Motif ID: HSF4
Z-value: 1.407
Transcription factors associated with HSF4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| HSF4 | ENSG00000102878.11 | HSF4 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.8 | GO:0008218 | bioluminescence(GO:0008218) |
| 0.5 | 4.6 | GO:0006564 | L-serine biosynthetic process(GO:0006564) |
| 0.3 | 3.3 | GO:0051085 | chaperone mediated protein folding requiring cofactor(GO:0051085) |
| 0.3 | 3.1 | GO:0006776 | vitamin A metabolic process(GO:0006776) |
| 0.3 | 5.1 | GO:1904031 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031) |
| 0.3 | 0.8 | GO:0071603 | negative regulation of Wnt signaling pathway involved in heart development(GO:0003308) endothelial cell-cell adhesion(GO:0071603) |
| 0.3 | 1.1 | GO:0060839 | radial pattern formation(GO:0009956) lymphatic endothelial cell fate commitment(GO:0060838) endothelial cell fate commitment(GO:0060839) regulation of transcription involved in lymphatic endothelial cell fate commitment(GO:0060849) |
| 0.2 | 0.9 | GO:0006556 | S-adenosylmethionine biosynthetic process(GO:0006556) |
| 0.2 | 1.3 | GO:0060710 | chorio-allantoic fusion(GO:0060710) |
| 0.2 | 15.5 | GO:0009408 | response to heat(GO:0009408) |
| 0.2 | 0.6 | GO:0046007 | negative regulation of activated T cell proliferation(GO:0046007) |
| 0.1 | 0.3 | GO:0051451 | myoblast migration(GO:0051451) |
| 0.1 | 8.0 | GO:0006986 | response to unfolded protein(GO:0006986) |
| 0.1 | 1.0 | GO:0055015 | ventricular cardiac muscle cell development(GO:0055015) |
| 0.1 | 0.2 | GO:0007412 | axon target recognition(GO:0007412) |
| 0.1 | 0.4 | GO:0017183 | peptidyl-diphthamide metabolic process(GO:0017182) peptidyl-diphthamide biosynthetic process from peptidyl-histidine(GO:0017183) |
| 0.0 | 0.4 | GO:0007097 | nuclear migration(GO:0007097) |
| 0.0 | 1.4 | GO:0007030 | Golgi organization(GO:0007030) |
| 0.0 | 0.9 | GO:0043968 | histone H2A acetylation(GO:0043968) |
| 0.0 | 0.1 | GO:0033127 | regulation of histone phosphorylation(GO:0033127) |
| 0.0 | 0.2 | GO:0017055 | negative regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0017055) |
| 0.0 | 0.4 | GO:0031115 | negative regulation of microtubule polymerization(GO:0031115) |
| 0.0 | 1.5 | GO:0051084 | 'de novo' posttranslational protein folding(GO:0051084) |
| 0.0 | 0.3 | GO:0015780 | nucleotide-sugar transport(GO:0015780) |
| 0.0 | 0.5 | GO:0031670 | cellular response to nutrient(GO:0031670) |
| 0.0 | 0.4 | GO:0075713 | establishment of viral latency(GO:0019043) establishment of integrated proviral latency(GO:0075713) |
| 0.0 | 0.4 | GO:0006596 | polyamine biosynthetic process(GO:0006596) |
| 0.0 | 1.8 | GO:0007219 | Notch signaling pathway(GO:0007219) |
| 0.0 | 0.1 | GO:0030263 | apoptotic chromosome condensation(GO:0030263) |
| 0.0 | 0.1 | GO:0008228 | opsonization(GO:0008228) |
| 0.0 | 1.3 | GO:0000079 | regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0000079) regulation of cyclin-dependent protein kinase activity(GO:1904029) |
| 0.0 | 0.2 | GO:0042738 | exogenous drug catabolic process(GO:0042738) |
| 0.0 | 0.2 | GO:0051014 | actin filament severing(GO:0051014) |
| 0.0 | 0.0 | GO:0072369 | regulation of lipid transport by positive regulation of transcription from RNA polymerase II promoter(GO:0072369) |
| 0.0 | 1.4 | GO:0009062 | fatty acid catabolic process(GO:0009062) |
| 0.0 | 0.1 | GO:0031503 | protein complex localization(GO:0031503) |
| 0.0 | 0.2 | GO:0051281 | positive regulation of release of sequestered calcium ion into cytosol(GO:0051281) |
| 0.0 | 2.4 | GO:0051170 | nuclear import(GO:0051170) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 7.0 | GO:0061200 | clathrin-sculpted gamma-aminobutyric acid transport vesicle(GO:0061200) clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane(GO:0061202) |
| 0.2 | 5.1 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.1 | 1.4 | GO:0005832 | chaperonin-containing T-complex(GO:0005832) |
| 0.1 | 1.0 | GO:0034045 | pre-autophagosomal structure membrane(GO:0034045) |
| 0.1 | 0.8 | GO:0071664 | catenin-TCF7L2 complex(GO:0071664) |
| 0.0 | 0.9 | GO:0070822 | Sin3 complex(GO:0016580) Sin3-type complex(GO:0070822) |
| 0.0 | 0.1 | GO:0044295 | axonal growth cone(GO:0044295) |
| 0.0 | 0.2 | GO:0031618 | nuclear pericentric heterochromatin(GO:0031618) |
| 0.0 | 0.1 | GO:0035145 | exon-exon junction complex(GO:0035145) |
| 0.0 | 0.7 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.0 | 1.6 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 4.3 | GO:0019717 | obsolete synaptosome(GO:0019717) |
| 0.0 | 1.1 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 0.2 | GO:0005916 | fascia adherens(GO:0005916) |
| 0.0 | 0.3 | GO:0000421 | autophagosome membrane(GO:0000421) |
| 0.0 | 0.3 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.0 | 0.1 | GO:0001741 | XY body(GO:0001741) |
| 0.0 | 0.4 | GO:0030530 | obsolete heterogeneous nuclear ribonucleoprotein complex(GO:0030530) |
| 0.0 | 0.3 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 0.2 | GO:0033276 | transcription factor TFTC complex(GO:0033276) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.8 | 3.9 | GO:0004647 | phosphoserine phosphatase activity(GO:0004647) |
| 0.5 | 12.4 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.4 | 3.1 | GO:0001758 | retinal dehydrogenase activity(GO:0001758) |
| 0.2 | 3.7 | GO:0030544 | Hsp70 protein binding(GO:0030544) |
| 0.2 | 1.2 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.2 | 1.4 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.1 | 1.0 | GO:0008159 | obsolete positive transcription elongation factor activity(GO:0008159) |
| 0.1 | 0.4 | GO:0098847 | single-stranded telomeric DNA binding(GO:0043047) sequence-specific single stranded DNA binding(GO:0098847) |
| 0.1 | 1.0 | GO:0001671 | ATPase activator activity(GO:0001671) |
| 0.1 | 0.8 | GO:0042153 | obsolete RPTP-like protein binding(GO:0042153) alpha-catenin binding(GO:0045294) |
| 0.1 | 1.1 | GO:0003706 | obsolete ligand-regulated transcription factor activity(GO:0003706) |
| 0.1 | 1.3 | GO:0030742 | GTP-dependent protein binding(GO:0030742) |
| 0.1 | 3.3 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 0.4 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
| 0.1 | 1.8 | GO:0016620 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620) |
| 0.1 | 1.3 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.1 | 0.2 | GO:0004947 | bradykinin receptor activity(GO:0004947) |
| 0.0 | 0.4 | GO:0016018 | cyclosporin A binding(GO:0016018) |
| 0.0 | 0.2 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
| 0.0 | 0.5 | GO:0005123 | death receptor binding(GO:0005123) |
| 0.0 | 0.4 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.0 | 0.3 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.0 | 0.7 | GO:0005095 | GTPase inhibitor activity(GO:0005095) |
| 0.0 | 0.2 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
| 0.0 | 0.1 | GO:0048156 | tau protein binding(GO:0048156) |
| 0.0 | 0.3 | GO:0005338 | nucleotide-sugar transmembrane transporter activity(GO:0005338) |
| 0.0 | 0.1 | GO:0047617 | acyl-CoA hydrolase activity(GO:0047617) |
| 0.0 | 0.3 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
| 0.0 | 6.6 | GO:0042623 | ATPase activity, coupled(GO:0042623) |
| 0.0 | 0.8 | GO:0043130 | ubiquitin binding(GO:0043130) |
| 0.0 | 1.2 | GO:0031072 | heat shock protein binding(GO:0031072) |
| 0.0 | 0.2 | GO:0016565 | obsolete general transcriptional repressor activity(GO:0016565) |
| 0.0 | 4.7 | GO:0019901 | protein kinase binding(GO:0019901) |
| 0.0 | 0.2 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.0 | 0.9 | GO:0016765 | transferase activity, transferring alkyl or aryl (other than methyl) groups(GO:0016765) |
| 0.0 | 0.2 | GO:0051635 | obsolete bacterial cell surface binding(GO:0051635) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.3 | ST_JAK_STAT_PATHWAY | Jak-STAT Pathway |
| 0.0 | 1.1 | ST_P38_MAPK_PATHWAY | p38 MAPK Pathway |
