Motif ID: IRF6_IRF4_IRF5
Z-value: 2.030
Transcription factors associated with IRF6_IRF4_IRF5:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| IRF4 | ENSG00000137265.10 | IRF4 |
| IRF5 | ENSG00000128604.14 | IRF5 |
| IRF6 | ENSG00000117595.6 | IRF6 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 13.6 | GO:0032727 | positive regulation of interferon-alpha production(GO:0032727) |
| 0.7 | 7.2 | GO:0017121 | phospholipid scrambling(GO:0017121) |
| 0.5 | 3.5 | GO:2000111 | positive regulation of macrophage apoptotic process(GO:2000111) |
| 0.3 | 1.6 | GO:0032020 | ISG15-protein conjugation(GO:0032020) |
| 0.3 | 27.7 | GO:0071357 | response to type I interferon(GO:0034340) type I interferon signaling pathway(GO:0060337) cellular response to type I interferon(GO:0071357) |
| 0.3 | 0.5 | GO:0033689 | negative regulation of osteoblast proliferation(GO:0033689) |
| 0.2 | 0.7 | GO:0032938 | negative regulation of translation in response to oxidative stress(GO:0032938) regulation of translation in response to oxidative stress(GO:0043556) |
| 0.2 | 0.9 | GO:0042986 | positive regulation of amyloid precursor protein biosynthetic process(GO:0042986) |
| 0.2 | 1.7 | GO:0006600 | creatine metabolic process(GO:0006600) |
| 0.1 | 0.4 | GO:0019441 | tryptophan catabolic process to kynurenine(GO:0019441) |
| 0.1 | 1.9 | GO:0048873 | homeostasis of number of cells within a tissue(GO:0048873) |
| 0.1 | 0.3 | GO:0002431 | Fc receptor mediated stimulatory signaling pathway(GO:0002431) regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060368) positive regulation of Fc receptor mediated stimulatory signaling pathway(GO:0060369) |
| 0.1 | 4.5 | GO:0032480 | negative regulation of type I interferon production(GO:0032480) |
| 0.1 | 0.4 | GO:0002553 | histamine production involved in inflammatory response(GO:0002349) histamine secretion involved in inflammatory response(GO:0002441) histamine secretion by mast cell(GO:0002553) |
| 0.1 | 1.0 | GO:0006596 | polyamine biosynthetic process(GO:0006596) |
| 0.0 | 0.9 | GO:0070206 | protein trimerization(GO:0070206) |
| 0.0 | 0.2 | GO:0045085 | negative regulation of interleukin-2 biosynthetic process(GO:0045085) |
| 0.0 | 0.1 | GO:0045715 | negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) |
| 0.0 | 0.7 | GO:0005513 | detection of calcium ion(GO:0005513) |
| 0.0 | 0.9 | GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504) |
| 0.0 | 0.1 | GO:0051781 | regulation of cell division(GO:0051302) positive regulation of cell division(GO:0051781) |
| 0.0 | 0.7 | GO:0031529 | ruffle organization(GO:0031529) |
| 0.0 | 0.9 | GO:0033209 | tumor necrosis factor-mediated signaling pathway(GO:0033209) |
| 0.0 | 0.1 | GO:0019853 | L-ascorbic acid biosynthetic process(GO:0019853) |
| 0.0 | 0.1 | GO:0006931 | substrate-dependent cell migration, cell attachment to substrate(GO:0006931) |
| 0.0 | 3.5 | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules(GO:0007156) |
| 0.0 | 0.4 | GO:1901224 | activation of NF-kappaB-inducing kinase activity(GO:0007250) NIK/NF-kappaB signaling(GO:0038061) regulation of NIK/NF-kappaB signaling(GO:1901222) positive regulation of NIK/NF-kappaB signaling(GO:1901224) |
| 0.0 | 0.2 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
| 0.0 | 0.2 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
| 0.0 | 0.2 | GO:0045746 | negative regulation of Notch signaling pathway(GO:0045746) |
| 0.0 | 0.1 | GO:0002430 | complement receptor mediated signaling pathway(GO:0002430) |
| 0.0 | 3.9 | GO:0007601 | visual perception(GO:0007601) |
| 0.0 | 0.1 | GO:0015886 | heme transport(GO:0015886) |
| 0.0 | 0.8 | GO:0006821 | chloride transport(GO:0006821) |
| 0.0 | 0.2 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.0 | 0.3 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.7 | GO:0042406 | extrinsic component of endoplasmic reticulum membrane(GO:0042406) |
| 0.1 | 0.7 | GO:0060201 | clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201) |
| 0.1 | 0.6 | GO:0030936 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.1 | 0.5 | GO:0030681 | nucleolar ribonuclease P complex(GO:0005655) ribonuclease P complex(GO:0030677) multimeric ribonuclease P complex(GO:0030681) |
| 0.0 | 2.6 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 0.9 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.0 | 12.5 | GO:0005792 | obsolete microsome(GO:0005792) |
| 0.0 | 1.0 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 0.9 | GO:0005758 | mitochondrial intermembrane space(GO:0005758) |
| 0.0 | 1.9 | GO:0005764 | lytic vacuole(GO:0000323) lysosome(GO:0005764) |
| 0.0 | 1.4 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 1.1 | GO:0005624 | obsolete membrane fraction(GO:0005624) |
| 0.0 | 3.5 | GO:0010008 | endosome membrane(GO:0010008) |
| 0.0 | 0.3 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 0.7 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 7.2 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
| 0.6 | 1.9 | GO:0004771 | sterol esterase activity(GO:0004771) |
| 0.5 | 3.5 | GO:0055105 | ubiquitin-protein transferase inhibitor activity(GO:0055105) |
| 0.3 | 0.9 | GO:0004607 | phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607) |
| 0.2 | 0.7 | GO:0032183 | SUMO binding(GO:0032183) |
| 0.2 | 0.5 | GO:0004694 | eukaryotic translation initiation factor 2alpha kinase activity(GO:0004694) |
| 0.2 | 0.8 | GO:0005534 | galactose binding(GO:0005534) |
| 0.1 | 0.6 | GO:0019956 | chemokine binding(GO:0019956) |
| 0.1 | 1.1 | GO:0043208 | glycosphingolipid binding(GO:0043208) |
| 0.1 | 0.6 | GO:0045569 | TRAIL binding(GO:0045569) |
| 0.1 | 1.6 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) |
| 0.1 | 11.3 | GO:0016779 | nucleotidyltransferase activity(GO:0016779) |
| 0.1 | 8.2 | GO:0008026 | ATP-dependent helicase activity(GO:0008026) purine NTP-dependent helicase activity(GO:0070035) |
| 0.1 | 0.3 | GO:0003726 | double-stranded RNA adenosine deaminase activity(GO:0003726) |
| 0.1 | 0.9 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.1 | 0.7 | GO:0050750 | low-density lipoprotein particle receptor binding(GO:0050750) |
| 0.1 | 0.2 | GO:0042289 | MHC class II protein binding(GO:0042289) |
| 0.0 | 1.7 | GO:0016769 | transferase activity, transferring nitrogenous groups(GO:0016769) |
| 0.0 | 4.9 | GO:0003704 | obsolete specific RNA polymerase II transcription factor activity(GO:0003704) |
| 0.0 | 0.5 | GO:0004526 | ribonuclease P activity(GO:0004526) |
| 0.0 | 0.7 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.0 | 0.2 | GO:0008467 | [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity(GO:0008467) |
| 0.0 | 10.6 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 0.4 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.0 | 0.1 | GO:0042910 | xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910) |
| 0.0 | 0.2 | GO:0030021 | extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345) |
| 0.0 | 3.3 | GO:0016881 | acid-amino acid ligase activity(GO:0016881) |
| 0.0 | 0.1 | GO:0004032 | alditol:NADP+ 1-oxidoreductase activity(GO:0004032) |
| 0.0 | 2.4 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 1.0 | GO:0043021 | ribonucleoprotein complex binding(GO:0043021) |
| 0.0 | 0.4 | GO:0004532 | exoribonuclease activity(GO:0004532) |
| 0.0 | 0.1 | GO:0051766 | inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766) |
| 0.0 | 0.1 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 0.0 | 0.1 | GO:0004875 | complement receptor activity(GO:0004875) |
| 0.0 | 0.3 | GO:0004622 | lysophospholipase activity(GO:0004622) |
| 0.0 | 0.1 | GO:0016944 | obsolete RNA polymerase II transcription elongation factor activity(GO:0016944) |
| 0.0 | 2.6 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 1.4 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.0 | 0.9 | GO:0008080 | N-acetyltransferase activity(GO:0008080) |
| 0.0 | 0.1 | GO:0047045 | testosterone 17-beta-dehydrogenase (NADP+) activity(GO:0047045) |
| 0.0 | 0.1 | GO:0046592 | polyamine oxidase activity(GO:0046592) |
| 0.0 | 0.0 | GO:0015187 | glycine transmembrane transporter activity(GO:0015187) glycine:sodium symporter activity(GO:0015375) |
| 0.0 | 0.0 | GO:0004663 | Rab geranylgeranyltransferase activity(GO:0004663) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 0.9 | ST_JAK_STAT_PATHWAY | Jak-STAT Pathway |
| 0.1 | 3.5 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 1.2 | ST_INTERFERON_GAMMA_PATHWAY | Interferon gamma pathway. |
| 0.0 | 1.1 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.7 | SIG_CD40PATHWAYMAP | Genes related to CD40 signaling |
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