042153)
0.5 2.3 GO:0060961 phospholipase D inhibitor activity(GO:0060961)
0.4 2.7 GO:0001609 G-protein coupled adenosine receptor activity(GO:0001609)
0.4 3.2 GO:0003847 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847)
0.4 1.9 GO:0004647 phosphoserine phosphatase activity(GO:0004647)
0.4 1.4 GO:0005229 intracellular calcium activated chloride channel activity(GO:0005229)
0.2 0.7 GO:0033765 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765)
0.2 0.7 GO:0048184 obsolete follistatin binding(GO:0048184)
0.2 1.5 GO:0003960 NADPH:quinone reductase activity(GO:0003960)
0.2 2.4 GO:0005172 vascular endothelial growth factor receptor binding(GO:0005172)
0.2 2.0 GO:0030297 transmembrane receptor protein tyrosine kinase activator activity(GO:0030297)
0.2 0.6 GO:0004392 heme oxygenase (decyclizing) activity(GO:0004392)
0.2 0.6 GO:0016309 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309)
0.2 0.8 GO:0018685 alkane 1-monooxygenase activity(GO:0018685)
0.2 0.9 GO:0009922 fatty acid elongase activity(GO:0009922)
0.2 0.9 GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827)
0.2 0.5 GO:0003854 3-beta-hydroxy-delta5-steroid dehydrogenase activity(GO:0003854)
0.2 0.6 GO:0000247 C-8 sterol isomerase activity(GO:0000247)
0.2 2.1 GO:0046870 cadmium ion binding(GO:0046870)
0.1 0.7 GO:0004337 dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337)
0.1 1.0 GO:0030506 ankyrin binding(GO:0030506)
0.1 0.6 GO:0046703 natural killer cell lectin-like receptor binding(GO:0046703)
0.1 1.1 GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717)
0.1 0.4 GO:0033858 N-acetylgalactosamine kinase activity(GO:0033858)
0.1 0.5 GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity(GO:0042328) N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity(GO:0050509)
0.1 3.2 GO:0008430 selenium binding(GO:0008430)
0.1 0.5 GO:0008112 nicotinamide N-methyltransferase activity(GO:0008112) pyridine N-methyltransferase activity(GO:0030760)
0.1 0.7 GO:0050815 phosphoserine binding(GO:0050815)
0.1 0.3 GO:0017077 oxidative phosphorylation uncoupler activity(GO:0017077)
0.1 0.3 GO:0004962 endothelin receptor activity(GO:0004962)
0.1 1.1 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.1 1.4 GO:0016174 NAD(P)H oxidase activity(GO:0016174)
0.1 0.5 GO:0004064 arylesterase activity(GO:0004064)
0.1 3.3 GO:0051117 ATPase binding(GO:0051117)
0.1 0.9 GO:0008517 folic acid transporter activity(GO:0008517)
0.1 0.5 GO:0005112 Notch binding(GO:0005112)
0.1 0.5 GO:0001102 RNA polymerase II activating transcription factor binding(GO:0001102)
0.1 0.5 GO:0003747 translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079)
0.1 0.9 GO:0051400 BH domain binding(GO:0051400)
0.1 2.5 GO:0008656 cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656)
0.1 0.3 GO:0032183 SUMO binding(GO:0032183)
0.1 1.1 GO:0001619 obsolete lysosphingolipid and lysophosphatidic acid receptor activity(GO:0001619)
0.1 0.2 GO:0004965 G-protein coupled GABA receptor activity(GO:0004965)
0.1 0.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.1 0.7 GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579)
0.1 0.6 GO:0001968 fibronectin binding(GO:0001968)
0.1 0.3 GO:0004735 pyrroline-5-carboxylate reductase activity(GO:0004735)
0.1 0.4 GO:0042577 lipid phosphatase activity(GO:0042577)
0.1 0.8 GO:0043325 phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1 0.2 GO:0031493 nucleosomal histone binding(GO:0031493) SAM domain binding(GO:0032093)
0.1 0.8 GO:0047372 acylglycerol lipase activity(GO:0047372)
0.1 0.2 GO:0019855 calcium channel inhibitor activity(GO:0019855)
0.1 0.2 GO:0008934 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.1 7.2 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 4.1 GO:0008307 structural constituent of muscle(GO:0008307)
0.1 0.6 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1 1.8 GO:0001972 retinoic acid binding(GO:0001972)
0.1 0.2 GO:0019862 IgA binding(GO:0019862)
0.1 0.4 GO:0016417 S-acyltransferase activity(GO:0016417)
0.1 0.3 GO:0004875 complement receptor activity(GO:0004875)
0.1 0.2 GO:0042806 fucose binding(GO:0042806)
0.1 0.2 GO:0004376 glycolipid mannosyltransferase activity(GO:0004376)
0.1 0.2 GO:0019788 NEDD8 transferase activity(GO:0019788)
0.0 0.3 GO:0000293 ferric-chelate reductase activity(GO:0000293)
0.0 0.2 GO:0008428 ribonuclease inhibitor activity(GO:0008428)
0.0 8.6 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.7 GO:0050786 RAGE receptor binding(GO:0050786)
0.0 0.3 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.0 0.2 GO:0047237 glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237)
0.0 0.3 GO:0004301 epoxide hydrolase activity(GO:0004301)
0.0 0.2 GO:0003938 IMP dehydrogenase activity(GO:0003938)
0.0 0.7 GO:0019206 nucleoside kinase activity(GO:0019206)
0.0 0.2 GO:0071208 histone pre-mRNA DCP binding(GO:0071208)
0.0 0.2 GO:0003985 acetyl-CoA C-acetyltransferase activity(GO:0003985)
0.0 0.5 GO:0000014 single-stranded DNA endodeoxyribonuclease activity(GO:0000014)
0.0 1.0 GO:0016538 cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538)
0.0 0.2 GO:0001512 dihydronicotinamide riboside quinone reductase activity(GO:0001512)
0.0 0.3 GO:0008271 secondary active sulfate transmembrane transporter activity(GO:0008271)
0.0 0.1 GO:0004608 phosphatidylethanolamine N-methyltransferase activity(GO:0004608)
0.0 0.6 GO:0043560 insulin receptor substrate binding(GO:0043560)
0.0 0.3 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.5 GO:0009881 photoreceptor activity(GO:0009881)
0.0 0.7 GO:0022839 ion gated channel activity(GO:0022839)
0.0 0.2 GO:0015410 manganese-transporting ATPase activity(GO:0015410)
0.0 0.2 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.2 GO:0032266 phosphatidylinositol-3-phosphate binding(GO:0032266)
0.0 0.2 GO:0004652 polynucleotide adenylyltransferase activity(GO:0004652)
0.0 0.1 GO:0002114 interleukin-33 receptor activity(GO:0002114)
0.0 0.3 GO:0019864 IgG binding(GO:0019864)
0.0 0.2 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.0 0.4 GO:0004017 adenylate kinase activity(GO:0004017)
0.0 0.1 GO:0004817 cysteine-tRNA ligase activity(GO:0004817)
0.0 0.1 GO:0005105 type 1 fibroblast growth factor receptor binding(GO:0005105) type 2 fibroblast growth factor receptor binding(GO:0005111)
0.0 0.1 GO:0017096 acetylserotonin O-methyltransferase activity(GO:0017096)
0.0 0.1 GO:0004844 uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506)
0.0 0.4 GO:0016289 CoA hydrolase activity(GO:0016289)
0.0 0.1 GO:0035197 siRNA binding(GO:0035197)
0.0 0.1 GO:0042285 UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285)
0.0 0.1 GO:0016882 cyclo-ligase activity(GO:0016882)
0.0 0.1 GO:0016635 succinate dehydrogenase activity(GO:0000104) oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.0 0.4 GO:0005313 L-glutamate transmembrane transporter activity(GO:0005313) acidic amino acid transmembrane transporter activity(GO:0015172)
0.0 1.3 GO:0005507 copper ion binding(GO:0005507)
0.0 0.7 GO:0005242 inward rectifier potassium channel activity(GO:0005242)
0.0 0.2 GO:0015280 ligand-gated sodium channel activity(GO:0015280)
0.0 1.2 GO:0008009 chemokine activity(GO:0008009)
0.0 0.0 GO:0004517 nitric-oxide synthase activity(GO:0004517)
0.0 0.2 GO:0004563 beta-N-acetylhexosaminidase activity(GO:0004563)
0.0 0.8 GO:0015035 protein disulfide oxidoreductase activity(GO:0015035)
0.0 0.2 GO:0003857 3-hydroxyacyl-CoA dehydrogenase activity(GO:0003857)
0.0 0.6 GO:0004198 calcium-dependent cysteine-type endopeptidase activity(GO:0004198)
0.0 0.1 GO:0003910 DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910)
0.0 0.3 GO:0004190 aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001)
0.0 0.5 GO:0005212 structural constituent of eye lens(GO:0005212)
0.0 0.1 GO:0004126 cytidine deaminase activity(GO:0004126)
0.0 0.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.2 GO:0042975 peroxisome proliferator activated receptor binding(GO:0042975)
0.0 0.2 GO:0008494 translation activator activity(GO:0008494)
0.0 0.2 GO:0017176 phosphatidylinositol N-acetylglucosaminyltransferase activity(GO:0017176)
0.0 12.3 GO:0005198 structural molecule activity(GO:0005198)
0.0 1.4 GO:0051287 NAD binding(GO:0051287)
0.0 0.3 GO:0070577 lysine-acetylated histone binding(GO:0070577)
0.0 0.1 GO:0042910 xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910)
0.0 0.1 GO:0019841 retinol binding(GO:0019841)
0.0 0.1 GO:0030676 Rac guanyl-nucleotide exchange factor activity(GO:0030676)
0.0 0.5 GO:0004298 threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003)
0.0 0.1 GO:0016004 phospholipase activator activity(GO:0016004)
0.0 0.1 GO:0004351 glutamate decarboxylase activity(GO:0004351)
0.0 0.1 GO:0048495 Roundabout binding(GO:0048495)
0.0 0.1 GO:0050811 GABA receptor binding(GO:0050811)
0.0 0.3 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.3 GO:0004016 adenylate cyclase activity(GO:0004016)
0.0 0.1 GO:0004969 histamine receptor activity(GO:0004969)
0.0 0.1 GO:0008160 protein tyrosine phosphatase activator activity(GO:0008160) protein phosphatase activator activity(GO:0072542)
0.0 0.1 GO:0008241 peptidyl-dipeptidase activity(GO:0008241)
0.0 0.1 GO:0060590 ATPase regulator activity(GO:0060590)
0.0 0.1 GO:0016944 obsolete RNA polymerase II transcription elongation factor activity(GO:0016944)
0.0 0.0 GO:0030899 calcium-dependent ATPase activity(GO:0030899)
0.0 0.1 GO:0055056 D-glucose transmembrane transporter activity(GO:0055056)
0.0 1.9 GO:0008083 growth factor activity(GO:0008083)
0.0 0.4 GO:0003724 RNA helicase activity(GO:0003724)
0.0 0.2 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.0 0.2 GO:0015277 kainate selective glutamate receptor activity(GO:0015277)
0.0 7.9 GO:0005509 calcium ion binding(GO:0005509)
0.0 0.1 GO:0003810 protein-glutamine gamma-glutamyltransferase activity(GO:0003810)
0.0 0.1 GO:0043425 bHLH transcription factor binding(GO:0043425)
0.0 0.1 GO:0015250 water channel activity(GO:0015250)
0.0 0.0 GO:0004607 phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607)
0.0 0.4 GO:0005518 collagen binding(GO:0005518)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 2.3 ST_WNT_BETA_CATENIN_PATHWAY Wnt/beta-catenin Pathway
0.0 4.4 ST_FAS_SIGNALING_PATHWAY Fas Signaling Pathway
0.0 1.5 SIG_BCR_SIGNALING_PATHWAY Members of the BCR signaling pathway
0.0 1.3 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.
0.0 0.7 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes
0.0 3.0 SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES Genes related to PIP3 signaling in cardiac myocytes
0.0 0.4 SIG_INSULIN_RECEPTOR_PATHWAY_IN_CARDIAC_MYOCYTES Genes related to the insulin receptor pathway
0.0 0.1 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.0 0.3 ST_WNT_CA2_CYCLIC_GMP_PATHWAY Wnt/Ca2+/cyclic GMP signaling.