Motif ID: IKZF2
Z-value: 1.677
Transcription factors associated with IKZF2:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| IKZF2 | ENSG00000030419.12 | IKZF2 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 9.9 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.5 | 5.0 | GO:0097435 | extracellular fibril organization(GO:0043206) fibril organization(GO:0097435) |
| 0.4 | 1.5 | GO:0002158 | osteoclast proliferation(GO:0002158) |
| 0.4 | 1.9 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.4 | 2.2 | GO:0022614 | membrane to membrane docking(GO:0022614) chorio-allantoic fusion(GO:0060710) |
| 0.4 | 1.1 | GO:0043371 | negative regulation of CD4-positive, alpha-beta T cell differentiation(GO:0043371) negative regulation of T-helper cell differentiation(GO:0045623) negative regulation of CD4-positive, alpha-beta T cell activation(GO:2000515) |
| 0.4 | 3.2 | GO:0008354 | germ cell migration(GO:0008354) |
| 0.2 | 0.7 | GO:0014889 | muscle atrophy(GO:0014889) regulation of skeletal muscle tissue growth(GO:0048631) |
| 0.2 | 0.7 | GO:0071529 | cementum mineralization(GO:0071529) |
| 0.2 | 5.0 | GO:0030224 | monocyte differentiation(GO:0030224) |
| 0.2 | 3.4 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.2 | 0.5 | GO:0007403 | glial cell fate determination(GO:0007403) |
| 0.1 | 0.6 | GO:0071418 | uroporphyrinogen III biosynthetic process(GO:0006780) cellular response to amine stimulus(GO:0071418) |
| 0.1 | 0.9 | GO:0030007 | cellular potassium ion homeostasis(GO:0030007) negative regulation of cell volume(GO:0045794) |
| 0.1 | 1.3 | GO:0006030 | chitin metabolic process(GO:0006030) chitin catabolic process(GO:0006032) |
| 0.1 | 0.9 | GO:0006685 | sphingomyelin catabolic process(GO:0006685) |
| 0.1 | 1.0 | GO:0090292 | nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292) |
| 0.1 | 0.3 | GO:0014063 | regulation of serotonin secretion(GO:0014062) negative regulation of serotonin secretion(GO:0014063) |
| 0.1 | 0.5 | GO:0002313 | mature B cell differentiation involved in immune response(GO:0002313) |
| 0.1 | 2.9 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.1 | 0.5 | GO:0051387 | negative regulation of neurotrophin TRK receptor signaling pathway(GO:0051387) |
| 0.1 | 0.6 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.1 | 0.3 | GO:0010761 | fibroblast migration(GO:0010761) |
| 0.1 | 1.3 | GO:0031000 | response to caffeine(GO:0031000) |
| 0.1 | 0.3 | GO:0050653 | UDP-N-acetylgalactosamine metabolic process(GO:0019276) chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653) |
| 0.1 | 0.1 | GO:0033157 | regulation of intracellular protein transport(GO:0033157) |
| 0.1 | 0.2 | GO:0060318 | CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation(GO:0002361) definitive erythrocyte differentiation(GO:0060318) |
| 0.0 | 1.1 | GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504) |
| 0.0 | 0.2 | GO:0042268 | regulation of cytolysis(GO:0042268) |
| 0.0 | 3.5 | GO:0030198 | extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062) |
| 0.0 | 2.4 | GO:0071377 | cellular response to glucagon stimulus(GO:0071377) |
| 0.0 | 0.4 | GO:0051014 | actin filament severing(GO:0051014) |
| 0.0 | 0.6 | GO:0015884 | folic acid transport(GO:0015884) |
| 0.0 | 0.2 | GO:0035520 | monoubiquitinated protein deubiquitination(GO:0035520) |
| 0.0 | 0.7 | GO:0031529 | ruffle organization(GO:0031529) |
| 0.0 | 1.9 | GO:0001837 | epithelial to mesenchymal transition(GO:0001837) |
| 0.0 | 0.5 | GO:0008634 | obsolete negative regulation of survival gene product expression(GO:0008634) |
| 0.0 | 0.1 | GO:0033590 | response to cobalamin(GO:0033590) |
| 0.0 | 0.2 | GO:0019321 | pentose metabolic process(GO:0019321) |
| 0.0 | 0.2 | GO:0016075 | rRNA catabolic process(GO:0016075) |
| 0.0 | 0.5 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 0.7 | GO:0048008 | platelet-derived growth factor receptor signaling pathway(GO:0048008) |
| 0.0 | 0.3 | GO:0050930 | induction of positive chemotaxis(GO:0050930) |
| 0.0 | 1.0 | GO:0042384 | cilium assembly(GO:0042384) |
| 0.0 | 0.1 | GO:0060052 | neurofilament cytoskeleton organization(GO:0060052) |
| 0.0 | 0.5 | GO:0015701 | bicarbonate transport(GO:0015701) |
| 0.0 | 0.6 | GO:0006099 | tricarboxylic acid cycle(GO:0006099) |
| 0.0 | 0.1 | GO:0006975 | DNA damage induced protein phosphorylation(GO:0006975) |
| 0.0 | 0.2 | GO:0060390 | regulation of SMAD protein import into nucleus(GO:0060390) positive regulation of SMAD protein import into nucleus(GO:0060391) |
| 0.0 | 3.3 | GO:0007565 | female pregnancy(GO:0007565) |
| 0.0 | 0.1 | GO:0006013 | mannose metabolic process(GO:0006013) |
| 0.0 | 0.1 | GO:0006848 | pyruvate transport(GO:0006848) |
| 0.0 | 1.0 | GO:0007585 | respiratory gaseous exchange(GO:0007585) |
| 0.0 | 0.2 | GO:0009223 | pyrimidine deoxyribonucleotide catabolic process(GO:0009223) |
| 0.0 | 0.3 | GO:0033540 | fatty acid beta-oxidation using acyl-CoA oxidase(GO:0033540) |
| 0.0 | 0.1 | GO:0010799 | regulation of peptidyl-threonine phosphorylation(GO:0010799) positive regulation of peptidyl-threonine phosphorylation(GO:0010800) |
| 0.0 | 0.3 | GO:0030889 | negative regulation of B cell proliferation(GO:0030889) |
| 0.0 | 0.2 | GO:0019228 | neuronal action potential(GO:0019228) |
| 0.0 | 0.1 | GO:0002553 | histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553) |
| 0.0 | 0.4 | GO:0090263 | positive regulation of canonical Wnt signaling pathway(GO:0090263) |
| 0.0 | 0.4 | GO:0030520 | intracellular estrogen receptor signaling pathway(GO:0030520) |
| 0.0 | 3.9 | GO:0007517 | muscle organ development(GO:0007517) |
| 0.0 | 0.1 | GO:0032472 | cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) Golgi calcium ion transport(GO:0032472) manganese ion homeostasis(GO:0055071) |
| 0.0 | 0.1 | GO:0006896 | Golgi to endosome transport(GO:0006895) Golgi to vacuole transport(GO:0006896) |
| 0.0 | 0.2 | GO:0048207 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114) |
| 0.0 | 0.2 | GO:0030048 | actin filament-based movement(GO:0030048) |
| 0.0 | 0.3 | GO:0042771 | intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator(GO:0042771) |
| 0.0 | 2.8 | GO:0006979 | response to oxidative stress(GO:0006979) |
| 0.0 | 1.3 | GO:0006367 | transcription initiation from RNA polymerase II promoter(GO:0006367) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.4 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.7 | 2.2 | GO:0071065 | alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065) |
| 0.7 | 9.9 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.6 | 5.0 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.2 | 2.9 | GO:0008091 | spectrin(GO:0008091) |
| 0.1 | 3.1 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.1 | 1.0 | GO:0034464 | BBSome(GO:0034464) |
| 0.1 | 1.0 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.1 | 0.3 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 1.1 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 2.3 | GO:0005834 | heterotrimeric G-protein complex(GO:0005834) |
| 0.0 | 0.5 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 0.3 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 0.1 | GO:0001891 | phagocytic cup(GO:0001891) |
| 0.0 | 0.2 | GO:0071778 | obsolete WINAC complex(GO:0071778) |
| 0.0 | 0.6 | GO:0030018 | Z disc(GO:0030018) |
| 0.0 | 1.0 | GO:0005793 | endoplasmic reticulum-Golgi intermediate compartment(GO:0005793) |
| 0.0 | 5.0 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 0.2 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 3.7 | GO:0005912 | adherens junction(GO:0005912) |
| 0.0 | 0.1 | GO:0005883 | neurofilament(GO:0005883) |
| 0.0 | 0.2 | GO:0019005 | SCF ubiquitin ligase complex(GO:0019005) |
| 0.0 | 0.1 | GO:0031588 | nucleotide-activated protein kinase complex(GO:0031588) |
| 0.0 | 0.2 | GO:0000178 | exosome (RNase complex)(GO:0000178) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.9 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.6 | 3.5 | GO:0042577 | lipid phosphatase activity(GO:0042577) |
| 0.4 | 4.7 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.4 | 2.9 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.3 | 1.6 | GO:0097493 | extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493) |
| 0.3 | 1.5 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
| 0.2 | 9.9 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.1 | 2.3 | GO:0050786 | RAGE receptor binding(GO:0050786) |
| 0.1 | 0.6 | GO:0004852 | uroporphyrinogen-III synthase activity(GO:0004852) |
| 0.1 | 3.4 | GO:0008430 | selenium binding(GO:0008430) |
| 0.1 | 0.9 | GO:0060072 | large conductance calcium-activated potassium channel activity(GO:0060072) |
| 0.1 | 0.5 | GO:0017040 | ceramidase activity(GO:0017040) |
| 0.1 | 1.3 | GO:0004568 | chitinase activity(GO:0004568) |
| 0.1 | 1.5 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093) |
| 0.1 | 0.7 | GO:0004035 | alkaline phosphatase activity(GO:0004035) |
| 0.1 | 1.5 | GO:0005521 | lamin binding(GO:0005521) |
| 0.1 | 0.9 | GO:0004767 | sphingomyelin phosphodiesterase activity(GO:0004767) |
| 0.1 | 0.3 | GO:0008955 | peptidoglycan glycosyltransferase activity(GO:0008955) |
| 0.1 | 1.1 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.1 | 0.5 | GO:0048406 | nerve growth factor binding(GO:0048406) |
| 0.1 | 0.9 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.1 | 1.0 | GO:0005161 | platelet-derived growth factor receptor binding(GO:0005161) |
| 0.1 | 0.5 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) bicarbonate transmembrane transporter activity(GO:0015106) |
| 0.1 | 0.2 | GO:0019870 | potassium channel inhibitor activity(GO:0019870) |
| 0.1 | 0.4 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390) |
| 0.1 | 0.3 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.1 | 0.3 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.1 | 1.1 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.4 | GO:0005068 | transmembrane receptor protein tyrosine kinase adaptor activity(GO:0005068) |
| 0.0 | 3.2 | GO:0046332 | SMAD binding(GO:0046332) |
| 0.0 | 0.4 | GO:1901567 | icosanoid binding(GO:0050542) arachidonic acid binding(GO:0050544) fatty acid derivative binding(GO:1901567) |
| 0.0 | 0.4 | GO:0003988 | acetyl-CoA C-acyltransferase activity(GO:0003988) |
| 0.0 | 4.0 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 0.2 | GO:0019103 | pyrimidine nucleotide binding(GO:0019103) |
| 0.0 | 0.7 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 0.1 | GO:0003704 | obsolete specific RNA polymerase II transcription factor activity(GO:0003704) |
| 0.0 | 0.8 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 0.6 | GO:0005542 | folic acid binding(GO:0005542) |
| 0.0 | 0.6 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.0 | 5.0 | GO:0003690 | double-stranded DNA binding(GO:0003690) |
| 0.0 | 0.2 | GO:0008494 | translation activator activity(GO:0008494) |
| 0.0 | 0.9 | GO:0004177 | aminopeptidase activity(GO:0004177) |
| 0.0 | 0.1 | GO:0050833 | pyruvate secondary active transmembrane transporter activity(GO:0005477) pyruvate transmembrane transporter activity(GO:0050833) |
| 0.0 | 1.1 | GO:0003823 | antigen binding(GO:0003823) |
| 0.0 | 0.3 | GO:0019992 | diacylglycerol binding(GO:0019992) |
| 0.0 | 0.3 | GO:0005247 | voltage-gated chloride channel activity(GO:0005247) |
| 0.0 | 1.1 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 0.6 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 0.1 | GO:0070530 | K63-linked polyubiquitin binding(GO:0070530) |
| 0.0 | 0.1 | GO:0015410 | manganese-transporting ATPase activity(GO:0015410) |
| 0.0 | 0.1 | GO:0008607 | phosphorylase kinase regulator activity(GO:0008607) |
| 0.0 | 0.1 | GO:0016408 | C-acyltransferase activity(GO:0016408) |
| 0.0 | 0.2 | GO:0000175 | 3'-5'-exoribonuclease activity(GO:0000175) |
| 0.0 | 0.2 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.0 | 0.2 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
| 0.0 | 0.0 | GO:0030611 | arsenate reductase activity(GO:0030611) |
| 0.0 | 0.2 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
| 0.0 | 1.4 | GO:0008201 | heparin binding(GO:0008201) |
| 0.0 | 0.1 | GO:0030676 | Rac guanyl-nucleotide exchange factor activity(GO:0030676) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.5 | ST_PAC1_RECEPTOR_PATHWAY | PAC1 Receptor Pathway |
