Motif ID: HOXB13

Z-value: 0.960


Transcription factors associated with HOXB13:

Gene SymbolEntrez IDGene Name
HOXB13 ENSG00000159184.7 HOXB13



Activity profile for motif HOXB13.

activity profile for motif HOXB13


Sorted Z-values histogram for motif HOXB13

Sorted Z-values for motif HOXB13



Network of associatons between targets according to the STRING database.



First level regulatory network of HOXB13

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr2_-_190044480 1.623 ENST00000374866.3
 COL5A2
collagen, type V, alpha 2
chr18_-_52989525 1.524 ENST00000457482.3
 TCF4
transcription factor 4
chr18_-_52989217 1.483 ENST00000570287.2
 TCF4
transcription factor 4
chr17_-_10560619 1.145 ENST00000583535.1
 MYH3
myosin, heavy chain 3, skeletal muscle, embryonic
chr2_-_175629135 1.063 ENST00000409542.1
ENST00000409219.1
 CHRNA1

cholinergic receptor, nicotinic, alpha 1 (muscle)

chr3_-_114790179 0.997 ENST00000462705.1
 ZBTB20
zinc finger and BTB domain containing 20
chr1_+_84630645 0.838 ENST00000394839.2
 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_+_66458072 0.824 ENST00000423207.2
 PDE4B
phosphodiesterase 4B, cAMP-specific
chr1_-_155880672 0.630 ENST00000609492.1
ENST00000368322.3
 RIT1

Ras-like without CAAX 1

chr7_-_50860565 0.623 ENST00000403097.1
 GRB10
growth factor receptor-bound protein 10
chr2_-_175629164 0.540 ENST00000409323.1
ENST00000261007.5
ENST00000348749.5
 CHRNA1


cholinergic receptor, nicotinic, alpha 1 (muscle)


chr1_+_84630053 0.519 ENST00000394838.2
ENST00000370682.3
ENST00000432111.1
 PRKACB


protein kinase, cAMP-dependent, catalytic, beta


chr9_-_14180778 0.452 ENST00000380924.1
ENST00000543693.1
 NFIB

nuclear factor I/B

chr16_-_24942411 0.424 ENST00000571843.1
 ARHGAP17
Rho GTPase activating protein 17
chr1_+_23037323 0.410 ENST00000544305.1
ENST00000374630.3
ENST00000400191.3
ENST00000374632.3
 EPHB2



EPH receptor B2



chr16_-_24942273 0.366 ENST00000571406.1
 ARHGAP17
Rho GTPase activating protein 17
chr15_+_66994561 0.353 ENST00000288840.5
 SMAD6
SMAD family member 6
chr8_+_97597148 0.344 ENST00000521590.1
 SDC2
syndecan 2
chr19_+_1440838 0.278 ENST00000594262.1
 AC027307.3
Uncharacterized protein
chr7_-_11871815 0.253 ENST00000423059.4
 THSD7A
thrombospondin, type I, domain containing 7A
chr5_-_140053152 0.190 ENST00000542735.1
 DND1
DND microRNA-mediated repression inhibitor 1
chr11_-_102826434 0.175 ENST00000340273.4
ENST00000260302.3
 MMP13

matrix metallopeptidase 13 (collagenase 3)

chr8_+_77593448 0.166 ENST00000521891.2
 ZFHX4
zinc finger homeobox 4
chr1_+_210501589 0.147 ENST00000413764.2
ENST00000541565.1
 HHAT

hedgehog acyltransferase

chr8_+_77593474 0.145 ENST00000455469.2
ENST00000050961.6
 ZFHX4

zinc finger homeobox 4

chr17_-_46806540 0.138 ENST00000290295.7
 HOXB13
homeobox B13
chr14_-_50583271 0.103 ENST00000395860.2
ENST00000395859.2
 VCPKMT

valosin containing protein lysine (K) methyltransferase

chr11_+_118401706 0.090 ENST00000411589.2
ENST00000442938.2
ENST00000359862.4
 TMEM25


transmembrane protein 25


chr2_+_67624430 0.074 ENST00000272342.5
 ETAA1
Ewing tumor-associated antigen 1
chr11_-_102714534 0.066 ENST00000299855.5
 MMP3
matrix metallopeptidase 3 (stromelysin 1, progelatinase)
chr6_-_27782548 0.058 ENST00000333151.3
 HIST1H2AJ
histone cluster 1, H2aj
chr1_-_45956822 0.053 ENST00000372086.3
ENST00000341771.6
 TESK2

testis-specific kinase 2

chr4_-_164534657 0.050 ENST00000339875.5
 MARCH1
membrane-associated ring finger (C3HC4) 1, E3 ubiquitin protein ligase
chr18_+_3252265 0.047 ENST00000580887.1
ENST00000536605.1
 MYL12A

myosin, light chain 12A, regulatory, non-sarcomeric

chr2_-_136288113 0.025 ENST00000401392.1
 ZRANB3
zinc finger, RAN-binding domain containing 3
chr18_+_3252206 0.016 ENST00000578562.2
 MYL12A
myosin, light chain 12A, regulatory, non-sarcomeric
chr6_-_43021612 0.013 ENST00000535468.1
 CUL7
cullin 7
chr8_+_119294456 0.012 ENST00000366457.2
 AC023590.1
Uncharacterized protein
chr3_-_123710199 0.006 ENST00000184183.4
 ROPN1
rhophilin associated tail protein 1
chr16_+_30669720 0.003 ENST00000356166.6
 FBRS
fibrosin

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.6 GO:0070050 neuron cellular homeostasis(GO:0070050)
0.2 0.6 GO:0045719 negative regulation of glycogen biosynthetic process(GO:0045719)
0.1 0.4 GO:0048170 optic nerve morphogenesis(GO:0021631) positive regulation of long-term neuronal synaptic plasticity(GO:0048170)
0.1 0.4 GO:0060394 obsolete positive regulation of S phase of mitotic cell cycle(GO:0045750) negative regulation of pathway-restricted SMAD protein phosphorylation(GO:0060394)
0.1 1.6 GO:0030199 collagen fibril organization(GO:0030199)
0.1 1.4 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.0 0.8 GO:0006198 cAMP catabolic process(GO:0006198)
0.0 0.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.2 GO:0060969 negative regulation of gene silencing(GO:0060969)
0.0 3.0 GO:0006367 transcription initiation from RNA polymerase II promoter(GO:0006367)
0.0 0.1 GO:0071460 cellular response to cell-matrix adhesion(GO:0071460)
0.0 0.1 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.3 GO:0031000 response to caffeine(GO:0031000)
0.0 1.1 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 0.8 GO:0017156 calcium ion regulated exocytosis(GO:0017156)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.5 1.6 GO:0005588 collagen type V trimer(GO:0005588)
0.1 1.6 GO:0005892 acetylcholine-gated channel complex(GO:0005892)
0.1 1.1 GO:0032982 myosin filament(GO:0032982)
0.0 1.4 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 1.6 GO:0005626 obsolete insoluble fraction(GO:0005626)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 3.0 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093)
0.1 1.6 GO:0042166 acetylcholine binding(GO:0042166)
0.1 1.4 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.1 0.2 GO:0035198 miRNA binding(GO:0035198)
0.1 0.4 GO:0005005 transmembrane-ephrin receptor activity(GO:0005005) axon guidance receptor activity(GO:0008046)
0.0 1.1 GO:0000146 microfilament motor activity(GO:0000146)
0.0 0.4 GO:0070696 transmembrane receptor protein serine/threonine kinase binding(GO:0070696)
0.0 1.5 GO:0046332 SMAD binding(GO:0046332)
0.0 0.8 GO:0004115 3',5'-cyclic-AMP phosphodiesterase activity(GO:0004115)
0.0 0.6 GO:0005158 insulin receptor binding(GO:0005158)
0.0 0.1 GO:0016409 palmitoyltransferase activity(GO:0016409)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 ST_MYOCYTE_AD_PATHWAY Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway.