Motif ID: HOXD11_HOXA11

Z-value: 1.020

Transcription factors associated with HOXD11_HOXA11:

Gene SymbolEntrez IDGene Name
HOXA11 ENSG00000005073.5 HOXA11
HOXD11 ENSG00000128713.11 HOXD11






Network of associatons between targets according to the STRING database.



First level regulatory network of HOXD11_HOXA11

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chrX_+_65382433 2.201 ENST00000374727.3
HEPH
hephaestin
chrX_+_65384182 1.485 ENST00000441993.2
ENST00000419594.1
HEPH

hephaestin

chrX_+_65384052 1.303 ENST00000336279.5
ENST00000458621.1
HEPH

hephaestin

chr15_-_58571445 1.148 ENST00000558231.1
ALDH1A2
aldehyde dehydrogenase 1 family, member A2
chr19_-_10446449 1.055 ENST00000592439.1
ICAM3
intercellular adhesion molecule 3
chr12_-_25055177 0.884 ENST00000538118.1
BCAT1
branched chain amino-acid transaminase 1, cytosolic
chrX_+_65382381 0.831 ENST00000519389.1
HEPH
hephaestin
chr18_-_52989217 0.820 ENST00000570287.2
TCF4
transcription factor 4
chrX_+_30261847 0.716 ENST00000378981.3
ENST00000397550.1
MAGEB1

melanoma antigen family B, 1

chr7_+_150065278 0.700 ENST00000519397.1
ENST00000479668.1
ENST00000540729.1
REPIN1


replication initiator 1


chr17_+_58018269 0.630 ENST00000591035.1
RP11-178C3.1
Uncharacterized protein
chr6_+_12958137 0.620 ENST00000457702.2
ENST00000379345.2
PHACTR1

phosphatase and actin regulator 1

chr4_+_120056939 0.595 ENST00000307128.5
MYOZ2
myozenin 2
chr18_-_53069419 0.589 ENST00000570177.2
TCF4
transcription factor 4
chrX_-_100604184 0.578 ENST00000372902.3
TIMM8A
translocase of inner mitochondrial membrane 8 homolog A (yeast)
chr3_-_141747950 0.562 ENST00000497579.1
TFDP2
transcription factor Dp-2 (E2F dimerization partner 2)
chr12_-_71148357 0.562 ENST00000378778.1
PTPRR
protein tyrosine phosphatase, receptor type, R
chrX_+_49294472 0.560 ENST00000361446.5
GAGE12B
G antigen 12B
chr18_-_53177984 0.548 ENST00000543082.1
TCF4
transcription factor 4
chr14_-_25479811 0.547 ENST00000550887.1
STXBP6
syntaxin binding protein 6 (amisyn)
chr8_+_107738240 0.545 ENST00000449762.2
ENST00000297447.6
OXR1

oxidation resistance 1

chr4_+_40198527 0.541 ENST00000381799.5
RHOH
ras homolog family member H
chr1_-_144995074 0.521 ENST00000534536.1
PDE4DIP
phosphodiesterase 4D interacting protein
chr18_+_32556892 0.510 ENST00000591734.1
ENST00000413393.1
ENST00000589180.1
ENST00000587359.1
MAPRE2



microtubule-associated protein, RP/EB family, member 2



chr6_-_32498046 0.502 ENST00000374975.3
HLA-DRB5
major histocompatibility complex, class II, DR beta 5
chr5_-_111093167 0.497 ENST00000446294.2
ENST00000419114.2
NREP

neuronal regeneration related protein

chr2_+_109204743 0.489 ENST00000332345.6
LIMS1
LIM and senescent cell antigen-like domains 1
chr19_+_1440838 0.483 ENST00000594262.1
AC027307.3
Uncharacterized protein
chr6_+_42584847 0.463 ENST00000372883.3
UBR2
ubiquitin protein ligase E3 component n-recognin 2
chr4_+_86396265 0.450 ENST00000395184.1
ARHGAP24
Rho GTPase activating protein 24
chr12_-_71148413 0.450 ENST00000440835.2
ENST00000549308.1
ENST00000550661.1
PTPRR


protein tyrosine phosphatase, receptor type, R


chr6_+_13272904 0.444 ENST00000379335.3
ENST00000379329.1
PHACTR1

phosphatase and actin regulator 1

chr1_-_160231451 0.442 ENST00000495887.1
DCAF8
DDB1 and CUL4 associated factor 8
chr6_+_26156551 0.435 ENST00000304218.3
HIST1H1E
histone cluster 1, H1e
chr21_+_35736302 0.429 ENST00000290310.3
KCNE2
potassium voltage-gated channel, Isk-related family, member 2
chr4_+_170581213 0.421 ENST00000507875.1
CLCN3
chloride channel, voltage-sensitive 3
chr3_+_15045419 0.419 ENST00000406272.2
NR2C2
nuclear receptor subfamily 2, group C, member 2
chr3_+_169629354 0.414 ENST00000428432.2
ENST00000335556.3
SAMD7

sterile alpha motif domain containing 7

chr16_+_20775358 0.410 ENST00000440284.2
ACSM3
acyl-CoA synthetase medium-chain family member 3
chr1_+_192544857 0.406 ENST00000367459.3
ENST00000469578.2
RGS1

regulator of G-protein signaling 1

chr3_+_157827841 0.397 ENST00000295930.3
ENST00000471994.1
ENST00000464171.1
ENST00000312179.6
ENST00000475278.2
RSRC1




arginine/serine-rich coiled-coil 1




chr1_-_155880672 0.396 ENST00000609492.1
ENST00000368322.3
RIT1

Ras-like without CAAX 1

chr15_+_66797455 0.389 ENST00000446801.2
ZWILCH
zwilch kinetochore protein
chr12_-_90049828 0.388 ENST00000261173.2
ENST00000348959.3
ATP2B1

ATPase, Ca++ transporting, plasma membrane 1

chr22_+_41956767 0.375 ENST00000306149.7
CSDC2
cold shock domain containing C2, RNA binding
chr2_+_109204909 0.372 ENST00000393310.1
LIMS1
LIM and senescent cell antigen-like domains 1
chr11_-_5255861 0.372 ENST00000380299.3
HBD
hemoglobin, delta
chr5_+_53751445 0.371 ENST00000302005.1
HSPB3
heat shock 27kDa protein 3
chr19_-_36233332 0.369 ENST00000592537.1
ENST00000246532.1
ENST00000344990.3
ENST00000588992.1
IGFLR1



IGF-like family receptor 1



chr6_+_151042224 0.368 ENST00000358517.2
PLEKHG1
pleckstrin homology domain containing, family G (with RhoGef domain) member 1
chr10_+_94352956 0.367 ENST00000260731.3
KIF11
kinesin family member 11
chr18_-_52989525 0.367 ENST00000457482.3
TCF4
transcription factor 4
chrX_-_33229636 0.360 ENST00000357033.4
DMD
dystrophin
chr15_+_66797627 0.360 ENST00000565627.1
ENST00000564179.1
ZWILCH

zwilch kinetochore protein

chr12_-_90049878 0.355 ENST00000359142.3
ATP2B1
ATPase, Ca++ transporting, plasma membrane 1
chr1_+_23345943 0.355 ENST00000400181.4
ENST00000542151.1
KDM1A

lysine (K)-specific demethylase 1A

chr1_+_23345930 0.355 ENST00000356634.3
KDM1A
lysine (K)-specific demethylase 1A
chr5_-_145562147 0.352 ENST00000545646.1
ENST00000274562.9
ENST00000510191.1
ENST00000394434.2
LARS



leucyl-tRNA synthetase



chr15_-_55541227 0.352 ENST00000566877.1
RAB27A
RAB27A, member RAS oncogene family
chr6_+_26199737 0.352 ENST00000359985.1
HIST1H2BF
histone cluster 1, H2bf
chr6_-_32157947 0.351 ENST00000375050.4
PBX2
pre-B-cell leukemia homeobox 2
chr15_+_67841330 0.346 ENST00000354498.5
MAP2K5
mitogen-activated protein kinase kinase 5
chr7_+_73106926 0.337 ENST00000453316.1
WBSCR22
Williams Beuren syndrome chromosome region 22
chr9_+_108463234 0.331 ENST00000374688.1
TMEM38B
transmembrane protein 38B
chr16_+_68119764 0.323 ENST00000570212.1
ENST00000562926.1
NFATC3

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 3

chr2_-_157198860 0.322 ENST00000409572.1
NR4A2
nuclear receptor subfamily 4, group A, member 2
chr1_+_183774240 0.321 ENST00000360851.3
RGL1
ral guanine nucleotide dissociation stimulator-like 1
chr12_-_9913489 0.306 ENST00000228434.3
ENST00000536709.1
CD69

CD69 molecule

chr6_-_26189304 0.305 ENST00000340756.2
HIST1H4D
histone cluster 1, H4d
chr10_-_115614127 0.304 ENST00000369305.1
DCLRE1A
DNA cross-link repair 1A
chr3_-_98241358 0.295 ENST00000503004.1
ENST00000506575.1
ENST00000513452.1
ENST00000515620.1
CLDND1



claudin domain containing 1



chr8_-_90996459 0.291 ENST00000517337.1
ENST00000409330.1
NBN

nibrin

chr3_+_173116225 0.291 ENST00000457714.1
NLGN1
neuroligin 1
chr4_+_41258786 0.286 ENST00000503431.1
ENST00000284440.4
ENST00000508768.1
ENST00000512788.1
UCHL1



ubiquitin carboxyl-terminal esterase L1 (ubiquitin thiolesterase)



chr17_-_46690839 0.280 ENST00000498634.2
HOXB8
homeobox B8
chrX_-_55057403 0.279 ENST00000396198.3
ENST00000335854.4
ENST00000455688.1
ENST00000330807.5
ALAS2



aminolevulinate, delta-, synthase 2



chr1_-_68962805 0.276 ENST00000370966.5
DEPDC1
DEP domain containing 1
chr19_-_54618650 0.276 ENST00000391757.1
TFPT
TCF3 (E2A) fusion partner (in childhood Leukemia)
chr12_-_6233828 0.276 ENST00000572068.1
ENST00000261405.5
VWF

von Willebrand factor

chr2_+_109271481 0.276 ENST00000542845.1
ENST00000393314.2
LIMS1

LIM and senescent cell antigen-like domains 1

chr7_+_138145076 0.275 ENST00000343526.4
TRIM24
tripartite motif containing 24
chr7_-_37026108 0.275 ENST00000396045.3
ELMO1
engulfment and cell motility 1
chr3_+_157154578 0.274 ENST00000295927.3
PTX3
pentraxin 3, long
chr1_+_6640108 0.274 ENST00000377674.4
ENST00000488936.1
ZBTB48

zinc finger and BTB domain containing 48

chr14_-_21493123 0.272 ENST00000556147.1
ENST00000554489.1
ENST00000555657.1
ENST00000557274.1
ENST00000555158.1
ENST00000554833.1
ENST00000555384.1
ENST00000556420.1
ENST00000554893.1
ENST00000553503.1
ENST00000555733.1
ENST00000553867.1
ENST00000397856.3
ENST00000397855.3
ENST00000556008.1
ENST00000557182.1
ENST00000554483.1
ENST00000556688.1
ENST00000397853.3
ENST00000556329.2
ENST00000554143.1
ENST00000397851.2
ENST00000555142.1
ENST00000557676.1
ENST00000556924.1
NDRG2
























NDRG family member 2
























chr8_-_91095099 0.272 ENST00000265431.3
CALB1
calbindin 1, 28kDa
chr6_-_25042231 0.271 ENST00000510784.2
FAM65B
family with sequence similarity 65, member B
chr1_+_227127981 0.271 ENST00000366778.1
ENST00000366777.3
ENST00000458507.2
ADCK3


aarF domain containing kinase 3


chr1_+_150898812 0.270 ENST00000271640.5
ENST00000448029.1
ENST00000368962.2
ENST00000534805.1
ENST00000368969.4
ENST00000368963.1
ENST00000498193.1
SETDB1






SET domain, bifurcated 1






chr8_+_77593448 0.269 ENST00000521891.2
ZFHX4
zinc finger homeobox 4
chr21_-_28338732 0.267 ENST00000284987.5
ADAMTS5
ADAM metallopeptidase with thrombospondin type 1 motif, 5
chr4_-_84035868 0.264 ENST00000426923.2
ENST00000509973.1
PLAC8

placenta-specific 8

chr17_-_38545799 0.264 ENST00000577541.1
TOP2A
topoisomerase (DNA) II alpha 170kDa
chr19_+_54619125 0.263 ENST00000445811.1
ENST00000419967.1
ENST00000445124.1
ENST00000447810.1
PRPF31



pre-mRNA processing factor 31



chrX_-_135962876 0.262 ENST00000431446.3
ENST00000570135.1
ENST00000320676.7
ENST00000562646.1
RBMX



RNA binding motif protein, X-linked



chr8_-_95220775 0.261 ENST00000441892.2
ENST00000521491.1
ENST00000027335.3
CDH17


cadherin 17, LI cadherin (liver-intestine)


chr6_+_108487245 0.260 ENST00000368986.4
NR2E1
nuclear receptor subfamily 2, group E, member 1
chr1_-_27961720 0.258 ENST00000545953.1
ENST00000374005.3
FGR

feline Gardner-Rasheed sarcoma viral oncogene homolog

chr2_-_207023918 0.258 ENST00000455934.2
ENST00000449699.1
ENST00000454195.1
NDUFS1


NADH dehydrogenase (ubiquinone) Fe-S protein 1, 75kDa (NADH-coenzyme Q reductase)


chr12_+_25205568 0.254 ENST00000548766.1
ENST00000556887.1
LRMP

lymphoid-restricted membrane protein

chr4_-_84035905 0.249 ENST00000311507.4
PLAC8
placenta-specific 8
chr9_-_26892765 0.248 ENST00000520187.1
ENST00000333916.5
CAAP1

caspase activity and apoptosis inhibitor 1

chr15_-_55563072 0.246 ENST00000567380.1
ENST00000565972.1
ENST00000569493.1
RAB27A


RAB27A, member RAS oncogene family


chr6_-_111804905 0.245 ENST00000358835.3
ENST00000435970.1
REV3L

REV3-like, polymerase (DNA directed), zeta, catalytic subunit

chr10_+_21823079 0.243 ENST00000377100.3
ENST00000377072.3
ENST00000446906.2
MLLT10


myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 10


chr8_-_90996837 0.242 ENST00000519426.1
ENST00000265433.3
NBN

nibrin

chr1_+_62439037 0.242 ENST00000545929.1
INADL
InaD-like (Drosophila)
chr2_-_176046391 0.241 ENST00000392541.3
ENST00000409194.1
ATP5G3

ATP synthase, H+ transporting, mitochondrial Fo complex, subunit C3 (subunit 9)

chrX_-_101771645 0.241 ENST00000289373.4
TMSB15A
thymosin beta 15a
chr4_+_174089904 0.240 ENST00000265000.4
GALNT7
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7 (GalNAc-T7)
chr1_-_144995002 0.239 ENST00000369356.4
PDE4DIP
phosphodiesterase 4D interacting protein
chr3_+_190105909 0.237 ENST00000456423.1
CLDN16
claudin 16
chr18_-_5396271 0.236 ENST00000579951.1
EPB41L3
erythrocyte membrane protein band 4.1-like 3
chr10_+_35456444 0.235 ENST00000361599.4
CREM
cAMP responsive element modulator
chr1_-_25291475 0.234 ENST00000338888.3
ENST00000399916.1
RUNX3

runt-related transcription factor 3

chr2_-_136678123 0.233 ENST00000422708.1
DARS
aspartyl-tRNA synthetase
chr10_+_88428206 0.233 ENST00000429277.2
ENST00000458213.2
ENST00000352360.5
LDB3


LIM domain binding 3


chr22_+_23248512 0.233 ENST00000390325.2
IGLC3
immunoglobulin lambda constant 3 (Kern-Oz+ marker)
chr15_+_35270552 0.225 ENST00000391457.2
AC114546.1
HCG37415; PRO1914; Uncharacterized protein
chr19_-_10420459 0.224 ENST00000403352.1
ENST00000403903.3
ZGLP1

zinc finger, GATA-like protein 1

chr12_+_51318513 0.222 ENST00000332160.4
METTL7A
methyltransferase like 7A
chr9_+_2029019 0.220 ENST00000382194.1
SMARCA2
SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 2
chr1_+_26798955 0.217 ENST00000361427.5
HMGN2
high mobility group nucleosomal binding domain 2
chr9_+_131549610 0.216 ENST00000223865.8
TBC1D13
TBC1 domain family, member 13
chr5_-_79950775 0.215 ENST00000439211.2
DHFR
dihydrofolate reductase
chr12_+_25205666 0.214 ENST00000547044.1
LRMP
lymphoid-restricted membrane protein
chr12_+_52056548 0.213 ENST00000545061.1
ENST00000355133.3
SCN8A

sodium channel, voltage gated, type VIII, alpha subunit

chr7_-_38394118 0.212 ENST00000390345.2
TRGV4
T cell receptor gamma variable 4
chr9_+_106856831 0.210 ENST00000303219.8
ENST00000374787.3
SMC2

structural maintenance of chromosomes 2

chr12_-_49418407 0.209 ENST00000526209.1
KMT2D
lysine (K)-specific methyltransferase 2D
chr5_-_111093759 0.209 ENST00000509979.1
ENST00000513100.1
ENST00000508161.1
ENST00000455559.2
NREP



neuronal regeneration related protein



chr6_+_42847348 0.205 ENST00000493763.1
ENST00000304734.5
RPL7L1

ribosomal protein L7-like 1

chr6_-_166582107 0.202 ENST00000296946.2
ENST00000461348.2
ENST00000366871.3
T


T, brachyury homolog (mouse)


chr5_-_98262240 0.202 ENST00000284049.3
CHD1
chromodomain helicase DNA binding protein 1
chr1_-_28527152 0.200 ENST00000321830.5
AL353354.1
Uncharacterized protein
chr18_-_67624160 0.198 ENST00000581982.1
ENST00000280200.4
CD226

CD226 molecule

chr12_-_49504655 0.198 ENST00000551782.1
ENST00000267102.8
LMBR1L

limb development membrane protein 1-like

chr2_-_169887827 0.198 ENST00000263817.6
ABCB11
ATP-binding cassette, sub-family B (MDR/TAP), member 11
chr1_+_70876926 0.198 ENST00000370938.3
ENST00000346806.2
CTH

cystathionase (cystathionine gamma-lyase)

chr11_-_47447970 0.197 ENST00000298852.3
ENST00000530912.1
PSMC3

proteasome (prosome, macropain) 26S subunit, ATPase, 3

chr15_-_35047166 0.197 ENST00000290374.4
GJD2
gap junction protein, delta 2, 36kDa
chr2_-_191115229 0.193 ENST00000409820.2
ENST00000410045.1
HIBCH

3-hydroxyisobutyryl-CoA hydrolase

chr12_-_49504623 0.193 ENST00000550137.1
ENST00000547382.1
LMBR1L

limb development membrane protein 1-like

chr12_-_100486668 0.192 ENST00000550544.1
ENST00000551980.1
ENST00000548045.1
ENST00000545232.2
ENST00000551973.1
UHRF1BP1L




UHRF1 binding protein 1-like




chr8_+_1993173 0.192 ENST00000523438.1
MYOM2
myomesin 2
chr2_+_90198535 0.190 ENST00000390276.2
IGKV1D-12
immunoglobulin kappa variable 1D-12
chr12_-_47219733 0.189 ENST00000547477.1
ENST00000447411.1
ENST00000266579.4
SLC38A4


solute carrier family 38, member 4


chr4_+_95376396 0.189 ENST00000508216.1
ENST00000514743.1
PDLIM5

PDZ and LIM domain 5

chrX_+_99899180 0.186 ENST00000373004.3
SRPX2
sushi-repeat containing protein, X-linked 2
chr8_+_21823726 0.186 ENST00000433566.4
XPO7
exportin 7
chr3_+_35722487 0.186 ENST00000441454.1
ARPP21
cAMP-regulated phosphoprotein, 21kDa
chr4_-_76957214 0.186 ENST00000306621.3
CXCL11
chemokine (C-X-C motif) ligand 11
chr6_+_44215603 0.183 ENST00000371554.1
HSP90AB1
heat shock protein 90kDa alpha (cytosolic), class B member 1
chr13_-_47012325 0.182 ENST00000409879.2
KIAA0226L
KIAA0226-like
chr15_-_80263506 0.181 ENST00000335661.6
BCL2A1
BCL2-related protein A1
chr8_-_117886955 0.180 ENST00000297338.2
RAD21
RAD21 homolog (S. pombe)
chr15_+_41549105 0.179 ENST00000560965.1
CHP1
calcineurin-like EF-hand protein 1
chr8_+_1993152 0.179 ENST00000262113.4
MYOM2
myomesin 2
chr11_+_128563652 0.175 ENST00000527786.2
FLI1
Fli-1 proto-oncogene, ETS transcription factor
chr11_-_102576537 0.175 ENST00000260229.4
MMP27
matrix metallopeptidase 27
chr17_+_7155819 0.174 ENST00000570322.1
ENST00000576496.1
ENST00000574841.2
ELP5


elongator acetyltransferase complex subunit 5


chr12_-_56236734 0.174 ENST00000548629.1
MMP19
matrix metallopeptidase 19
chr3_-_164796269 0.173 ENST00000264382.3
SI
sucrase-isomaltase (alpha-glucosidase)
chr10_-_98031265 0.173 ENST00000224337.5
ENST00000371176.2
BLNK

B-cell linker

chr14_-_106926724 0.173 ENST00000434710.1
IGHV3-43
immunoglobulin heavy variable 3-43
chr1_+_65730385 0.172 ENST00000263441.7
ENST00000395325.3
DNAJC6

DnaJ (Hsp40) homolog, subfamily C, member 6

chr22_-_50700140 0.171 ENST00000215659.8
MAPK12
mitogen-activated protein kinase 12
chrX_+_78003204 0.170 ENST00000435339.3
ENST00000514744.1
LPAR4

lysophosphatidic acid receptor 4

chr3_+_155838337 0.170 ENST00000490337.1
ENST00000389636.5
KCNAB1

potassium voltage-gated channel, shaker-related subfamily, beta member 1

chr8_+_94241867 0.169 ENST00000598428.1
AC016885.1
Uncharacterized protein
chr11_-_47447767 0.168 ENST00000530651.1
ENST00000524447.2
ENST00000531051.2
ENST00000526993.1
ENST00000602866.1
PSMC3




proteasome (prosome, macropain) 26S subunit, ATPase, 3




chr11_-_62473706 0.164 ENST00000403550.1
BSCL2
Berardinelli-Seip congenital lipodystrophy 2 (seipin)
chr3_+_157828152 0.163 ENST00000476899.1
RSRC1
arginine/serine-rich coiled-coil 1
chr17_-_47755436 0.163 ENST00000505581.1
ENST00000514121.1
ENST00000393328.2
ENST00000509079.1
ENST00000393331.3
ENST00000347630.2
ENST00000504102.1
SPOP






speckle-type POZ protein






chr6_-_27114577 0.163 ENST00000356950.1
ENST00000396891.4
HIST1H2BK

histone cluster 1, H2bk

chr11_-_60674037 0.163 ENST00000541371.1
ENST00000227524.4
PRPF19

pre-mRNA processing factor 19

chr18_+_21032781 0.163 ENST00000339486.3
RIOK3
RIO kinase 3
chr14_-_21492113 0.162 ENST00000554094.1
NDRG2
NDRG family member 2
chr11_+_64001962 0.162 ENST00000309422.2
VEGFB
vascular endothelial growth factor B
chr19_-_50083822 0.162 ENST00000596358.1
NOSIP
nitric oxide synthase interacting protein
chr11_-_3400442 0.161 ENST00000429541.2
ENST00000532539.1
ZNF195

zinc finger protein 195

chr1_-_9129598 0.159 ENST00000535586.1
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr11_-_3400330 0.157 ENST00000427810.2
ENST00000005082.9
ENST00000534569.1
ENST00000438262.2
ENST00000528796.1
ENST00000528410.1
ENST00000529678.1
ENST00000354599.6
ENST00000526601.1
ENST00000525502.1
ENST00000533036.1
ENST00000399602.4
ZNF195











zinc finger protein 195











chr1_-_246357029 0.155 ENST00000391836.2
SMYD3
SET and MYND domain containing 3
chr19_-_54619006 0.153 ENST00000391759.1
TFPT
TCF3 (E2A) fusion partner (in childhood Leukemia)
chr15_+_93749295 0.149 ENST00000599897.1
AC112693.2
AC112693.2
chr8_+_125486939 0.149 ENST00000303545.3
RNF139
ring finger protein 139
chr6_-_116447283 0.149 ENST00000452729.1
ENST00000243222.4
COL10A1

collagen, type X, alpha 1

chr8_+_76452097 0.148 ENST00000396423.2
HNF4G
hepatocyte nuclear factor 4, gamma
chr2_+_68592305 0.148 ENST00000234313.7
PLEK
pleckstrin
chr11_-_62473776 0.148 ENST00000278893.7
ENST00000407022.3
ENST00000421906.1
BSCL2


Berardinelli-Seip congenital lipodystrophy 2 (seipin)


chr9_-_93405352 0.147 ENST00000375765.3
DIRAS2
DIRAS family, GTP-binding RAS-like 2
chr19_-_50083803 0.145 ENST00000391853.3
ENST00000339093.3
NOSIP

nitric oxide synthase interacting protein

chr8_-_29120580 0.144 ENST00000524189.1
KIF13B
kinesin family member 13B
chr19_+_50084561 0.144 ENST00000246794.5
PRRG2
proline rich Gla (G-carboxyglutamic acid) 2
chrX_+_1455478 0.144 ENST00000331035.4
IL3RA
interleukin 3 receptor, alpha (low affinity)
chr1_-_9129631 0.143 ENST00000377414.3
SLC2A5
solute carrier family 2 (facilitated glucose/fructose transporter), member 5
chr19_-_23941680 0.141 ENST00000402377.3
ZNF681
zinc finger protein 681
chr15_-_22448819 0.141 ENST00000604066.1
IGHV1OR15-1
immunoglobulin heavy variable 1/OR15-1 (non-functional)
chr14_-_51027838 0.141 ENST00000555216.1
MAP4K5
mitogen-activated protein kinase kinase kinase kinase 5

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 5.8 GO:0006825 copper ion transport(GO:0006825)
0.2 0.7 GO:0034720 histone H3-K4 demethylation(GO:0034720)
0.1 0.9 GO:0009082 branched-chain amino acid biosynthetic process(GO:0009082)
0.1 0.7 GO:0001832 blastocyst growth(GO:0001832)
0.1 1.1 GO:0006776 vitamin A metabolic process(GO:0006776)
0.1 0.4 GO:0008217 regulation of blood pressure(GO:0008217)
0.1 0.6 GO:0043316 natural killer cell activation involved in immune response(GO:0002323) cytotoxic T cell degranulation(GO:0043316) natural killer cell degranulation(GO:0043320)
0.1 0.3 GO:0007412 axon target recognition(GO:0007412)
0.1 0.3 GO:1901419 regulation of response to alcohol(GO:1901419)
0.1 0.4 GO:0048388 endosomal lumen acidification(GO:0048388)
0.1 0.4 GO:0007100 mitotic centrosome separation(GO:0007100)
0.1 0.6 GO:0045039 protein import into mitochondrial inner membrane(GO:0045039)
0.1 0.2 GO:0002431 Fc receptor mediated stimulatory signaling pathway(GO:0002431) regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060368) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369)
0.1 0.4 GO:0006398 mRNA 3'-end processing by stem-loop binding and cleavage(GO:0006398)
0.1 0.4 GO:0016584 nucleosome positioning(GO:0016584)
0.1 0.6 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 0.2 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.1 0.1 GO:1901798 positive regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043517) positive regulation of signal transduction by p53 class mediator(GO:1901798)
0.1 0.3 GO:0006857 oligopeptide transport(GO:0006857)
0.0 0.2 GO:0018352 protein-pyridoxal-5-phosphate linkage(GO:0018352)
0.0 0.1 GO:0070527 platelet aggregation(GO:0070527)
0.0 0.2 GO:0015693 magnesium ion transport(GO:0015693)
0.0 0.3 GO:0016080 synaptic vesicle targeting(GO:0016080)
0.0 0.3 GO:0072207 metanephric tubule development(GO:0072170) metanephric epithelium development(GO:0072207) metanephric nephron tubule development(GO:0072234) metanephric nephron epithelium development(GO:0072243)
0.0 0.1 GO:0010430 ethanol catabolic process(GO:0006068) fatty acid omega-oxidation(GO:0010430)
0.0 0.5 GO:0007141 male meiosis I(GO:0007141)
0.0 0.3 GO:0016265 obsolete death(GO:0016265) dopamine biosynthetic process(GO:0042416)
0.0 0.3 GO:0008228 opsonization(GO:0008228)
0.0 0.2 GO:0015722 canalicular bile acid transport(GO:0015722) bile acid secretion(GO:0032782)
0.0 0.3 GO:0015755 fructose transport(GO:0015755)
0.0 0.1 GO:0043366 beta selection(GO:0043366)
0.0 0.1 GO:0019441 tryptophan catabolic process to kynurenine(GO:0019441)
0.0 0.2 GO:0019985 translesion synthesis(GO:0019985)
0.0 0.2 GO:0035470 positive regulation of vascular wound healing(GO:0035470)
0.0 0.2 GO:0090009 primitive streak formation(GO:0090009)
0.0 0.2 GO:0006422 aspartyl-tRNA aminoacylation(GO:0006422)
0.0 0.3 GO:0046653 tetrahydrofolate metabolic process(GO:0046653)
0.0 0.1 GO:0016926 protein desumoylation(GO:0016926)
0.0 0.3 GO:0000244 spliceosomal tri-snRNP complex assembly(GO:0000244)
0.0 0.2 GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672)
0.0 0.2 GO:0071168 protein localization to chromatin(GO:0071168)
0.0 0.2 GO:0042989 sequestering of actin monomers(GO:0042989)
0.0 0.6 GO:0000380 alternative mRNA splicing, via spliceosome(GO:0000380)
0.0 0.2 GO:0006611 protein export from nucleus(GO:0006611)
0.0 0.1 GO:0002125 maternal aggressive behavior(GO:0002125) obsolete negative regulation of diuresis(GO:0003077) positive regulation of norepinephrine secretion(GO:0010701)
0.0 0.1 GO:0002523 leukocyte migration involved in inflammatory response(GO:0002523)
0.0 0.1 GO:0060164 regulation of timing of neuron differentiation(GO:0060164)
0.0 0.3 GO:0021516 dorsal spinal cord development(GO:0021516)
0.0 0.3 GO:0051001 negative regulation of nitric-oxide synthase activity(GO:0051001)
0.0 0.1 GO:0035455 response to interferon-alpha(GO:0035455)
0.0 0.1 GO:0043438 acetoacetic acid metabolic process(GO:0043438)
0.0 0.5 GO:0006906 vesicle fusion(GO:0006906)
0.0 0.1 GO:0006104 succinyl-CoA metabolic process(GO:0006104)
0.0 0.3 GO:0032364 oxygen homeostasis(GO:0032364)
0.0 0.6 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.0 0.1 GO:0019276 UDP-N-acetylgalactosamine metabolic process(GO:0019276)
0.0 0.2 GO:0001554 luteolysis(GO:0001554)
0.0 0.1 GO:0042118 endothelial cell activation(GO:0042118)
0.0 0.2 GO:0051918 negative regulation of fibrinolysis(GO:0051918)
0.0 3.1 GO:0065004 protein-DNA complex assembly(GO:0065004)
0.0 0.2 GO:0009744 response to sucrose(GO:0009744) response to disaccharide(GO:0034285)
0.0 0.1 GO:2000644 low-density lipoprotein particle receptor catabolic process(GO:0032802) regulation of low-density lipoprotein particle receptor catabolic process(GO:0032803) regulation of neurotrophin production(GO:0032899) negative regulation of neurotrophin production(GO:0032900) negative regulation of transforming growth factor beta production(GO:0071635) regulation of receptor catabolic process(GO:2000644)
0.0 0.1 GO:0036503 ER-associated ubiquitin-dependent protein catabolic process(GO:0030433) response to endoplasmic reticulum stress(GO:0034976) ERAD pathway(GO:0036503)
0.0 0.0 GO:0002689 negative regulation of leukocyte chemotaxis(GO:0002689)
0.0 0.1 GO:0046855 phosphorylated carbohydrate dephosphorylation(GO:0046838) inositol phosphate dephosphorylation(GO:0046855)
0.0 0.1 GO:0060743 epithelial cell maturation involved in prostate gland development(GO:0060743)
0.0 0.1 GO:0060398 regulation of growth hormone receptor signaling pathway(GO:0060398)
0.0 0.1 GO:0070537 histone H2A K63-linked deubiquitination(GO:0070537)
0.0 0.1 GO:0051967 negative regulation of synaptic transmission, glutamatergic(GO:0051967)
0.0 0.3 GO:0050830 defense response to Gram-positive bacterium(GO:0050830)
0.0 0.1 GO:0072369 regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369)
0.0 0.1 GO:0032000 positive regulation of fatty acid beta-oxidation(GO:0032000)
0.0 0.1 GO:0007525 somatic muscle development(GO:0007525)
0.0 0.1 GO:0071436 sodium ion export(GO:0071436)
0.0 0.0 GO:0006041 glucosamine metabolic process(GO:0006041)
0.0 0.1 GO:0016576 histone dephosphorylation(GO:0016576)
0.0 0.2 GO:0006975 DNA damage induced protein phosphorylation(GO:0006975)
0.0 0.1 GO:0045163 clustering of voltage-gated potassium channels(GO:0045163)
0.0 0.3 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.0 GO:0045744 negative regulation of G-protein coupled receptor protein signaling pathway(GO:0045744)
0.0 0.2 GO:0007076 mitotic chromosome condensation(GO:0007076)
0.0 0.1 GO:0008653 lipopolysaccharide metabolic process(GO:0008653)
0.0 0.0 GO:0015742 alpha-ketoglutarate transport(GO:0015742)
0.0 0.3 GO:0043252 sodium-independent organic anion transport(GO:0043252)
0.0 0.5 GO:0043124 negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124)
0.0 0.1 GO:0048386 positive regulation of retinoic acid receptor signaling pathway(GO:0048386) epithelial cell proliferation involved in mammary gland duct elongation(GO:0060750)
0.0 0.0 GO:0019918 peptidyl-arginine methylation, to symmetrical-dimethyl arginine(GO:0019918)
0.0 0.0 GO:0007028 cytoplasm organization(GO:0007028) ribonucleoprotein complex disassembly(GO:0032988)
0.0 0.1 GO:0001507 acetylcholine catabolic process in synaptic cleft(GO:0001507) acetylcholine catabolic process(GO:0006581)
0.0 0.4 GO:0060338 regulation of type I interferon-mediated signaling pathway(GO:0060338)
0.0 0.1 GO:0007023 post-chaperonin tubulin folding pathway(GO:0007023)
0.0 0.2 GO:0007597 blood coagulation, intrinsic pathway(GO:0007597)
0.0 0.1 GO:0032099 negative regulation of appetite(GO:0032099)
0.0 0.2 GO:0051963 regulation of synapse assembly(GO:0051963)
0.0 0.1 GO:0016255 attachment of GPI anchor to protein(GO:0016255)
0.0 0.3 GO:0043297 apical junction assembly(GO:0043297)
0.0 0.1 GO:0007064 mitotic sister chromatid cohesion(GO:0007064)
0.0 0.0 GO:0048659 smooth muscle cell proliferation(GO:0048659)
0.0 0.4 GO:0009954 proximal/distal pattern formation(GO:0009954)
0.0 0.2 GO:0034605 cellular response to heat(GO:0034605)
0.0 0.7 GO:0007569 cell aging(GO:0007569)
0.0 0.3 GO:0071804 cellular potassium ion transport(GO:0071804) potassium ion transmembrane transport(GO:0071805)
0.0 0.3 GO:0030866 cortical actin cytoskeleton organization(GO:0030866)
0.0 0.0 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0 1.0 GO:0034339 obsolete regulation of transcription from RNA polymerase II promoter by nuclear hormone receptor(GO:0034339)
0.0 0.4 GO:0050817 coagulation(GO:0050817)
0.0 0.2 GO:0007628 adult walking behavior(GO:0007628) walking behavior(GO:0090659)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.5 GO:0042405 nuclear inclusion body(GO:0042405)
0.1 0.3 GO:0005726 perichromatin fibrils(GO:0005726)
0.1 0.6 GO:0042719 mitochondrial intermembrane space protein transporter complex(GO:0042719)
0.1 0.3 GO:0005687 U4 snRNP(GO:0005687) U4/U6 x U5 tri-snRNP complex(GO:0046540) spliceosomal tri-snRNP complex(GO:0097526)
0.1 0.2 GO:0005863 striated muscle myosin thick filament(GO:0005863)
0.1 0.3 GO:0033093 Weibel-Palade body(GO:0033093)
0.1 0.7 GO:0000808 origin recognition complex(GO:0000808) nuclear origin of replication recognition complex(GO:0005664)
0.0 0.2 GO:0033270 paranode region of axon(GO:0033270)
0.0 0.6 GO:0032982 myosin filament(GO:0032982)
0.0 0.2 GO:0042575 DNA polymerase complex(GO:0042575)
0.0 0.2 GO:0033268 node of Ranvier(GO:0033268)
0.0 0.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.4 GO:0016585 obsolete chromatin remodeling complex(GO:0016585)
0.0 0.1 GO:0042765 GPI-anchor transamidase complex(GO:0042765)
0.0 0.2 GO:0046581 intercellular canaliculus(GO:0046581)
0.0 0.1 GO:0072669 tRNA-splicing ligase complex(GO:0072669)
0.0 0.4 GO:0005833 hemoglobin complex(GO:0005833)
0.0 0.3 GO:0071778 obsolete WINAC complex(GO:0071778)
0.0 0.2 GO:0000796 condensin complex(GO:0000796)
0.0 0.2 GO:0008278 cohesin complex(GO:0008278)
0.0 0.1 GO:0019815 immunoglobulin complex(GO:0019814) B cell receptor complex(GO:0019815)
0.0 0.6 GO:0016010 dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665)
0.0 1.0 GO:0044815 nucleosome(GO:0000786) DNA packaging complex(GO:0044815)
0.0 0.1 GO:0045179 apical cortex(GO:0045179)
0.0 0.1 GO:0000124 SAGA complex(GO:0000124)
0.0 0.4 GO:0080008 Cul4-RING E3 ubiquitin ligase complex(GO:0080008)
0.0 0.2 GO:0031143 pseudopodium(GO:0031143)
0.0 0.1 GO:0030121 AP-1 adaptor complex(GO:0030121)
0.0 0.3 GO:0033017 sarcoplasmic reticulum membrane(GO:0033017)
0.0 0.3 GO:0000795 synaptonemal complex(GO:0000795)
0.0 0.1 GO:0017119 Golgi transport complex(GO:0017119)
0.0 0.4 GO:0005811 lipid particle(GO:0005811)
0.0 0.6 GO:0030018 Z disc(GO:0030018)
0.0 0.2 GO:0005922 connexon complex(GO:0005922)
0.0 0.1 GO:0033162 melanosome membrane(GO:0033162) chitosome(GO:0045009)
0.0 0.0 GO:0033269 internode region of axon(GO:0033269)
0.0 0.2 GO:0045263 proton-transporting ATP synthase complex, coupling factor F(o)(GO:0045263)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.7 GO:0043426 histone demethylase activity (H3-K4 specific)(GO:0032453) histone demethylase activity (H3-dimethyl-K4 specific)(GO:0034648) MRF binding(GO:0043426)
0.2 2.3 GO:0001011 transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093)
0.1 0.9 GO:0052654 branched-chain-amino-acid transaminase activity(GO:0004084) L-leucine transaminase activity(GO:0052654) L-valine transaminase activity(GO:0052655) L-isoleucine transaminase activity(GO:0052656)
0.1 1.1 GO:0001758 retinal dehydrogenase activity(GO:0001758)
0.1 0.3 GO:0003870 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749)
0.1 0.3 GO:0061505 DNA topoisomerase type II (ATP-hydrolyzing) activity(GO:0003918) DNA topoisomerase II activity(GO:0061505)
0.1 5.9 GO:0005507 copper ion binding(GO:0005507)
0.1 0.2 GO:0015095 magnesium ion transmembrane transporter activity(GO:0015095)
0.1 0.2 GO:0004146 dihydrofolate reductase activity(GO:0004146)
0.1 0.6 GO:0031489 myosin V binding(GO:0031489)
0.1 0.3 GO:0031694 alpha-2A adrenergic receptor binding(GO:0031694)
0.1 0.3 GO:0042043 neurexin family protein binding(GO:0042043)
0.1 0.2 GO:0047708 biotinidase activity(GO:0047708)
0.0 0.3 GO:0005499 vitamin D binding(GO:0005499)
0.0 0.1 GO:0035276 ethanol binding(GO:0035276)
0.0 0.3 GO:0008321 Ral guanyl-nucleotide exchange factor activity(GO:0008321)
0.0 0.6 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.0 0.1 GO:0019962 type I interferon binding(GO:0019962)
0.0 0.3 GO:0005353 fructose transmembrane transporter activity(GO:0005353)
0.0 0.5 GO:0002162 dystroglycan binding(GO:0002162)
0.0 0.4 GO:0034056 estrogen response element binding(GO:0034056)
0.0 0.2 GO:0004815 aspartate-tRNA ligase activity(GO:0004815)
0.0 0.1 GO:0016929 SUMO-specific protease activity(GO:0016929)
0.0 1.0 GO:0005001 transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198)
0.0 0.3 GO:0035673 oligopeptide transmembrane transporter activity(GO:0035673)
0.0 0.2 GO:0005049 nuclear export signal receptor activity(GO:0005049)
0.0 0.4 GO:0047760 butyrate-CoA ligase activity(GO:0047760)
0.0 0.1 GO:0042296 ISG15 transferase activity(GO:0042296)
0.0 1.1 GO:0004864 protein phosphatase inhibitor activity(GO:0004864)
0.0 0.1 GO:0050528 acyloxyacyl hydrolase activity(GO:0050528)
0.0 0.1 GO:0008898 S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898)
0.0 0.1 GO:0001515 opioid peptide activity(GO:0001515)
0.0 0.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.4 GO:0015125 bile acid transmembrane transporter activity(GO:0015125)
0.0 0.4 GO:0005344 oxygen transporter activity(GO:0005344)
0.0 0.1 GO:0005010 insulin-like growth factor-activated receptor activity(GO:0005010)
0.0 0.3 GO:0005068 transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068)
0.0 0.1 GO:0003923 GPI-anchor transamidase activity(GO:0003923)
0.0 0.2 GO:0043183 vascular endothelial growth factor receptor 1 binding(GO:0043183)
0.0 0.2 GO:0030911 TPR domain binding(GO:0030911)
0.0 0.1 GO:0008934 inositol monophosphate 1-phosphatase activity(GO:0008934) inositol monophosphate phosphatase activity(GO:0052834)
0.0 0.1 GO:0070530 K63-linked polyubiquitin binding(GO:0070530)
0.0 0.1 GO:0000156 phosphorelay response regulator activity(GO:0000156)
0.0 0.5 GO:0005095 GTPase inhibitor activity(GO:0005095)
0.0 0.2 GO:0031432 titin binding(GO:0031432)
0.0 0.6 GO:0005388 calcium-transporting ATPase activity(GO:0005388)
0.0 0.3 GO:0030247 pattern binding(GO:0001871) polysaccharide binding(GO:0030247)
0.0 0.1 GO:0070492 oligosaccharide binding(GO:0070492)
0.0 0.1 GO:0004833 tryptophan 2,3-dioxygenase activity(GO:0004833)
0.0 0.5 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.2 GO:0005243 gap junction channel activity(GO:0005243)
0.0 0.2 GO:0008140 cAMP response element binding protein binding(GO:0008140)
0.0 0.1 GO:0005250 A-type (transient outward) potassium channel activity(GO:0005250)
0.0 0.7 GO:0004003 ATP-dependent DNA helicase activity(GO:0004003)
0.0 1.9 GO:0005178 integrin binding(GO:0005178)
0.0 0.1 GO:0004774 succinate-CoA ligase activity(GO:0004774)
0.0 0.4 GO:0005247 voltage-gated chloride channel activity(GO:0005247)
0.0 0.2 GO:0061659 ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659)
0.0 0.2 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.0 0.1 GO:0042731 PH domain binding(GO:0042731)
0.0 0.1 GO:0005132 type I interferon receptor binding(GO:0005132)
0.0 0.1 GO:0019166 trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166)
0.0 0.2 GO:0042805 actinin binding(GO:0042805)
0.0 0.1 GO:0008107 galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127)
0.0 1.4 GO:0003707 steroid hormone receptor activity(GO:0003707)
0.0 0.0 GO:0035243 protein-arginine omega-N symmetric methyltransferase activity(GO:0035243)
0.0 0.7 GO:0015459 potassium channel regulator activity(GO:0015459)
0.0 0.1 GO:0016165 linoleate 13S-lipoxygenase activity(GO:0016165)
0.0 0.3 GO:0003887 DNA-directed DNA polymerase activity(GO:0003887)
0.0 0.1 GO:0048406 nerve growth factor binding(GO:0048406)
0.0 0.1 GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159)
0.0 0.1 GO:0004591 oxoglutarate dehydrogenase (succinyl-transferring) activity(GO:0004591)
0.0 0.1 GO:0016018 cyclosporin A binding(GO:0016018)
0.0 0.3 GO:0005184 neuropeptide hormone activity(GO:0005184)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 ST_JNK_MAPK_PATHWAY JNK MAPK Pathway
0.0 0.4 SA_B_CELL_RECEPTOR_COMPLEXES Antigen binding to B cell receptors activates protein tyrosine kinases, such as the Src family, which ultimate activate MAP kinases.