Motif ID: IRF3
Z-value: 1.857
Transcription factors associated with IRF3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| IRF3 | ENSG00000126456.11 | IRF3 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 2.8 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.5 | 1.4 | GO:0002678 | positive regulation of chronic inflammatory response(GO:0002678) regulation of chronic inflammatory response to antigenic stimulus(GO:0002874) |
| 0.3 | 0.6 | GO:0046967 | cytosol to ER transport(GO:0046967) |
| 0.2 | 1.6 | GO:0002478 | antigen processing and presentation of exogenous peptide antigen(GO:0002478) |
| 0.2 | 1.2 | GO:0042518 | negative regulation of tyrosine phosphorylation of Stat3 protein(GO:0042518) |
| 0.2 | 0.6 | GO:0046341 | CDP-diacylglycerol metabolic process(GO:0046341) |
| 0.2 | 0.6 | GO:0006273 | lagging strand elongation(GO:0006273) |
| 0.2 | 5.0 | GO:0015949 | nucleobase-containing small molecule interconversion(GO:0015949) |
| 0.2 | 1.4 | GO:0048712 | negative regulation of astrocyte differentiation(GO:0048712) |
| 0.1 | 0.7 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 0.1 | 0.9 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 0.1 | 0.4 | GO:0014831 | intestine smooth muscle contraction(GO:0014827) gastro-intestinal system smooth muscle contraction(GO:0014831) |
| 0.1 | 0.7 | GO:0033539 | fatty acid beta-oxidation using acyl-CoA dehydrogenase(GO:0033539) |
| 0.1 | 0.7 | GO:0043247 | protection from non-homologous end joining at telomere(GO:0031848) telomere maintenance in response to DNA damage(GO:0043247) |
| 0.1 | 0.6 | GO:0043316 | natural killer cell activation involved in immune response(GO:0002323) cytotoxic T cell degranulation(GO:0043316) natural killer cell degranulation(GO:0043320) |
| 0.1 | 0.4 | GO:0042519 | tyrosine phosphorylation of Stat4 protein(GO:0042504) regulation of tyrosine phosphorylation of Stat4 protein(GO:0042519) positive regulation of tyrosine phosphorylation of Stat4 protein(GO:0042520) |
| 0.1 | 5.8 | GO:0006521 | regulation of cellular amino acid metabolic process(GO:0006521) |
| 0.1 | 0.5 | GO:0016265 | obsolete death(GO:0016265) dopamine biosynthetic process(GO:0042416) dopaminergic neuron differentiation(GO:0071542) |
| 0.1 | 0.2 | GO:0034498 | early endosome to Golgi transport(GO:0034498) |
| 0.1 | 0.9 | GO:0034446 | substrate adhesion-dependent cell spreading(GO:0034446) |
| 0.1 | 0.5 | GO:0050912 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) detection of chemical stimulus involved in sensory perception of taste(GO:0050912) |
| 0.1 | 5.0 | GO:0071357 | response to type I interferon(GO:0034340) type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.0 | 1.3 | GO:0007263 | nitric oxide mediated signal transduction(GO:0007263) |
| 0.0 | 0.4 | GO:0009249 | protein lipoylation(GO:0009249) |
| 0.0 | 0.3 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.0 | 0.1 | GO:0009992 | cellular water homeostasis(GO:0009992) |
| 0.0 | 0.1 | GO:0045091 | regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091) |
| 0.0 | 0.3 | GO:0030502 | negative regulation of bone mineralization(GO:0030502) |
| 0.0 | 0.1 | GO:0030917 | midbrain-hindbrain boundary development(GO:0030917) |
| 0.0 | 1.3 | GO:0032480 | negative regulation of type I interferon production(GO:0032480) |
| 0.0 | 0.3 | GO:0000381 | regulation of alternative mRNA splicing, via spliceosome(GO:0000381) |
| 0.0 | 0.4 | GO:0021846 | cell proliferation in forebrain(GO:0021846) |
| 0.0 | 0.4 | GO:0042346 | positive regulation of NF-kappaB import into nucleus(GO:0042346) |
| 0.0 | 0.1 | GO:0005984 | disaccharide metabolic process(GO:0005984) |
| 0.0 | 0.3 | GO:0033036 | macromolecule localization(GO:0033036) |
| 0.0 | 0.1 | GO:0006572 | tyrosine catabolic process(GO:0006572) |
| 0.0 | 0.1 | GO:0045008 | depyrimidination(GO:0045008) |
| 0.0 | 0.0 | GO:0045347 | regulation of cytolysis(GO:0042268) negative regulation of MHC class II biosynthetic process(GO:0045347) |
| 0.0 | 1.2 | GO:0042157 | lipoprotein metabolic process(GO:0042157) |
| 0.0 | 1.0 | GO:0051607 | defense response to virus(GO:0051607) |
| 0.0 | 0.4 | GO:0006298 | mismatch repair(GO:0006298) |
| 0.0 | 0.4 | GO:0000245 | spliceosomal complex assembly(GO:0000245) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.4 | 2.4 | GO:0008537 | proteasome activator complex(GO:0008537) |
| 0.2 | 12.6 | GO:0030863 | cortical cytoskeleton(GO:0030863) |
| 0.1 | 1.3 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 3.3 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.1 | 0.4 | GO:0071797 | LUBAC complex(GO:0071797) |
| 0.1 | 0.7 | GO:0030870 | Mre11 complex(GO:0030870) |
| 0.1 | 0.4 | GO:0005712 | chiasma(GO:0005712) MutLbeta complex(GO:0032390) |
| 0.1 | 0.6 | GO:0042575 | DNA polymerase complex(GO:0042575) |
| 0.1 | 0.9 | GO:0031527 | filopodium membrane(GO:0031527) |
| 0.0 | 0.1 | GO:0030895 | apolipoprotein B mRNA editing enzyme complex(GO:0030895) |
| 0.0 | 0.5 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.0 | 0.1 | GO:0005697 | telomerase holoenzyme complex(GO:0005697) |
| 0.0 | 0.4 | GO:0005840 | ribosome(GO:0005840) |
| 0.0 | 1.5 | GO:0005770 | late endosome(GO:0005770) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 5.0 | GO:0015038 | glutathione disulfide oxidoreductase activity(GO:0015038) |
| 0.2 | 0.6 | GO:0003881 | CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity(GO:0003881) |
| 0.1 | 3.3 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.1 | 0.8 | GO:0031404 | chloride ion binding(GO:0031404) |
| 0.1 | 1.0 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.1 | 0.5 | GO:0008409 | 5'-3' exonuclease activity(GO:0008409) |
| 0.1 | 0.4 | GO:0005534 | galactose binding(GO:0005534) |
| 0.1 | 0.2 | GO:0017108 | 5'-flap endonuclease activity(GO:0017108) |
| 0.1 | 1.3 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.1 | 0.5 | GO:0005138 | interleukin-6 receptor binding(GO:0005138) |
| 0.1 | 0.6 | GO:0031489 | myosin V binding(GO:0031489) |
| 0.1 | 0.4 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.1 | 0.4 | GO:0003696 | satellite DNA binding(GO:0003696) |
| 0.0 | 2.5 | GO:0016667 | oxidoreductase activity, acting on a sulfur group of donors(GO:0016667) |
| 0.0 | 1.0 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.0 | 0.4 | GO:0005143 | interleukin-12 receptor binding(GO:0005143) |
| 0.0 | 0.3 | GO:0008296 | 3'-5'-exodeoxyribonuclease activity(GO:0008296) |
| 0.0 | 0.7 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.0 | 1.2 | GO:0005159 | insulin-like growth factor receptor binding(GO:0005159) |
| 0.0 | 0.7 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.0 | 0.1 | GO:0003720 | telomerase activity(GO:0003720) RNA-directed DNA polymerase activity(GO:0003964) |
| 0.0 | 3.1 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.0 | 0.1 | GO:0004126 | cytidine deaminase activity(GO:0004126) |
| 0.0 | 0.1 | GO:0004461 | lactose synthase activity(GO:0004461) |
| 0.0 | 0.3 | GO:0043236 | laminin binding(GO:0043236) |
| 0.0 | 0.3 | GO:0016409 | palmitoyltransferase activity(GO:0016409) |
| 0.0 | 0.1 | GO:0015185 | gamma-aminobutyric acid:sodium symporter activity(GO:0005332) gamma-aminobutyric acid transmembrane transporter activity(GO:0015185) |
| 0.0 | 0.6 | GO:0043531 | ADP binding(GO:0043531) |
| 0.0 | 0.1 | GO:0004844 | uracil DNA N-glycosylase activity(GO:0004844) deaminated base DNA N-glycosylase activity(GO:0097506) |
| 0.0 | 0.1 | GO:0015016 | [heparan sulfate]-glucosamine N-sulfotransferase activity(GO:0015016) |
| 0.0 | 0.5 | GO:0005164 | tumor necrosis factor receptor binding(GO:0005164) |
| 0.0 | 0.1 | GO:0061659 | ubiquitin-ubiquitin ligase activity(GO:0034450) ubiquitin protein ligase activity(GO:0061630) ubiquitin-like protein ligase activity(GO:0061659) |
| 0.0 | 0.0 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.0 | 0.9 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.8 | GO:0036459 | thiol-dependent ubiquitin-specific protease activity(GO:0004843) thiol-dependent ubiquitinyl hydrolase activity(GO:0036459) ubiquitinyl hydrolase activity(GO:0101005) |
| 0.0 | 0.5 | GO:0043021 | ribonucleoprotein complex binding(GO:0043021) |
| 0.0 | 1.1 | GO:0005319 | lipid transporter activity(GO:0005319) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
| 0.0 | 1.2 | SIG_IL4RECEPTOR_IN_B_LYPHOCYTES | Genes related to IL4 rceptor signaling in B lymphocytes |
| 0.0 | 0.5 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
