ISMARA results: HOXB5

Motif ID: HOXB5

Z-value: 0.769

Transcription factors associated with HOXB5:

Gene Symbol	Entrez ID	Gene Name
HOXB5	ENSG00000120075.5	HOXB5

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Top targets:

Promoter	Score	Refseq	Gene Symbol	Gene Name
chr19_-_50143452	2.290	ENST00000246792.3	RRAS	related RAS viral (r-ras) oncogene homolog
chr6_+_121756809	1.728	ENST00000282561.3	GJA1	gap junction protein, alpha 1, 43kDa
chr12_+_66217911	1.334	ENST00000403681.2	HMGA2	high mobility group AT-hook 2
chr3_-_127541194	1.260	ENST00000453507.2	MGLL	monoglyceride lipase
chrX_+_135230712	1.187	ENST00000535737.1	FHL1	four and a half LIM domains 1
chr1_+_146373546	1.187	ENST00000446760.2	NBPF12	neuroblastoma breakpoint family, member 12
chr15_+_74218787	1.074	ENST00000261921.7	LOXL1	lysyl oxidase-like 1
chr4_-_114900831	0.821	ENST00000315366.7	ARSJ	arylsulfatase family, member J
chr12_+_56915776	0.771	ENST00000550726.1 ENST00000542360.1	RBMS2	RNA binding motif, single stranded interacting protein 2
chrX_+_100333709	0.723	ENST00000372930.4	TMEM35	transmembrane protein 35
chr12_+_56915713	0.719	ENST00000262031.5 ENST00000552247.2	RBMS2	RNA binding motif, single stranded interacting protein 2
chr3_+_51422478	0.677	ENST00000528157.1	MANF	mesencephalic astrocyte-derived neurotrophic factor
chr12_+_53693466	0.489	ENST00000267103.5 ENST00000548632.1	C12orf10	chromosome 12 open reading frame 10
chr15_-_75017711	0.449	ENST00000567032.1 ENST00000564596.1 ENST00000566503.1 ENST00000395049.4 ENST00000395048.2 ENST00000379727.3	CYP1A1	cytochrome P450, family 1, subfamily A, polypeptide 1
chr14_-_102704783	0.437	ENST00000522534.1	MOK	MOK protein kinase
chr8_-_93107443	0.397	ENST00000360348.2 ENST00000520428.1 ENST00000518992.1 ENST00000520556.1 ENST00000518317.1 ENST00000521319.1 ENST00000521375.1 ENST00000518449.1	RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr2_-_188430478	0.380	ENST00000421427.1	TFPI	tissue factor pathway inhibitor (lipoprotein-associated coagulation inhibitor)
chr5_-_141061777	0.377	ENST00000239440.4	ARAP3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr5_-_141061759	0.338	ENST00000508305.1	ARAP3	ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 3
chr8_-_93107696	0.272	ENST00000436581.2 ENST00000520583.1 ENST00000519061.1	RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr1_+_145575980	0.270	ENST00000393045.2	PIAS3	protein inhibitor of activated STAT, 3
chr1_+_145576007	0.266	ENST00000369298.1	PIAS3	protein inhibitor of activated STAT, 3
chr15_-_72523454	0.226	ENST00000565154.1 ENST00000565184.1 ENST00000389093.3 ENST00000449901.2 ENST00000335181.5 ENST00000319622.6	PKM	pyruvate kinase, muscle
chrX_+_47077632	0.216	ENST00000457458.2	CDK16	cyclin-dependent kinase 16
chr2_+_17721920	0.208	ENST00000295156.4	VSNL1	visinin-like 1
chr6_-_32820529	0.207	ENST00000425148.2	TAP1	transporter 1, ATP-binding cassette, sub-family B (MDR/TAP)
chr3_+_130613226	0.203	ENST00000509662.1 ENST00000328560.8 ENST00000428331.2 ENST00000359644.3 ENST00000422190.2	ATP2C1	ATPase, Ca++ transporting, type 2C, member 1
chr19_+_34745442	0.187	ENST00000299505.6 ENST00000588470.1 ENST00000589583.1 ENST00000588338.2	KIAA0355	KIAA0355
chr20_-_48184638	0.185	ENST00000244043.4	PTGIS	prostaglandin I2 (prostacyclin) synthase
chr2_-_47168906	0.184	ENST00000444761.2 ENST00000409147.1	MCFD2	multiple coagulation factor deficiency 2
chr7_+_120969045	0.182	ENST00000222462.2	WNT16	wingless-type MMTV integration site family, member 16
chr12_-_6798523	0.182	ENST00000319770.3	ZNF384	zinc finger protein 384
chrX_-_139587225	0.181	ENST00000370536.2	SOX3	SRY (sex determining region Y)-box 3
chr12_-_6798616	0.177	ENST00000355772.4 ENST00000417772.3 ENST00000396801.3 ENST00000396799.2	ZNF384	zinc finger protein 384
chr12_-_6798410	0.162	ENST00000361959.3 ENST00000436774.2 ENST00000544482.1	ZNF384	zinc finger protein 384
chr8_-_93107827	0.146	ENST00000520724.1 ENST00000518844.1	RUNX1T1	runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chrM_+_12331	0.138	ENST00000361567.2	MT-ND5	mitochondrially encoded NADH dehydrogenase 5
chr17_+_46970134	0.106	ENST00000503641.1 ENST00000514808.1	ATP5G1	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr17_+_46970178	0.095	ENST00000393366.2 ENST00000506855.1	ATP5G1	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr8_-_133097902	0.077	ENST00000262283.5	OC90	Otoconin-90
chr17_+_46970127	0.071	ENST00000355938.5	ATP5G1	ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C1 (subunit 9)
chr17_+_2496971	0.071	ENST00000397195.5	PAFAH1B1	platelet-activating factor acetylhydrolase 1b, regulatory subunit 1 (45kDa)
chr5_+_149569520	0.053	ENST00000230671.2 ENST00000524041.1	SLC6A7	solute carrier family 6 (neurotransmitter transporter), member 7
chr12_+_54955235	0.048	ENST00000550620.1	PDE1B	phosphodiesterase 1B, calmodulin-dependent
chr1_+_41157421	0.046	ENST00000372654.1	NFYC	nuclear transcription factor Y, gamma
chr10_-_103603568	0.034	ENST00000356640.2	KCNIP2	Kv channel interacting protein 2
chr16_-_30381580	0.032	ENST00000409939.3	TBC1D10B	TBC1 domain family, member 10B
chr6_-_29396243	0.022	ENST00000377148.1	OR11A1	olfactory receptor, family 11, subfamily A, member 1
chrX_-_107225600	0.021	ENST00000302917.1	TEX13B	testis expressed 13B
chr1_+_41157361	0.012	ENST00000427410.2 ENST00000447388.3 ENST00000425457.2 ENST00000453631.1 ENST00000456393.2	NFYC	nuclear transcription factor Y, gamma
chr18_+_32558208	0.011	ENST00000436190.2	MAPRE2	microtubule-associated protein, RP/EB family, member 2
chr20_-_3687775	0.008	ENST00000344754.4 ENST00000202578.4	SIGLEC1	sialic acid binding Ig-like lectin 1, sialoadhesin
chr16_-_30102547	0.006	ENST00000279386.2	TBX6	T-box 6
chr1_+_155579979	0.004	ENST00000452804.2 ENST00000538143.1 ENST00000245564.2 ENST00000368341.4	MSTO1	misato 1, mitochondrial distribution and morphology regulator
chr12_-_53614155	0.001	ENST00000543726.1	RARG	retinoic acid receptor, gamma

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.4	1.7	GO:0051503	purine ribonucleotide transport(GO:0015868) adenine nucleotide transport(GO:0051503)
0.2	0.7	GO:0035021	negative regulation of Rac protein signal transduction(GO:0035021)
0.2	1.3	GO:2000124	cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926) regulation of endocannabinoid signaling pathway(GO:2000124)
0.2	0.5	GO:0045838	positive regulation of membrane potential(GO:0045838)
0.1	1.3	GO:1904893	negative regulation of JAK-STAT cascade(GO:0046426) negative regulation of STAT cascade(GO:1904893)
0.1	0.4	GO:0050665	hydrogen peroxide biosynthetic process(GO:0050665)
0.1	0.2	GO:0003408	optic cup formation involved in camera-type eye development(GO:0003408)
0.1	0.2	GO:0046967	cytosol to ER transport(GO:0046967)
0.0	0.4	GO:0007598	blood coagulation, extrinsic pathway(GO:0007598)
0.0	0.2	GO:0032472	cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) Golgi calcium ion transport(GO:0032472) manganese ion homeostasis(GO:0055071)
0.0	2.3	GO:0030336	negative regulation of cell migration(GO:0030336) negative regulation of cell motility(GO:2000146)
0.0	0.1	GO:0021819	layer formation in cerebral cortex(GO:0021819)
0.0	0.8	GO:0051101	regulation of DNA binding(GO:0051101)
0.0	0.3	GO:0042776	mitochondrial ATP synthesis coupled proton transport(GO:0042776)

Gene overrepresentation in cellular_component category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.2	1.7	GO:0005916	fascia adherens(GO:0005916)
0.0	0.2	GO:0042825	TAP complex(GO:0042825)
0.0	0.3	GO:0045263	proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)
0.0	0.1	GO:0031512	motile primary cilium(GO:0031512)

Gene overrepresentation in molecular_function category:

Log-likelihood per target	Total log-likelihood	Term	Description
0.3	1.3	GO:0003680	AT DNA binding(GO:0003680)
0.1	1.7	GO:0005243	gap junction channel activity(GO:0005243)
0.1	0.5	GO:0042156	obsolete zinc-mediated transcriptional activator activity(GO:0042156)
0.1	1.3	GO:0047372	acylglycerol lipase activity(GO:0047372)
0.1	0.4	GO:0070576	vitamin D 24-hydroxylase activity(GO:0070576)
0.1	1.1	GO:0016641	oxidoreductase activity, acting on the CH-NH2 group of donors, oxygen as acceptor(GO:0016641)
0.1	2.3	GO:0019003	GDP binding(GO:0019003)
0.1	0.5	GO:0019789	SUMO transferase activity(GO:0019789)
0.1	0.7	GO:0043325	phosphatidylinositol-3,4-bisphosphate binding(GO:0043325)
0.1	0.8	GO:0004065	arylsulfatase activity(GO:0004065)
0.0	0.2	GO:0046980	oligopeptide-transporting ATPase activity(GO:0015421) tapasin binding(GO:0046980)
0.0	0.2	GO:0015410	manganese-transporting ATPase activity(GO:0015410)
0.0	0.1	GO:0015193	L-proline transmembrane transporter activity(GO:0015193)
0.0	0.1	GO:0034452	dynactin binding(GO:0034452)