Motif ID: HNF1A_HNF1B

Z-value: 6.240

Transcription factors associated with HNF1A_HNF1B:

Gene SymbolEntrez IDGene Name
HNF1A ENSG00000135100.13 HNF1A
HNF1B ENSG00000108753.8 HNF1B






Network of associatons between targets according to the STRING database.



First level regulatory network of HNF1A_HNF1B

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_74301880 66.795 ENST00000395792.2
ENST00000226359.2
AFP

alpha-fetoprotein

chr17_-_64225508 41.879 ENST00000205948.6
APOH
apolipoprotein H (beta-2-glycoprotein I)
chrX_-_105282712 27.111 ENST00000372563.1
SERPINA7
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7
chr9_-_123812542 25.504 ENST00000223642.1
C5
complement component 5
chr4_-_110723335 22.700 ENST00000394634.2
CFI
complement factor I
chr4_-_155511887 22.563 ENST00000302053.3
ENST00000403106.3
FGA

fibrinogen alpha chain

chr4_-_110723194 22.184 ENST00000394635.3
CFI
complement factor I
chr4_-_110723134 22.137 ENST00000510800.1
ENST00000512148.1
CFI

complement factor I

chr14_-_94854926 18.802 ENST00000402629.1
ENST00000556091.1
ENST00000554720.1
SERPINA1


serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 1


chr10_+_5135981 17.365 ENST00000380554.3
AKR1C3
aldo-keto reductase family 1, member C3
chr4_+_155484155 16.664 ENST00000509493.1
FGB
fibrinogen beta chain
chr4_+_74269956 16.549 ENST00000295897.4
ENST00000415165.2
ENST00000503124.1
ENST00000509063.1
ENST00000401494.3
ALB




albumin




chr19_-_36304201 16.521 ENST00000301175.3
PRODH2
proline dehydrogenase (oxidase) 2
chr7_+_45927956 16.156 ENST00000275525.3
ENST00000457280.1
IGFBP1

insulin-like growth factor binding protein 1

chr19_+_11350278 15.644 ENST00000252453.8
C19orf80
chromosome 19 open reading frame 80
chr7_+_45928079 15.503 ENST00000468955.1
IGFBP1
insulin-like growth factor binding protein 1
chr1_+_207277590 15.297 ENST00000367070.3
C4BPA
complement component 4 binding protein, alpha
chr15_+_58724184 15.222 ENST00000433326.2
LIPC
lipase, hepatic
chr10_+_101542462 14.699 ENST00000370449.4
ENST00000370434.1
ABCC2

ATP-binding cassette, sub-family C (CFTR/MRP), member 2

chr4_-_69817481 13.712 ENST00000251566.4
UGT2A3
UDP glucuronosyltransferase 2 family, polypeptide A3
chr14_-_94759595 13.662 ENST00000261994.4
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr5_+_176513868 13.451 ENST00000292408.4
FGFR4
fibroblast growth factor receptor 4
chr14_-_94759361 13.284 ENST00000393096.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr14_-_94759408 13.057 ENST00000554723.1
SERPINA10
serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 10
chr2_-_88427568 12.752 ENST00000393750.3
ENST00000295834.3
FABP1

fatty acid binding protein 1, liver

chr8_-_17752996 12.715 ENST00000381841.2
ENST00000427924.1
FGL1

fibrinogen-like 1

chr4_+_155484103 12.589 ENST00000302068.4
FGB
fibrinogen beta chain
chr5_+_176513895 12.059 ENST00000503708.1
ENST00000393648.2
ENST00000514472.1
ENST00000502906.1
ENST00000292410.3
ENST00000510911.1
FGFR4





fibroblast growth factor receptor 4





chr4_+_100495864 11.628 ENST00000265517.5
ENST00000422897.2
MTTP

microsomal triglyceride transfer protein

chr14_+_21156915 11.382 ENST00000397990.4
ENST00000555597.1
ANG
RNASE4
angiogenin, ribonuclease, RNase A family, 5
ribonuclease, RNase A family, 4
chr1_+_207262170 9.860 ENST00000367078.3
C4BPB
complement component 4 binding protein, beta
chr6_+_7541845 8.951 ENST00000418664.2
DSP
desmoplakin
chr7_-_50633078 8.799 ENST00000444124.2
DDC
dopa decarboxylase (aromatic L-amino acid decarboxylase)
chr12_+_100867486 8.666 ENST00000548884.1
NR1H4
nuclear receptor subfamily 1, group H, member 4
chr6_-_25930819 8.610 ENST00000360488.3
SLC17A2
solute carrier family 17, member 2
chr19_+_50016610 8.399 ENST00000596975.1
FCGRT
Fc fragment of IgG, receptor, transporter, alpha
chr6_-_25930904 8.022 ENST00000377850.3
SLC17A2
solute carrier family 17, member 2
chr11_+_46740730 7.875 ENST00000311907.5
ENST00000530231.1
ENST00000442468.1
F2


coagulation factor II (thrombin)


chr17_+_1646130 7.652 ENST00000453066.1
ENST00000324015.3
ENST00000450523.2
ENST00000453723.1
ENST00000382061.4
SERPINF2




serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 2




chr1_+_207262881 7.583 ENST00000451804.2
C4BPB
complement component 4 binding protein, beta
chr17_+_41052808 6.856 ENST00000592383.1
ENST00000253801.2
ENST00000585489.1
G6PC


glucose-6-phosphatase, catalytic subunit


chr14_-_65409438 6.704 ENST00000557049.1
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr1_+_207262627 6.641 ENST00000391923.1
C4BPB
complement component 4 binding protein, beta
chr22_-_30970560 6.632 ENST00000402369.1
ENST00000406361.1
GAL3ST1

galactose-3-O-sulfotransferase 1

chr6_+_167704798 6.577 ENST00000230256.3
UNC93A
unc-93 homolog A (C. elegans)
chr19_+_50016411 6.508 ENST00000426395.3
ENST00000600273.1
ENST00000599988.1
FCGRT


Fc fragment of IgG, receptor, transporter, alpha


chr6_+_167704838 6.504 ENST00000366829.2
UNC93A
unc-93 homolog A (C. elegans)
chr1_+_207262578 6.392 ENST00000243611.5
ENST00000367076.3
C4BPB

complement component 4 binding protein, beta

chr17_+_79953310 6.336 ENST00000582355.2
ASPSCR1
alveolar soft part sarcoma chromosome region, candidate 1
chr10_-_52645379 6.266 ENST00000395489.2
A1CF
APOBEC1 complementation factor
chr12_+_100867694 6.262 ENST00000392986.3
ENST00000549996.1
NR1H4

nuclear receptor subfamily 1, group H, member 4

chr10_-_52645416 6.115 ENST00000374001.2
ENST00000373997.3
ENST00000373995.3
ENST00000282641.2
ENST00000395495.1
ENST00000414883.1
A1CF





APOBEC1 complementation factor





chr14_-_65409502 5.957 ENST00000389614.5
GPX2
glutathione peroxidase 2 (gastrointestinal)
chr14_+_95027772 5.860 ENST00000555095.1
ENST00000298841.5
ENST00000554220.1
ENST00000553780.1
SERPINA4

SERPINA5

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 4

serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 5

chr4_+_187187098 5.786 ENST00000403665.2
ENST00000264692.4
F11

coagulation factor XI

chr2_+_27719697 5.421 ENST00000264717.2
ENST00000424318.2
GCKR

glucokinase (hexokinase 4) regulator

chr8_+_21911054 5.416 ENST00000519850.1
ENST00000381470.3
DMTN

dematin actin binding protein

chr7_-_44580861 5.303 ENST00000546276.1
ENST00000289547.4
ENST00000381160.3
ENST00000423141.1
NPC1L1



NPC1-like 1



chr16_-_87970122 5.221 ENST00000309893.2
CA5A
carbonic anhydrase VA, mitochondrial
chr20_+_35973080 5.141 ENST00000445403.1
SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr5_+_175976324 5.051 ENST00000261944.5
CDHR2
cadherin-related family member 2
chr14_+_39703084 4.957 ENST00000553728.1
RP11-407N17.3
cTAGE family member 5 isoform 4
chr17_-_202579 4.860 ENST00000577079.1
ENST00000331302.7
ENST00000536489.2
RPH3AL


rabphilin 3A-like (without C2 domains)


chr1_+_17906970 4.350 ENST00000375415.1
ARHGEF10L
Rho guanine nucleotide exchange factor (GEF) 10-like
chr12_+_100897130 4.167 ENST00000551379.1
ENST00000188403.7
ENST00000551184.1
NR1H4


nuclear receptor subfamily 1, group H, member 4


chr12_+_70132632 3.673 ENST00000378815.6
ENST00000483530.2
ENST00000325555.9
RAB3IP


RAB3A interacting protein


chr16_+_20775358 3.584 ENST00000440284.2
ACSM3
acyl-CoA synthetase medium-chain family member 3
chr11_-_117695449 3.533 ENST00000292079.2
FXYD2
FXYD domain containing ion transport regulator 2
chr2_-_55920952 3.315 ENST00000447944.2
PNPT1
polyribonucleotide nucleotidyltransferase 1
chr7_-_47579188 3.300 ENST00000398879.1
ENST00000355730.3
ENST00000442536.2
ENST00000458317.2
TNS3



tensin 3



chr2_-_162931052 3.293 ENST00000360534.3
DPP4
dipeptidyl-peptidase 4
chr6_+_161123270 3.258 ENST00000366924.2
ENST00000308192.9
ENST00000418964.1
PLG


plasminogen


chr16_+_20775024 3.223 ENST00000289416.5
ACSM3
acyl-CoA synthetase medium-chain family member 3
chr21_-_47575481 3.149 ENST00000291670.5
ENST00000397748.1
ENST00000359679.2
ENST00000355384.2
ENST00000397746.3
ENST00000397743.1
FTCD





formimidoyltransferase cyclodeaminase





chr14_+_24590560 3.105 ENST00000558325.1
RP11-468E2.6
RP11-468E2.6
chr4_+_8201091 3.059 ENST00000382521.3
ENST00000245105.3
ENST00000457650.2
ENST00000539824.1
SH3TC1



SH3 domain and tetratricopeptide repeats 1



chr22_-_30968813 3.013 ENST00000443111.2
ENST00000443136.1
ENST00000426220.1
GAL3ST1


galactose-3-O-sulfotransferase 1


chr16_+_20462783 2.856 ENST00000574251.1
ENST00000576361.1
ENST00000417235.2
ENST00000573854.1
ENST00000424070.1
ENST00000536134.1
ENST00000219054.6
ENST00000575690.1
ENST00000571894.1
ACSM2A








acyl-CoA synthetase medium-chain family member 2A








chr2_-_169104651 2.839 ENST00000355999.4
STK39
serine threonine kinase 39
chr16_-_20587599 2.753 ENST00000566384.1
ENST00000565232.1
ENST00000567001.1
ENST00000565322.1
ENST00000569344.1
ENST00000329697.6
ENST00000414188.2
ENST00000568882.1
ACSM2B







acyl-CoA synthetase medium-chain family member 2B







chr16_-_57831914 2.642 ENST00000421376.2
KIFC3
kinesin family member C3
chr6_-_52628271 2.535 ENST00000493422.1
GSTA2
glutathione S-transferase alpha 2
chr12_-_24102576 2.404 ENST00000537393.1
ENST00000309359.1
ENST00000381381.2
ENST00000451604.2
SOX5



SRY (sex determining region Y)-box 5



chr4_-_1166954 2.357 ENST00000514490.1
ENST00000431380.1
ENST00000503765.1
SPON2


spondin 2, extracellular matrix protein


chr17_+_41363854 2.261 ENST00000588693.1
ENST00000588659.1
ENST00000541594.1
ENST00000536052.1
ENST00000331615.3
TMEM106A




transmembrane protein 106A




chrX_+_107288197 2.214 ENST00000415430.3
VSIG1
V-set and immunoglobulin domain containing 1
chr10_-_72648541 2.213 ENST00000299299.3
PCBD1
pterin-4 alpha-carbinolamine dehydratase/dimerization cofactor of hepatocyte nuclear factor 1 alpha
chr1_-_110284384 2.161 ENST00000540225.1
GSTM3
glutathione S-transferase mu 3 (brain)
chr1_+_36789335 2.110 ENST00000373137.2
RP11-268J15.5
RP11-268J15.5
chr4_+_3443614 2.087 ENST00000382774.3
ENST00000511533.1
HGFAC

HGF activator

chr16_+_89696692 2.080 ENST00000261615.4
DPEP1
dipeptidase 1 (renal)
chr6_-_25874440 2.071 ENST00000361703.6
ENST00000397060.4
SLC17A3

solute carrier family 17 (organic anion transporter), member 3

chr16_-_15474904 2.022 ENST00000534094.1
NPIPA5
nuclear pore complex interacting protein family, member A5
chr12_+_70133152 1.903 ENST00000550536.1
ENST00000362025.5
RAB3IP

RAB3A interacting protein

chrX_+_107288239 1.832 ENST00000217957.5
VSIG1
V-set and immunoglobulin domain containing 1
chr1_+_57320437 1.693 ENST00000361249.3
C8A
complement component 8, alpha polypeptide
chr11_-_128894053 1.688 ENST00000392657.3
ARHGAP32
Rho GTPase activating protein 32
chr17_-_36904437 1.628 ENST00000585100.1
ENST00000360797.2
ENST00000578109.1
ENST00000579882.1
PCGF2



polycomb group ring finger 2



chr7_+_120629653 1.539 ENST00000450913.2
ENST00000340646.5
CPED1

cadherin-like and PC-esterase domain containing 1

chr4_-_166034029 1.460 ENST00000306480.6
TMEM192
transmembrane protein 192
chr1_+_229406847 1.325 ENST00000366690.4
RAB4A
RAB4A, member RAS oncogene family
chr16_-_57831676 1.299 ENST00000465878.2
ENST00000539578.1
ENST00000561524.1
KIFC3


kinesin family member C3


chrX_+_120181457 1.243 ENST00000328078.1
GLUD2
glutamate dehydrogenase 2
chr5_+_67586465 1.223 ENST00000336483.5
PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr1_-_20141763 1.209 ENST00000375121.2
RNF186
ring finger protein 186
chr9_-_98079965 1.069 ENST00000289081.3
FANCC
Fanconi anemia, complementation group C
chr3_-_49466686 1.002 ENST00000273598.3
ENST00000436744.2
NICN1

nicolin 1

chr20_+_62371206 1.002 ENST00000266077.2
SLC2A4RG
SLC2A4 regulator
chr17_+_48823896 0.967 ENST00000511974.1
LUC7L3
LUC7-like 3 (S. cerevisiae)
chr6_+_144904334 0.964 ENST00000367526.4
UTRN
utrophin
chr3_-_192445289 0.938 ENST00000430714.1
ENST00000418610.1
ENST00000448795.1
ENST00000445105.2
FGF12



fibroblast growth factor 12



chr4_+_39408470 0.833 ENST00000257408.4
KLB
klotho beta
chr19_+_54466179 0.804 ENST00000270458.2
CACNG8
calcium channel, voltage-dependent, gamma subunit 8
chr16_-_66952779 0.798 ENST00000570262.1
ENST00000394055.3
ENST00000299752.4
CDH16


cadherin 16, KSP-cadherin


chr11_+_20620946 0.776 ENST00000525748.1
SLC6A5
solute carrier family 6 (neurotransmitter transporter), member 5
chr11_+_1860200 0.717 ENST00000381911.1
TNNI2
troponin I type 2 (skeletal, fast)
chr20_+_45947246 0.665 ENST00000599904.1
AL031666.2
HCG2018772; Uncharacterized protein; cDNA FLJ31609 fis, clone NT2RI2002852
chr7_-_6098770 0.663 ENST00000536084.1
ENST00000446699.1
ENST00000199389.6
EIF2AK1


eukaryotic translation initiation factor 2-alpha kinase 1


chr2_-_47572105 0.629 ENST00000419035.1
ENST00000448713.1
ENST00000450550.1
ENST00000413185.2
AC073283.4



AC073283.4



chr16_-_66952742 0.604 ENST00000565235.2
ENST00000568632.1
ENST00000565796.1
CDH16


cadherin 16, KSP-cadherin


chr10_-_38146510 0.600 ENST00000395867.3
ZNF248
zinc finger protein 248
chr15_+_48498480 0.541 ENST00000380993.3
ENST00000396577.3
SLC12A1

solute carrier family 12 (sodium/potassium/chloride transporter), member 1

chr5_-_111093167 0.539 ENST00000446294.2
ENST00000419114.2
NREP

neuronal regeneration related protein

chr7_+_130126012 0.536 ENST00000341441.5
MEST
mesoderm specific transcript
chr20_+_57414743 0.520 ENST00000313949.7
GNAS
GNAS complex locus
chr9_-_215744 0.442 ENST00000382387.2
C9orf66
chromosome 9 open reading frame 66
chr2_-_228244013 0.395 ENST00000304568.3
TM4SF20
transmembrane 4 L six family member 20
chr19_-_11639931 0.384 ENST00000592312.1
ENST00000590480.1
ENST00000585318.1
ENST00000252440.7
ENST00000417981.2
ENST00000270517.7
ECSIT





ECSIT signalling integrator





chr19_-_11639910 0.374 ENST00000588998.1
ENST00000586149.1
ECSIT

ECSIT signalling integrator

chr7_+_130126165 0.290 ENST00000427521.1
ENST00000416162.2
ENST00000378576.4
MEST


mesoderm specific transcript


chr8_-_124749609 0.215 ENST00000262219.6
ENST00000419625.1
ANXA13

annexin A13

chr5_+_6714718 0.178 ENST00000230859.6
ENST00000515721.1
PAPD7

PAP associated domain containing 7

chr3_+_38307293 0.170 ENST00000311856.4
SLC22A13
solute carrier family 22 (organic anion/urate transporter), member 13
chr4_-_70518941 0.158 ENST00000286604.4
ENST00000505512.1
ENST00000514019.1
UGT2A1

UGT2A1
UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus

UDP glucuronosyltransferase 2 family, polypeptide A1, complex locus
chr20_+_57414795 0.157 ENST00000371098.2
ENST00000371075.3
GNAS

GNAS complex locus

chr7_+_152456904 0.149 ENST00000537264.1
ACTR3B
ARP3 actin-related protein 3 homolog B (yeast)
chr5_-_77844974 0.129 ENST00000515007.2
LHFPL2
lipoma HMGIC fusion partner-like 2
chr12_-_18243119 0.113 ENST00000538724.1
ENST00000229002.2
RERGL

RERG/RAS-like

chr10_+_115312766 0.110 ENST00000351270.3
HABP2
hyaluronan binding protein 2
chr13_+_96085847 0.074 ENST00000376873.3
CLDN10
claudin 10
chr13_-_41593425 0.055 ENST00000239882.3
ELF1
E74-like factor 1 (ets domain transcription factor)
chr7_+_152456829 0.047 ENST00000377776.3
ENST00000256001.8
ENST00000397282.2
ACTR3B


ARP3 actin-related protein 3 homolog B (yeast)


chr6_+_106534192 0.041 ENST00000369091.2
ENST00000369096.4
PRDM1

PR domain containing 1, with ZNF domain


Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
7.4 66.8 GO:0042448 progesterone metabolic process(GO:0042448)
6.4 25.5 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689)
6.1 60.7 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
5.5 16.5 GO:0001907 cytolysis by symbiont of host cells(GO:0001897) killing by symbiont of host cells(GO:0001907) hemolysis by symbiont of host erythrocytes(GO:0019836) disruption by symbiont of host cell(GO:0044004) hemolysis in other organism(GO:0044179) positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010) cytolysis in other organism(GO:0051715) cytolysis in other organism involved in symbiotic interaction(GO:0051801) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
4.7 18.8 GO:0033986 response to methanol(GO:0033986) response to chromate(GO:0046687)
4.1 12.4 GO:0016554 cytidine to uridine editing(GO:0016554)
4.0 40.0 GO:0060046 regulation of acrosome reaction(GO:0060046)
3.4 27.1 GO:0034695 response to prostaglandin E(GO:0034695)
3.2 12.7 GO:0009609 response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609)
2.8 16.5 GO:0006562 proline catabolic process(GO:0006562)
2.4 9.6 GO:0006682 galactosylceramide biosynthetic process(GO:0006682) galactolipid biosynthetic process(GO:0019375)
2.3 11.4 GO:0006651 diacylglycerol biosynthetic process(GO:0006651)
2.0 113.4 GO:0006958 complement activation, classical pathway(GO:0006958)
1.9 5.8 GO:0051919 positive regulation of fibrinolysis(GO:0051919)
1.8 8.9 GO:0015712 hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760)
1.5 13.3 GO:0034638 phosphatidylcholine catabolic process(GO:0034638)
1.3 5.1 GO:0033622 integrin activation(GO:0033622) regulation of integrin activation(GO:0033623) positive regulation of integrin activation(GO:0033625)
1.3 12.8 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
1.3 8.8 GO:0042416 dopamine biosynthetic process(GO:0042416)
1.1 5.4 GO:1903301 regulation of glucokinase activity(GO:0033131) positive regulation of glucokinase activity(GO:0033133) regulation of hexokinase activity(GO:1903299) positive regulation of hexokinase activity(GO:1903301)
1.0 3.1 GO:0052805 histidine catabolic process(GO:0006548) imidazole-containing compound catabolic process(GO:0052805)
1.0 3.9 GO:0045218 zonula adherens maintenance(GO:0045218)
0.8 3.3 GO:0010716 regulation of extracellular matrix disassembly(GO:0010715) negative regulation of extracellular matrix disassembly(GO:0010716) regulation of extracellular matrix organization(GO:1903053) negative regulation of extracellular matrix organization(GO:1903054)
0.7 5.6 GO:0006893 Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876)
0.6 29.9 GO:0042246 tissue regeneration(GO:0042246)
0.5 17.4 GO:0006693 prostaglandin metabolic process(GO:0006693)
0.5 2.2 GO:0008065 establishment of blood-nerve barrier(GO:0008065)
0.5 51.8 GO:0051592 response to calcium ion(GO:0051592)
0.5 2.4 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.4 1.2 GO:0006537 glutamate biosynthetic process(GO:0006537)
0.4 2.8 GO:0043268 positive regulation of potassium ion transport(GO:0043268)
0.4 5.3 GO:0030299 intestinal cholesterol absorption(GO:0030299) intestinal lipid absorption(GO:0098856)
0.4 2.2 GO:0006729 tetrahydrobiopterin biosynthetic process(GO:0006729)
0.3 4.9 GO:0017158 regulation of calcium ion-dependent exocytosis(GO:0017158)
0.3 17.1 GO:0008206 bile acid metabolic process(GO:0008206)
0.3 5.9 GO:0007342 fusion of sperm to egg plasma membrane(GO:0007342)
0.3 28.5 GO:0008543 fibroblast growth factor receptor signaling pathway(GO:0008543)
0.2 0.7 GO:0046984 regulation of hemoglobin biosynthetic process(GO:0046984)
0.2 14.9 GO:0019882 antigen processing and presentation(GO:0019882)
0.1 5.2 GO:0006730 one-carbon metabolic process(GO:0006730)
0.1 6.3 GO:0046324 regulation of glucose import(GO:0046324)
0.1 9.0 GO:0030216 keratinocyte differentiation(GO:0030216)
0.1 3.3 GO:0048286 lung alveolus development(GO:0048286)
0.1 9.2 GO:0042157 lipoprotein metabolic process(GO:0042157)
0.1 0.7 GO:0040032 post-embryonic body morphogenesis(GO:0040032)
0.1 10.5 GO:0006814 sodium ion transport(GO:0006814)
0.0 2.5 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 1.0 GO:0001954 positive regulation of cell-matrix adhesion(GO:0001954)
0.0 0.8 GO:0051925 obsolete regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051925)
0.0 3.3 GO:0006402 mRNA catabolic process(GO:0006402)
0.0 7.3 GO:0015711 organic anion transport(GO:0015711)
0.0 1.6 GO:0048704 embryonic skeletal system morphogenesis(GO:0048704)
0.0 0.7 GO:0003009 skeletal muscle contraction(GO:0003009)
0.0 0.8 GO:0001707 mesoderm formation(GO:0001707)
0.0 2.9 GO:0030308 negative regulation of cell growth(GO:0030308)
0.0 2.0 GO:0008217 regulation of blood pressure(GO:0008217)
0.0 0.2 GO:0015695 organic cation transport(GO:0015695)
0.0 0.8 GO:0007498 mesoderm development(GO:0007498)
0.0 0.2 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 1.3 GO:0007265 Ras protein signal transduction(GO:0007265)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
5.9 64.5 GO:0005577 fibrinogen complex(GO:0005577)
4.1 12.4 GO:0030895 apolipoprotein B mRNA editing enzyme complex(GO:0030895)
3.0 27.2 GO:0005579 membrane attack complex(GO:0005579)
2.2 18.0 GO:0046581 intercellular canaliculus(GO:0046581)
2.1 12.8 GO:0045179 apical cortex(GO:0045179)
1.9 41.9 GO:0042627 chylomicron(GO:0042627)
1.9 11.4 GO:0032311 angiogenin-PRI complex(GO:0032311)
0.9 6.3 GO:0000300 obsolete peripheral to membrane of membrane fraction(GO:0000300)
0.8 3.3 GO:0031232 extrinsic component of external side of plasma membrane(GO:0031232)
0.8 9.0 GO:0005916 fascia adherens(GO:0005916)
0.6 14.9 GO:0042612 MHC class I protein complex(GO:0042612)
0.6 15.2 GO:0034364 high-density lipoprotein particle(GO:0034364)
0.5 35.2 GO:0031093 platelet alpha granule lumen(GO:0031093)
0.4 3.9 GO:0005915 zonula adherens(GO:0005915)
0.3 1.3 GO:0032593 insulin-responsive compartment(GO:0032593)
0.3 1.2 GO:0097651 phosphatidylinositol 3-kinase complex, class IA(GO:0005943) phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.3 7.9 GO:0005796 Golgi lumen(GO:0005796)
0.2 3.1 GO:0005890 sodium:potassium-exchanging ATPase complex(GO:0005890)
0.2 1.6 GO:0001739 sex chromatin(GO:0001739)
0.2 163.1 GO:0005615 extracellular space(GO:0005615)
0.1 5.6 GO:0036064 ciliary basal body(GO:0036064)
0.1 2.1 GO:0031528 microvillus membrane(GO:0031528)
0.1 11.6 GO:0005788 endoplasmic reticulum lumen(GO:0005788)
0.1 6.9 GO:0030176 integral component of endoplasmic reticulum membrane(GO:0030176)
0.1 3.1 GO:0005814 centriole(GO:0005814)
0.1 5.1 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.1 68.1 GO:0005576 extracellular region(GO:0005576)
0.1 1.8 GO:0031526 brush border membrane(GO:0031526)
0.1 3.3 GO:0005758 mitochondrial intermembrane space(GO:0005758)
0.1 14.0 GO:0005759 mitochondrial matrix(GO:0005759)
0.0 16.5 GO:0005743 mitochondrial inner membrane(GO:0005743)
0.0 4.9 GO:0030658 transport vesicle membrane(GO:0030658)
0.0 1.7 GO:0043197 dendritic spine(GO:0043197)
0.0 23.7 GO:0005624 obsolete membrane fraction(GO:0005624)
0.0 10.8 GO:0005625 obsolete soluble fraction(GO:0005625)
0.0 0.7 GO:0005861 troponin complex(GO:0005861)
0.0 6.1 GO:0030659 cytoplasmic vesicle membrane(GO:0030659)
0.0 3.3 GO:0005925 focal adhesion(GO:0005925)
0.0 1.5 GO:0005770 late endosome(GO:0005770)
0.0 19.9 GO:0005654 nucleoplasm(GO:0005654)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
8.4 41.9 GO:0060230 lipoprotein lipase activator activity(GO:0060230)
5.8 17.4 GO:0047718 indanol dehydrogenase activity(GO:0047718)
4.1 16.5 GO:0004657 proline dehydrogenase activity(GO:0004657)
3.7 14.9 GO:0030881 beta-2-microglobulin binding(GO:0030881)
3.2 12.8 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
2.6 25.5 GO:0005007 fibroblast growth factor-activated receptor activity(GO:0005007)
2.3 49.8 GO:0043499 obsolete eukaryotic cell surface binding(GO:0043499)
2.0 18.2 GO:0005436 sodium:phosphate symporter activity(GO:0005436)
1.7 6.9 GO:0004346 glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309)
1.5 16.5 GO:0015643 toxic substance binding(GO:0015643)
1.4 11.4 GO:0004522 ribonuclease A activity(GO:0004522)
1.4 9.6 GO:0001733 galactosylceramide sulfotransferase activity(GO:0001733) galactose 3-O-sulfotransferase activity(GO:0050694)
1.3 16.1 GO:0034185 apolipoprotein binding(GO:0034185)
1.3 64.8 GO:0005044 scavenger receptor activity(GO:0005044)
1.3 19.1 GO:0004887 thyroid hormone receptor activity(GO:0004887)
1.1 31.7 GO:0005520 insulin-like growth factor binding(GO:0005520)
1.1 12.4 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
1.0 5.9 GO:0032190 acrosin binding(GO:0032190)
0.9 11.3 GO:0015020 glucuronosyltransferase activity(GO:0015020)
0.9 93.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.8 7.9 GO:0070053 thrombospondin receptor activity(GO:0070053)
0.8 3.1 GO:0016841 ammonia-lyase activity(GO:0016841)
0.7 5.4 GO:0070095 fructose-6-phosphate binding(GO:0070095)
0.7 12.7 GO:0004602 glutathione peroxidase activity(GO:0004602)
0.7 5.3 GO:0008158 hedgehog receptor activity(GO:0008158)
0.6 2.2 GO:0004505 phenylalanine 4-monooxygenase activity(GO:0004505)
0.5 24.7 GO:0008009 chemokine activity(GO:0008009)
0.4 4.9 GO:0030274 LIM domain binding(GO:0030274)
0.4 12.4 GO:0019239 deaminase activity(GO:0019239)
0.3 5.2 GO:0004089 carbonate dehydratase activity(GO:0004089)
0.3 5.4 GO:0008239 dipeptidyl-peptidase activity(GO:0008239)
0.2 1.2 GO:0043559 insulin binding(GO:0043559)
0.2 3.5 GO:0005391 sodium:potassium-exchanging ATPase activity(GO:0005391)
0.2 0.7 GO:0004694 eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694)
0.2 3.3 GO:0000175 3'-5'-exoribonuclease activity(GO:0000175)
0.2 0.8 GO:0015187 glycine transmembrane transporter activity(GO:0015187) glycine:sodium symporter activity(GO:0015375)
0.2 8.8 GO:0016831 carboxy-lyase activity(GO:0016831)
0.2 4.7 GO:0004364 glutathione transferase activity(GO:0004364)
0.1 1.3 GO:0001671 ATPase activator activity(GO:0001671)
0.1 12.8 GO:0042626 ATPase activity, coupled to transmembrane movement of substances(GO:0042626)
0.1 5.1 GO:0042169 SH2 domain binding(GO:0042169)
0.1 9.7 GO:0005319 lipid transporter activity(GO:0005319)
0.1 1.2 GO:0016638 oxidoreductase activity, acting on the CH-NH2 group of donors(GO:0016638)
0.1 0.7 GO:0031852 mu-type opioid receptor binding(GO:0031852)
0.1 8.8 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.1 0.9 GO:0005104 fibroblast growth factor receptor binding(GO:0005104)
0.1 0.8 GO:0017134 fibroblast growth factor binding(GO:0017134)
0.1 0.7 GO:0031014 troponin T binding(GO:0031014)
0.0 3.9 GO:0003777 microtubule motor activity(GO:0003777)
0.0 8.0 GO:0004252 serine-type endopeptidase activity(GO:0004252)
0.0 0.5 GO:0015377 cation:chloride symporter activity(GO:0015377)
0.0 2.8 GO:0004702 receptor signaling protein serine/threonine kinase activity(GO:0004702)
0.0 6.3 GO:0005085 guanyl-nucleotide exchange factor activity(GO:0005085)
0.0 0.8 GO:0005245 voltage-gated calcium channel activity(GO:0005245)
0.0 1.7 GO:0035091 phosphatidylinositol binding(GO:0035091)
0.0 2.4 GO:0010843 obsolete promoter binding(GO:0010843)
0.0 0.2 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 31.7 ST_PHOSPHOINOSITIDE_3_KINASE_PATHWAY PI3K Pathway
0.5 11.0 ST_INTERLEUKIN_4_PATHWAY Interleukin 4 (IL-4) Pathway
0.2 7.9 ST_GA12_PATHWAY G alpha 12 Pathway
0.1 1.2 SIG_IL4RECEPTOR_IN_B_LYPHOCYTES Genes related to IL4 rceptor signaling in B lymphocytes