Motif ID: HOXC12_HOXD12
Z-value: 1.726
Transcription factors associated with HOXC12_HOXD12:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
HOXC12 | ENSG00000123407.3 | HOXC12 |
HOXD12 | ENSG00000170178.5 | HOXD12 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.6 | 1.8 | GO:0071460 | negative regulation of necrotic cell death(GO:0060547) cellular response to cell-matrix adhesion(GO:0071460) |
0.3 | 1.0 | GO:0001732 | formation of cytoplasmic translation initiation complex(GO:0001732) cytoplasmic translation(GO:0002181) cytoplasmic translational initiation(GO:0002183) |
0.3 | 0.8 | GO:0006348 | chromatin silencing at telomere(GO:0006348) |
0.3 | 1.3 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
0.2 | 0.7 | GO:0071380 | cellular response to prostaglandin E stimulus(GO:0071380) |
0.2 | 1.0 | GO:0070537 | histone H2A K63-linked deubiquitination(GO:0070537) |
0.1 | 0.4 | GO:0021896 | forebrain astrocyte differentiation(GO:0021896) forebrain astrocyte development(GO:0021897) |
0.1 | 2.0 | GO:0050718 | positive regulation of interleukin-1 beta secretion(GO:0050718) |
0.1 | 0.4 | GO:1901419 | regulation of response to alcohol(GO:1901419) |
0.1 | 0.3 | GO:0009107 | lipoate biosynthetic process(GO:0009107) |
0.1 | 0.4 | GO:0071025 | RNA surveillance(GO:0071025) nuclear RNA surveillance(GO:0071027) nuclear mRNA surveillance(GO:0071028) |
0.1 | 1.6 | GO:0050812 | acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812) |
0.1 | 0.4 | GO:0043653 | mitochondrial fragmentation involved in apoptotic process(GO:0043653) |
0.1 | 0.6 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672) |
0.1 | 0.6 | GO:0000012 | single strand break repair(GO:0000012) |
0.1 | 1.5 | GO:0030260 | entry into host cell(GO:0030260) entry into host(GO:0044409) entry into cell of other organism involved in symbiotic interaction(GO:0051806) entry into other organism involved in symbiotic interaction(GO:0051828) |
0.1 | 0.2 | GO:0030205 | dermatan sulfate metabolic process(GO:0030205) dermatan sulfate biosynthetic process(GO:0030208) |
0.1 | 0.6 | GO:0030903 | notochord development(GO:0030903) |
0.1 | 1.4 | GO:0043968 | histone H2A acetylation(GO:0043968) |
0.1 | 0.4 | GO:1901881 | positive regulation of protein depolymerization(GO:1901881) |
0.1 | 1.4 | GO:0032781 | positive regulation of ATPase activity(GO:0032781) |
0.1 | 0.4 | GO:0034501 | protein localization to kinetochore(GO:0034501) |
0.1 | 0.2 | GO:0006269 | DNA replication, synthesis of RNA primer(GO:0006269) |
0.1 | 0.2 | GO:0051661 | Golgi localization(GO:0051645) maintenance of centrosome location(GO:0051661) |
0.1 | 0.2 | GO:0061032 | visceral serous pericardium development(GO:0061032) |
0.1 | 0.4 | GO:0006102 | isocitrate metabolic process(GO:0006102) |
0.0 | 0.4 | GO:0043923 | positive regulation by host of viral transcription(GO:0043923) |
0.0 | 0.8 | GO:0006700 | C21-steroid hormone biosynthetic process(GO:0006700) |
0.0 | 0.2 | GO:0001831 | trophectodermal cellular morphogenesis(GO:0001831) |
0.0 | 1.1 | GO:0030224 | monocyte differentiation(GO:0030224) |
0.0 | 0.4 | GO:0015074 | DNA integration(GO:0015074) |
0.0 | 0.3 | GO:0043615 | astrocyte cell migration(GO:0043615) |
0.0 | 0.5 | GO:0007076 | mitotic chromosome condensation(GO:0007076) |
0.0 | 0.1 | GO:0009296 | obsolete flagellum assembly(GO:0009296) |
0.0 | 0.3 | GO:0060261 | positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144) |
0.0 | 0.1 | GO:0000491 | small nucleolar ribonucleoprotein complex assembly(GO:0000491) box C/D snoRNP assembly(GO:0000492) |
0.0 | 0.2 | GO:0010447 | response to acidic pH(GO:0010447) |
0.0 | 1.5 | GO:0034968 | histone lysine methylation(GO:0034968) |
0.0 | 0.1 | GO:0010157 | response to chlorate(GO:0010157) |
0.0 | 0.7 | GO:0000291 | nuclear-transcribed mRNA catabolic process, exonucleolytic(GO:0000291) exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay(GO:0043928) |
0.0 | 4.4 | GO:0065004 | protein-DNA complex assembly(GO:0065004) |
0.0 | 0.2 | GO:0017183 | peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) |
0.0 | 0.2 | GO:0042448 | progesterone metabolic process(GO:0042448) |
0.0 | 1.5 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
0.0 | 1.6 | GO:0043038 | tRNA aminoacylation for protein translation(GO:0006418) amino acid activation(GO:0043038) tRNA aminoacylation(GO:0043039) |
0.0 | 0.1 | GO:0019482 | beta-alanine metabolic process(GO:0019482) |
0.0 | 0.5 | GO:0042403 | thyroid hormone metabolic process(GO:0042403) |
0.0 | 0.9 | GO:0000387 | spliceosomal snRNP assembly(GO:0000387) |
0.0 | 0.4 | GO:0000731 | DNA synthesis involved in DNA repair(GO:0000731) |
0.0 | 0.4 | GO:0048024 | regulation of mRNA splicing, via spliceosome(GO:0048024) |
0.0 | 0.3 | GO:0048821 | erythrocyte development(GO:0048821) myeloid cell development(GO:0061515) |
0.0 | 1.8 | GO:0030833 | regulation of actin filament polymerization(GO:0030833) |
0.0 | 0.2 | GO:0051205 | protein insertion into membrane(GO:0051205) |
0.0 | 0.2 | GO:0009223 | pyrimidine deoxyribonucleotide catabolic process(GO:0009223) |
0.0 | 0.2 | GO:0016998 | cell wall macromolecule catabolic process(GO:0016998) |
0.0 | 0.2 | GO:0048712 | negative regulation of astrocyte differentiation(GO:0048712) |
0.0 | 0.2 | GO:0031670 | cellular response to nutrient(GO:0031670) |
0.0 | 0.0 | GO:0051967 | negative regulation of synaptic transmission, glutamatergic(GO:0051967) |
0.0 | 0.2 | GO:0008608 | attachment of spindle microtubules to kinetochore(GO:0008608) |
0.0 | 0.3 | GO:0045070 | positive regulation of viral genome replication(GO:0045070) |
0.0 | 0.4 | GO:0009954 | proximal/distal pattern formation(GO:0009954) |
0.0 | 0.1 | GO:0031580 | membrane raft polarization(GO:0001766) membrane raft distribution(GO:0031580) |
0.0 | 0.6 | GO:0000080 | mitotic G1 phase(GO:0000080) |
0.0 | 0.1 | GO:0006166 | purine ribonucleoside salvage(GO:0006166) |
0.0 | 0.5 | GO:0007062 | sister chromatid cohesion(GO:0007062) |
0.0 | 1.0 | GO:0007193 | adenylate cyclase-inhibiting G-protein coupled receptor signaling pathway(GO:0007193) |
0.0 | 0.7 | GO:0008633 | obsolete activation of pro-apoptotic gene products(GO:0008633) |
0.0 | 0.1 | GO:0030277 | epithelial structure maintenance(GO:0010669) maintenance of gastrointestinal epithelium(GO:0030277) |
0.0 | 0.3 | GO:0090399 | replicative senescence(GO:0090399) |
0.0 | 0.1 | GO:0006768 | biotin metabolic process(GO:0006768) |
0.0 | 0.1 | GO:0043030 | regulation of macrophage activation(GO:0043030) |
0.0 | 0.5 | GO:0030866 | cortical cytoskeleton organization(GO:0030865) cortical actin cytoskeleton organization(GO:0030866) |
0.0 | 0.6 | GO:0006611 | protein export from nucleus(GO:0006611) |
0.0 | 0.4 | GO:0030574 | collagen catabolic process(GO:0030574) |
0.0 | 1.9 | GO:0007162 | negative regulation of cell adhesion(GO:0007162) |
0.0 | 0.1 | GO:0043248 | proteasome assembly(GO:0043248) |
0.0 | 0.1 | GO:0045671 | negative regulation of osteoclast differentiation(GO:0045671) |
0.0 | 0.1 | GO:0070050 | neuron cellular homeostasis(GO:0070050) |
0.0 | 0.5 | GO:0046320 | regulation of fatty acid oxidation(GO:0046320) |
0.0 | 0.8 | GO:0000236 | mitotic prometaphase(GO:0000236) |
0.0 | 0.1 | GO:0018125 | peptidyl-cysteine methylation(GO:0018125) |
0.0 | 0.2 | GO:0009268 | response to pH(GO:0009268) |
0.0 | 0.9 | GO:0097696 | JAK-STAT cascade(GO:0007259) STAT cascade(GO:0097696) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.9 | GO:0045254 | pyruvate dehydrogenase complex(GO:0045254) |
0.2 | 1.3 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
0.2 | 0.5 | GO:0000308 | cytoplasmic cyclin-dependent protein kinase holoenzyme complex(GO:0000308) |
0.1 | 0.4 | GO:0005726 | perichromatin fibrils(GO:0005726) |
0.1 | 1.5 | GO:0000808 | origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664) |
0.1 | 0.4 | GO:0033270 | paranode region of axon(GO:0033270) |
0.1 | 1.0 | GO:0070531 | BRCA1-A complex(GO:0070531) |
0.1 | 0.4 | GO:0032133 | chromosome passenger complex(GO:0032133) |
0.1 | 0.6 | GO:0031095 | platelet dense tubular network membrane(GO:0031095) |
0.1 | 1.4 | GO:0031672 | A band(GO:0031672) |
0.1 | 0.5 | GO:0000796 | condensin complex(GO:0000796) |
0.1 | 1.4 | GO:0035267 | NuA4 histone acetyltransferase complex(GO:0035267) |
0.0 | 0.9 | GO:0097525 | spliceosomal snRNP complex(GO:0097525) |
0.0 | 1.0 | GO:0005852 | eukaryotic translation initiation factor 3 complex(GO:0005852) |
0.0 | 0.2 | GO:0031235 | intrinsic component of the cytoplasmic side of the plasma membrane(GO:0031235) |
0.0 | 0.6 | GO:0071778 | obsolete WINAC complex(GO:0071778) |
0.0 | 0.5 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
0.0 | 0.5 | GO:0005833 | hemoglobin complex(GO:0005833) |
0.0 | 1.8 | GO:0044815 | DNA packaging complex(GO:0044815) |
0.0 | 0.4 | GO:0005744 | mitochondrial inner membrane presequence translocase complex(GO:0005744) |
0.0 | 0.5 | GO:0000178 | exosome (RNase complex)(GO:0000178) |
0.0 | 0.2 | GO:0005658 | alpha DNA polymerase:primase complex(GO:0005658) |
0.0 | 0.2 | GO:0045179 | apical cortex(GO:0045179) |
0.0 | 0.5 | GO:0032982 | myosin filament(GO:0032982) |
0.0 | 1.5 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
0.0 | 0.2 | GO:0005663 | DNA replication factor C complex(GO:0005663) |
0.0 | 0.2 | GO:0005827 | polar microtubule(GO:0005827) |
0.0 | 0.1 | GO:0070761 | pre-snoRNP complex(GO:0070761) |
0.0 | 0.2 | GO:0031616 | spindle pole centrosome(GO:0031616) |
0.0 | 0.4 | GO:0005669 | transcription factor TFIID complex(GO:0005669) |
0.0 | 0.4 | GO:0005746 | mitochondrial respiratory chain(GO:0005746) |
0.0 | 0.1 | GO:0034464 | BBSome(GO:0034464) |
0.0 | 0.4 | GO:0005801 | cis-Golgi network(GO:0005801) |
0.0 | 0.8 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
0.0 | 0.3 | GO:0008023 | transcription elongation factor complex(GO:0008023) |
0.0 | 0.0 | GO:0043198 | dendritic shaft(GO:0043198) |
0.0 | 0.3 | GO:0030427 | growth cone(GO:0030426) site of polarized growth(GO:0030427) |
0.0 | 1.1 | GO:0000777 | condensed chromosome kinetochore(GO:0000777) |
0.0 | 0.4 | GO:0000932 | cytoplasmic mRNA processing body(GO:0000932) |
0.0 | 0.8 | GO:0016459 | myosin complex(GO:0016459) |
0.0 | 3.4 | GO:0005667 | transcription factor complex(GO:0005667) |
0.0 | 0.1 | GO:0005858 | axonemal dynein complex(GO:0005858) axoneme part(GO:0044447) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.7 | 2.0 | GO:0032089 | NACHT domain binding(GO:0032089) |
0.6 | 1.9 | GO:0016418 | S-acetyltransferase activity(GO:0016418) |
0.4 | 1.4 | GO:0032038 | myosin II heavy chain binding(GO:0032038) |
0.3 | 2.2 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
0.2 | 2.5 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
0.2 | 1.0 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
0.2 | 2.8 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093) |
0.2 | 1.8 | GO:0008432 | JUN kinase binding(GO:0008432) |
0.1 | 0.4 | GO:0004609 | phosphatidylserine decarboxylase activity(GO:0004609) |
0.1 | 0.6 | GO:0070259 | tyrosyl-DNA phosphodiesterase activity(GO:0070259) |
0.1 | 1.3 | GO:0016494 | C-X-C chemokine receptor activity(GO:0016494) |
0.1 | 0.4 | GO:0019215 | intermediate filament binding(GO:0019215) |
0.1 | 0.6 | GO:0005220 | inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity(GO:0005220) |
0.1 | 0.3 | GO:0070283 | lipoate-protein ligase activity(GO:0016979) lipoate synthase activity(GO:0016992) radical SAM enzyme activity(GO:0070283) |
0.1 | 0.4 | GO:0004449 | isocitrate dehydrogenase (NAD+) activity(GO:0004449) |
0.1 | 0.4 | GO:0008907 | integrase activity(GO:0008907) |
0.1 | 0.3 | GO:0004083 | bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619) |
0.1 | 0.2 | GO:0001618 | virus receptor activity(GO:0001618) |
0.1 | 1.3 | GO:0016780 | phosphotransferase activity, for other substituted phosphate groups(GO:0016780) |
0.1 | 0.4 | GO:0004749 | ribose phosphate diphosphokinase activity(GO:0004749) |
0.1 | 0.2 | GO:0003896 | DNA primase activity(GO:0003896) |
0.1 | 0.2 | GO:0034481 | chondroitin sulfotransferase activity(GO:0034481) |
0.1 | 0.2 | GO:0008431 | vitamin E binding(GO:0008431) |
0.0 | 1.4 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
0.0 | 0.3 | GO:0008649 | rRNA methyltransferase activity(GO:0008649) |
0.0 | 0.2 | GO:0019103 | pyrimidine nucleotide binding(GO:0019103) |
0.0 | 0.9 | GO:0017069 | snRNA binding(GO:0017069) |
0.0 | 0.5 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
0.0 | 0.4 | GO:0034056 | estrogen response element binding(GO:0034056) |
0.0 | 0.8 | GO:0017091 | AU-rich element binding(GO:0017091) |
0.0 | 0.2 | GO:0034701 | tripeptidase activity(GO:0034701) |
0.0 | 0.2 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
0.0 | 0.5 | GO:0005344 | oxygen transporter activity(GO:0005344) |
0.0 | 1.5 | GO:0004864 | protein phosphatase inhibitor activity(GO:0004864) |
0.0 | 0.5 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
0.0 | 0.2 | GO:0003689 | DNA clamp loader activity(GO:0003689) protein-DNA loading ATPase activity(GO:0033170) |
0.0 | 0.6 | GO:0030332 | cyclin binding(GO:0030332) |
0.0 | 0.4 | GO:0015450 | P-P-bond-hydrolysis-driven protein transmembrane transporter activity(GO:0015450) |
0.0 | 1.5 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
0.0 | 0.5 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
0.0 | 0.1 | GO:0030197 | extracellular matrix constituent, lubricant activity(GO:0030197) |
0.0 | 0.3 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
0.0 | 0.1 | GO:0002054 | nucleobase binding(GO:0002054) |
0.0 | 1.6 | GO:0016875 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
0.0 | 1.5 | GO:0050136 | NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
0.0 | 0.1 | GO:0005113 | patched binding(GO:0005113) |
0.0 | 0.1 | GO:0005223 | intracellular cGMP activated cation channel activity(GO:0005223) |
0.0 | 0.3 | GO:0017127 | cholesterol transporter activity(GO:0017127) |
0.0 | 0.4 | GO:0042809 | vitamin D receptor binding(GO:0042809) |
0.0 | 0.6 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
0.0 | 0.1 | GO:0004667 | prostaglandin-D synthase activity(GO:0004667) |
0.0 | 0.1 | GO:0008523 | sodium-dependent multivitamin transmembrane transporter activity(GO:0008523) |
0.0 | 1.7 | GO:0008094 | DNA-dependent ATPase activity(GO:0008094) |
0.0 | 0.2 | GO:0005123 | death receptor binding(GO:0005123) |
0.0 | 0.4 | GO:0016755 | transferase activity, transferring amino-acyl groups(GO:0016755) |
0.0 | 0.8 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
0.0 | 0.3 | GO:0017025 | TBP-class protein binding(GO:0017025) |
0.0 | 1.3 | GO:0003743 | translation initiation factor activity(GO:0003743) |
0.0 | 0.1 | GO:0008312 | 7S RNA binding(GO:0008312) |
0.0 | 0.1 | GO:0032266 | phosphatidylinositol-3-phosphate binding(GO:0032266) |
0.0 | 0.4 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
0.0 | 0.2 | GO:0047035 | testosterone dehydrogenase (NAD+) activity(GO:0047035) |
0.0 | 0.1 | GO:0016167 | glial cell-derived neurotrophic factor receptor activity(GO:0016167) |
0.0 | 3.6 | GO:0016564 | obsolete transcription repressor activity(GO:0016564) |
0.0 | 0.2 | GO:0008536 | Ran GTPase binding(GO:0008536) |
0.0 | 0.1 | GO:0001530 | lipopolysaccharide binding(GO:0001530) |
0.0 | 0.2 | GO:0001104 | transcription factor activity, RNA polymerase II transcription factor binding(GO:0001076) RNA polymerase II transcription cofactor activity(GO:0001104) |
0.0 | 0.2 | GO:0001972 | retinoic acid binding(GO:0001972) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 0.6 | ST_WNT_CA2_CYCLIC_GMP_PATHWAY | Wnt/Ca2+/cyclic GMP signaling. |
0.0 | 0.5 | SA_B_CELL_RECEPTOR_COMPLEXES | Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases. |