Motif ID: HSF1
Z-value: 2.676
Transcription factors associated with HSF1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| HSF1 | ENSG00000185122.6 | HSF1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 5.2 | GO:0043316 | natural killer cell activation involved in immune response(GO:0002323) cytotoxic T cell degranulation(GO:0043316) natural killer cell degranulation(GO:0043320) |
| 0.8 | 2.3 | GO:0031642 | negative regulation of myelination(GO:0031642) negative regulation of axon regeneration(GO:0048681) negative regulation of neuron projection regeneration(GO:0070571) |
| 0.6 | 2.4 | GO:0051712 | positive regulation of killing of cells of other organism(GO:0051712) |
| 0.6 | 1.8 | GO:0071603 | negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) endothelial cell-cell adhesion(GO:0071603) |
| 0.6 | 14.0 | GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504) |
| 0.4 | 0.8 | GO:0042501 | serine phosphorylation of STAT protein(GO:0042501) |
| 0.4 | 3.2 | GO:0046831 | regulation of RNA export from nucleus(GO:0046831) |
| 0.3 | 3.7 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
| 0.3 | 1.0 | GO:0010792 | DNA double-strand break processing involved in repair via single-strand annealing(GO:0010792) double-strand break repair via single-strand annealing(GO:0045002) |
| 0.3 | 2.2 | GO:0040032 | post-embryonic body morphogenesis(GO:0040032) |
| 0.3 | 2.4 | GO:0042149 | cellular response to glucose starvation(GO:0042149) |
| 0.3 | 1.4 | GO:0010508 | positive regulation of autophagy(GO:0010508) |
| 0.2 | 0.7 | GO:0006478 | peptidyl-tyrosine sulfation(GO:0006478) |
| 0.2 | 1.4 | GO:0010832 | negative regulation of myotube differentiation(GO:0010832) |
| 0.2 | 0.7 | GO:0045838 | CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361) positive regulation of regulatory T cell differentiation(GO:0045591) positive regulation of membrane potential(GO:0045838) |
| 0.2 | 6.4 | GO:0031581 | hemidesmosome assembly(GO:0031581) |
| 0.2 | 0.9 | GO:0046477 | glycosylceramide catabolic process(GO:0046477) |
| 0.2 | 4.1 | GO:1904031 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031) |
| 0.2 | 1.5 | GO:0015671 | oxygen transport(GO:0015671) |
| 0.2 | 1.0 | GO:0051852 | disruption by host of symbiont cells(GO:0051852) killing by host of symbiont cells(GO:0051873) |
| 0.2 | 1.2 | GO:0006196 | AMP catabolic process(GO:0006196) |
| 0.2 | 2.1 | GO:0035095 | behavioral response to nicotine(GO:0035095) |
| 0.2 | 0.6 | GO:0009202 | purine deoxyribonucleotide biosynthetic process(GO:0009153) deoxyribonucleoside triphosphate biosynthetic process(GO:0009202) |
| 0.2 | 3.9 | GO:0043330 | response to exogenous dsRNA(GO:0043330) |
| 0.2 | 2.1 | GO:0019987 | obsolete negative regulation of anti-apoptosis(GO:0019987) |
| 0.2 | 1.2 | GO:0032472 | cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) Golgi calcium ion transport(GO:0032472) manganese ion homeostasis(GO:0055071) |
| 0.2 | 1.3 | GO:0006855 | drug transmembrane transport(GO:0006855) |
| 0.2 | 0.9 | GO:0045948 | positive regulation of translational initiation(GO:0045948) |
| 0.2 | 0.5 | GO:0070734 | histone H3-K27 methylation(GO:0070734) |
| 0.2 | 2.0 | GO:0042832 | defense response to protozoan(GO:0042832) |
| 0.2 | 0.5 | GO:0048659 | smooth muscle cell proliferation(GO:0048659) |
| 0.2 | 1.7 | GO:0002544 | chronic inflammatory response(GO:0002544) |
| 0.2 | 0.3 | GO:0043049 | otic placode formation(GO:0043049) |
| 0.2 | 0.5 | GO:0003351 | epithelial cilium movement(GO:0003351) epithelial cilium movement involved in determination of left/right asymmetry(GO:0060287) |
| 0.2 | 0.5 | GO:0032609 | interferon-gamma production(GO:0032609) regulation of interferon-gamma production(GO:0032649) positive regulation of interferon-gamma production(GO:0032729) |
| 0.1 | 0.7 | GO:0022614 | membrane to membrane docking(GO:0022614) |
| 0.1 | 0.4 | GO:0046826 | negative regulation of protein export from nucleus(GO:0046826) |
| 0.1 | 0.5 | GO:0006104 | succinyl-CoA metabolic process(GO:0006104) |
| 0.1 | 0.3 | GO:0090206 | relaxation of smooth muscle(GO:0044557) negative regulation of cholesterol biosynthetic process(GO:0045541) relaxation of vascular smooth muscle(GO:0060087) negative regulation of cholesterol metabolic process(GO:0090206) |
| 0.1 | 0.4 | GO:0030259 | lipid glycosylation(GO:0030259) |
| 0.1 | 0.7 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
| 0.1 | 0.7 | GO:0045040 | outer mitochondrial membrane organization(GO:0007008) protein import into mitochondrial outer membrane(GO:0045040) |
| 0.1 | 0.3 | GO:0048295 | positive regulation of isotype switching to IgE isotypes(GO:0048295) |
| 0.1 | 0.5 | GO:1902624 | positive regulation of neutrophil chemotaxis(GO:0090023) positive regulation of neutrophil migration(GO:1902624) |
| 0.1 | 0.8 | GO:0007616 | long-term memory(GO:0007616) |
| 0.1 | 0.5 | GO:0032203 | telomere formation via telomerase(GO:0032203) |
| 0.1 | 0.3 | GO:0034126 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) positive regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034126) |
| 0.1 | 0.6 | GO:0002726 | positive regulation of T cell cytokine production(GO:0002726) |
| 0.1 | 2.4 | GO:0045745 | positive regulation of G-protein coupled receptor protein signaling pathway(GO:0045745) |
| 0.1 | 0.6 | GO:0050689 | negative regulation of defense response to virus by host(GO:0050689) |
| 0.1 | 6.3 | GO:0030183 | B cell differentiation(GO:0030183) |
| 0.1 | 1.2 | GO:0021522 | spinal cord motor neuron differentiation(GO:0021522) |
| 0.1 | 0.3 | GO:0032223 | negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212) |
| 0.1 | 0.3 | GO:2000008 | regulation of protein localization to cell surface(GO:2000008) |
| 0.1 | 0.3 | GO:0010944 | regulation of keratinocyte proliferation(GO:0010837) negative regulation of transcription by competitive promoter binding(GO:0010944) endocardium formation(GO:0060214) |
| 0.1 | 0.4 | GO:0017055 | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055) |
| 0.1 | 1.8 | GO:0006825 | copper ion transport(GO:0006825) |
| 0.1 | 0.7 | GO:0001510 | RNA methylation(GO:0001510) |
| 0.1 | 1.0 | GO:0034643 | establishment of mitochondrion localization, microtubule-mediated(GO:0034643) mitochondrion transport along microtubule(GO:0047497) |
| 0.1 | 0.6 | GO:0051895 | negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392) |
| 0.1 | 0.3 | GO:0021506 | anterior neuropore closure(GO:0021506) neuropore closure(GO:0021995) |
| 0.1 | 1.7 | GO:0050853 | B cell receptor signaling pathway(GO:0050853) |
| 0.1 | 1.5 | GO:0061077 | chaperone-mediated protein folding(GO:0061077) |
| 0.1 | 1.1 | GO:0050930 | induction of positive chemotaxis(GO:0050930) |
| 0.1 | 2.3 | GO:0060338 | regulation of type I interferon-mediated signaling pathway(GO:0060338) |
| 0.1 | 0.4 | GO:0042769 | DNA damage response, detection of DNA damage(GO:0042769) |
| 0.1 | 1.4 | GO:0046676 | negative regulation of insulin secretion(GO:0046676) |
| 0.1 | 1.0 | GO:0001662 | behavioral fear response(GO:0001662) |
| 0.1 | 0.3 | GO:0050685 | regulation of mRNA 3'-end processing(GO:0031440) positive regulation of mRNA 3'-end processing(GO:0031442) positive regulation of mRNA processing(GO:0050685) positive regulation of mRNA metabolic process(GO:1903313) |
| 0.1 | 0.4 | GO:0007021 | tubulin complex assembly(GO:0007021) |
| 0.0 | 0.3 | GO:0006999 | nuclear pore organization(GO:0006999) |
| 0.0 | 0.6 | GO:0001522 | pseudouridine synthesis(GO:0001522) |
| 0.0 | 0.7 | GO:0071214 | cellular response to abiotic stimulus(GO:0071214) |
| 0.0 | 0.2 | GO:0032776 | DNA methylation on cytosine(GO:0032776) C-5 methylation of cytosine(GO:0090116) |
| 0.0 | 0.1 | GO:0048143 | regulation of photoreceptor cell differentiation(GO:0046532) astrocyte activation(GO:0048143) regulation of resting membrane potential(GO:0060075) |
| 0.0 | 0.2 | GO:1902745 | positive regulation of lamellipodium assembly(GO:0010592) positive regulation of lamellipodium organization(GO:1902745) |
| 0.0 | 0.4 | GO:0006787 | porphyrin-containing compound catabolic process(GO:0006787) tetrapyrrole catabolic process(GO:0033015) heme catabolic process(GO:0042167) heme metabolic process(GO:0042168) pigment catabolic process(GO:0046149) |
| 0.0 | 0.3 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.0 | 0.4 | GO:0007271 | synaptic transmission, cholinergic(GO:0007271) |
| 0.0 | 1.0 | GO:0046834 | lipid phosphorylation(GO:0046834) |
| 0.0 | 0.2 | GO:0018106 | peptidyl-histidine phosphorylation(GO:0018106) |
| 0.0 | 0.1 | GO:0006782 | protoporphyrinogen IX biosynthetic process(GO:0006782) |
| 0.0 | 2.9 | GO:0006821 | chloride transport(GO:0006821) |
| 0.0 | 0.1 | GO:0043116 | negative regulation of vascular permeability(GO:0043116) |
| 0.0 | 0.4 | GO:0001539 | cilium or flagellum-dependent cell motility(GO:0001539) |
| 0.0 | 0.3 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.0 | 0.0 | GO:0032899 | regulation of neurotrophin production(GO:0032899) negative regulation of neurotrophin production(GO:0032900) |
| 0.0 | 0.7 | GO:0019674 | NAD metabolic process(GO:0019674) |
| 0.0 | 0.5 | GO:0051131 | chaperone-mediated protein complex assembly(GO:0051131) |
| 0.0 | 5.3 | GO:0051028 | mRNA transport(GO:0051028) |
| 0.0 | 0.3 | GO:0032516 | positive regulation of phosphoprotein phosphatase activity(GO:0032516) |
| 0.0 | 0.3 | GO:0070327 | thyroid hormone transport(GO:0070327) |
| 0.0 | 0.9 | GO:0001937 | negative regulation of endothelial cell proliferation(GO:0001937) |
| 0.0 | 0.3 | GO:0016198 | axon choice point recognition(GO:0016198) |
| 0.0 | 0.7 | GO:0007620 | copulation(GO:0007620) |
| 0.0 | 1.2 | GO:0018149 | peptide cross-linking(GO:0018149) |
| 0.0 | 0.1 | GO:0014889 | muscle atrophy(GO:0014889) |
| 0.0 | 0.1 | GO:0046520 | diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520) |
| 0.0 | 0.2 | GO:0006405 | RNA export from nucleus(GO:0006405) |
| 0.0 | 0.6 | GO:0031146 | SCF-dependent proteasomal ubiquitin-dependent protein catabolic process(GO:0031146) |
| 0.0 | 0.3 | GO:0019359 | nicotinamide nucleotide biosynthetic process(GO:0019359) |
| 0.0 | 1.6 | GO:0006695 | cholesterol biosynthetic process(GO:0006695) |
| 0.0 | 0.1 | GO:0009136 | ADP biosynthetic process(GO:0006172) purine nucleoside diphosphate biosynthetic process(GO:0009136) purine ribonucleoside diphosphate biosynthetic process(GO:0009180) ribonucleoside diphosphate biosynthetic process(GO:0009188) |
| 0.0 | 9.9 | GO:0007283 | spermatogenesis(GO:0007283) male gamete generation(GO:0048232) |
| 0.0 | 0.9 | GO:0007189 | adenylate cyclase-activating G-protein coupled receptor signaling pathway(GO:0007189) |
| 0.0 | 0.1 | GO:0032506 | barrier septum assembly(GO:0000917) cytokinetic process(GO:0032506) cell septum assembly(GO:0090529) mitotic cytokinetic process(GO:1902410) |
| 0.0 | 0.3 | GO:0006027 | glycosaminoglycan catabolic process(GO:0006027) |
| 0.0 | 0.4 | GO:0006359 | regulation of transcription from RNA polymerase III promoter(GO:0006359) |
| 0.0 | 0.5 | GO:0031055 | DNA replication-independent nucleosome assembly(GO:0006336) chromatin remodeling at centromere(GO:0031055) CENP-A containing nucleosome assembly(GO:0034080) DNA replication-independent nucleosome organization(GO:0034724) CENP-A containing chromatin organization(GO:0061641) |
| 0.0 | 0.6 | GO:0007212 | dopamine receptor signaling pathway(GO:0007212) |
| 0.0 | 1.0 | GO:0000725 | double-strand break repair via homologous recombination(GO:0000724) recombinational repair(GO:0000725) |
| 0.0 | 0.4 | GO:1902583 | multi-organism transport(GO:0044766) transport of virus(GO:0046794) intracellular transport of virus(GO:0075733) multi-organism localization(GO:1902579) multi-organism intracellular transport(GO:1902583) |
| 0.0 | 0.1 | GO:0060192 | negative regulation of lipase activity(GO:0060192) |
| 0.0 | 0.4 | GO:0007131 | reciprocal meiotic recombination(GO:0007131) reciprocal DNA recombination(GO:0035825) |
| 0.0 | 0.8 | GO:0006730 | one-carbon metabolic process(GO:0006730) |
| 0.0 | 0.8 | GO:0006885 | regulation of pH(GO:0006885) |
| 0.0 | 0.9 | GO:0051084 | 'de novo' posttranslational protein folding(GO:0051084) |
| 0.0 | 0.5 | GO:0002026 | regulation of the force of heart contraction(GO:0002026) |
| 0.0 | 0.2 | GO:0007585 | respiratory gaseous exchange(GO:0007585) |
| 0.0 | 0.2 | GO:0031444 | slow-twitch skeletal muscle fiber contraction(GO:0031444) |
| 0.0 | 1.5 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.0 | 3.2 | GO:0006813 | potassium ion transport(GO:0006813) |
| 0.0 | 0.3 | GO:0042127 | regulation of cell proliferation(GO:0042127) |
| 0.0 | 1.6 | GO:0007605 | sensory perception of sound(GO:0007605) |
| 0.0 | 0.1 | GO:0006707 | cholesterol catabolic process(GO:0006707) sterol catabolic process(GO:0016127) |
| 0.0 | 0.6 | GO:0098609 | cell-cell adhesion(GO:0098609) |
| 0.0 | 0.1 | GO:0031047 | gene silencing by RNA(GO:0031047) |
| 0.0 | 0.9 | GO:0043038 | tRNA aminoacylation for protein translation(GO:0006418) amino acid activation(GO:0043038) tRNA aminoacylation(GO:0043039) |
| 0.0 | 0.2 | GO:0015939 | pantothenate metabolic process(GO:0015939) |
| 0.0 | 0.7 | GO:0015914 | phospholipid transport(GO:0015914) |
| 0.0 | 0.5 | GO:0040008 | regulation of growth(GO:0040008) |
| 0.0 | 0.1 | GO:0070189 | kynurenine metabolic process(GO:0070189) |
| 0.0 | 0.2 | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling(GO:0043124) |
| 0.0 | 1.4 | GO:0072164 | ureteric bud development(GO:0001657) mesonephric epithelium development(GO:0072163) mesonephric tubule development(GO:0072164) |
| 0.0 | 0.4 | GO:0051181 | cofactor transport(GO:0051181) |
| 0.0 | 0.3 | GO:0006000 | fructose metabolic process(GO:0006000) |
| 0.0 | 0.0 | GO:0006893 | Golgi to plasma membrane transport(GO:0006893) vesicle-mediated transport to the plasma membrane(GO:0098876) |
| 0.0 | 0.2 | GO:0042255 | ribosome assembly(GO:0042255) |
| 0.0 | 0.3 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.0 | 0.4 | GO:0010467 | gene expression(GO:0010467) |
| 0.0 | 1.0 | GO:0006094 | gluconeogenesis(GO:0006094) |
| 0.0 | 0.1 | GO:0003416 | endochondral bone growth(GO:0003416) growth plate cartilage development(GO:0003417) bone growth(GO:0098868) |
| 0.0 | 0.2 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.0 | 0.1 | GO:0006577 | amino-acid betaine metabolic process(GO:0006577) carnitine metabolic process(GO:0009437) |
| 0.0 | 0.4 | GO:0007030 | Golgi organization(GO:0007030) |
| 0.0 | 0.0 | GO:0002051 | osteoblast fate commitment(GO:0002051) |
| 0.0 | 0.3 | GO:0006783 | heme biosynthetic process(GO:0006783) |
| 0.0 | 0.4 | GO:1900181 | negative regulation of protein import into nucleus(GO:0042308) negative regulation of nucleocytoplasmic transport(GO:0046823) negative regulation of intracellular protein transport(GO:0090317) negative regulation of protein localization to nucleus(GO:1900181) negative regulation of protein import(GO:1904590) |
| 0.0 | 0.4 | GO:0050663 | cytokine secretion(GO:0050663) |
| 0.0 | 0.2 | GO:0010039 | response to iron ion(GO:0010039) |
| 0.0 | 0.0 | GO:0010940 | positive regulation of necrotic cell death(GO:0010940) |
| 0.0 | 0.5 | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone(GO:0006120) |
| 0.0 | 0.3 | GO:0018208 | peptidyl-proline modification(GO:0018208) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 13.6 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.4 | 1.8 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.4 | 1.6 | GO:0031229 | integral component of nuclear inner membrane(GO:0005639) intrinsic component of nuclear inner membrane(GO:0031229) nuclear membrane part(GO:0044453) |
| 0.4 | 1.5 | GO:0031838 | haptoglobin-hemoglobin complex(GO:0031838) |
| 0.2 | 3.5 | GO:0005606 | laminin-1 complex(GO:0005606) |
| 0.2 | 1.8 | GO:0071664 | catenin-TCF7L2 complex(GO:0071664) |
| 0.2 | 2.2 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.2 | 0.8 | GO:0016533 | cyclin-dependent protein kinase 5 holoenzyme complex(GO:0016533) |
| 0.2 | 0.5 | GO:0009279 | cell outer membrane(GO:0009279) |
| 0.2 | 2.5 | GO:0031080 | nuclear pore outer ring(GO:0031080) |
| 0.1 | 0.6 | GO:0032585 | multivesicular body membrane(GO:0032585) |
| 0.1 | 4.1 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 2.5 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.1 | 1.2 | GO:0005678 | obsolete chromatin assembly complex(GO:0005678) |
| 0.1 | 0.9 | GO:0005851 | eukaryotic translation initiation factor 2B complex(GO:0005851) |
| 0.1 | 1.6 | GO:0005922 | connexon complex(GO:0005922) |
| 0.1 | 0.9 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.1 | 0.5 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.1 | 0.5 | GO:0030062 | mitochondrial tricarboxylic acid cycle enzyme complex(GO:0030062) |
| 0.1 | 1.0 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.1 | 1.1 | GO:0044224 | juxtaparanode region of axon(GO:0044224) |
| 0.1 | 1.3 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.1 | 0.4 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.1 | 2.6 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 1.3 | GO:0042581 | specific granule(GO:0042581) |
| 0.1 | 0.8 | GO:0045111 | intermediate filament cytoskeleton(GO:0045111) |
| 0.1 | 0.5 | GO:0016272 | prefoldin complex(GO:0016272) |
| 0.1 | 1.1 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.1 | 0.2 | GO:0045257 | mitochondrial respiratory chain complex II, succinate dehydrogenase complex (ubiquinone)(GO:0005749) succinate dehydrogenase complex (ubiquinone)(GO:0045257) respiratory chain complex II(GO:0045273) succinate dehydrogenase complex(GO:0045281) fumarate reductase complex(GO:0045283) |
| 0.1 | 0.4 | GO:0005666 | DNA-directed RNA polymerase III complex(GO:0005666) |
| 0.0 | 0.4 | GO:0032389 | MutLalpha complex(GO:0032389) |
| 0.0 | 1.4 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 0.3 | GO:0034518 | mRNA cap binding complex(GO:0005845) RNA cap binding complex(GO:0034518) |
| 0.0 | 5.0 | GO:0070382 | exocytic vesicle(GO:0070382) |
| 0.0 | 0.8 | GO:0016235 | aggresome(GO:0016235) |
| 0.0 | 0.2 | GO:0038201 | TORC2 complex(GO:0031932) TOR complex(GO:0038201) |
| 0.0 | 0.5 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.0 | 0.7 | GO:0031528 | microvillus membrane(GO:0031528) |
| 0.0 | 1.1 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.0 | 0.4 | GO:0005858 | axonemal dynein complex(GO:0005858) axoneme part(GO:0044447) |
| 0.0 | 0.5 | GO:0032838 | cell projection cytoplasm(GO:0032838) |
| 0.0 | 2.8 | GO:0034707 | chloride channel complex(GO:0034707) |
| 0.0 | 0.3 | GO:0070822 | Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822) |
| 0.0 | 1.0 | GO:0005753 | mitochondrial proton-transporting ATP synthase complex(GO:0005753) |
| 0.0 | 1.5 | GO:0005761 | organellar ribosome(GO:0000313) mitochondrial ribosome(GO:0005761) |
| 0.0 | 0.2 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.0 | 1.6 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 1.7 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 1.8 | GO:0017053 | transcriptional repressor complex(GO:0017053) |
| 0.0 | 0.6 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 1.6 | GO:0005643 | nuclear pore(GO:0005643) |
| 0.0 | 0.8 | GO:0000786 | nucleosome(GO:0000786) |
| 0.0 | 1.5 | GO:0008076 | voltage-gated potassium channel complex(GO:0008076) |
| 0.0 | 0.3 | GO:0005605 | basal lamina(GO:0005605) |
| 0.0 | 1.2 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 2.8 | GO:0016323 | basolateral plasma membrane(GO:0016323) |
| 0.0 | 0.4 | GO:0005640 | nuclear outer membrane(GO:0005640) |
| 0.0 | 0.7 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 0.5 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 0.3 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 2.8 | GO:0030424 | axon(GO:0030424) |
| 0.0 | 0.1 | GO:0005594 | collagen type IX trimer(GO:0005594) |
| 0.0 | 1.0 | GO:0005769 | early endosome(GO:0005769) |
| 0.0 | 0.1 | GO:0016442 | RISC complex(GO:0016442) RNAi effector complex(GO:0031332) |
| 0.0 | 0.1 | GO:0005847 | mRNA cleavage and polyadenylation specificity factor complex(GO:0005847) |
| 0.0 | 0.4 | GO:0098644 | complex of collagen trimers(GO:0098644) |
| 0.0 | 0.1 | GO:0060170 | ciliary membrane(GO:0060170) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.7 | 6.9 | GO:0047179 | platelet-activating factor acetyltransferase activity(GO:0047179) |
| 0.8 | 11.5 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.6 | 3.2 | GO:0008486 | diphosphoinositol-polyphosphate diphosphatase activity(GO:0008486) |
| 0.6 | 1.9 | GO:0004769 | steroid delta-isomerase activity(GO:0004769) |
| 0.6 | 5.2 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.6 | 1.7 | GO:0008525 | phosphatidylcholine transporter activity(GO:0008525) |
| 0.5 | 1.6 | GO:0050613 | delta14-sterol reductase activity(GO:0050613) |
| 0.5 | 2.3 | GO:0004910 | interleukin-1, Type II, blocking receptor activity(GO:0004910) |
| 0.4 | 2.4 | GO:0019863 | IgE binding(GO:0019863) |
| 0.4 | 1.6 | GO:0004727 | prenylated protein tyrosine phosphatase activity(GO:0004727) |
| 0.4 | 1.1 | GO:0004618 | phosphoglycerate kinase activity(GO:0004618) |
| 0.3 | 2.7 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) |
| 0.3 | 2.0 | GO:0030911 | TPR domain binding(GO:0030911) |
| 0.2 | 2.2 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
| 0.2 | 0.7 | GO:0003870 | 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749) |
| 0.2 | 0.7 | GO:0008476 | protein-tyrosine sulfotransferase activity(GO:0008476) |
| 0.2 | 1.8 | GO:0035259 | glucocorticoid receptor binding(GO:0035259) |
| 0.2 | 0.9 | GO:0015925 | galactosidase activity(GO:0015925) |
| 0.2 | 1.8 | GO:0045294 | alpha-catenin binding(GO:0045294) |
| 0.2 | 0.6 | GO:0005174 | CD40 receptor binding(GO:0005174) |
| 0.2 | 1.2 | GO:0015410 | manganese-transporting ATPase activity(GO:0015410) |
| 0.2 | 1.5 | GO:0015166 | polyol transmembrane transporter activity(GO:0015166) |
| 0.2 | 0.7 | GO:0003951 | NAD+ kinase activity(GO:0003951) |
| 0.2 | 0.5 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.2 | 0.5 | GO:0003878 | ATP citrate synthase activity(GO:0003878) |
| 0.2 | 0.2 | GO:0005329 | dopamine transmembrane transporter activity(GO:0005329) |
| 0.2 | 0.8 | GO:0005176 | ErbB-2 class receptor binding(GO:0005176) tau-protein kinase activity(GO:0050321) |
| 0.2 | 0.8 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.1 | 0.9 | GO:0008294 | calcium- and calmodulin-responsive adenylate cyclase activity(GO:0008294) |
| 0.1 | 0.6 | GO:0046703 | natural killer cell lectin-like receptor binding(GO:0046703) |
| 0.1 | 1.0 | GO:0001515 | opioid peptide activity(GO:0001515) |
| 0.1 | 1.2 | GO:0003876 | AMP deaminase activity(GO:0003876) adenosine-phosphate deaminase activity(GO:0047623) |
| 0.1 | 1.0 | GO:0016918 | retinal binding(GO:0016918) |
| 0.1 | 1.5 | GO:0005344 | oxygen transporter activity(GO:0005344) |
| 0.1 | 1.7 | GO:0000155 | phosphorelay sensor kinase activity(GO:0000155) |
| 0.1 | 3.2 | GO:0005487 | nucleocytoplasmic transporter activity(GO:0005487) |
| 0.1 | 1.6 | GO:0003841 | 1-acylglycerol-3-phosphate O-acyltransferase activity(GO:0003841) lysophosphatidic acid acyltransferase activity(GO:0042171) lysophospholipid acyltransferase activity(GO:0071617) |
| 0.1 | 2.8 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.1 | 1.3 | GO:0005243 | gap junction channel activity(GO:0005243) |
| 0.1 | 1.4 | GO:0031078 | histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970) |
| 0.1 | 0.3 | GO:0019784 | NEDD8-specific protease activity(GO:0019784) |
| 0.1 | 0.4 | GO:0004083 | bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619) |
| 0.1 | 0.4 | GO:0004074 | biliverdin reductase activity(GO:0004074) |
| 0.1 | 0.5 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.1 | 0.2 | GO:0004914 | interleukin-5 receptor activity(GO:0004914) |
| 0.1 | 0.6 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.1 | 1.4 | GO:0070403 | NAD+ binding(GO:0070403) |
| 0.1 | 0.8 | GO:0015385 | sodium:proton antiporter activity(GO:0015385) |
| 0.1 | 1.0 | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity(GO:0000014) |
| 0.1 | 0.2 | GO:0070891 | lipoteichoic acid binding(GO:0070891) |
| 0.1 | 2.1 | GO:0043027 | cysteine-type endopeptidase inhibitor activity involved in apoptotic process(GO:0043027) |
| 0.1 | 0.1 | GO:0050816 | phosphothreonine binding(GO:0050816) |
| 0.1 | 0.9 | GO:0001727 | lipid kinase activity(GO:0001727) |
| 0.1 | 0.9 | GO:0031369 | translation initiation factor binding(GO:0031369) |
| 0.1 | 0.6 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.1 | 0.5 | GO:0015651 | quaternary ammonium group transmembrane transporter activity(GO:0015651) |
| 0.1 | 0.3 | GO:0042132 | fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132) |
| 0.1 | 0.3 | GO:0003990 | acetylcholinesterase activity(GO:0003990) |
| 0.1 | 0.6 | GO:0009982 | pseudouridine synthase activity(GO:0009982) |
| 0.1 | 0.6 | GO:0016004 | phospholipase activator activity(GO:0016004) |
| 0.1 | 1.0 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.1 | 0.5 | GO:0043422 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) protein kinase B binding(GO:0043422) |
| 0.1 | 0.2 | GO:0000104 | succinate dehydrogenase activity(GO:0000104) |
| 0.1 | 0.5 | GO:0005384 | manganese ion transmembrane transporter activity(GO:0005384) |
| 0.1 | 0.5 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.0 | 0.6 | GO:0050780 | dopamine receptor binding(GO:0050780) |
| 0.0 | 0.2 | GO:0003956 | NAD(P)+-protein-arginine ADP-ribosyltransferase activity(GO:0003956) |
| 0.0 | 0.3 | GO:0005005 | transmembrane-ephrin receptor activity(GO:0005005) |
| 0.0 | 0.1 | GO:0005127 | ciliary neurotrophic factor receptor binding(GO:0005127) |
| 0.0 | 0.4 | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499) |
| 0.0 | 0.5 | GO:0043531 | ADP binding(GO:0043531) |
| 0.0 | 8.0 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.1 | GO:0000033 | alpha-1,3-mannosyltransferase activity(GO:0000033) |
| 0.0 | 0.4 | GO:0015037 | peptide disulfide oxidoreductase activity(GO:0015037) |
| 0.0 | 0.3 | GO:0004784 | superoxide dismutase activity(GO:0004784) oxidoreductase activity, acting on superoxide radicals as acceptor(GO:0016721) |
| 0.0 | 1.2 | GO:0016251 | obsolete general RNA polymerase II transcription factor activity(GO:0016251) |
| 0.0 | 0.7 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 0.1 | GO:0030350 | iron-responsive element binding(GO:0030350) |
| 0.0 | 0.2 | GO:0004980 | melanocyte-stimulating hormone receptor activity(GO:0004980) |
| 0.0 | 1.1 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 0.7 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.0 | 2.0 | GO:0004402 | histone acetyltransferase activity(GO:0004402) |
| 0.0 | 0.3 | GO:0015349 | thyroid hormone transmembrane transporter activity(GO:0015349) |
| 0.0 | 0.6 | GO:0019206 | nucleoside kinase activity(GO:0019206) |
| 0.0 | 0.3 | GO:0030297 | transmembrane receptor protein tyrosine kinase activator activity(GO:0030297) |
| 0.0 | 2.4 | GO:0003697 | single-stranded DNA binding(GO:0003697) |
| 0.0 | 0.3 | GO:1901567 | icosanoid binding(GO:0050542) arachidonic acid binding(GO:0050544) fatty acid derivative binding(GO:1901567) |
| 0.0 | 1.0 | GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656) |
| 0.0 | 0.9 | GO:0008173 | RNA methyltransferase activity(GO:0008173) |
| 0.0 | 0.4 | GO:0030983 | mismatched DNA binding(GO:0030983) |
| 0.0 | 0.3 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.0 | 0.1 | GO:0004140 | dephospho-CoA kinase activity(GO:0004140) |
| 0.0 | 0.4 | GO:0004143 | diacylglycerol kinase activity(GO:0004143) |
| 0.0 | 0.9 | GO:0051117 | ATPase binding(GO:0051117) |
| 0.0 | 0.1 | GO:0047315 | kynurenine-glyoxylate transaminase activity(GO:0047315) |
| 0.0 | 1.5 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 0.6 | GO:0004806 | triglyceride lipase activity(GO:0004806) |
| 0.0 | 0.1 | GO:0047617 | acyl-CoA hydrolase activity(GO:0047617) |
| 0.0 | 0.3 | GO:0000339 | RNA cap binding(GO:0000339) |
| 0.0 | 0.4 | GO:0030332 | cyclin binding(GO:0030332) |
| 0.0 | 0.4 | GO:0008139 | nuclear localization sequence binding(GO:0008139) |
| 0.0 | 2.6 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 0.7 | GO:0016620 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620) |
| 0.0 | 0.3 | GO:0016493 | C-C chemokine receptor activity(GO:0016493) |
| 0.0 | 0.1 | GO:0005412 | glucose:sodium symporter activity(GO:0005412) |
| 0.0 | 0.5 | GO:0048487 | beta-tubulin binding(GO:0048487) |
| 0.0 | 1.1 | GO:0015459 | potassium channel regulator activity(GO:0015459) |
| 0.0 | 0.6 | GO:0050699 | WW domain binding(GO:0050699) |
| 0.0 | 0.2 | GO:0016565 | obsolete general transcriptional repressor activity(GO:0016565) |
| 0.0 | 0.7 | GO:0016836 | hydro-lyase activity(GO:0016836) |
| 0.0 | 0.1 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.0 | 0.9 | GO:0016875 | aminoacyl-tRNA ligase activity(GO:0004812) ligase activity, forming carbon-oxygen bonds(GO:0016875) ligase activity, forming aminoacyl-tRNA and related compounds(GO:0016876) |
| 0.0 | 0.4 | GO:0003950 | NAD+ ADP-ribosyltransferase activity(GO:0003950) |
| 0.0 | 0.1 | GO:0045029 | UDP-activated nucleotide receptor activity(GO:0045029) |
| 0.0 | 1.6 | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding(GO:0003705) |
| 0.0 | 0.1 | GO:0051087 | chaperone binding(GO:0051087) |
| 0.0 | 0.3 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.0 | 0.3 | GO:0019903 | protein phosphatase binding(GO:0019903) |
| 0.0 | 0.1 | GO:0051766 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766) |
| 0.0 | 0.3 | GO:0005242 | inward rectifier potassium channel activity(GO:0005242) |
| 0.0 | 0.2 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.0 | 0.3 | GO:0043022 | ribosome binding(GO:0043022) |
| 0.0 | 0.1 | GO:0008553 | hydrogen-exporting ATPase activity, phosphorylative mechanism(GO:0008553) |
| 0.0 | 2.5 | GO:0003735 | structural constituent of ribosome(GO:0003735) |
| 0.0 | 0.2 | GO:0031014 | troponin T binding(GO:0031014) |
| 0.0 | 0.1 | GO:0003810 | protein-glutamine gamma-glutamyltransferase activity(GO:0003810) |
| 0.0 | 0.3 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 0.1 | GO:0035014 | phosphatidylinositol 3-kinase regulator activity(GO:0035014) |
| 0.0 | 0.5 | GO:0050136 | NADH dehydrogenase activity(GO:0003954) NADH dehydrogenase (ubiquinone) activity(GO:0008137) NADH dehydrogenase (quinone) activity(GO:0050136) |
| 0.0 | 0.1 | GO:0008109 | N-acetyllactosaminide beta-1,6-N-acetylglucosaminyltransferase activity(GO:0008109) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.9 | ST_TYPE_I_INTERFERON_PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 0.7 | ST_PAC1_RECEPTOR_PATHWAY | PAC1 Receptor Pathway |
| 0.0 | 2.4 | ST_B_CELL_ANTIGEN_RECEPTOR | B Cell Antigen Receptor |
| 0.0 | 1.2 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 0.8 | SIG_CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 2.1 | SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 0.5 | ST_T_CELL_SIGNAL_TRANSDUCTION | T Cell Signal Transduction |
| 0.0 | 0.4 | ST_JNK_MAPK_PATHWAY | JNK MAPK Pathway |
