Motif ID: HOXB4_LHX9
Z-value: 2.336
Transcription factors associated with HOXB4_LHX9:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| HOXB4 | ENSG00000182742.5 | HOXB4 |
| LHX9 | ENSG00000143355.11 | LHX9 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 3.0 | 11.8 | GO:0045110 | intermediate filament bundle assembly(GO:0045110) |
| 1.5 | 4.5 | GO:0014029 | neural crest formation(GO:0014029) neural crest cell fate commitment(GO:0014034) convergent extension involved in axis elongation(GO:0060028) cellular response to prostaglandin E stimulus(GO:0071380) response to heparin(GO:0071503) cellular response to heparin(GO:0071504) negative regulation of non-canonical Wnt signaling pathway(GO:2000051) |
| 1.1 | 6.4 | GO:0006880 | intracellular sequestering of iron ion(GO:0006880) sequestering of iron ion(GO:0097577) |
| 0.9 | 5.2 | GO:0007499 | ectoderm and mesoderm interaction(GO:0007499) |
| 0.9 | 4.3 | GO:0006789 | bilirubin conjugation(GO:0006789) biphenyl metabolic process(GO:0018879) biphenyl catabolic process(GO:0070980) |
| 0.5 | 2.2 | GO:0019371 | cyclooxygenase pathway(GO:0019371) |
| 0.5 | 1.5 | GO:0033278 | cell proliferation in midbrain(GO:0033278) |
| 0.5 | 3.2 | GO:0042420 | dopamine catabolic process(GO:0042420) |
| 0.4 | 1.7 | GO:0045715 | negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) |
| 0.4 | 2.9 | GO:0006264 | mitochondrial DNA replication(GO:0006264) |
| 0.4 | 11.4 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.3 | 1.9 | GO:0002903 | negative regulation of B cell apoptotic process(GO:0002903) negative regulation of plasma membrane long-chain fatty acid transport(GO:0010748) negative regulation of anion transmembrane transport(GO:1903960) negative regulation of fatty acid transport(GO:2000192) |
| 0.3 | 1.5 | GO:0051611 | negative regulation of neurotransmitter uptake(GO:0051581) negative regulation of dopamine uptake involved in synaptic transmission(GO:0051585) serotonin uptake(GO:0051610) regulation of serotonin uptake(GO:0051611) negative regulation of serotonin uptake(GO:0051612) norepinephrine uptake(GO:0051620) regulation of norepinephrine uptake(GO:0051621) negative regulation of norepinephrine uptake(GO:0051622) negative regulation of catecholamine uptake involved in synaptic transmission(GO:0051945) regulation of thrombin receptor signaling pathway(GO:0070494) negative regulation of thrombin receptor signaling pathway(GO:0070495) |
| 0.3 | 5.5 | GO:0070206 | protein trimerization(GO:0070206) |
| 0.3 | 1.0 | GO:0009438 | methylglyoxal metabolic process(GO:0009438) |
| 0.2 | 1.2 | GO:0032224 | positive regulation of synaptic transmission, cholinergic(GO:0032224) |
| 0.2 | 1.3 | GO:0002726 | positive regulation of T cell cytokine production(GO:0002726) |
| 0.2 | 0.8 | GO:0045356 | positive regulation of interferon-alpha biosynthetic process(GO:0045356) |
| 0.2 | 1.3 | GO:0042693 | muscle cell fate commitment(GO:0042693) |
| 0.2 | 0.5 | GO:0060012 | synaptic transmission, glycinergic(GO:0060012) |
| 0.2 | 2.1 | GO:1901797 | negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797) |
| 0.2 | 0.9 | GO:0008228 | opsonization(GO:0008228) |
| 0.1 | 1.2 | GO:0006553 | lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554) |
| 0.1 | 1.5 | GO:0033687 | osteoblast proliferation(GO:0033687) |
| 0.1 | 0.7 | GO:0001514 | selenocysteine incorporation(GO:0001514) translational readthrough(GO:0006451) |
| 0.1 | 2.1 | GO:0035329 | hippo signaling(GO:0035329) |
| 0.1 | 1.4 | GO:0034446 | substrate adhesion-dependent cell spreading(GO:0034446) |
| 0.1 | 0.6 | GO:0043415 | positive regulation of skeletal muscle tissue regeneration(GO:0043415) regulation of skeletal muscle tissue regeneration(GO:0043416) |
| 0.1 | 0.6 | GO:0060665 | regulation of branching involved in salivary gland morphogenesis by mesenchymal-epithelial signaling(GO:0060665) |
| 0.1 | 0.3 | GO:1902414 | protein localization to adherens junction(GO:0071896) protein localization to cell junction(GO:1902414) |
| 0.1 | 0.2 | GO:0007197 | adenylate cyclase-inhibiting G-protein coupled acetylcholine receptor signaling pathway(GO:0007197) |
| 0.1 | 0.2 | GO:0019482 | beta-alanine metabolic process(GO:0019482) |
| 0.1 | 0.5 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.1 | 0.3 | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162) |
| 0.1 | 0.3 | GO:0044413 | evasion or tolerance of host defenses by virus(GO:0019049) avoidance of host defenses(GO:0044413) evasion or tolerance of host defenses(GO:0044415) avoidance of defenses of other organism involved in symbiotic interaction(GO:0051832) evasion or tolerance of defenses of other organism involved in symbiotic interaction(GO:0051834) |
| 0.1 | 0.6 | GO:0050435 | beta-amyloid metabolic process(GO:0050435) |
| 0.0 | 0.1 | GO:0003056 | regulation of vascular smooth muscle contraction(GO:0003056) |
| 0.0 | 0.7 | GO:0071230 | cellular response to amino acid stimulus(GO:0071230) |
| 0.0 | 1.2 | GO:0006555 | methionine metabolic process(GO:0006555) |
| 0.0 | 1.2 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 1.2 | GO:0008299 | isoprenoid biosynthetic process(GO:0008299) |
| 0.0 | 35.9 | GO:0007010 | cytoskeleton organization(GO:0007010) |
| 0.0 | 0.2 | GO:0046621 | negative regulation of organ growth(GO:0046621) |
| 0.0 | 1.3 | GO:0006513 | protein monoubiquitination(GO:0006513) |
| 0.0 | 2.9 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
| 0.0 | 2.6 | GO:0030521 | androgen receptor signaling pathway(GO:0030521) |
| 0.0 | 0.1 | GO:0008354 | germ cell migration(GO:0008354) |
| 0.0 | 1.8 | GO:0001837 | epithelial to mesenchymal transition(GO:0001837) |
| 0.0 | 0.6 | GO:0046580 | negative regulation of Ras protein signal transduction(GO:0046580) negative regulation of small GTPase mediated signal transduction(GO:0051058) |
| 0.0 | 0.1 | GO:0045103 | intermediate filament-based process(GO:0045103) |
| 0.0 | 8.7 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.0 | 1.4 | GO:0044839 | G2/M transition of mitotic cell cycle(GO:0000086) cell cycle G2/M phase transition(GO:0044839) |
| 0.0 | 0.9 | GO:0050909 | sensory perception of taste(GO:0050909) |
| 0.0 | 0.6 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 1.8 | GO:0017148 | negative regulation of translation(GO:0017148) |
| 0.0 | 0.8 | GO:0019835 | cytolysis(GO:0019835) |
| 0.0 | 3.1 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 1.5 | GO:0007588 | excretion(GO:0007588) |
| 0.0 | 0.3 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.0 | 0.3 | GO:0000768 | syncytium formation by plasma membrane fusion(GO:0000768) myoblast fusion(GO:0007520) |
| 0.0 | 1.1 | GO:0006749 | glutathione metabolic process(GO:0006749) |
| 0.0 | 0.2 | GO:0042354 | fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355) |
| 0.0 | 0.4 | GO:0034605 | cellular response to heat(GO:0034605) |
| 0.0 | 0.8 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
| 0.0 | 0.4 | GO:0050892 | intestinal absorption(GO:0050892) |
| 0.0 | 1.2 | GO:0007608 | sensory perception of smell(GO:0007608) |
| 0.0 | 0.1 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
| 0.0 | 0.0 | GO:0060748 | tertiary branching involved in mammary gland duct morphogenesis(GO:0060748) |
| 0.0 | 2.8 | GO:0007517 | muscle organ development(GO:0007517) |
| 0.0 | 0.7 | GO:0042981 | regulation of apoptotic process(GO:0042981) |
| 0.0 | 0.3 | GO:0042246 | tissue regeneration(GO:0042246) |
| 0.0 | 0.7 | GO:0030336 | negative regulation of cell migration(GO:0030336) negative regulation of cell motility(GO:2000146) |
| 0.0 | 0.1 | GO:0090084 | negative regulation of inclusion body assembly(GO:0090084) |
| 0.0 | 0.1 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 6.0 | GO:0030056 | hemidesmosome(GO:0030056) |
| 0.5 | 8.1 | GO:0005606 | laminin-1 complex(GO:0005606) |
| 0.5 | 27.2 | GO:0005884 | actin filament(GO:0005884) |
| 0.4 | 6.8 | GO:0001527 | microfibril(GO:0001527) |
| 0.4 | 7.0 | GO:0031258 | lamellipodium membrane(GO:0031258) |
| 0.3 | 11.8 | GO:0045095 | keratin filament(GO:0045095) |
| 0.2 | 6.4 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.2 | 1.5 | GO:0043205 | fibril(GO:0043205) |
| 0.2 | 1.5 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.1 | 3.9 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.1 | 1.3 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.1 | 2.9 | GO:0030057 | desmosome(GO:0030057) |
| 0.1 | 4.6 | GO:0098636 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.1 | 5.5 | GO:0015030 | Cajal body(GO:0015030) |
| 0.1 | 0.4 | GO:0045179 | apical cortex(GO:0045179) |
| 0.1 | 0.7 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.1 | 10.3 | GO:0030055 | cell-substrate junction(GO:0030055) |
| 0.1 | 0.8 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 1.8 | GO:0030286 | dynein complex(GO:0030286) |
| 0.0 | 0.7 | GO:0043073 | germ cell nucleus(GO:0043073) |
| 0.0 | 0.1 | GO:0042765 | GPI-anchor transamidase complex(GO:0042765) |
| 0.0 | 0.2 | GO:0098984 | asymmetric synapse(GO:0032279) neuron to neuron synapse(GO:0098984) |
| 0.0 | 0.5 | GO:0008180 | COP9 signalosome(GO:0008180) |
| 0.0 | 0.4 | GO:0035098 | ESC/E(Z) complex(GO:0035098) |
| 0.0 | 3.2 | GO:0005741 | mitochondrial outer membrane(GO:0005741) |
| 0.0 | 0.6 | GO:0000159 | protein phosphatase type 2A complex(GO:0000159) |
| 0.0 | 0.1 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.0 | 5.9 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 1.1 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 0.7 | GO:0030530 | obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530) |
| 0.0 | 4.9 | GO:0005792 | obsolete microsome(GO:0005792) |
| 0.0 | 0.3 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 0.1 | GO:0070852 | cell body fiber(GO:0070852) |
| 0.0 | 0.5 | GO:0042641 | actomyosin(GO:0042641) |
| 0.0 | 0.1 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.0 | 0.4 | GO:0043197 | dendritic spine(GO:0043197) |
| 0.0 | 1.3 | GO:0031253 | cell projection membrane(GO:0031253) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 5.1 | 30.7 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 1.1 | 4.5 | GO:0061133 | endopeptidase activator activity(GO:0061133) |
| 1.0 | 2.9 | GO:0004797 | thymidine kinase activity(GO:0004797) |
| 0.6 | 3.2 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.5 | 2.2 | GO:0004666 | prostaglandin-endoperoxide synthase activity(GO:0004666) |
| 0.4 | 2.7 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.3 | 1.5 | GO:0060961 | phospholipase D inhibitor activity(GO:0060961) |
| 0.3 | 1.8 | GO:0019863 | IgE binding(GO:0019863) |
| 0.3 | 1.8 | GO:0048027 | mRNA 5'-UTR binding(GO:0048027) |
| 0.3 | 1.3 | GO:0004910 | interleukin-1, Type II, blocking receptor activity(GO:0004910) |
| 0.2 | 1.2 | GO:0004337 | dimethylallyltranstransferase activity(GO:0004161) geranyltranstransferase activity(GO:0004337) |
| 0.2 | 6.9 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.2 | 6.4 | GO:0005246 | calcium channel regulator activity(GO:0005246) |
| 0.2 | 0.6 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.1 | 1.2 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
| 0.1 | 0.4 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
| 0.1 | 0.7 | GO:0004800 | thyroxine 5'-deiodinase activity(GO:0004800) |
| 0.1 | 12.9 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 0.5 | GO:0016933 | extracellular-glycine-gated ion channel activity(GO:0016933) extracellular-glycine-gated chloride channel activity(GO:0016934) |
| 0.1 | 3.1 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.1 | 1.6 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.1 | 0.3 | GO:0047273 | galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273) |
| 0.1 | 2.3 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.1 | 0.9 | GO:0030247 | pattern binding(GO:0001871) polysaccharide binding(GO:0030247) |
| 0.1 | 0.4 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.1 | 2.8 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.1 | 1.5 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.1 | 1.2 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 0.1 | 0.9 | GO:0008527 | taste receptor activity(GO:0008527) |
| 0.1 | 0.2 | GO:0047718 | indanol dehydrogenase activity(GO:0047718) |
| 0.1 | 8.4 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
| 0.1 | 1.7 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 0.3 | GO:0008466 | glycogenin glucosyltransferase activity(GO:0008466) |
| 0.1 | 1.0 | GO:0016846 | carbon-sulfur lyase activity(GO:0016846) |
| 0.1 | 0.3 | GO:0001102 | RNA polymerase II activating transcription factor binding(GO:0001102) |
| 0.1 | 0.5 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.0 | 0.4 | GO:0016004 | phospholipase activator activity(GO:0016004) |
| 0.0 | 1.3 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.6 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.0 | 1.9 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.0 | 0.2 | GO:0016907 | G-protein coupled acetylcholine receptor activity(GO:0016907) |
| 0.0 | 0.1 | GO:0003923 | GPI-anchor transamidase activity(GO:0003923) |
| 0.0 | 3.3 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 1.1 | GO:0004364 | glutathione transferase activity(GO:0004364) |
| 0.0 | 0.5 | GO:0005522 | profilin binding(GO:0005522) |
| 0.0 | 6.4 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 2.7 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 0.9 | GO:0005080 | protein kinase C binding(GO:0005080) |
| 0.0 | 0.2 | GO:0008107 | galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127) |
| 0.0 | 1.1 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 0.5 | GO:0004709 | MAP kinase kinase kinase activity(GO:0004709) |
| 0.0 | 0.3 | GO:0000155 | phosphorelay sensor kinase activity(GO:0000155) |
| 0.0 | 0.4 | GO:0015020 | glucuronosyltransferase activity(GO:0015020) |
| 0.0 | 0.1 | GO:0042577 | lipid phosphatase activity(GO:0042577) |
| 0.0 | 0.1 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.0 | 0.9 | GO:0004984 | olfactory receptor activity(GO:0004984) |
| 0.0 | 0.3 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 0.5 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 0.2 | GO:0003711 | obsolete transcription elongation regulator activity(GO:0003711) |
| 0.0 | 0.3 | GO:0008200 | ion channel inhibitor activity(GO:0008200) |
| 0.0 | 1.3 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.0 | 2.1 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 0.3 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 0.1 | GO:0016615 | malate dehydrogenase activity(GO:0016615) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 4.6 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.1 | 2.1 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 1.9 | SIG_IL4RECEPTOR_IN_B_LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.0 | 0.9 | ST_MYOCYTE_AD_PATHWAY | Myocyte Adrenergic Pathway is a specific case of the generalized Adrenergic Pathway. |
| 0.0 | 1.3 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
| 0.0 | 0.1 | SA_TRKA_RECEPTOR | The TrkA receptor binds nerve growth factor to activate MAP kinase pathways and promote cell growth. |
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