Motif ID: HOXA10_HOXB9
Z-value: 1.735
Transcription factors associated with HOXA10_HOXB9:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| HOXA10 | ENSG00000253293.3 | HOXA10 |
| HOXB9 | ENSG00000170689.8 | HOXB9 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 4.5 | GO:0043316 | natural killer cell activation involved in immune response(GO:0002323) cytotoxic T cell degranulation(GO:0043316) natural killer cell degranulation(GO:0043320) |
| 0.6 | 1.9 | GO:0019441 | tryptophan catabolic process to kynurenine(GO:0019441) |
| 0.4 | 1.1 | GO:0034720 | histone H3-K4 demethylation(GO:0034720) |
| 0.3 | 1.0 | GO:0006269 | DNA replication, synthesis of RNA primer(GO:0006269) |
| 0.2 | 1.0 | GO:0034310 | primary alcohol catabolic process(GO:0034310) |
| 0.2 | 1.2 | GO:0006216 | cytidine catabolic process(GO:0006216) cytidine deamination(GO:0009972) cytidine metabolic process(GO:0046087) |
| 0.2 | 2.4 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
| 0.2 | 1.4 | GO:0036037 | maintenance of cell polarity(GO:0030011) positive regulation of cell adhesion mediated by integrin(GO:0033630) CD8-positive, alpha-beta T cell activation(GO:0036037) CD8-positive, alpha-beta T cell differentiation(GO:0043374) |
| 0.2 | 0.8 | GO:0060025 | regulation of synaptic activity(GO:0060025) |
| 0.2 | 3.2 | GO:0006906 | vesicle fusion(GO:0006906) |
| 0.2 | 0.8 | GO:0090009 | primitive streak formation(GO:0090009) |
| 0.2 | 0.5 | GO:0002035 | brain renin-angiotensin system(GO:0002035) |
| 0.1 | 0.6 | GO:0019348 | polyprenol metabolic process(GO:0016093) dolichol metabolic process(GO:0019348) |
| 0.1 | 1.0 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.1 | 1.1 | GO:0023041 | neuronal signal transduction(GO:0023041) |
| 0.1 | 0.5 | GO:0009698 | phenylpropanoid metabolic process(GO:0009698) coumarin metabolic process(GO:0009804) |
| 0.1 | 0.5 | GO:0006207 | 'de novo' pyrimidine nucleobase biosynthetic process(GO:0006207) pyrimidine nucleobase biosynthetic process(GO:0019856) |
| 0.1 | 0.4 | GO:0007181 | transforming growth factor beta receptor complex assembly(GO:0007181) |
| 0.1 | 0.5 | GO:0010944 | negative regulation of transcription by competitive promoter binding(GO:0010944) |
| 0.1 | 0.4 | GO:0060398 | regulation of growth hormone receptor signaling pathway(GO:0060398) |
| 0.1 | 0.8 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
| 0.1 | 0.4 | GO:0071436 | sodium ion export(GO:0071436) |
| 0.1 | 0.3 | GO:0050917 | sensory perception of umami taste(GO:0050917) |
| 0.1 | 0.3 | GO:0002575 | basophil chemotaxis(GO:0002575) |
| 0.1 | 1.1 | GO:0045616 | regulation of keratinocyte differentiation(GO:0045616) |
| 0.1 | 0.4 | GO:0006857 | oligopeptide transport(GO:0006857) |
| 0.1 | 0.7 | GO:0045039 | protein import into mitochondrial inner membrane(GO:0045039) |
| 0.1 | 0.4 | GO:0032916 | transforming growth factor beta3 production(GO:0032907) regulation of transforming growth factor beta3 production(GO:0032910) positive regulation of transforming growth factor beta3 production(GO:0032916) |
| 0.1 | 0.4 | GO:0006196 | AMP catabolic process(GO:0006196) |
| 0.1 | 0.3 | GO:0060743 | epithelial cell maturation involved in prostate gland development(GO:0060743) |
| 0.1 | 0.8 | GO:0007141 | male meiosis I(GO:0007141) |
| 0.1 | 0.2 | GO:0002384 | hepatic immune response(GO:0002384) |
| 0.1 | 0.3 | GO:0034723 | DNA replication-dependent nucleosome organization(GO:0034723) |
| 0.1 | 0.2 | GO:0018283 | metal incorporation into metallo-sulfur cluster(GO:0018282) iron incorporation into metallo-sulfur cluster(GO:0018283) |
| 0.1 | 0.2 | GO:0060164 | regulation of timing of neuron differentiation(GO:0060164) |
| 0.1 | 0.6 | GO:0046784 | viral mRNA export from host cell nucleus(GO:0046784) |
| 0.1 | 1.1 | GO:0000380 | alternative mRNA splicing, via spliceosome(GO:0000380) |
| 0.1 | 0.2 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780) |
| 0.1 | 0.3 | GO:0070537 | histone H2A K63-linked deubiquitination(GO:0070537) |
| 0.1 | 0.7 | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197) |
| 0.0 | 0.3 | GO:0043457 | regulation of cellular respiration(GO:0043457) |
| 0.0 | 0.2 | GO:0010727 | negative regulation of hydrogen peroxide metabolic process(GO:0010727) |
| 0.0 | 0.1 | GO:0045475 | locomotor rhythm(GO:0045475) |
| 0.0 | 1.0 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.0 | 0.1 | GO:0048670 | regulation of collateral sprouting(GO:0048670) |
| 0.0 | 0.2 | GO:0070071 | proton-transporting two-sector ATPase complex assembly(GO:0070071) |
| 0.0 | 0.3 | GO:0045163 | clustering of voltage-gated potassium channels(GO:0045163) |
| 0.0 | 0.1 | GO:0050942 | positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942) |
| 0.0 | 0.5 | GO:0008612 | peptidyl-lysine modification to peptidyl-hypusine(GO:0008612) |
| 0.0 | 0.2 | GO:1901798 | positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798) |
| 0.0 | 1.1 | GO:0060334 | regulation of response to interferon-gamma(GO:0060330) regulation of interferon-gamma-mediated signaling pathway(GO:0060334) |
| 0.0 | 1.1 | GO:0015985 | energy coupled proton transport, down electrochemical gradient(GO:0015985) ATP synthesis coupled proton transport(GO:0015986) |
| 0.0 | 1.4 | GO:0006309 | DNA catabolic process, endonucleolytic(GO:0000737) apoptotic DNA fragmentation(GO:0006309) |
| 0.0 | 1.7 | GO:0007416 | synapse assembly(GO:0007416) |
| 0.0 | 0.1 | GO:0045591 | positive regulation of regulatory T cell differentiation(GO:0045591) |
| 0.0 | 1.8 | GO:0061025 | membrane fusion(GO:0061025) |
| 0.0 | 0.1 | GO:0001550 | ovarian cumulus expansion(GO:0001550) fused antrum stage(GO:0048165) |
| 0.0 | 1.7 | GO:0030183 | B cell differentiation(GO:0030183) |
| 0.0 | 1.0 | GO:0006611 | protein export from nucleus(GO:0006611) |
| 0.0 | 0.4 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.0 | 0.2 | GO:0006265 | DNA topological change(GO:0006265) |
| 0.0 | 2.2 | GO:0006338 | chromatin remodeling(GO:0006338) |
| 0.0 | 0.2 | GO:0030262 | apoptotic nuclear changes(GO:0030262) |
| 0.0 | 0.1 | GO:0010457 | centriole-centriole cohesion(GO:0010457) |
| 0.0 | 0.5 | GO:0015721 | bile acid and bile salt transport(GO:0015721) |
| 0.0 | 0.2 | GO:0007258 | JUN phosphorylation(GO:0007258) |
| 0.0 | 0.6 | GO:0031424 | keratinization(GO:0031424) |
| 0.0 | 0.5 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.0 | 1.5 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.0 | 0.4 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 0.1 | GO:0045822 | negative regulation of heart contraction(GO:0045822) |
| 0.0 | 0.2 | GO:0001660 | fever generation(GO:0001660) |
| 0.0 | 0.1 | GO:0045059 | positive thymic T cell selection(GO:0045059) |
| 0.0 | 0.4 | GO:0032729 | positive regulation of interferon-gamma production(GO:0032729) |
| 0.0 | 0.3 | GO:0051930 | regulation of sensory perception of pain(GO:0051930) regulation of sensory perception(GO:0051931) |
| 0.0 | 0.4 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation(GO:0033138) |
| 0.0 | 0.2 | GO:0060338 | regulation of type I interferon-mediated signaling pathway(GO:0060338) |
| 0.0 | 0.0 | GO:0046621 | negative regulation of organ growth(GO:0046621) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.8 | GO:0097651 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) phosphatidylinositol 3-kinase complex, class I(GO:0097651) |
| 0.2 | 2.5 | GO:0071778 | obsolete WINAC complex(GO:0071778) |
| 0.2 | 1.0 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
| 0.1 | 0.4 | GO:0019718 | obsolete rough microsome(GO:0019718) |
| 0.1 | 0.6 | GO:0000445 | THO complex(GO:0000347) THO complex part of transcription export complex(GO:0000445) |
| 0.1 | 0.7 | GO:0042719 | mitochondrial intermembrane space protein transporter complex(GO:0042719) |
| 0.1 | 0.2 | GO:0032982 | myosin filament(GO:0032982) |
| 0.1 | 1.2 | GO:0000178 | exosome (RNase complex)(GO:0000178) |
| 0.1 | 4.4 | GO:0030667 | secretory granule membrane(GO:0030667) |
| 0.1 | 0.7 | GO:0001917 | photoreceptor inner segment(GO:0001917) |
| 0.1 | 0.2 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
| 0.0 | 1.1 | GO:0045263 | proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263) |
| 0.0 | 0.2 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.0 | 0.3 | GO:0005642 | annulate lamellae(GO:0005642) |
| 0.0 | 0.2 | GO:0005750 | mitochondrial respiratory chain complex III(GO:0005750) respiratory chain complex III(GO:0045275) |
| 0.0 | 0.1 | GO:0033011 | perinuclear theca(GO:0033011) cytoskeletal calyx(GO:0033150) |
| 0.0 | 0.2 | GO:0030868 | smooth endoplasmic reticulum membrane(GO:0030868) smooth endoplasmic reticulum part(GO:0097425) |
| 0.0 | 0.1 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.0 | 0.2 | GO:0042382 | paraspeckles(GO:0042382) |
| 0.0 | 0.4 | GO:0030315 | T-tubule(GO:0030315) |
| 0.0 | 1.5 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 0.9 | GO:0030530 | obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530) |
| 0.0 | 1.2 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 0.6 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 0.3 | GO:0070531 | BRCA1-A complex(GO:0070531) |
| 0.0 | 1.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 1.4 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 1.5 | GO:0000790 | nuclear chromatin(GO:0000790) |
| 0.0 | 2.0 | GO:0016607 | nuclear speck(GO:0016607) |
| 0.0 | 0.3 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.0 | 0.6 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 0.5 | GO:0032993 | protein-DNA complex(GO:0032993) |
| 0.0 | 1.0 | GO:0005643 | nuclear pore(GO:0005643) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 4.5 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.4 | 1.1 | GO:0043426 | histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648) MRF binding(GO:0043426) |
| 0.3 | 1.0 | GO:0003896 | DNA primase activity(GO:0003896) |
| 0.3 | 2.4 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) |
| 0.2 | 0.7 | GO:0035276 | ethanol binding(GO:0035276) |
| 0.2 | 1.2 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.2 | 0.6 | GO:0004768 | stearoyl-CoA 9-desaturase activity(GO:0004768) acyl-CoA desaturase activity(GO:0016215) |
| 0.2 | 0.5 | GO:0001618 | virus receptor activity(GO:0001618) |
| 0.1 | 1.9 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.1 | 0.3 | GO:0016623 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, oxygen as acceptor(GO:0016623) |
| 0.1 | 0.8 | GO:0043559 | insulin binding(GO:0043559) |
| 0.1 | 0.9 | GO:0030911 | TPR domain binding(GO:0030911) |
| 0.1 | 0.5 | GO:0008190 | eukaryotic initiation factor 4E binding(GO:0008190) |
| 0.1 | 3.3 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
| 0.1 | 1.4 | GO:0016888 | endodeoxyribonuclease activity, producing 5'-phosphomonoesters(GO:0016888) |
| 0.1 | 1.0 | GO:0031013 | troponin I binding(GO:0031013) |
| 0.1 | 0.6 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.1 | 0.2 | GO:0019981 | interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981) |
| 0.1 | 0.3 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 0.1 | 0.3 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.1 | 0.5 | GO:0031434 | mitogen-activated protein kinase kinase binding(GO:0031434) |
| 0.1 | 0.4 | GO:0035673 | oligopeptide transmembrane transporter activity(GO:0035673) |
| 0.1 | 0.3 | GO:0043184 | vascular endothelial growth factor receptor 2 binding(GO:0043184) |
| 0.1 | 0.3 | GO:0005250 | A-type (transient outward) potassium channel activity(GO:0005250) |
| 0.0 | 0.4 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.0 | 0.2 | GO:0004906 | interferon-gamma receptor activity(GO:0004906) |
| 0.0 | 0.4 | GO:0005432 | calcium:sodium antiporter activity(GO:0005432) |
| 0.0 | 2.3 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 0.5 | GO:0016884 | carbon-nitrogen ligase activity, with glutamine as amido-N-donor(GO:0016884) |
| 0.0 | 1.1 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.0 | 0.3 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.0 | 0.2 | GO:0003917 | DNA topoisomerase type I activity(GO:0003917) |
| 0.0 | 1.4 | GO:0030295 | protein kinase activator activity(GO:0030295) |
| 0.0 | 1.0 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.0 | 0.3 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 0.0 | 0.6 | GO:0016780 | phosphotransferase activity, for other substituted phosphate groups(GO:0016780) |
| 0.0 | 0.2 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.0 | 0.2 | GO:0016681 | ubiquinol-cytochrome-c reductase activity(GO:0008121) oxidoreductase activity, acting on diphenols and related substances as donors(GO:0016679) oxidoreductase activity, acting on diphenols and related substances as donors, cytochrome as acceptor(GO:0016681) |
| 0.0 | 0.8 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.0 | 0.4 | GO:0004859 | phospholipase inhibitor activity(GO:0004859) |
| 0.0 | 0.2 | GO:0030492 | hemoglobin binding(GO:0030492) |
| 0.0 | 0.4 | GO:0005003 | ephrin receptor activity(GO:0005003) |
| 0.0 | 0.2 | GO:0016909 | JUN kinase activity(GO:0004705) SAP kinase activity(GO:0016909) |
| 0.0 | 0.2 | GO:0031210 | phosphatidylcholine binding(GO:0031210) |
| 0.0 | 2.2 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
| 0.0 | 0.3 | GO:0017070 | U6 snRNA binding(GO:0017070) |
| 0.0 | 0.8 | GO:0005504 | fatty acid binding(GO:0005504) |
| 0.0 | 0.1 | GO:0004882 | androgen receptor activity(GO:0004882) |
| 0.0 | 0.9 | GO:0008009 | chemokine activity(GO:0008009) |
| 0.0 | 0.2 | GO:0008252 | nucleotidase activity(GO:0008252) |
| 0.0 | 0.1 | GO:0051766 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766) |
| 0.0 | 0.1 | GO:0003678 | DNA helicase activity(GO:0003678) |
| 0.0 | 1.0 | GO:0005507 | copper ion binding(GO:0005507) |
| 0.0 | 0.1 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
| 0.0 | 0.2 | GO:0016783 | sulfurtransferase activity(GO:0016783) |
| 0.0 | 0.6 | GO:0004115 | 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115) |
| 0.0 | 0.4 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.0 | 0.1 | GO:0001517 | N-acetylglucosamine 6-O-sulfotransferase activity(GO:0001517) |
| 0.0 | 0.4 | GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656) |
| 0.0 | 0.7 | GO:0016875 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 0.0 | 0.1 | GO:0051787 | misfolded protein binding(GO:0051787) |
| 0.0 | 1.2 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 0.3 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 0.7 | GO:0042562 | hormone binding(GO:0042562) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.0 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.0 | 1.0 | ST_ADRENERGIC | Adrenergic Pathway |
| 0.0 | 0.2 | ST_STAT3_PATHWAY | STAT3 Pathway |
| 0.0 | 0.2 | ST_INTERFERON_GAMMA_PATHWAY | Interferon gamma pathway. |
| 0.0 | 0.7 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
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