Motif ID: GRHL1

Z-value: 1.317


Transcription factors associated with GRHL1:

Gene SymbolEntrez IDGene Name
GRHL1 ENSG00000134317.13 GRHL1



Activity profile for motif GRHL1.

activity profile for motif GRHL1


Sorted Z-values histogram for motif GRHL1

Sorted Z-values for motif GRHL1



Network of associatons between targets according to the STRING database.



First level regulatory network of GRHL1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_+_35247859 3.667 ENST00000373362.3
 GJB3
gap junction protein, beta 3, 31kDa
chr7_-_80551671 2.059 ENST00000419255.2
ENST00000544525.1
 SEMA3C

sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C

chr1_-_201368707 1.911 ENST00000391967.2
 LAD1
ladinin 1
chr5_+_125758865 1.896 ENST00000542322.1
ENST00000544396.1
 GRAMD3

GRAM domain containing 3

chr5_+_125758813 1.818 ENST00000285689.3
ENST00000515200.1
 GRAMD3

GRAM domain containing 3

chr1_-_201368653 1.801 ENST00000367313.3
 LAD1
ladinin 1
chr13_+_48807334 1.401 ENST00000378549.5
 ITM2B
integral membrane protein 2B
chr19_-_291133 1.346 ENST00000327790.3
 PPAP2C
phosphatidic acid phosphatase type 2C
chr13_+_48807288 1.330 ENST00000378565.5
 ITM2B
integral membrane protein 2B
chr2_-_85641162 1.164 ENST00000447219.2
ENST00000409670.1
ENST00000409724.1
 CAPG


capping protein (actin filament), gelsolin-like


chr20_-_18038521 1.125 ENST00000278780.6
 OVOL2
ovo-like zinc finger 2
chr1_-_153113927 1.055 ENST00000368752.4
 SPRR2B
small proline-rich protein 2B
chr3_+_101568349 1.002 ENST00000326151.5
ENST00000326172.5
 NFKBIZ

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta

chrX_-_119603138 0.709 ENST00000200639.4
ENST00000371335.4
ENST00000538785.1
ENST00000434600.2
 LAMP2



lysosomal-associated membrane protein 2



chr2_-_209118974 0.610 ENST00000415913.1
ENST00000415282.1
ENST00000446179.1
 IDH1


isocitrate dehydrogenase 1 (NADP+), soluble


chr5_-_132299313 0.535 ENST00000265343.5
 AFF4
AF4/FMR2 family, member 4
chr4_-_99850243 0.459 ENST00000280892.6
ENST00000511644.1
ENST00000504432.1
ENST00000505992.1
 EIF4E



eukaryotic translation initiation factor 4E



chr1_+_44440575 0.397 ENST00000532642.1
ENST00000236067.4
ENST00000471859.2
 ATP6V0B


ATPase, H+ transporting, lysosomal 21kDa, V0 subunit b


chr16_+_2564254 0.394 ENST00000565223.1
 ATP6V0C
ATPase, H+ transporting, lysosomal 16kDa, V0 subunit c
chr19_+_45312347 0.366 ENST00000270233.6
ENST00000591520.1
 BCAM

basal cell adhesion molecule (Lutheran blood group)

chr3_-_172241250 0.336 ENST00000420541.2
ENST00000241261.2
 TNFSF10

tumor necrosis factor (ligand) superfamily, member 10

chr7_+_76139741 0.331 ENST00000334348.3
ENST00000419923.2
ENST00000448265.3
ENST00000443097.2
 UPK3B



uroplakin 3B



chr9_-_77703115 0.317 ENST00000361092.4
ENST00000376808.4
 NMRK1

nicotinamide riboside kinase 1

chr9_+_130565487 0.303 ENST00000373225.3
ENST00000431857.1
 FPGS

folylpolyglutamate synthase

chr10_+_81838792 0.278 ENST00000372273.3
 TMEM254
transmembrane protein 254
chr2_+_113816215 0.235 ENST00000346807.3
 IL36RN
interleukin 36 receptor antagonist
chr19_-_40596767 0.230 ENST00000599972.1
ENST00000450241.2
ENST00000595687.2
 ZNF780A


zinc finger protein 780A


chr1_+_155023757 0.226 ENST00000356955.2
ENST00000449910.2
ENST00000359280.4
ENST00000360674.4
ENST00000368412.3
ENST00000355956.2
ENST00000368410.2
ENST00000271836.6
ENST00000368413.1
ENST00000531455.1
ENST00000447332.3
 ADAM15










ADAM metallopeptidase domain 15










chr9_+_71736177 0.211 ENST00000606364.1
ENST00000453658.2
 TJP2

tight junction protein 2

chr10_+_105036909 0.210 ENST00000369849.4
 INA
internexin neuronal intermediate filament protein, alpha
chr12_-_10959892 0.207 ENST00000240615.2
 TAS2R8
taste receptor, type 2, member 8
chr1_+_40723779 0.202 ENST00000372759.3
 ZMPSTE24
zinc metallopeptidase STE24
chr1_-_24469602 0.180 ENST00000270800.1
 IL22RA1
interleukin 22 receptor, alpha 1
chr10_+_81838411 0.158 ENST00000372281.3
ENST00000372277.3
ENST00000372275.1
ENST00000372274.1
 TMEM254



transmembrane protein 254



chr11_+_15095108 0.129 ENST00000324229.6
ENST00000533448.1
 CALCB

calcitonin-related polypeptide beta

chr19_+_12035913 0.129 ENST00000591944.1
 ZNF763
Uncharacterized protein; Zinc finger protein 763
chr3_+_186383741 0.127 ENST00000232003.4
 HRG
histidine-rich glycoprotein
chr19_-_17356697 0.116 ENST00000291442.3
 NR2F6
nuclear receptor subfamily 2, group F, member 6
chr15_+_49170083 0.116 ENST00000530028.2
 EID1
EP300 interacting inhibitor of differentiation 1
chr14_+_23938891 0.115 ENST00000408901.3
ENST00000397154.3
ENST00000555128.1
 NGDN


neuroguidin, EIF4E binding protein


chr12_+_18414446 0.110 ENST00000433979.1
 PIK3C2G
phosphatidylinositol-4-phosphate 3-kinase, catalytic subunit type 2 gamma
chr14_-_23540826 0.108 ENST00000357481.2
 ACIN1
apoptotic chromatin condensation inducer 1
chr4_+_110736659 0.105 ENST00000394631.3
ENST00000226796.6
 GAR1

GAR1 ribonucleoprotein

chr7_-_138794081 0.101 ENST00000464606.1
 ZC3HAV1
zinc finger CCCH-type, antiviral 1
chr7_-_102184083 0.092 ENST00000379357.5
 POLR2J3
polymerase (RNA) II (DNA directed) polypeptide J3
chr14_-_80677815 0.085 ENST00000557125.1
ENST00000555750.1
 DIO2

deiodinase, iodothyronine, type II

chr7_-_102283238 0.078 ENST00000340457.8
 UPK3BL
uroplakin 3B-like
chr14_-_80677613 0.065 ENST00000556811.1
 DIO2
deiodinase, iodothyronine, type II
chr14_-_23540747 0.056 ENST00000555566.1
ENST00000338631.6
ENST00000557515.1
ENST00000397341.3
 ACIN1



apoptotic chromatin condensation inducer 1



chr6_-_31107127 0.054 ENST00000259845.4
 PSORS1C2
psoriasis susceptibility 1 candidate 2
chr1_-_28384598 0.045 ENST00000373864.1
 EYA3
eyes absent homolog 3 (Drosophila)
chr10_+_96443204 0.044 ENST00000339022.5
 CYP2C18
cytochrome P450, family 2, subfamily C, polypeptide 18
chr7_+_76139925 0.034 ENST00000394849.1
 UPK3B
uroplakin 3B
chrX_+_146993449 0.034 ENST00000218200.8
ENST00000370471.3
ENST00000370477.1
 FMR1


fragile X mental retardation 1


chr19_+_58038683 0.031 ENST00000240719.3
ENST00000376233.3
ENST00000594943.1
ENST00000602149.1
 ZNF549



zinc finger protein 549



chr11_+_119039414 0.029 ENST00000409991.1
ENST00000292199.2
ENST00000409265.4
ENST00000409109.1
 NLRX1



NLR family member X1



chr1_+_206643787 0.021 ENST00000367120.3
 IKBKE
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase epsilon
chr7_+_76139833 0.016 ENST00000257632.5
 UPK3B
uroplakin 3B
chr3_-_3152031 0.003 ENST00000383846.1
ENST00000427088.1
ENST00000446632.2
ENST00000438560.1
 IL5RA



interleukin 5 receptor, alpha




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.7 2.1 GO:0003350 pulmonary myocardium development(GO:0003350)
0.4 1.1 GO:0010837 regulation of keratinocyte proliferation(GO:0010837)
0.2 0.6 GO:0006740 glyoxylate cycle(GO:0006097) NADPH regeneration(GO:0006740)
0.1 1.2 GO:0051016 barbed-end actin filament capping(GO:0051016)
0.0 0.1 GO:0009648 photoperiodism(GO:0009648)
0.0 0.3 GO:0009396 folic acid-containing compound biosynthetic process(GO:0009396)
0.0 0.2 GO:0060052 neurofilament cytoskeleton organization(GO:0060052)
0.0 1.1 GO:0031424 keratinization(GO:0031424)
0.0 3.7 GO:0007605 sensory perception of sound(GO:0007605)
0.0 0.2 GO:0030263 apoptotic chromosome condensation(GO:0030263)
0.0 0.2 GO:0060317 cardiac epithelial to mesenchymal transition(GO:0060317)
0.0 0.1 GO:0001514 selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451)
0.0 0.8 GO:0033572 ferric iron transport(GO:0015682) transferrin transport(GO:0033572) trivalent inorganic cation transport(GO:0072512)
0.0 0.2 GO:0006998 nuclear envelope organization(GO:0006998)
0.0 1.3 GO:0006665 sphingolipid metabolic process(GO:0006665)
0.0 0.0 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.5 GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.7 GO:0005922 connexon complex(GO:0005922)
0.1 0.8 GO:0033179 proton-transporting V-type ATPase, V0 domain(GO:0033179)
0.1 1.2 GO:0008290 F-actin capping protein complex(GO:0008290)
0.0 0.7 GO:0031088 platelet dense granule membrane(GO:0031088)
0.0 0.5 GO:0016442 RISC complex(GO:0016442) RNAi effector complex(GO:0031332)
0.0 3.7 GO:0005604 basement membrane(GO:0005604)
0.0 1.1 GO:0001533 cornified envelope(GO:0001533)
0.0 0.2 GO:0005883 neurofilament(GO:0005883)
0.0 0.6 GO:0005782 peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907)
0.0 0.2 GO:0019861 obsolete flagellum(GO:0019861)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 2.1 GO:0030215 semaphorin receptor binding(GO:0030215)
0.3 3.7 GO:0005243 gap junction channel activity(GO:0005243)
0.2 0.6 GO:0004450 isocitrate dehydrogenase (NADP+) activity(GO:0004450)
0.2 1.3 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.1 2.7 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.5 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.4 GO:0043236 laminin binding(GO:0043236)
0.0 0.1 GO:0004800 thyroxine 5'-deiodinase activity(GO:0004800)
0.0 0.2 GO:0008527 taste receptor activity(GO:0008527)
0.0 0.4 GO:0046933 proton-transporting ATP synthase activity, rotational mechanism(GO:0046933)
0.0 0.2 GO:0004904 interferon receptor activity(GO:0004904)
0.0 0.1 GO:0016307 phosphatidylinositol phosphate kinase activity(GO:0016307)
0.0 0.3 GO:0005164 tumor necrosis factor receptor binding(GO:0005164)
0.0 0.1 GO:0009982 pseudouridine synthase activity(GO:0009982) snoRNA binding(GO:0030515)