Motif ID: HDX

Z-value: 1.025


Transcription factors associated with HDX:

Gene SymbolEntrez IDGene Name
HDX ENSG00000165259.9 HDX



Activity profile for motif HDX.

activity profile for motif HDX


Sorted Z-values histogram for motif HDX

Sorted Z-values for motif HDX



Network of associatons between targets according to the STRING database.



First level regulatory network of HDX

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_113594279 3.565 ENST00000416750.1
ENST00000418817.1
ENST00000263341.2
 IL1B


interleukin 1, beta


chr1_-_153363452 3.360 ENST00000368732.1
ENST00000368733.3
 S100A8

S100 calcium binding protein A8

chr1_-_209825674 2.968 ENST00000367030.3
ENST00000356082.4
 LAMB3

laminin, beta 3

chr18_+_29027696 1.971 ENST00000257189.4
 DSG3
desmoglein 3
chr12_+_54422142 1.179 ENST00000243108.4
 HOXC6
homeobox C6
chr2_+_113735575 0.374 ENST00000376489.2
ENST00000259205.4
 IL36G

interleukin 36, gamma

chr5_+_140165876 0.326 ENST00000504120.2
ENST00000394633.3
ENST00000378133.3
 PCDHA1


protocadherin alpha 1


chr5_-_35230771 0.261 ENST00000342362.5
 PRLR
prolactin receptor
chr5_-_41213607 0.220 ENST00000337836.5
ENST00000433294.1
 C6

complement component 6

chr22_+_40440804 0.201 ENST00000441751.1
ENST00000301923.9
 TNRC6B

trinucleotide repeat containing 6B

chr5_-_35230649 0.165 ENST00000382002.5
 PRLR
prolactin receptor
chr11_+_9685604 0.157 ENST00000447399.2
ENST00000318950.6
 SWAP70

SWAP switching B-cell complex 70kDa subunit

chr1_+_117602925 0.137 ENST00000369466.4
 TTF2
transcription termination factor, RNA polymerase II
chr19_+_36602104 0.130 ENST00000585332.1
ENST00000262637.4
 OVOL3

ovo-like zinc finger 3

chr5_+_140625147 0.123 ENST00000231173.3
 PCDHB15
protocadherin beta 15
chr1_-_48866517 0.108 ENST00000371841.1
 SPATA6
spermatogenesis associated 6
chr1_-_159684371 0.102 ENST00000255030.5
ENST00000437342.1
ENST00000368112.1
ENST00000368111.1
ENST00000368110.1
ENST00000343919.2
 CRP





C-reactive protein, pentraxin-related





chr1_+_84630053 0.092 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
 PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr12_-_118797475 0.088 ENST00000541786.1
ENST00000419821.2
ENST00000541878.1
 TAOK3


TAO kinase 3


chr12_+_10460549 0.086 ENST00000543420.1
ENST00000543777.1
 KLRD1

killer cell lectin-like receptor subfamily D, member 1

chr8_+_24151620 0.075 ENST00000437154.2
 ADAM28
ADAM metallopeptidase domain 28
chr11_-_66675371 0.050 ENST00000393955.2
 PC
pyruvate carboxylase
chr3_+_54157480 0.047 ENST00000490478.1
 CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr5_-_135290705 0.044 ENST00000274507.1
 LECT2
leukocyte cell-derived chemotaxin 2
chr8_+_110098850 0.040 ENST00000518632.1
 TRHR
thyrotropin-releasing hormone receptor
chr12_+_10460417 0.032 ENST00000381908.3
ENST00000336164.4
ENST00000350274.5
 KLRD1


killer cell lectin-like receptor subfamily D, member 1


chr6_-_116381918 0.031 ENST00000606080.1
 FRK
fyn-related kinase
chr1_+_197237352 0.025 ENST00000538660.1
ENST00000367400.3
ENST00000367399.2
 CRB1


crumbs homolog 1 (Drosophila)



Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 3.6 GO:0071639 positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) positive regulation of monocyte chemotactic protein-1 production(GO:0071639)
0.3 3.4 GO:0002544 chronic inflammatory response(GO:0002544)
0.1 3.0 GO:0031581 hemidesmosome assembly(GO:0031581)
0.1 0.2 GO:0001969 activation of membrane attack complex(GO:0001905) regulation of activation of membrane attack complex(GO:0001969) positive regulation of activation of membrane attack complex(GO:0001970) positive regulation of complement activation(GO:0045917) positive regulation of protein activation cascade(GO:2000259)
0.0 0.1 GO:0008228 opsonization(GO:0008228)
0.0 2.4 GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156)
0.0 0.2 GO:0042977 activation of JAK2 kinase activity(GO:0042977)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
1.0 3.0 GO:0005610 laminin-5 complex(GO:0005610)
0.1 2.0 GO:0030057 desmosome(GO:0030057)
0.0 0.2 GO:0005579 membrane attack complex(GO:0005579)
0.0 3.6 GO:0030141 secretory granule(GO:0030141)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 3.6 GO:0005149 interleukin-1 receptor binding(GO:0005149)
0.0 0.2 GO:0004925 prolactin receptor activity(GO:0004925)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 3.3 SA_MMP_CYTOKINE_CONNECTION Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix.