Motif ID: HIC1
Z-value: 2.224
Transcription factors associated with HIC1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| HIC1 | ENSG00000177374.8 | HIC1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 7.0 | GO:0010757 | negative regulation of plasminogen activation(GO:0010757) |
| 1.4 | 2.8 | GO:0071504 | response to heparin(GO:0071503) cellular response to heparin(GO:0071504) |
| 1.3 | 3.8 | GO:0021836 | chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923) |
| 1.2 | 4.9 | GO:0009609 | response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609) |
| 1.0 | 4.8 | GO:0046836 | glycolipid transport(GO:0046836) |
| 1.0 | 2.9 | GO:0010273 | detoxification of copper ion(GO:0010273) stress response to copper ion(GO:1990169) |
| 0.9 | 7.1 | GO:0003065 | regulation of heart rate by chemical signal(GO:0003062) positive regulation of heart rate by epinephrine(GO:0003065) |
| 0.9 | 2.6 | GO:0061302 | smooth muscle cell-matrix adhesion(GO:0061302) |
| 0.8 | 3.3 | GO:0030913 | paranodal junction assembly(GO:0030913) |
| 0.8 | 2.3 | GO:2000064 | regulation of cortisol biosynthetic process(GO:2000064) |
| 0.7 | 2.2 | GO:0006015 | 5-phosphoribose 1-diphosphate biosynthetic process(GO:0006015) 5-phosphoribose 1-diphosphate metabolic process(GO:0046391) |
| 0.7 | 2.0 | GO:0002514 | B cell tolerance induction(GO:0002514) regulation of B cell tolerance induction(GO:0002661) positive regulation of B cell tolerance induction(GO:0002663) |
| 0.6 | 1.8 | GO:0003350 | pulmonary myocardium development(GO:0003350) |
| 0.6 | 2.8 | GO:0045989 | positive regulation of striated muscle contraction(GO:0045989) |
| 0.5 | 1.6 | GO:0009174 | UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049) |
| 0.5 | 1.6 | GO:0008218 | bioluminescence(GO:0008218) |
| 0.5 | 5.2 | GO:0031017 | exocrine pancreas development(GO:0031017) |
| 0.5 | 2.5 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 0.5 | 0.9 | GO:0002072 | optic cup morphogenesis involved in camera-type eye development(GO:0002072) |
| 0.5 | 1.4 | GO:0042094 | interleukin-2 production(GO:0032623) interleukin-2 biosynthetic process(GO:0042094) |
| 0.4 | 1.3 | GO:0071679 | commissural neuron axon guidance(GO:0071679) |
| 0.4 | 1.8 | GO:0033197 | response to vitamin E(GO:0033197) |
| 0.4 | 3.5 | GO:0060325 | face morphogenesis(GO:0060325) |
| 0.4 | 3.0 | GO:2000111 | positive regulation of macrophage apoptotic process(GO:2000111) |
| 0.4 | 1.7 | GO:2000008 | regulation of protein localization to cell surface(GO:2000008) |
| 0.4 | 2.1 | GO:0055098 | response to low-density lipoprotein particle(GO:0055098) regulation of cholesterol transporter activity(GO:0060694) |
| 0.4 | 1.6 | GO:0030035 | microspike assembly(GO:0030035) |
| 0.4 | 1.2 | GO:0003011 | diaphragm contraction(GO:0002086) involuntary skeletal muscle contraction(GO:0003011) |
| 0.4 | 1.4 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.4 | 1.4 | GO:0072048 | pattern specification involved in kidney development(GO:0061004) renal system pattern specification(GO:0072048) |
| 0.3 | 1.7 | GO:0006927 | obsolete transformed cell apoptotic process(GO:0006927) |
| 0.3 | 1.8 | GO:2000124 | cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926) regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.3 | 0.3 | GO:0002890 | negative regulation of B cell mediated immunity(GO:0002713) negative regulation of immunoglobulin mediated immune response(GO:0002890) |
| 0.3 | 1.5 | GO:0002036 | regulation of L-glutamate transport(GO:0002036) |
| 0.3 | 0.9 | GO:0009996 | negative regulation of cell fate specification(GO:0009996) |
| 0.3 | 0.3 | GO:0031284 | positive regulation of guanylate cyclase activity(GO:0031284) |
| 0.3 | 1.1 | GO:0072180 | nephric duct morphogenesis(GO:0072178) mesonephric duct morphogenesis(GO:0072180) |
| 0.3 | 1.7 | GO:0060242 | contact inhibition(GO:0060242) |
| 0.3 | 3.9 | GO:1902668 | negative regulation of axon extension involved in axon guidance(GO:0048843) negative regulation of axon guidance(GO:1902668) |
| 0.3 | 0.8 | GO:1903115 | regulation of muscle filament sliding(GO:0032971) regulation of actin filament-based movement(GO:1903115) |
| 0.2 | 3.5 | GO:0006527 | arginine catabolic process(GO:0006527) |
| 0.2 | 0.7 | GO:0006543 | glutamine catabolic process(GO:0006543) |
| 0.2 | 6.9 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.2 | 0.7 | GO:0071883 | adrenergic receptor signaling pathway(GO:0071875) activation of MAPK activity by adrenergic receptor signaling pathway(GO:0071883) |
| 0.2 | 0.7 | GO:0051541 | elastin metabolic process(GO:0051541) |
| 0.2 | 1.3 | GO:0060710 | chorio-allantoic fusion(GO:0060710) |
| 0.2 | 1.0 | GO:0006651 | diacylglycerol biosynthetic process(GO:0006651) |
| 0.2 | 1.0 | GO:0006290 | pyrimidine dimer repair(GO:0006290) |
| 0.2 | 0.8 | GO:0071318 | cellular response to ATP(GO:0071318) |
| 0.2 | 0.2 | GO:0071364 | cellular response to epidermal growth factor stimulus(GO:0071364) |
| 0.2 | 1.1 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.2 | 1.8 | GO:0051014 | actin filament severing(GO:0051014) |
| 0.2 | 1.9 | GO:0033631 | cell-cell adhesion mediated by integrin(GO:0033631) |
| 0.2 | 0.5 | GO:0007000 | nucleolus organization(GO:0007000) |
| 0.2 | 0.5 | GO:1902803 | axon target recognition(GO:0007412) regulation of synaptic vesicle transport(GO:1902803) regulation of synaptic vesicle exocytosis(GO:2000300) |
| 0.1 | 0.3 | GO:0061030 | epithelial cell differentiation involved in mammary gland alveolus development(GO:0061030) |
| 0.1 | 0.6 | GO:0050653 | chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653) |
| 0.1 | 0.7 | GO:0032926 | negative regulation of activin receptor signaling pathway(GO:0032926) |
| 0.1 | 0.4 | GO:0071529 | cementum mineralization(GO:0071529) |
| 0.1 | 1.3 | GO:0048625 | myoblast fate commitment(GO:0048625) |
| 0.1 | 0.4 | GO:0071635 | negative regulation of transforming growth factor beta production(GO:0071635) |
| 0.1 | 1.6 | GO:0050872 | white fat cell differentiation(GO:0050872) |
| 0.1 | 0.6 | GO:0042268 | regulation of cytolysis(GO:0042268) |
| 0.1 | 0.8 | GO:0043415 | positive regulation of skeletal muscle tissue regeneration(GO:0043415) regulation of skeletal muscle tissue regeneration(GO:0043416) |
| 0.1 | 0.4 | GO:0030812 | negative regulation of nucleotide catabolic process(GO:0030812) |
| 0.1 | 1.0 | GO:0051386 | regulation of neurotrophin TRK receptor signaling pathway(GO:0051386) |
| 0.1 | 0.4 | GO:0007028 | cytoplasm organization(GO:0007028) |
| 0.1 | 0.9 | GO:0014049 | positive regulation of glutamate secretion(GO:0014049) |
| 0.1 | 0.4 | GO:0050917 | sensory perception of umami taste(GO:0050917) |
| 0.1 | 0.5 | GO:0032224 | positive regulation of synaptic transmission, cholinergic(GO:0032224) |
| 0.1 | 0.9 | GO:0030579 | ubiquitin-dependent SMAD protein catabolic process(GO:0030579) |
| 0.1 | 0.6 | GO:0051894 | positive regulation of focal adhesion assembly(GO:0051894) positive regulation of cell junction assembly(GO:1901890) positive regulation of adherens junction organization(GO:1903393) |
| 0.1 | 0.6 | GO:0007182 | common-partner SMAD protein phosphorylation(GO:0007182) |
| 0.1 | 0.5 | GO:0000394 | RNA splicing, via endonucleolytic cleavage and ligation(GO:0000394) tRNA splicing, via endonucleolytic cleavage and ligation(GO:0006388) |
| 0.1 | 0.2 | GO:0001999 | renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure(GO:0001999) |
| 0.1 | 0.7 | GO:0009649 | entrainment of circadian clock(GO:0009649) |
| 0.1 | 1.1 | GO:0006621 | protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437) |
| 0.1 | 0.7 | GO:0010713 | negative regulation of collagen metabolic process(GO:0010713) negative regulation of collagen biosynthetic process(GO:0032966) negative regulation of multicellular organismal metabolic process(GO:0044252) |
| 0.1 | 2.0 | GO:0045104 | intermediate filament cytoskeleton organization(GO:0045104) |
| 0.1 | 1.9 | GO:0001960 | negative regulation of cytokine-mediated signaling pathway(GO:0001960) |
| 0.1 | 0.9 | GO:0042249 | establishment of planar polarity of embryonic epithelium(GO:0042249) |
| 0.1 | 0.3 | GO:0051102 | DNA ligation involved in DNA recombination(GO:0051102) |
| 0.1 | 0.5 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.1 | 8.1 | GO:0008064 | regulation of actin polymerization or depolymerization(GO:0008064) |
| 0.1 | 0.7 | GO:0007185 | transmembrane receptor protein tyrosine phosphatase signaling pathway(GO:0007185) |
| 0.1 | 2.1 | GO:0030514 | negative regulation of BMP signaling pathway(GO:0030514) |
| 0.1 | 0.8 | GO:0006379 | mRNA cleavage(GO:0006379) |
| 0.1 | 0.3 | GO:0045062 | extrathymic T cell differentiation(GO:0033078) extrathymic T cell selection(GO:0045062) |
| 0.1 | 0.3 | GO:0060253 | regulation of Schwann cell proliferation(GO:0010624) negative regulation of Schwann cell proliferation(GO:0010626) negative regulation of glial cell proliferation(GO:0060253) |
| 0.1 | 1.0 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 0.1 | 0.2 | GO:0003128 | heart field specification(GO:0003128) heart induction(GO:0003129) regulation of heart morphogenesis(GO:2000826) |
| 0.1 | 0.3 | GO:0033578 | protein glycosylation in Golgi(GO:0033578) |
| 0.1 | 0.8 | GO:0010875 | positive regulation of cholesterol efflux(GO:0010875) |
| 0.1 | 1.4 | GO:0031000 | response to caffeine(GO:0031000) |
| 0.1 | 0.4 | GO:0019369 | arachidonic acid metabolic process(GO:0019369) |
| 0.1 | 0.3 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.1 | 0.8 | GO:0009650 | UV protection(GO:0009650) |
| 0.1 | 6.3 | GO:0017148 | negative regulation of translation(GO:0017148) |
| 0.1 | 0.8 | GO:0032288 | myelin assembly(GO:0032288) |
| 0.1 | 0.5 | GO:0046322 | negative regulation of fatty acid oxidation(GO:0046322) |
| 0.1 | 1.5 | GO:0000768 | syncytium formation by plasma membrane fusion(GO:0000768) myoblast fusion(GO:0007520) |
| 0.1 | 0.6 | GO:0006896 | Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896) |
| 0.1 | 1.3 | GO:1902603 | carnitine shuttle(GO:0006853) carnitine transmembrane transport(GO:1902603) |
| 0.1 | 1.0 | GO:0010226 | response to lithium ion(GO:0010226) |
| 0.1 | 2.1 | GO:0072164 | ureteric bud development(GO:0001657) mesonephric epithelium development(GO:0072163) mesonephric tubule development(GO:0072164) |
| 0.1 | 0.3 | GO:0006398 | mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398) |
| 0.1 | 0.6 | GO:0070972 | protein targeting to ER(GO:0045047) protein localization to endoplasmic reticulum(GO:0070972) establishment of protein localization to endoplasmic reticulum(GO:0072599) |
| 0.1 | 0.2 | GO:0034086 | maintenance of sister chromatid cohesion(GO:0034086) maintenance of mitotic sister chromatid cohesion(GO:0034088) |
| 0.1 | 0.5 | GO:0030186 | melatonin metabolic process(GO:0030186) melatonin biosynthetic process(GO:0030187) |
| 0.1 | 0.5 | GO:0046618 | drug export(GO:0046618) |
| 0.1 | 0.2 | GO:0016081 | synaptic vesicle docking(GO:0016081) |
| 0.1 | 0.5 | GO:0070296 | sarcoplasmic reticulum calcium ion transport(GO:0070296) |
| 0.1 | 0.8 | GO:0045408 | regulation of interleukin-6 biosynthetic process(GO:0045408) |
| 0.1 | 0.4 | GO:0051043 | regulation of membrane protein ectodomain proteolysis(GO:0051043) |
| 0.1 | 0.4 | GO:0009756 | carbohydrate mediated signaling(GO:0009756) |
| 0.1 | 2.2 | GO:0008154 | actin polymerization or depolymerization(GO:0008154) |
| 0.1 | 1.5 | GO:0032400 | melanosome localization(GO:0032400) |
| 0.1 | 0.5 | GO:0006537 | glutamate biosynthetic process(GO:0006537) |
| 0.1 | 0.1 | GO:0072201 | negative regulation of mesenchymal cell proliferation(GO:0072201) |
| 0.1 | 3.0 | GO:0015914 | phospholipid transport(GO:0015914) |
| 0.1 | 0.4 | GO:0016322 | neuron remodeling(GO:0016322) |
| 0.1 | 0.5 | GO:0005981 | regulation of glycogen catabolic process(GO:0005981) |
| 0.1 | 0.1 | GO:0060087 | regulation of neurotrophin production(GO:0032899) negative regulation of neurotrophin production(GO:0032900) relaxation of smooth muscle(GO:0044557) negative regulation of vasodilation(GO:0045908) negative regulation of smooth muscle contraction(GO:0045986) relaxation of vascular smooth muscle(GO:0060087) regulation of mucus secretion(GO:0070255) negative regulation of mucus secretion(GO:0070256) |
| 0.1 | 0.1 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 0.1 | 1.3 | GO:0006911 | phagocytosis, engulfment(GO:0006911) membrane invagination(GO:0010324) |
| 0.1 | 1.1 | GO:0051319 | mitotic G2 phase(GO:0000085) G2 phase(GO:0051319) |
| 0.1 | 0.3 | GO:0050689 | negative regulation of defense response to virus by host(GO:0050689) |
| 0.1 | 0.3 | GO:0031338 | regulation of vesicle fusion(GO:0031338) positive regulation of vesicle fusion(GO:0031340) |
| 0.1 | 0.5 | GO:0006452 | translational frameshifting(GO:0006452) positive regulation of translational elongation(GO:0045901) positive regulation of translational termination(GO:0045905) |
| 0.1 | 0.2 | GO:0008298 | intracellular mRNA localization(GO:0008298) |
| 0.1 | 0.4 | GO:0034465 | cellular potassium ion homeostasis(GO:0030007) response to carbon monoxide(GO:0034465) negative regulation of cell volume(GO:0045794) |
| 0.1 | 1.4 | GO:0007157 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0007157) |
| 0.1 | 0.7 | GO:0090286 | cytoskeletal anchoring at nuclear membrane(GO:0090286) |
| 0.1 | 0.3 | GO:0007616 | long-term memory(GO:0007616) |
| 0.1 | 1.0 | GO:0035329 | hippo signaling(GO:0035329) |
| 0.1 | 0.3 | GO:0048702 | embryonic neurocranium morphogenesis(GO:0048702) |
| 0.1 | 0.9 | GO:0007128 | meiotic prophase I(GO:0007128) |
| 0.1 | 0.3 | GO:0045103 | intermediate filament-based process(GO:0045103) |
| 0.1 | 0.2 | GO:0007175 | negative regulation of epidermal growth factor-activated receptor activity(GO:0007175) |
| 0.1 | 0.8 | GO:0006700 | C21-steroid hormone biosynthetic process(GO:0006700) |
| 0.1 | 0.8 | GO:0042921 | glucocorticoid receptor signaling pathway(GO:0042921) |
| 0.1 | 0.2 | GO:0032367 | intracellular sterol transport(GO:0032366) intracellular cholesterol transport(GO:0032367) |
| 0.1 | 0.9 | GO:0045749 | obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749) |
| 0.1 | 0.6 | GO:0045600 | positive regulation of fat cell differentiation(GO:0045600) |
| 0.0 | 1.2 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.0 | 0.2 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 0.0 | 1.9 | GO:0050772 | positive regulation of axonogenesis(GO:0050772) |
| 0.0 | 0.3 | GO:0010955 | negative regulation of protein processing(GO:0010955) negative regulation of protein maturation(GO:1903318) |
| 0.0 | 0.3 | GO:0098927 | early endosome to late endosome transport(GO:0045022) vesicle-mediated transport between endosomal compartments(GO:0098927) |
| 0.0 | 0.0 | GO:0060831 | hindgut morphogenesis(GO:0007442) smoothened signaling pathway involved in dorsal/ventral neural tube patterning(GO:0060831) hindgut development(GO:0061525) |
| 0.0 | 2.3 | GO:0060271 | cilium morphogenesis(GO:0060271) |
| 0.0 | 0.1 | GO:0035623 | renal glucose absorption(GO:0035623) |
| 0.0 | 0.1 | GO:0034551 | respiratory chain complex III assembly(GO:0017062) mitochondrial respiratory chain complex III assembly(GO:0034551) mitochondrial respiratory chain complex III biogenesis(GO:0097033) |
| 0.0 | 1.1 | GO:0031572 | G2 DNA damage checkpoint(GO:0031572) |
| 0.0 | 0.6 | GO:0007172 | signal complex assembly(GO:0007172) |
| 0.0 | 1.3 | GO:0007041 | lysosomal transport(GO:0007041) |
| 0.0 | 0.3 | GO:0008535 | respiratory chain complex IV assembly(GO:0008535) |
| 0.0 | 1.8 | GO:2000181 | negative regulation of angiogenesis(GO:0016525) negative regulation of blood vessel morphogenesis(GO:2000181) |
| 0.0 | 0.3 | GO:0042541 | response to increased oxygen levels(GO:0036296) hemoglobin biosynthetic process(GO:0042541) response to hyperoxia(GO:0055093) |
| 0.0 | 0.4 | GO:0015780 | nucleotide-sugar transport(GO:0015780) |
| 0.0 | 0.2 | GO:0060155 | platelet dense granule organization(GO:0060155) |
| 0.0 | 2.5 | GO:0006914 | autophagy(GO:0006914) |
| 0.0 | 0.2 | GO:0000389 | mRNA 3'-splice site recognition(GO:0000389) |
| 0.0 | 2.4 | GO:0007623 | circadian rhythm(GO:0007623) |
| 0.0 | 0.5 | GO:0002040 | sprouting angiogenesis(GO:0002040) |
| 0.0 | 0.1 | GO:0043276 | anoikis(GO:0043276) |
| 0.0 | 0.3 | GO:0090398 | cellular senescence(GO:0090398) |
| 0.0 | 2.4 | GO:0006939 | smooth muscle contraction(GO:0006939) |
| 0.0 | 0.3 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
| 0.0 | 0.2 | GO:0001947 | heart looping(GO:0001947) embryonic heart tube morphogenesis(GO:0003143) determination of heart left/right asymmetry(GO:0061371) |
| 0.0 | 0.1 | GO:0003148 | outflow tract septum morphogenesis(GO:0003148) |
| 0.0 | 0.1 | GO:0001977 | renal system process involved in regulation of blood volume(GO:0001977) |
| 0.0 | 2.7 | GO:0002756 | MyD88-independent toll-like receptor signaling pathway(GO:0002756) |
| 0.0 | 0.8 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
| 0.0 | 0.2 | GO:0033148 | positive regulation of intracellular estrogen receptor signaling pathway(GO:0033148) |
| 0.0 | 0.3 | GO:0034260 | negative regulation of GTPase activity(GO:0034260) |
| 0.0 | 4.9 | GO:0043087 | regulation of GTPase activity(GO:0043087) |
| 0.0 | 0.1 | GO:0003214 | cardiac left ventricle morphogenesis(GO:0003214) |
| 0.0 | 0.1 | GO:0046952 | cellular ketone body metabolic process(GO:0046950) ketone body catabolic process(GO:0046952) |
| 0.0 | 0.9 | GO:0006023 | aminoglycan biosynthetic process(GO:0006023) |
| 0.0 | 1.4 | GO:0006754 | ATP biosynthetic process(GO:0006754) |
| 0.0 | 2.8 | GO:0035023 | regulation of Rho protein signal transduction(GO:0035023) |
| 0.0 | 0.2 | GO:0010745 | negative regulation of macrophage derived foam cell differentiation(GO:0010745) |
| 0.0 | 0.3 | GO:0051085 | chaperone mediated protein folding requiring cofactor(GO:0051085) |
| 0.0 | 0.2 | GO:0019835 | cytolysis(GO:0019835) |
| 0.0 | 1.1 | GO:0007266 | Rho protein signal transduction(GO:0007266) |
| 0.0 | 0.3 | GO:0002675 | positive regulation of acute inflammatory response(GO:0002675) |
| 0.0 | 0.4 | GO:0035036 | binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) |
| 0.0 | 0.4 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.0 | 0.1 | GO:0006998 | nuclear envelope organization(GO:0006998) |
| 0.0 | 0.8 | GO:0031424 | keratinization(GO:0031424) |
| 0.0 | 0.2 | GO:0006553 | lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554) |
| 0.0 | 0.3 | GO:0009629 | response to gravity(GO:0009629) |
| 0.0 | 0.1 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.0 | 2.4 | GO:0007605 | sensory perception of sound(GO:0007605) |
| 0.0 | 0.1 | GO:0046826 | negative regulation of protein export from nucleus(GO:0046826) |
| 0.0 | 0.1 | GO:0045080 | positive regulation of chemokine biosynthetic process(GO:0045080) |
| 0.0 | 1.3 | GO:0034332 | adherens junction organization(GO:0034332) |
| 0.0 | 0.4 | GO:0035115 | embryonic forelimb morphogenesis(GO:0035115) |
| 0.0 | 0.1 | GO:0035136 | forelimb morphogenesis(GO:0035136) |
| 0.0 | 0.1 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.0 | 0.4 | GO:0009086 | methionine biosynthetic process(GO:0009086) |
| 0.0 | 0.1 | GO:0042542 | response to hydrogen peroxide(GO:0042542) |
| 0.0 | 0.3 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.0 | 0.6 | GO:0046464 | triglyceride catabolic process(GO:0019433) neutral lipid catabolic process(GO:0046461) acylglycerol catabolic process(GO:0046464) |
| 0.0 | 1.2 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 0.5 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
| 0.0 | 0.5 | GO:0090263 | positive regulation of canonical Wnt signaling pathway(GO:0090263) |
| 0.0 | 0.9 | GO:0000289 | nuclear-transcribed mRNA poly(A) tail shortening(GO:0000289) |
| 0.0 | 0.1 | GO:0070682 | proteasome regulatory particle assembly(GO:0070682) |
| 0.0 | 0.4 | GO:1901224 | activation of NF-kappaB-inducing kinase activity(GO:0007250) NIK/NF-kappaB signaling(GO:0038061) regulation of NIK/NF-kappaB signaling(GO:1901222) positive regulation of NIK/NF-kappaB signaling(GO:1901224) |
| 0.0 | 0.1 | GO:0070265 | necrotic cell death(GO:0070265) |
| 0.0 | 0.9 | GO:0070979 | protein K11-linked ubiquitination(GO:0070979) |
| 0.0 | 0.1 | GO:0042986 | positive regulation of amyloid precursor protein biosynthetic process(GO:0042986) |
| 0.0 | 0.4 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
| 0.0 | 0.1 | GO:0030071 | regulation of mitotic metaphase/anaphase transition(GO:0030071) regulation of metaphase/anaphase transition of cell cycle(GO:1902099) |
| 0.0 | 0.5 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 0.3 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.0 | 0.4 | GO:0007613 | memory(GO:0007613) |
| 0.0 | 1.2 | GO:0030521 | androgen receptor signaling pathway(GO:0030521) |
| 0.0 | 0.4 | GO:0045844 | positive regulation of striated muscle tissue development(GO:0045844) positive regulation of muscle organ development(GO:0048636) positive regulation of muscle tissue development(GO:1901863) |
| 0.0 | 0.0 | GO:0060393 | regulation of pathway-restricted SMAD protein phosphorylation(GO:0060393) |
| 0.0 | 1.9 | GO:0006633 | fatty acid biosynthetic process(GO:0006633) |
| 0.0 | 0.4 | GO:0042776 | mitochondrial ATP synthesis coupled proton transport(GO:0042776) |
| 0.0 | 0.1 | GO:0090343 | positive regulation of cell aging(GO:0090343) |
| 0.0 | 0.1 | GO:0000019 | regulation of mitotic recombination(GO:0000019) |
| 0.0 | 1.3 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.0 | 0.1 | GO:0006423 | cysteinyl-tRNA aminoacylation(GO:0006423) |
| 0.0 | 0.1 | GO:0070934 | CRD-mediated mRNA stabilization(GO:0070934) |
| 0.0 | 0.2 | GO:0006702 | androgen biosynthetic process(GO:0006702) |
| 0.0 | 1.0 | GO:0009408 | response to heat(GO:0009408) |
| 0.0 | 0.1 | GO:0045072 | regulation of interferon-gamma biosynthetic process(GO:0045072) positive regulation of interferon-gamma biosynthetic process(GO:0045078) |
| 0.0 | 0.0 | GO:0045040 | outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040) |
| 0.0 | 0.2 | GO:0046546 | male gonad development(GO:0008584) development of primary male sexual characteristics(GO:0046546) |
| 0.0 | 1.2 | GO:0007218 | neuropeptide signaling pathway(GO:0007218) |
| 0.0 | 0.7 | GO:0043473 | pigmentation(GO:0043473) |
| 0.0 | 0.2 | GO:0018214 | peptidyl-glutamic acid carboxylation(GO:0017187) protein carboxylation(GO:0018214) |
| 0.0 | 0.1 | GO:0090399 | replicative senescence(GO:0090399) |
| 0.0 | 0.7 | GO:0042446 | hormone biosynthetic process(GO:0042446) |
| 0.0 | 0.3 | GO:1902600 | energy coupled proton transmembrane transport, against electrochemical gradient(GO:0015988) ATP hydrolysis coupled proton transport(GO:0015991) ATP hydrolysis coupled transmembrane transport(GO:0090662) hydrogen ion transmembrane transport(GO:1902600) |
| 0.0 | 0.1 | GO:0051205 | protein insertion into membrane(GO:0051205) |
| 0.0 | 0.2 | GO:0042994 | cytoplasmic sequestering of transcription factor(GO:0042994) |
| 0.0 | 0.1 | GO:0018026 | peptidyl-lysine monomethylation(GO:0018026) |
| 0.0 | 0.1 | GO:0001824 | blastocyst development(GO:0001824) |
| 0.0 | 2.0 | GO:0030036 | actin cytoskeleton organization(GO:0030036) |
| 0.0 | 2.2 | GO:0001525 | angiogenesis(GO:0001525) |
| 0.0 | 0.1 | GO:0002089 | lens morphogenesis in camera-type eye(GO:0002089) |
| 0.0 | 0.0 | GO:0010002 | cardioblast differentiation(GO:0010002) |
| 0.0 | 0.1 | GO:0006003 | fructose 2,6-bisphosphate metabolic process(GO:0006003) |
| 0.0 | 0.0 | GO:0071109 | thalamus development(GO:0021794) superior temporal gyrus development(GO:0071109) |
| 0.0 | 0.1 | GO:0006613 | cotranslational protein targeting to membrane(GO:0006613) |
| 0.0 | 0.2 | GO:0050812 | acetyl-CoA biosynthetic process(GO:0006085) acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812) |
| 0.0 | 0.2 | GO:0043252 | sodium-independent organic anion transport(GO:0043252) |
| 0.0 | 0.6 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.0 | 0.1 | GO:0009268 | response to pH(GO:0009268) |
| 0.0 | 0.1 | GO:0032464 | regulation of protein homooligomerization(GO:0032462) positive regulation of protein homooligomerization(GO:0032464) |
| 0.0 | 0.1 | GO:0006658 | phosphatidylserine metabolic process(GO:0006658) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.4 | 7.0 | GO:0031232 | extrinsic component of external side of plasma membrane(GO:0031232) |
| 0.6 | 5.0 | GO:0005587 | collagen type IV trimer(GO:0005587) |
| 0.6 | 7.1 | GO:0032059 | bleb(GO:0032059) |
| 0.3 | 1.7 | GO:0060171 | stereocilium membrane(GO:0060171) |
| 0.3 | 2.0 | GO:0070022 | transforming growth factor beta receptor homodimeric complex(GO:0070022) |
| 0.3 | 0.3 | GO:0098645 | network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) |
| 0.3 | 1.9 | GO:1990752 | microtubule plus-end(GO:0035371) microtubule end(GO:1990752) |
| 0.2 | 0.7 | GO:0035032 | phosphatidylinositol 3-kinase complex, class III(GO:0035032) PAS complex(GO:0070772) |
| 0.2 | 3.2 | GO:0005606 | laminin-1 complex(GO:0005606) |
| 0.2 | 3.3 | GO:0031092 | platelet alpha granule membrane(GO:0031092) |
| 0.2 | 0.6 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.2 | 1.5 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 1.2 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.1 | 0.6 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 0.8 | GO:0032311 | angiogenin-PRI complex(GO:0032311) |
| 0.1 | 0.5 | GO:0000214 | tRNA-intron endonuclease complex(GO:0000214) |
| 0.1 | 1.3 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.1 | 3.1 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 0.5 | GO:0032449 | CBM complex(GO:0032449) |
| 0.1 | 1.0 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 2.6 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.1 | 1.4 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
| 0.1 | 2.2 | GO:0030132 | clathrin coat of coated pit(GO:0030132) |
| 0.1 | 0.8 | GO:0016461 | unconventional myosin complex(GO:0016461) |
| 0.1 | 0.3 | GO:0005900 | oncostatin-M receptor complex(GO:0005900) |
| 0.1 | 1.6 | GO:0008091 | spectrin(GO:0008091) |
| 0.1 | 0.4 | GO:0033596 | TSC1-TSC2 complex(GO:0033596) |
| 0.1 | 0.6 | GO:0031012 | extracellular matrix(GO:0031012) |
| 0.1 | 0.5 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.1 | 1.7 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.1 | 0.7 | GO:0043218 | compact myelin(GO:0043218) |
| 0.1 | 0.9 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
| 0.1 | 0.2 | GO:0070044 | synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044) |
| 0.1 | 1.5 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.1 | 4.2 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 0.5 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.1 | 7.7 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.1 | 0.7 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.1 | 4.1 | GO:0005905 | clathrin-coated pit(GO:0005905) |
| 0.1 | 0.4 | GO:0005791 | rough endoplasmic reticulum(GO:0005791) |
| 0.1 | 3.4 | GO:0032587 | ruffle membrane(GO:0032587) |
| 0.1 | 0.4 | GO:0032444 | activin responsive factor complex(GO:0032444) |
| 0.1 | 0.4 | GO:0030877 | beta-catenin destruction complex(GO:0030877) |
| 0.1 | 1.6 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 0.3 | GO:0032807 | DNA ligase IV complex(GO:0032807) |
| 0.1 | 0.2 | GO:1990316 | ATG1/ULK1 kinase complex(GO:1990316) |
| 0.1 | 4.6 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.1 | 4.2 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 0.4 | GO:0000275 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) |
| 0.0 | 0.9 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 0.4 | GO:0016942 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 0.0 | 4.3 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 0.3 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 0.2 | GO:0035189 | Rb-E2F complex(GO:0035189) |
| 0.0 | 2.4 | GO:1990777 | protein-lipid complex(GO:0032994) plasma lipoprotein particle(GO:0034358) lipoprotein particle(GO:1990777) |
| 0.0 | 0.9 | GO:0016281 | eukaryotic translation initiation factor 4F complex(GO:0016281) |
| 0.0 | 0.4 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.0 | 0.3 | GO:0005683 | U7 snRNP(GO:0005683) |
| 0.0 | 5.5 | GO:0019898 | extrinsic component of membrane(GO:0019898) |
| 0.0 | 4.6 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 1.6 | GO:0001726 | ruffle(GO:0001726) |
| 0.0 | 0.1 | GO:0008540 | proteasome regulatory particle, base subcomplex(GO:0008540) |
| 0.0 | 0.8 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 1.4 | GO:0098636 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.0 | 2.2 | GO:0031902 | late endosome membrane(GO:0031902) |
| 0.0 | 0.5 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.0 | 1.0 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 12.4 | GO:0015629 | actin cytoskeleton(GO:0015629) |
| 0.0 | 1.3 | GO:0005782 | peroxisomal matrix(GO:0005782) microbody lumen(GO:0031907) |
| 0.0 | 0.9 | GO:0090568 | NuRD complex(GO:0016581) CHD-type complex(GO:0090545) nuclear transcriptional repressor complex(GO:0090568) |
| 0.0 | 0.5 | GO:0031091 | platelet alpha granule(GO:0031091) |
| 0.0 | 0.2 | GO:0045240 | dihydrolipoyl dehydrogenase complex(GO:0045240) |
| 0.0 | 0.5 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 2.9 | GO:0009897 | external side of plasma membrane(GO:0009897) |
| 0.0 | 24.3 | GO:0005615 | extracellular space(GO:0005615) |
| 0.0 | 0.1 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
| 0.0 | 0.8 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.0 | 0.5 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 0.5 | GO:0032589 | neuron projection membrane(GO:0032589) |
| 0.0 | 0.2 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 0.1 | GO:0048786 | presynaptic active zone(GO:0048786) |
| 0.0 | 0.2 | GO:0001772 | immunological synapse(GO:0001772) |
| 0.0 | 0.0 | GO:0016589 | NURF complex(GO:0016589) |
| 0.0 | 0.2 | GO:0033256 | I-kappaB/NF-kappaB complex(GO:0033256) |
| 0.0 | 7.0 | GO:0005667 | transcription factor complex(GO:0005667) |
| 0.0 | 0.1 | GO:0005766 | primary lysosome(GO:0005766) azurophil granule(GO:0042582) |
| 0.0 | 0.3 | GO:0097014 | axoneme(GO:0005930) ciliary plasm(GO:0097014) |
| 0.0 | 0.1 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.0 | 1.7 | GO:0005788 | endoplasmic reticulum lumen(GO:0005788) |
| 0.0 | 0.3 | GO:0016471 | vacuolar proton-transporting V-type ATPase complex(GO:0016471) |
| 0.0 | 0.3 | GO:0031252 | cell leading edge(GO:0031252) |
| 0.0 | 0.1 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.0 | 0.1 | GO:0042587 | glycogen granule(GO:0042587) |
| 0.0 | 0.1 | GO:0005964 | phosphorylase kinase complex(GO:0005964) |
| 0.0 | 14.3 | GO:0005576 | extracellular region(GO:0005576) |
| 0.0 | 0.4 | GO:0030286 | dynein complex(GO:0030286) |
| 0.0 | 0.1 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 0.0 | GO:0071256 | Sec61 translocon complex(GO:0005784) translocon complex(GO:0071256) |
| 0.0 | 0.9 | GO:0070160 | bicellular tight junction(GO:0005923) occluding junction(GO:0070160) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.6 | GO:0005152 | interleukin-1 receptor antagonist activity(GO:0005152) |
| 0.9 | 2.6 | GO:0004782 | sulfinoalanine decarboxylase activity(GO:0004782) |
| 0.9 | 6.1 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.7 | 2.9 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 0.7 | 3.5 | GO:0016403 | dimethylargininase activity(GO:0016403) |
| 0.6 | 2.2 | GO:0008184 | purine nucleobase binding(GO:0002060) glycogen phosphorylase activity(GO:0008184) |
| 0.5 | 2.0 | GO:0005026 | transforming growth factor beta receptor activity, type II(GO:0005026) |
| 0.5 | 3.4 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
| 0.4 | 3.0 | GO:0055105 | ubiquitin-protein transferase inhibitor activity(GO:0055105) |
| 0.4 | 2.5 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.4 | 1.6 | GO:0016635 | oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635) |
| 0.4 | 0.4 | GO:0070679 | inositol 1,4,5 trisphosphate binding(GO:0070679) |
| 0.4 | 2.0 | GO:0017089 | glycolipid transporter activity(GO:0017089) |
| 0.4 | 1.9 | GO:0031995 | insulin-like growth factor II binding(GO:0031995) |
| 0.3 | 1.6 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.3 | 7.0 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.3 | 1.2 | GO:0032450 | maltose alpha-glucosidase activity(GO:0032450) |
| 0.3 | 1.1 | GO:0060422 | peptidyl-dipeptidase inhibitor activity(GO:0060422) |
| 0.3 | 1.3 | GO:0031013 | troponin I binding(GO:0031013) |
| 0.3 | 1.1 | GO:0005046 | KDEL sequence binding(GO:0005046) |
| 0.3 | 2.6 | GO:0004157 | dihydropyrimidinase activity(GO:0004157) |
| 0.3 | 2.6 | GO:0030172 | troponin C binding(GO:0030172) |
| 0.3 | 4.8 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.2 | 6.6 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.2 | 1.5 | GO:0004030 | aldehyde dehydrogenase [NAD(P)+] activity(GO:0004030) |
| 0.2 | 0.7 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
| 0.2 | 2.8 | GO:0036041 | long-chain fatty acid binding(GO:0036041) |
| 0.2 | 0.7 | GO:0004938 | alpha2-adrenergic receptor activity(GO:0004938) |
| 0.2 | 1.4 | GO:0030215 | semaphorin receptor binding(GO:0030215) |
| 0.2 | 2.5 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.2 | 1.8 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.2 | 0.2 | GO:0032036 | myosin heavy chain binding(GO:0032036) |
| 0.2 | 0.6 | GO:0042285 | UDP-xylosyltransferase activity(GO:0035252) xylosyltransferase activity(GO:0042285) |
| 0.2 | 1.1 | GO:0033691 | sialic acid binding(GO:0033691) |
| 0.2 | 1.2 | GO:0050656 | 3'-phosphoadenosine 5'-phosphosulfate binding(GO:0050656) |
| 0.2 | 1.6 | GO:0004522 | ribonuclease A activity(GO:0004522) |
| 0.2 | 0.6 | GO:0008545 | JUN kinase kinase activity(GO:0008545) |
| 0.2 | 0.6 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
| 0.2 | 0.5 | GO:0047273 | galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273) |
| 0.2 | 0.5 | GO:0019797 | procollagen-proline 3-dioxygenase activity(GO:0019797) peptidyl-proline 3-dioxygenase activity(GO:0031544) |
| 0.2 | 0.7 | GO:0004359 | glutaminase activity(GO:0004359) |
| 0.2 | 3.7 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.2 | 3.4 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.2 | 1.4 | GO:0004873 | asialoglycoprotein receptor activity(GO:0004873) |
| 0.2 | 1.6 | GO:0016671 | oxidoreductase activity, acting on a sulfur group of donors, disulfide as acceptor(GO:0016671) |
| 0.2 | 0.6 | GO:0047288 | monosialoganglioside sialyltransferase activity(GO:0047288) |
| 0.2 | 2.5 | GO:0008191 | metalloendopeptidase inhibitor activity(GO:0008191) |
| 0.2 | 0.9 | GO:0045159 | myosin II binding(GO:0045159) |
| 0.2 | 1.1 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.2 | 1.4 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.2 | 0.5 | GO:0000213 | tRNA-intron endonuclease activity(GO:0000213) |
| 0.2 | 3.0 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.1 | 1.8 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.1 | 0.6 | GO:0047237 | glucuronylgalactosylproteoglycan 4-beta-N-acetylgalactosaminyltransferase activity(GO:0047237) |
| 0.1 | 0.4 | GO:0016402 | pristanoyl-CoA oxidase activity(GO:0016402) |
| 0.1 | 2.4 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 0.8 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.1 | 1.9 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.1 | 1.3 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
| 0.1 | 0.4 | GO:0032794 | GTPase activating protein binding(GO:0032794) |
| 0.1 | 1.6 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 0.4 | GO:0044325 | ion channel binding(GO:0044325) |
| 0.1 | 0.7 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
| 0.1 | 10.0 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 0.3 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.1 | 0.7 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.1 | 1.0 | GO:1902936 | phosphatidylinositol bisphosphate binding(GO:1902936) |
| 0.1 | 0.7 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.1 | 1.6 | GO:0016638 | oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638) |
| 0.1 | 2.2 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.1 | 1.8 | GO:0016500 | protein-hormone receptor activity(GO:0016500) |
| 0.1 | 0.9 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 0.1 | 1.2 | GO:0050780 | dopamine receptor binding(GO:0050780) |
| 0.1 | 0.3 | GO:0004924 | oncostatin-M receptor activity(GO:0004924) |
| 0.1 | 0.5 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.1 | 1.8 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.1 | 0.3 | GO:0047150 | betaine-homocysteine S-methyltransferase activity(GO:0047150) |
| 0.1 | 0.7 | GO:0016670 | oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) |
| 0.1 | 1.4 | GO:0005391 | sodium:potassium-exchanging ATPase activity(GO:0005391) |
| 0.1 | 0.4 | GO:0005078 | MAP-kinase scaffold activity(GO:0005078) |
| 0.1 | 0.5 | GO:0017096 | acetylserotonin O-methyltransferase activity(GO:0017096) |
| 0.1 | 0.7 | GO:0001968 | fibronectin binding(GO:0001968) |
| 0.1 | 1.3 | GO:0000339 | RNA cap binding(GO:0000339) |
| 0.1 | 1.3 | GO:0032393 | MHC class I receptor activity(GO:0032393) |
| 0.1 | 1.4 | GO:0004908 | interleukin-1 receptor activity(GO:0004908) |
| 0.1 | 0.3 | GO:0008424 | glycoprotein 6-alpha-L-fucosyltransferase activity(GO:0008424) alpha-(1->6)-fucosyltransferase activity(GO:0046921) |
| 0.1 | 0.5 | GO:0015307 | drug:proton antiporter activity(GO:0015307) |
| 0.1 | 8.6 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 0.3 | GO:0004605 | phosphatidate cytidylyltransferase activity(GO:0004605) |
| 0.1 | 4.3 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.1 | 2.8 | GO:0015485 | cholesterol binding(GO:0015485) |
| 0.1 | 1.9 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.1 | 0.2 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.1 | 1.5 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.1 | 0.6 | GO:0003847 | 1-alkyl-2-acetylglycerophosphocholine esterase activity(GO:0003847) |
| 0.1 | 0.2 | GO:0004566 | beta-glucuronidase activity(GO:0004566) |
| 0.1 | 0.4 | GO:0004741 | magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724) [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.1 | 0.3 | GO:0008420 | CTD phosphatase activity(GO:0008420) |
| 0.1 | 0.1 | GO:0004439 | phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity(GO:0004439) phosphatidylinositol phosphate 5-phosphatase activity(GO:0034595) |
| 0.1 | 0.3 | GO:0017069 | snRNA binding(GO:0017069) |
| 0.1 | 1.6 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.1 | 1.8 | GO:0031418 | L-ascorbic acid binding(GO:0031418) |
| 0.1 | 0.2 | GO:0034236 | protein kinase A catalytic subunit binding(GO:0034236) |
| 0.1 | 0.4 | GO:0005534 | galactose binding(GO:0005534) |
| 0.1 | 0.4 | GO:0034187 | obsolete apolipoprotein E binding(GO:0034187) |
| 0.1 | 0.9 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
| 0.1 | 0.1 | GO:0032795 | heterotrimeric G-protein binding(GO:0032795) |
| 0.1 | 0.3 | GO:0004466 | long-chain-acyl-CoA dehydrogenase activity(GO:0004466) |
| 0.1 | 0.3 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.1 | 0.4 | GO:0052658 | lipid phosphatase activity(GO:0042577) inositol-1,4,5-trisphosphate 5-phosphatase activity(GO:0052658) inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity(GO:0052659) |
| 0.1 | 2.1 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 0.2 | GO:0003980 | UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980) |
| 0.1 | 0.7 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.1 | 0.2 | GO:0004719 | protein-L-isoaspartate (D-aspartate) O-methyltransferase activity(GO:0004719) |
| 0.1 | 0.3 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.1 | 0.4 | GO:0017110 | nucleoside-diphosphatase activity(GO:0017110) |
| 0.1 | 0.4 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
| 0.1 | 0.4 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.1 | 0.6 | GO:0030346 | protein phosphatase 2B binding(GO:0030346) |
| 0.1 | 0.6 | GO:0015355 | secondary active monocarboxylate transmembrane transporter activity(GO:0015355) |
| 0.1 | 0.8 | GO:0034483 | heparan sulfate sulfotransferase activity(GO:0034483) |
| 0.1 | 0.3 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.1 | 0.2 | GO:0033765 | 3-oxo-5-alpha-steroid 4-dehydrogenase activity(GO:0003865) steroid dehydrogenase activity, acting on the CH-CH group of donors(GO:0033765) |
| 0.1 | 0.7 | GO:0016861 | intramolecular oxidoreductase activity, interconverting aldoses and ketoses(GO:0016861) |
| 0.1 | 0.2 | GO:0034481 | chondroitin sulfotransferase activity(GO:0034481) |
| 0.1 | 0.5 | GO:0043236 | laminin binding(GO:0043236) |
| 0.1 | 0.1 | GO:0070815 | peptidyl-lysine 5-dioxygenase activity(GO:0070815) |
| 0.1 | 0.7 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.1 | 0.2 | GO:0016748 | succinyltransferase activity(GO:0016748) |
| 0.1 | 5.0 | GO:0005178 | integrin binding(GO:0005178) |
| 0.1 | 0.5 | GO:0034713 | type I transforming growth factor beta receptor binding(GO:0034713) |
| 0.1 | 0.3 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.1 | 0.3 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 0.0 | 1.5 | GO:0019003 | GDP binding(GO:0019003) |
| 0.0 | 0.3 | GO:0008157 | protein phosphatase 1 binding(GO:0008157) |
| 0.0 | 2.1 | GO:0032947 | protein complex scaffold(GO:0032947) |
| 0.0 | 1.2 | GO:0004385 | guanylate kinase activity(GO:0004385) |
| 0.0 | 0.1 | GO:0003845 | 11-beta-hydroxysteroid dehydrogenase [NAD(P)] activity(GO:0003845) |
| 0.0 | 0.1 | GO:0010861 | thyroid hormone receptor activator activity(GO:0010861) thyroid hormone receptor coactivator activity(GO:0030375) |
| 0.0 | 4.2 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.1 | GO:0004477 | methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) |
| 0.0 | 0.5 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.0 | 0.9 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 13.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
| 0.0 | 4.1 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.0 | 0.5 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.0 | 0.3 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
| 0.0 | 0.1 | GO:0005547 | phosphatidylinositol-3,4,5-trisphosphate binding(GO:0005547) |
| 0.0 | 0.2 | GO:0008967 | phosphoglycolate phosphatase activity(GO:0008967) |
| 0.0 | 0.2 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
| 0.0 | 0.2 | GO:0015057 | thrombin receptor activity(GO:0015057) |
| 0.0 | 0.6 | GO:0015347 | sodium-independent organic anion transmembrane transporter activity(GO:0015347) |
| 0.0 | 0.2 | GO:0004064 | arylesterase activity(GO:0004064) |
| 0.0 | 0.0 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.0 | 0.5 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.0 | 0.4 | GO:0005338 | nucleotide-sugar transmembrane transporter activity(GO:0005338) |
| 0.0 | 0.7 | GO:0043499 | obsolete eukaryotic cell surface binding(GO:0043499) |
| 0.0 | 1.0 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.0 | 0.2 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
| 0.0 | 0.4 | GO:0047760 | butyrate-CoA ligase activity(GO:0047760) |
| 0.0 | 0.1 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.0 | 0.1 | GO:0008138 | protein tyrosine/serine/threonine phosphatase activity(GO:0008138) |
| 0.0 | 0.1 | GO:0016297 | oleoyl-[acyl-carrier-protein] hydrolase activity(GO:0004320) myristoyl-[acyl-carrier-protein] hydrolase activity(GO:0016295) palmitoyl-[acyl-carrier-protein] hydrolase activity(GO:0016296) acyl-[acyl-carrier-protein] hydrolase activity(GO:0016297) S-acetyltransferase activity(GO:0016418) |
| 0.0 | 0.8 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
| 0.0 | 0.3 | GO:0016717 | oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water(GO:0016717) |
| 0.0 | 0.2 | GO:0043539 | protein serine/threonine kinase activator activity(GO:0043539) |
| 0.0 | 0.4 | GO:0030275 | LRR domain binding(GO:0030275) |
| 0.0 | 0.4 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 0.7 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.0 | 2.7 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 0.7 | GO:0046961 | proton-transporting ATPase activity, rotational mechanism(GO:0046961) |
| 0.0 | 0.5 | GO:0017075 | syntaxin-1 binding(GO:0017075) |
| 0.0 | 1.0 | GO:0008408 | 3'-5' exonuclease activity(GO:0008408) |
| 0.0 | 0.1 | GO:0004980 | melanocyte-stimulating hormone receptor activity(GO:0004980) |
| 0.0 | 0.1 | GO:0004803 | transposase activity(GO:0004803) |
| 0.0 | 0.2 | GO:0019211 | phosphatase activator activity(GO:0019211) |
| 0.0 | 0.4 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.3 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) |
| 0.0 | 1.5 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 0.2 | GO:0050811 | GABA receptor binding(GO:0050811) |
| 0.0 | 9.8 | GO:0003779 | actin binding(GO:0003779) |
| 0.0 | 0.7 | GO:0004198 | calcium-dependent cysteine-type endopeptidase activity(GO:0004198) |
| 0.0 | 0.1 | GO:0017057 | 6-phosphogluconolactonase activity(GO:0017057) |
| 0.0 | 1.4 | GO:0046332 | SMAD binding(GO:0046332) |
| 0.0 | 0.1 | GO:0016004 | phospholipase activator activity(GO:0016004) lipase activator activity(GO:0060229) |
| 0.0 | 1.0 | GO:0019955 | cytokine binding(GO:0019955) |
| 0.0 | 0.2 | GO:0001228 | transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
| 0.0 | 0.4 | GO:0070742 | C2H2 zinc finger domain binding(GO:0070742) |
| 0.0 | 0.2 | GO:0046790 | virion binding(GO:0046790) |
| 0.0 | 0.7 | GO:0051219 | phosphoprotein binding(GO:0051219) |
| 0.0 | 1.1 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 3.9 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.3 | GO:0004653 | polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653) |
| 0.0 | 0.1 | GO:0004738 | pyruvate dehydrogenase activity(GO:0004738) pyruvate dehydrogenase (acetyl-transferring) activity(GO:0004739) |
| 0.0 | 0.1 | GO:0030955 | potassium ion binding(GO:0030955) |
| 0.0 | 0.4 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.0 | 0.1 | GO:0004339 | glucan 1,4-alpha-glucosidase activity(GO:0004339) |
| 0.0 | 0.1 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390) |
| 0.0 | 0.1 | GO:0004817 | cysteine-tRNA ligase activity(GO:0004817) |
| 0.0 | 1.0 | GO:0016811 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides(GO:0016811) |
| 0.0 | 0.1 | GO:0015279 | store-operated calcium channel activity(GO:0015279) |
| 0.0 | 0.2 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.0 | 0.7 | GO:0097472 | cyclin-dependent protein serine/threonine kinase activity(GO:0004693) cyclin-dependent protein kinase activity(GO:0097472) |
| 0.0 | 0.7 | GO:0004869 | cysteine-type endopeptidase inhibitor activity(GO:0004869) |
| 0.0 | 1.9 | GO:0004725 | protein tyrosine phosphatase activity(GO:0004725) |
| 0.0 | 0.1 | GO:0017050 | sphinganine kinase activity(GO:0008481) D-erythro-sphingosine kinase activity(GO:0017050) |
| 0.0 | 0.1 | GO:0005087 | Ran guanyl-nucleotide exchange factor activity(GO:0005087) |
| 0.0 | 0.2 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.0 | 0.1 | GO:0043395 | heparan sulfate proteoglycan binding(GO:0043395) |
| 0.0 | 0.1 | GO:0004972 | NMDA glutamate receptor activity(GO:0004972) |
| 0.0 | 0.1 | GO:0030170 | pyridoxal phosphate binding(GO:0030170) |
| 0.0 | 0.1 | GO:0048365 | Rac GTPase binding(GO:0048365) |
| 0.0 | 1.9 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 0.3 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.1 | GO:0003873 | 6-phosphofructo-2-kinase activity(GO:0003873) |
| 0.0 | 0.1 | GO:0046980 | oligopeptide-transporting ATPase activity(GO:0015421) tapasin binding(GO:0046980) |
| 0.0 | 0.0 | GO:0004594 | pantothenate kinase activity(GO:0004594) |
| 0.0 | 0.2 | GO:0045182 | translation regulator activity(GO:0045182) |
| 0.0 | 0.1 | GO:0017169 | CDP-alcohol phosphatidyltransferase activity(GO:0017169) |
| 0.0 | 0.1 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
| 0.0 | 0.1 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 7.9 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.2 | 4.8 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 10.3 | ST_FAS_SIGNALING_PATHWAY | Fas Signaling Pathway |
| 0.0 | 0.4 | ST_IL_13_PATHWAY | Interleukin 13 (IL-13) Pathway |
| 0.0 | 0.3 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
| 0.0 | 3.4 | ST_INTEGRIN_SIGNALING_PATHWAY | Integrin Signaling Pathway |
| 0.0 | 0.6 | ST_GAQ_PATHWAY | G alpha q Pathway |
| 0.0 | 0.2 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |
| 0.0 | 0.1 | SA_PTEN_PATHWAY | PTEN is a tumor suppressor that dephosphorylates the lipid messenger phosphatidylinositol triphosphate. |
| 0.0 | 0.2 | ST_GA12_PATHWAY | G alpha 12 Pathway |
