Motif ID: HBP1
Z-value: 1.818
Transcription factors associated with HBP1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| HBP1 | ENSG00000105856.9 | HBP1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 4.3 | GO:0001969 | activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969) positive regulation of activation of membrane attack complex(GO:0001970) positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259) |
| 1.0 | 3.0 | GO:0035987 | endodermal cell fate commitment(GO:0001711) endodermal cell differentiation(GO:0035987) |
| 0.8 | 2.5 | GO:0071639 | positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) positive regulation of monocyte chemotactic protein-1 production(GO:0071639) |
| 0.4 | 1.3 | GO:0007206 | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) |
| 0.2 | 0.7 | GO:0001574 | ganglioside biosynthetic process(GO:0001574) |
| 0.2 | 0.9 | GO:0046022 | regulation of transcription from RNA polymerase II promoter, mitotic(GO:0046021) positive regulation of transcription from RNA polymerase II promoter during mitosis(GO:0046022) |
| 0.2 | 0.6 | GO:0034720 | histone H3-K4 demethylation(GO:0034720) |
| 0.2 | 5.0 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.2 | 1.3 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 0.2 | 1.6 | GO:0060046 | regulation of acrosome reaction(GO:0060046) |
| 0.2 | 0.5 | GO:0048865 | stem cell fate commitment(GO:0048865) stem cell fate determination(GO:0048867) |
| 0.1 | 0.9 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.1 | 0.4 | GO:0048003 | antigen processing and presentation of lipid antigen via MHC class Ib(GO:0048003) |
| 0.1 | 0.4 | GO:0001999 | renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure(GO:0001999) |
| 0.1 | 0.9 | GO:0007351 | tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595) |
| 0.1 | 0.4 | GO:0006682 | galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375) |
| 0.1 | 1.2 | GO:0006107 | oxaloacetate metabolic process(GO:0006107) |
| 0.1 | 0.4 | GO:0031117 | positive regulation of microtubule depolymerization(GO:0031117) |
| 0.1 | 0.4 | GO:0017183 | peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) |
| 0.1 | 0.3 | GO:0070933 | histone H3 deacetylation(GO:0070932) histone H4 deacetylation(GO:0070933) |
| 0.1 | 3.4 | GO:0050690 | regulation of defense response to virus by virus(GO:0050690) |
| 0.1 | 1.0 | GO:0042255 | ribosome assembly(GO:0042255) |
| 0.1 | 1.0 | GO:0006750 | glutathione biosynthetic process(GO:0006750) |
| 0.1 | 0.2 | GO:0042816 | pyridoxine metabolic process(GO:0008614) pyridoxine biosynthetic process(GO:0008615) vitamin B6 metabolic process(GO:0042816) vitamin B6 biosynthetic process(GO:0042819) |
| 0.1 | 0.5 | GO:0009396 | folic acid-containing compound biosynthetic process(GO:0009396) |
| 0.1 | 0.2 | GO:0000059 | protein import into nucleus, docking(GO:0000059) |
| 0.1 | 0.2 | GO:0032328 | alanine transport(GO:0032328) |
| 0.1 | 0.2 | GO:0071436 | sodium ion export(GO:0071436) |
| 0.0 | 0.3 | GO:0006295 | nucleotide-excision repair, DNA incision, 3'-to lesion(GO:0006295) |
| 0.0 | 0.4 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
| 0.0 | 0.2 | GO:0000103 | sulfate assimilation(GO:0000103) |
| 0.0 | 0.2 | GO:0007501 | mesodermal cell fate specification(GO:0007501) |
| 0.0 | 0.4 | GO:0006379 | mRNA cleavage(GO:0006379) |
| 0.0 | 0.2 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 0.0 | 0.2 | GO:0034063 | stress granule assembly(GO:0034063) |
| 0.0 | 0.3 | GO:0002860 | natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002420) natural killer cell mediated immune response to tumor cell(GO:0002423) regulation of natural killer cell mediated immune response to tumor cell(GO:0002855) positive regulation of natural killer cell mediated immune response to tumor cell(GO:0002857) regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002858) positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target(GO:0002860) |
| 0.0 | 0.3 | GO:0033089 | positive regulation of T cell differentiation in thymus(GO:0033089) positive regulation of thymocyte aggregation(GO:2000400) |
| 0.0 | 0.4 | GO:0070670 | response to interleukin-4(GO:0070670) |
| 0.0 | 0.1 | GO:0006427 | histidyl-tRNA aminoacylation(GO:0006427) |
| 0.0 | 2.7 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
| 0.0 | 1.6 | GO:0008206 | bile acid metabolic process(GO:0008206) |
| 0.0 | 0.9 | GO:0030866 | cortical cytoskeleton organization(GO:0030865) cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 0.1 | GO:0006591 | arginine biosynthetic process(GO:0006526) ornithine metabolic process(GO:0006591) |
| 0.0 | 1.1 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.0 | 0.1 | GO:0010216 | maintenance of DNA methylation(GO:0010216) |
| 0.0 | 0.1 | GO:0009822 | alkaloid catabolic process(GO:0009822) |
| 0.0 | 0.2 | GO:0007141 | male meiosis I(GO:0007141) |
| 0.0 | 3.3 | GO:0007266 | Rho protein signal transduction(GO:0007266) |
| 0.0 | 0.2 | GO:0008343 | adult feeding behavior(GO:0008343) |
| 0.0 | 0.2 | GO:0046514 | ceramide catabolic process(GO:0046514) |
| 0.0 | 0.1 | GO:0043030 | regulation of macrophage activation(GO:0043030) |
| 0.0 | 1.4 | GO:0030521 | androgen receptor signaling pathway(GO:0030521) |
| 0.0 | 0.2 | GO:0008612 | peptidyl-lysine modification to peptidyl-hypusine(GO:0008612) |
| 0.0 | 0.2 | GO:0016246 | RNA interference(GO:0016246) |
| 0.0 | 0.2 | GO:1901798 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798) |
| 0.0 | 0.1 | GO:0046473 | low-density lipoprotein particle remodeling(GO:0034374) phosphatidic acid metabolic process(GO:0046473) |
| 0.0 | 0.7 | GO:0006892 | post-Golgi vesicle-mediated transport(GO:0006892) |
| 0.0 | 1.0 | GO:0042157 | lipoprotein metabolic process(GO:0042157) |
| 0.0 | 0.3 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.8 | GO:0098636 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.1 | 3.4 | GO:0030131 | clathrin adaptor complex(GO:0030131) |
| 0.1 | 2.5 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 0.4 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.1 | 1.3 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 1.1 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 0.5 | GO:0043190 | ATP-binding cassette (ABC) transporter complex(GO:0043190) |
| 0.0 | 1.0 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 0.1 | GO:0036452 | ESCRT III complex(GO:0000815) ESCRT complex(GO:0036452) |
| 0.0 | 0.3 | GO:0000109 | nucleotide-excision repair complex(GO:0000109) |
| 0.0 | 0.2 | GO:0030017 | sarcomere(GO:0030017) |
| 0.0 | 0.2 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.0 | 0.1 | GO:0001739 | sex chromatin(GO:0001739) |
| 0.0 | 0.9 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 0.2 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 1.2 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 0.2 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 0.7 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.4 | GO:0005796 | Golgi lumen(GO:0005796) |
| 0.0 | 0.9 | GO:0019897 | extrinsic component of plasma membrane(GO:0019897) |
| 0.0 | 0.2 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.0 | 0.6 | GO:0005884 | actin filament(GO:0005884) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 1.3 | GO:0003978 | UDP-glucose 4-epimerase activity(GO:0003978) |
| 0.4 | 1.5 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 0.3 | 3.8 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.2 | 0.7 | GO:0016309 | 1-phosphatidylinositol-5-phosphate 4-kinase activity(GO:0016309) |
| 0.2 | 2.5 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.2 | 0.6 | GO:0043426 | histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648) MRF binding(GO:0043426) |
| 0.2 | 0.5 | GO:0004477 | methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) |
| 0.1 | 2.0 | GO:0003840 | gamma-glutamyltransferase activity(GO:0003840) |
| 0.1 | 0.9 | GO:0017110 | nucleoside-diphosphatase activity(GO:0017110) |
| 0.1 | 2.0 | GO:0004887 | thyroid hormone receptor activity(GO:0004887) |
| 0.1 | 1.2 | GO:0009374 | biotin binding(GO:0009374) |
| 0.1 | 0.4 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
| 0.1 | 0.1 | GO:0033549 | MAP kinase phosphatase activity(GO:0033549) |
| 0.1 | 0.2 | GO:0031402 | sodium ion binding(GO:0031402) |
| 0.1 | 0.4 | GO:0004647 | phosphoserine phosphatase activity(GO:0004647) |
| 0.1 | 1.2 | GO:0004017 | adenylate kinase activity(GO:0004017) |
| 0.1 | 0.2 | GO:0017040 | ceramidase activity(GO:0017040) |
| 0.1 | 0.4 | GO:0008568 | microtubule-severing ATPase activity(GO:0008568) |
| 0.1 | 0.3 | GO:0017159 | pantetheine hydrolase activity(GO:0017159) GPI anchor binding(GO:0034235) |
| 0.1 | 0.3 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.1 | 0.4 | GO:0001733 | galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694) |
| 0.1 | 0.2 | GO:0015193 | L-proline transmembrane transporter activity(GO:0015193) |
| 0.1 | 0.2 | GO:0000900 | translation repressor activity, nucleic acid binding(GO:0000900) |
| 0.0 | 2.8 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.0 | 1.4 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.5 | GO:0016594 | glycine binding(GO:0016594) |
| 0.0 | 0.9 | GO:0017147 | Wnt-protein binding(GO:0017147) |
| 0.0 | 1.0 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 6.2 | GO:0004866 | endopeptidase inhibitor activity(GO:0004866) |
| 0.0 | 0.2 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
| 0.0 | 0.1 | GO:0004821 | histidine-tRNA ligase activity(GO:0004821) |
| 0.0 | 0.1 | GO:0008466 | glycogenin glucosyltransferase activity(GO:0008466) |
| 0.0 | 0.8 | GO:0008376 | acetylgalactosaminyltransferase activity(GO:0008376) |
| 0.0 | 0.9 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.0 | 0.3 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970) |
| 0.0 | 2.6 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 0.2 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.0 | 0.2 | GO:0017056 | structural constituent of nuclear pore(GO:0017056) |
| 0.0 | 0.3 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.0 | 0.1 | GO:0004167 | dopachrome isomerase activity(GO:0004167) |
| 0.0 | 0.1 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.0 | 0.1 | GO:0016842 | amidine-lyase activity(GO:0016842) |
| 0.0 | 0.3 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 0.8 | GO:0052689 | carboxylic ester hydrolase activity(GO:0052689) |
| 0.0 | 0.1 | GO:0047498 | calcium-dependent phospholipase A2 activity(GO:0047498) |
| 0.0 | 1.0 | GO:0005319 | lipid transporter activity(GO:0005319) |
| 0.0 | 0.9 | GO:0003743 | translation initiation factor activity(GO:0003743) |
| 0.0 | 0.9 | GO:0015662 | ATPase activity, coupled to transmembrane movement of ions, phosphorylative mechanism(GO:0015662) |
| 0.0 | 3.2 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 0.4 | GO:0016831 | carboxy-lyase activity(GO:0016831) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.2 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.1 | 3.0 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 4.9 | ST_INTEGRIN_SIGNALING_PATHWAY | Integrin Signaling Pathway |
| 0.0 | 0.1 | ST_INTERFERON_GAMMA_PATHWAY | Interferon gamma pathway. |
