Motif ID: GLIS2
Z-value: 1.578
Transcription factors associated with GLIS2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
GLIS2 | ENSG00000126603.4 | GLIS2 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
3.7 | 14.7 | GO:0010900 | regulation of phosphatidylcholine catabolic process(GO:0010899) negative regulation of phosphatidylcholine catabolic process(GO:0010900) |
1.3 | 3.8 | GO:0046210 | nitric oxide catabolic process(GO:0046210) |
0.8 | 2.5 | GO:2000644 | low-density lipoprotein particle receptor catabolic process(GO:0032802) regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206) regulation of receptor catabolic process(GO:2000644) |
0.8 | 2.4 | GO:0060318 | definitive erythrocyte differentiation(GO:0060318) |
0.5 | 1.4 | GO:1901419 | regulation of response to alcohol(GO:1901419) |
0.4 | 1.7 | GO:0001969 | activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969) positive regulation of activation of membrane attack complex(GO:0001970) positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259) |
0.3 | 0.8 | GO:0033629 | negative regulation of cell adhesion mediated by integrin(GO:0033629) |
0.2 | 1.5 | GO:0046898 | response to cycloheximide(GO:0046898) |
0.2 | 0.7 | GO:0060370 | susceptibility to T cell mediated cytotoxicity(GO:0060370) |
0.2 | 0.7 | GO:0003011 | diaphragm contraction(GO:0002086) involuntary skeletal muscle contraction(GO:0003011) |
0.2 | 1.3 | GO:0006562 | proline catabolic process(GO:0006562) |
0.2 | 2.4 | GO:0046628 | positive regulation of insulin receptor signaling pathway(GO:0046628) positive regulation of cellular response to insulin stimulus(GO:1900078) |
0.2 | 1.1 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
0.2 | 0.7 | GO:0048025 | negative regulation of mRNA splicing, via spliceosome(GO:0048025) |
0.2 | 0.5 | GO:0045198 | establishment of epithelial cell apical/basal polarity(GO:0045198) |
0.2 | 1.9 | GO:0071391 | cellular response to estrogen stimulus(GO:0071391) |
0.2 | 0.8 | GO:0035444 | nickel cation transport(GO:0015675) vanadium ion transport(GO:0015676) ferrous iron transport(GO:0015684) lead ion transport(GO:0015692) nickel cation transmembrane transport(GO:0035444) ferrous iron import(GO:0070627) iron ion import(GO:0097286) |
0.2 | 1.0 | GO:0010832 | negative regulation of myotube differentiation(GO:0010832) |
0.2 | 0.3 | GO:0061198 | fungiform papilla development(GO:0061196) fungiform papilla morphogenesis(GO:0061197) fungiform papilla formation(GO:0061198) |
0.1 | 0.4 | GO:0048619 | embryonic hindgut morphogenesis(GO:0048619) |
0.1 | 0.3 | GO:0090034 | regulation of chaperone-mediated protein complex assembly(GO:0090034) positive regulation of chaperone-mediated protein complex assembly(GO:0090035) |
0.1 | 0.3 | GO:0034126 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) positive regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034126) |
0.1 | 0.3 | GO:0046732 | connective tissue replacement involved in inflammatory response wound healing(GO:0002248) induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by virus of host immune response(GO:0075528) connective tissue replacement(GO:0097709) |
0.1 | 1.1 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
0.1 | 0.3 | GO:0010755 | activation of plasma proteins involved in acute inflammatory response(GO:0002541) regulation of plasminogen activation(GO:0010755) |
0.1 | 0.6 | GO:0046498 | S-adenosylhomocysteine metabolic process(GO:0046498) |
0.1 | 0.5 | GO:0031943 | regulation of glucocorticoid metabolic process(GO:0031943) |
0.1 | 0.3 | GO:0060662 | tube lumen cavitation(GO:0060605) salivary gland cavitation(GO:0060662) |
0.1 | 0.9 | GO:0006198 | cAMP catabolic process(GO:0006198) |
0.1 | 0.3 | GO:0019509 | L-methionine biosynthetic process from methylthioadenosine(GO:0019509) |
0.1 | 0.8 | GO:0001885 | endothelial cell development(GO:0001885) |
0.0 | 0.3 | GO:0060155 | platelet dense granule organization(GO:0060155) |
0.0 | 0.3 | GO:0006999 | nuclear pore organization(GO:0006999) |
0.0 | 0.1 | GO:1903726 | negative regulation of phospholipid metabolic process(GO:1903726) |
0.0 | 1.1 | GO:0051923 | purine ribonucleoside bisphosphate metabolic process(GO:0034035) 3'-phosphoadenosine 5'-phosphosulfate metabolic process(GO:0050427) sulfation(GO:0051923) |
0.0 | 0.8 | GO:0000380 | alternative mRNA splicing, via spliceosome(GO:0000380) |
0.0 | 0.3 | GO:0006287 | base-excision repair, gap-filling(GO:0006287) |
0.0 | 0.2 | GO:0048296 | isotype switching to IgA isotypes(GO:0048290) regulation of isotype switching to IgA isotypes(GO:0048296) positive regulation of isotype switching to IgA isotypes(GO:0048298) |
0.0 | 1.1 | GO:0051225 | spindle assembly(GO:0051225) |
0.0 | 0.5 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
0.0 | 0.1 | GO:0070842 | aggresome assembly(GO:0070842) |
0.0 | 0.2 | GO:0035751 | lysosomal lumen acidification(GO:0007042) regulation of lysosomal lumen pH(GO:0035751) |
0.0 | 0.2 | GO:0033261 | obsolete regulation of S phase(GO:0033261) |
0.0 | 0.2 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
0.0 | 1.2 | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process(GO:0032436) positive regulation of proteasomal protein catabolic process(GO:1901800) |
0.0 | 0.1 | GO:0042159 | lipoprotein catabolic process(GO:0042159) |
0.0 | 0.4 | GO:0060644 | mammary gland epithelial cell differentiation(GO:0060644) |
0.0 | 0.6 | GO:0046854 | phosphatidylinositol phosphorylation(GO:0046854) |
0.0 | 0.3 | GO:0007168 | receptor guanylyl cyclase signaling pathway(GO:0007168) |
0.0 | 0.2 | GO:0007030 | Golgi organization(GO:0007030) |
0.0 | 0.1 | GO:0032959 | inositol trisphosphate biosynthetic process(GO:0032959) |
0.0 | 0.4 | GO:0006400 | tRNA modification(GO:0006400) |
0.0 | 0.3 | GO:0046718 | viral entry into host cell(GO:0046718) |
0.0 | 0.1 | GO:0045943 | positive regulation of transcription from RNA polymerase I promoter(GO:0045943) |
0.0 | 0.2 | GO:0006975 | DNA damage induced protein phosphorylation(GO:0006975) |
0.0 | 0.1 | GO:0046619 | optic placode formation(GO:0001743) optic placode formation involved in camera-type eye formation(GO:0046619) |
0.0 | 0.3 | GO:0006750 | glutathione biosynthetic process(GO:0006750) |
0.0 | 0.3 | GO:0035024 | negative regulation of Rho protein signal transduction(GO:0035024) |
0.0 | 0.1 | GO:0016188 | synaptic vesicle maturation(GO:0016188) |
0.0 | 0.3 | GO:0050812 | acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812) |
0.0 | 0.1 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
0.0 | 0.1 | GO:0040032 | post-embryonic body morphogenesis(GO:0040032) |
0.0 | 0.5 | GO:0009083 | branched-chain amino acid catabolic process(GO:0009083) |
0.0 | 0.5 | GO:0060334 | regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334) |
0.0 | 0.1 | GO:0010898 | positive regulation of triglyceride catabolic process(GO:0010898) |
0.0 | 0.2 | GO:0030157 | pancreatic juice secretion(GO:0030157) |
0.0 | 0.4 | GO:0006952 | defense response(GO:0006952) |
0.0 | 0.3 | GO:0016578 | histone deubiquitination(GO:0016578) |
0.0 | 0.5 | GO:0006631 | fatty acid metabolic process(GO:0006631) |
0.0 | 1.1 | GO:0042593 | carbohydrate homeostasis(GO:0033500) glucose homeostasis(GO:0042593) |
0.0 | 0.1 | GO:0036336 | dendritic cell chemotaxis(GO:0002407) dendritic cell migration(GO:0036336) |
0.0 | 0.2 | GO:0051568 | histone H3-K4 methylation(GO:0051568) |
0.0 | 1.7 | GO:0018279 | peptidyl-asparagine modification(GO:0018196) protein N-linked glycosylation via asparagine(GO:0018279) |
0.0 | 0.5 | GO:0001824 | blastocyst development(GO:0001824) |
0.0 | 0.2 | GO:0006349 | regulation of gene expression by genetic imprinting(GO:0006349) |
0.0 | 0.7 | GO:0051084 | 'de novo' posttranslational protein folding(GO:0051084) |
0.0 | 0.1 | GO:0006937 | regulation of muscle contraction(GO:0006937) |
0.0 | 0.6 | GO:0007224 | smoothened signaling pathway(GO:0007224) |
0.0 | 0.0 | GO:0035020 | regulation of Rac protein signal transduction(GO:0035020) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 17.5 | GO:0042627 | chylomicron(GO:0042627) |
0.6 | 2.4 | GO:0034673 | inhibin-betaglycan-ActRII complex(GO:0034673) |
0.5 | 1.4 | GO:0005726 | perichromatin fibrils(GO:0005726) |
0.2 | 0.8 | GO:0070826 | paraferritin complex(GO:0070826) |
0.2 | 1.1 | GO:0000300 | obsolete peripheral to membrane of membrane fraction(GO:0000300) |
0.1 | 1.0 | GO:0070652 | HAUS complex(GO:0070652) |
0.1 | 0.6 | GO:0008537 | proteasome activator complex(GO:0008537) |
0.1 | 0.7 | GO:0016272 | prefoldin complex(GO:0016272) |
0.1 | 0.7 | GO:0005638 | lamin filament(GO:0005638) |
0.1 | 0.4 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) beta-catenin-TCF complex(GO:1990907) |
0.1 | 0.8 | GO:0005915 | zonula adherens(GO:0005915) |
0.1 | 0.4 | GO:0005742 | mitochondrial outer membrane translocase complex(GO:0005742) |
0.0 | 0.7 | GO:0005849 | mRNA cleavage factor complex(GO:0005849) |
0.0 | 0.1 | GO:0016600 | flotillin complex(GO:0016600) |
0.0 | 0.2 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
0.0 | 0.9 | GO:0005861 | troponin complex(GO:0005861) |
0.0 | 0.5 | GO:0031088 | platelet dense granule membrane(GO:0031088) |
0.0 | 2.2 | GO:0000118 | histone deacetylase complex(GO:0000118) |
0.0 | 2.0 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
0.0 | 1.1 | GO:0043195 | terminal bouton(GO:0043195) |
0.0 | 0.4 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
0.0 | 0.4 | GO:0033180 | proton-transporting V-type ATPase, V1 domain(GO:0033180) |
0.0 | 1.6 | GO:0032587 | ruffle membrane(GO:0032587) |
0.0 | 0.1 | GO:0002080 | acrosomal membrane(GO:0002080) |
0.0 | 0.2 | GO:0048188 | Set1C/COMPASS complex(GO:0048188) |
0.0 | 0.3 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
0.0 | 0.1 | GO:0017101 | aminoacyl-tRNA synthetase multienzyme complex(GO:0017101) |
0.0 | 0.3 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
0.0 | 0.3 | GO:0030914 | STAGA complex(GO:0030914) |
0.0 | 0.2 | GO:0034362 | low-density lipoprotein particle(GO:0034362) |
0.0 | 0.1 | GO:0072357 | PTW/PP1 phosphatase complex(GO:0072357) |
0.0 | 0.7 | GO:0005798 | Golgi-associated vesicle(GO:0005798) |
0.0 | 0.1 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
0.0 | 0.8 | GO:0005626 | obsolete insoluble fraction(GO:0005626) |
0.0 | 0.2 | GO:0008180 | COP9 signalosome(GO:0008180) |
0.0 | 1.6 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
0.0 | 0.3 | GO:0005796 | Golgi lumen(GO:0005796) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
2.2 | 17.2 | GO:0060228 | phosphatidylcholine-sterol O-acyltransferase activator activity(GO:0060228) |
1.3 | 3.8 | GO:0003958 | NADPH-hemoprotein reductase activity(GO:0003958) |
0.3 | 0.8 | GO:0004119 | cGMP-inhibited cyclic-nucleotide phosphodiesterase activity(GO:0004119) |
0.3 | 2.7 | GO:0005114 | type II transforming growth factor beta receptor binding(GO:0005114) |
0.2 | 2.0 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
0.2 | 0.5 | GO:0004609 | phosphatidylserine decarboxylase activity(GO:0004609) |
0.2 | 0.7 | GO:0032450 | maltose alpha-glucosidase activity(GO:0032450) |
0.2 | 0.8 | GO:0015087 | cobalt ion transmembrane transporter activity(GO:0015087) ferrous iron transmembrane transporter activity(GO:0015093) lead ion transmembrane transporter activity(GO:0015094) nickel cation transmembrane transporter activity(GO:0015099) vanadium ion transmembrane transporter activity(GO:0015100) chromium ion transmembrane transporter activity(GO:0070835) |
0.2 | 1.4 | GO:0034056 | estrogen response element binding(GO:0034056) |
0.2 | 0.8 | GO:0004803 | transposase activity(GO:0004803) |
0.1 | 0.7 | GO:0019855 | calcium channel inhibitor activity(GO:0019855) |
0.1 | 1.6 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970) |
0.1 | 0.8 | GO:0008158 | hedgehog receptor activity(GO:0008158) |
0.1 | 0.5 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
0.1 | 1.3 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
0.1 | 0.6 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
0.1 | 0.6 | GO:0004430 | 1-phosphatidylinositol 4-kinase activity(GO:0004430) |
0.1 | 0.7 | GO:0050733 | RS domain binding(GO:0050733) |
0.1 | 0.3 | GO:0004738 | pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739) |
0.1 | 0.4 | GO:0044323 | retinoic acid-responsive element binding(GO:0044323) |
0.1 | 0.6 | GO:0008172 | S-methyltransferase activity(GO:0008172) |
0.1 | 0.4 | GO:0004427 | inorganic diphosphatase activity(GO:0004427) |
0.1 | 0.2 | GO:0050051 | leukotriene-B4 20-monooxygenase activity(GO:0050051) |
0.1 | 0.4 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
0.1 | 0.4 | GO:0004046 | aminoacylase activity(GO:0004046) |
0.1 | 0.4 | GO:0030911 | TPR domain binding(GO:0030911) |
0.1 | 0.2 | GO:0046404 | ATP-dependent polydeoxyribonucleotide 5'-hydroxyl-kinase activity(GO:0046404) polydeoxyribonucleotide kinase activity(GO:0051733) ATP-dependent polynucleotide kinase activity(GO:0051734) |
0.1 | 0.2 | GO:0047184 | 1-acylglycerophosphocholine O-acyltransferase activity(GO:0047184) |
0.1 | 0.8 | GO:0003840 | gamma-glutamyltransferase activity(GO:0003840) |
0.1 | 0.8 | GO:0001786 | phosphatidylserine binding(GO:0001786) |
0.0 | 0.3 | GO:0015057 | thrombin receptor activity(GO:0015057) |
0.0 | 0.3 | GO:0030229 | very-low-density lipoprotein particle receptor activity(GO:0030229) |
0.0 | 0.5 | GO:0004176 | ATP-dependent peptidase activity(GO:0004176) |
0.0 | 1.4 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
0.0 | 1.7 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
0.0 | 0.7 | GO:0005521 | lamin binding(GO:0005521) |
0.0 | 0.4 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
0.0 | 1.1 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
0.0 | 0.2 | GO:0004704 | NF-kappaB-inducing kinase activity(GO:0004704) |
0.0 | 0.2 | GO:0015056 | corticotrophin-releasing factor receptor activity(GO:0015056) |
0.0 | 0.3 | GO:0030506 | ankyrin binding(GO:0030506) |
0.0 | 0.2 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
0.0 | 0.2 | GO:0042800 | histone methyltransferase activity (H3-K4 specific)(GO:0042800) |
0.0 | 0.5 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
0.0 | 0.4 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
0.0 | 0.3 | GO:0017049 | GTP-Rho binding(GO:0017049) |
0.0 | 0.8 | GO:0005158 | insulin receptor binding(GO:0005158) |
0.0 | 0.4 | GO:0004017 | adenylate kinase activity(GO:0004017) |
0.0 | 0.4 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
0.0 | 0.3 | GO:0051787 | misfolded protein binding(GO:0051787) |
0.0 | 0.3 | GO:0008195 | phosphatidate phosphatase activity(GO:0008195) |
0.0 | 0.1 | GO:0019213 | deacetylase activity(GO:0019213) |
0.0 | 0.1 | GO:0004992 | platelet activating factor receptor activity(GO:0004992) |
0.0 | 0.8 | GO:0015026 | coreceptor activity(GO:0015026) |
0.0 | 0.3 | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity(GO:0004726) |
0.0 | 0.4 | GO:0019992 | diacylglycerol binding(GO:0019992) |
0.0 | 0.3 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
0.0 | 0.3 | GO:0005030 | neurotrophin receptor activity(GO:0005030) |
0.0 | 0.3 | GO:0003706 | obsolete ligand-regulated transcription factor activity(GO:0003706) |
0.0 | 0.8 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
0.0 | 0.6 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
0.0 | 0.5 | GO:0000049 | tRNA binding(GO:0000049) |
0.0 | 0.4 | GO:0004707 | MAP kinase activity(GO:0004707) |
0.0 | 0.1 | GO:0008599 | protein phosphatase type 1 regulator activity(GO:0008599) |
0.0 | 0.1 | GO:0004906 | interferon-gamma receptor activity(GO:0004906) |
0.0 | 0.5 | GO:0005184 | neuropeptide hormone activity(GO:0005184) |
0.0 | 1.0 | GO:0008146 | sulfotransferase activity(GO:0008146) |
0.0 | 0.2 | GO:0047555 | 3',5'-cyclic-GMP phosphodiesterase activity(GO:0047555) |
0.0 | 0.1 | GO:0034594 | phosphatidylinositol trisphosphate phosphatase activity(GO:0034594) |
0.0 | 0.4 | GO:0046933 | proton-transporting ATP synthase activity, rotational mechanism(GO:0046933) |
0.0 | 0.1 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
0.0 | 0.1 | GO:0003701 | obsolete RNA polymerase I transcription factor activity(GO:0003701) |
0.0 | 0.2 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) |
0.0 | 0.5 | GO:0008013 | beta-catenin binding(GO:0008013) |
0.0 | 0.3 | GO:0001085 | RNA polymerase II transcription factor binding(GO:0001085) |
0.0 | 0.0 | GO:0034187 | obsolete apolipoprotein E binding(GO:0034187) |
0.0 | 0.2 | GO:0030276 | clathrin binding(GO:0030276) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.4 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
0.0 | 0.8 | ST_STAT3_PATHWAY | STAT3 Pathway |
0.0 | 0.5 | ST_GAQ_PATHWAY | G alpha q Pathway |