Motif ID: HMBOX1
Z-value: 1.588
Transcription factors associated with HMBOX1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| HMBOX1 | ENSG00000147421.13 | HMBOX1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.6 | GO:0021837 | motogenic signaling involved in postnatal olfactory bulb interneuron migration(GO:0021837) regulation of mesodermal cell fate specification(GO:0042661) lateral mesodermal cell fate commitment(GO:0048372) lateral mesodermal cell fate specification(GO:0048377) regulation of lateral mesodermal cell fate specification(GO:0048378) regulation of mesoderm development(GO:2000380) |
| 0.8 | 2.5 | GO:0071380 | cellular response to prostaglandin E stimulus(GO:0071380) |
| 0.8 | 2.5 | GO:0034036 | purine ribonucleoside bisphosphate biosynthetic process(GO:0034036) 3'-phosphoadenosine 5'-phosphosulfate biosynthetic process(GO:0050428) |
| 0.4 | 1.3 | GO:0090598 | male genitalia morphogenesis(GO:0048808) lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) male anatomical structure morphogenesis(GO:0090598) |
| 0.3 | 1.4 | GO:0008065 | establishment of blood-nerve barrier(GO:0008065) |
| 0.3 | 1.4 | GO:2000008 | regulation of protein localization to cell surface(GO:2000008) |
| 0.3 | 1.2 | GO:0031340 | positive regulation of vesicle fusion(GO:0031340) |
| 0.3 | 1.6 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.2 | 0.9 | GO:0032780 | negative regulation of ATPase activity(GO:0032780) |
| 0.2 | 0.5 | GO:0019731 | antibacterial humoral response(GO:0019731) |
| 0.1 | 2.1 | GO:0060391 | positive regulation of SMAD protein import into nucleus(GO:0060391) |
| 0.1 | 4.7 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
| 0.1 | 0.6 | GO:0007389 | pattern specification process(GO:0007389) |
| 0.1 | 0.9 | GO:0050847 | progesterone receptor signaling pathway(GO:0050847) |
| 0.1 | 0.6 | GO:0042693 | muscle cell fate commitment(GO:0042693) |
| 0.1 | 0.6 | GO:0060261 | positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144) |
| 0.1 | 0.2 | GO:0034770 | histone H4-K20 methylation(GO:0034770) |
| 0.1 | 0.8 | GO:0009650 | UV protection(GO:0009650) |
| 0.1 | 0.5 | GO:0001554 | luteolysis(GO:0001554) |
| 0.1 | 2.0 | GO:0048286 | lung alveolus development(GO:0048286) |
| 0.1 | 0.2 | GO:0010966 | regulation of phosphate transport(GO:0010966) |
| 0.0 | 1.3 | GO:0034199 | activation of protein kinase A activity(GO:0034199) |
| 0.0 | 0.1 | GO:0032074 | negative regulation of nuclease activity(GO:0032074) |
| 0.0 | 0.5 | GO:0007216 | G-protein coupled glutamate receptor signaling pathway(GO:0007216) |
| 0.0 | 0.2 | GO:0015824 | proline transport(GO:0015824) |
| 0.0 | 0.1 | GO:0019441 | tryptophan catabolic process to kynurenine(GO:0019441) |
| 0.0 | 1.7 | GO:0045445 | myoblast differentiation(GO:0045445) |
| 0.0 | 0.2 | GO:0018106 | peptidyl-histidine phosphorylation(GO:0018106) |
| 0.0 | 0.2 | GO:0032007 | negative regulation of TOR signaling(GO:0032007) |
| 0.0 | 1.5 | GO:1900181 | negative regulation of protein import into nucleus(GO:0042308) negative regulation of protein localization to nucleus(GO:1900181) negative regulation of protein import(GO:1904590) |
| 0.0 | 1.3 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.0 | 1.5 | GO:0006941 | striated muscle contraction(GO:0006941) |
| 0.0 | 0.1 | GO:0051102 | DNA ligation involved in DNA recombination(GO:0051102) |
| 0.0 | 1.4 | GO:0001764 | neuron migration(GO:0001764) |
| 0.0 | 1.2 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 0.2 | GO:0050812 | acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812) |
| 0.0 | 0.8 | GO:0042384 | cilium assembly(GO:0042384) |
| 0.0 | 0.9 | GO:0008156 | negative regulation of DNA replication(GO:0008156) |
| 0.0 | 0.1 | GO:0042448 | progesterone metabolic process(GO:0042448) |
| 0.0 | 0.5 | GO:0008589 | regulation of smoothened signaling pathway(GO:0008589) |
| 0.0 | 1.2 | GO:0030049 | muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275) |
| 0.0 | 0.3 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 0.2 | GO:0000301 | retrograde transport, vesicle recycling within Golgi(GO:0000301) |
| 0.0 | 2.5 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.0 | 0.3 | GO:0007257 | activation of JUN kinase activity(GO:0007257) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.7 | GO:0060171 | stereocilium membrane(GO:0060171) |
| 0.1 | 1.5 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 1.0 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.1 | 0.9 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
| 0.1 | 0.8 | GO:0034464 | BBSome(GO:0034464) |
| 0.1 | 4.2 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
| 0.0 | 1.1 | GO:0005861 | troponin complex(GO:0005861) |
| 0.0 | 1.2 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 1.3 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 0.5 | GO:0042589 | phagocytic vesicle membrane(GO:0030670) zymogen granule membrane(GO:0042589) |
| 0.0 | 0.8 | GO:0005862 | muscle thin filament tropomyosin(GO:0005862) |
| 0.0 | 0.3 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.0 | 1.1 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 0.6 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
| 0.0 | 4.6 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 0.3 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 0.5 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 0.3 | GO:0070822 | Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822) |
| 0.0 | 1.3 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 0.7 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.4 | GO:0030530 | obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530) |
| 0.0 | 0.2 | GO:0005890 | sodium:potassium-exchanging ATPase complex(GO:0005890) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 2.5 | GO:0004781 | adenylylsulfate kinase activity(GO:0004020) sulfate adenylyltransferase activity(GO:0004779) sulfate adenylyltransferase (ATP) activity(GO:0004781) |
| 0.3 | 1.2 | GO:0019834 | phospholipase A2 inhibitor activity(GO:0019834) |
| 0.3 | 2.6 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.3 | 1.3 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 0.1 | 0.6 | GO:0033829 | O-fucosylpeptide 3-beta-N-acetylglucosaminyltransferase activity(GO:0033829) |
| 0.1 | 1.9 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.1 | 1.5 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.1 | 3.5 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 2.2 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.1 | 1.4 | GO:0003706 | obsolete ligand-regulated transcription factor activity(GO:0003706) |
| 0.1 | 1.3 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 1.2 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093) |
| 0.1 | 1.6 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 0.9 | GO:0044548 | S100 protein binding(GO:0044548) |
| 0.1 | 0.2 | GO:0003980 | UDP-glucose:glycoprotein glucosyltransferase activity(GO:0003980) |
| 0.1 | 2.7 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.1 | 2.0 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.1 | 0.2 | GO:0042799 | histone methyltransferase activity (H4-K20 specific)(GO:0042799) |
| 0.0 | 2.4 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.0 | 0.2 | GO:0004741 | magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724) [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.0 | 0.2 | GO:0004740 | pyruvate dehydrogenase (acetyl-transferring) kinase activity(GO:0004740) |
| 0.0 | 1.6 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 0.1 | GO:0004833 | tryptophan 2,3-dioxygenase activity(GO:0004833) |
| 0.0 | 0.6 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
| 0.0 | 0.6 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 4.7 | GO:0031625 | ubiquitin protein ligase binding(GO:0031625) ubiquitin-like protein ligase binding(GO:0044389) |
| 0.0 | 0.5 | GO:0030553 | cGMP binding(GO:0030553) |
| 0.0 | 0.2 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.0 | 0.3 | GO:0016565 | obsolete general transcriptional repressor activity(GO:0016565) |
| 0.0 | 0.2 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.0 | 0.3 | GO:0016805 | dipeptidase activity(GO:0016805) |
| 0.0 | 0.4 | GO:0003727 | single-stranded RNA binding(GO:0003727) |
| 0.0 | 0.3 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.0 | 0.1 | GO:0003910 | DNA ligase activity(GO:0003909) DNA ligase (ATP) activity(GO:0003910) |
| 0.0 | 0.2 | GO:0005328 | neurotransmitter:sodium symporter activity(GO:0005328) |
| 0.0 | 0.1 | GO:0003906 | DNA-(apurinic or apyrimidinic site) lyase activity(GO:0003906) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.3 | ST_ADRENERGIC | Adrenergic Pathway |
