Motif ID: IRF7
Z-value: 2.142
Transcription factors associated with IRF7:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| IRF7 | ENSG00000185507.15 | IRF7 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.9 | 21.2 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.9 | 4.6 | GO:0001778 | plasma membrane repair(GO:0001778) |
| 0.9 | 2.6 | GO:0021570 | rhombomere 4 development(GO:0021570) |
| 0.7 | 2.1 | GO:0051097 | negative regulation of helicase activity(GO:0051097) |
| 0.6 | 5.5 | GO:0048630 | skeletal muscle tissue growth(GO:0048630) |
| 0.6 | 2.4 | GO:0009956 | radial pattern formation(GO:0009956) |
| 0.5 | 1.4 | GO:0045062 | extrathymic T cell differentiation(GO:0033078) extrathymic T cell selection(GO:0045062) |
| 0.4 | 2.6 | GO:0060219 | camera-type eye photoreceptor cell differentiation(GO:0060219) |
| 0.4 | 1.2 | GO:0014831 | intestine smooth muscle contraction(GO:0014827) gastro-intestinal system smooth muscle contraction(GO:0014831) |
| 0.4 | 2.8 | GO:0007598 | blood coagulation, extrinsic pathway(GO:0007598) |
| 0.3 | 1.0 | GO:0002428 | antigen processing and presentation of peptide antigen via MHC class Ib(GO:0002428) antigen processing and presentation of exogenous peptide antigen via MHC class Ib(GO:0002477) antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent(GO:0002481) |
| 0.3 | 1.8 | GO:0090050 | positive regulation of cell migration involved in sprouting angiogenesis(GO:0090050) positive regulation of sprouting angiogenesis(GO:1903672) |
| 0.3 | 1.5 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 0.3 | 1.1 | GO:0002158 | osteoclast proliferation(GO:0002158) |
| 0.3 | 1.6 | GO:2000172 | regulation of branching morphogenesis of a nerve(GO:2000172) |
| 0.3 | 4.4 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.3 | 2.6 | GO:0050910 | detection of mechanical stimulus involved in sensory perception of sound(GO:0050910) |
| 0.3 | 1.0 | GO:0033197 | response to vitamin E(GO:0033197) |
| 0.2 | 0.7 | GO:0019858 | cytosine metabolic process(GO:0019858) |
| 0.2 | 5.8 | GO:0030224 | monocyte differentiation(GO:0030224) |
| 0.2 | 1.6 | GO:0003065 | regulation of heart rate by chemical signal(GO:0003062) positive regulation of heart rate by epinephrine(GO:0003065) |
| 0.2 | 6.8 | GO:0030325 | adrenal gland development(GO:0030325) |
| 0.2 | 3.5 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.2 | 1.6 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
| 0.2 | 0.6 | GO:0001780 | neutrophil homeostasis(GO:0001780) |
| 0.2 | 1.5 | GO:0010661 | positive regulation of muscle cell apoptotic process(GO:0010661) positive regulation of smooth muscle cell apoptotic process(GO:0034393) |
| 0.2 | 0.9 | GO:0022614 | membrane to membrane docking(GO:0022614) chorio-allantoic fusion(GO:0060710) |
| 0.1 | 3.3 | GO:0021846 | cell proliferation in forebrain(GO:0021846) |
| 0.1 | 1.4 | GO:0007351 | tripartite regional subdivision(GO:0007351) anterior/posterior axis specification, embryo(GO:0008595) |
| 0.1 | 2.0 | GO:0031529 | ruffle organization(GO:0031529) |
| 0.1 | 0.3 | GO:2000794 | positive regulation of epithelial cell proliferation involved in lung morphogenesis(GO:0060501) regulation of epithelial cell proliferation involved in lung morphogenesis(GO:2000794) |
| 0.1 | 0.8 | GO:0007499 | ectoderm and mesoderm interaction(GO:0007499) |
| 0.1 | 1.2 | GO:0006069 | ethanol metabolic process(GO:0006067) ethanol oxidation(GO:0006069) |
| 0.1 | 0.7 | GO:0035455 | response to interferon-alpha(GO:0035455) |
| 0.1 | 0.7 | GO:0007525 | somatic muscle development(GO:0007525) |
| 0.1 | 0.3 | GO:0034214 | protein hexamerization(GO:0034214) |
| 0.1 | 1.1 | GO:0007252 | I-kappaB phosphorylation(GO:0007252) |
| 0.1 | 1.3 | GO:0032727 | positive regulation of interferon-alpha production(GO:0032727) |
| 0.1 | 0.8 | GO:0060907 | regulation of phagocytosis, engulfment(GO:0060099) positive regulation of phagocytosis, engulfment(GO:0060100) positive regulation of macrophage cytokine production(GO:0060907) regulation of membrane invagination(GO:1905153) positive regulation of membrane invagination(GO:1905155) |
| 0.1 | 1.1 | GO:0050435 | beta-amyloid metabolic process(GO:0050435) |
| 0.1 | 0.4 | GO:0060586 | multicellular organismal iron ion homeostasis(GO:0060586) |
| 0.1 | 0.5 | GO:0006686 | sphingomyelin biosynthetic process(GO:0006686) |
| 0.1 | 0.3 | GO:0051083 | 'de novo' cotranslational protein folding(GO:0051083) |
| 0.1 | 1.0 | GO:0070389 | chaperone cofactor-dependent protein refolding(GO:0070389) |
| 0.1 | 0.2 | GO:0051409 | response to nitrosative stress(GO:0051409) |
| 0.1 | 1.1 | GO:0051103 | DNA ligation involved in DNA repair(GO:0051103) |
| 0.1 | 2.0 | GO:0034199 | activation of protein kinase A activity(GO:0034199) |
| 0.1 | 1.7 | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846) |
| 0.1 | 0.6 | GO:0060666 | dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666) |
| 0.1 | 0.6 | GO:0055003 | muscle cell fate commitment(GO:0042693) cardiac myofibril assembly(GO:0055003) |
| 0.1 | 0.2 | GO:0006597 | spermine biosynthetic process(GO:0006597) |
| 0.1 | 0.2 | GO:0014724 | regulation of twitch skeletal muscle contraction(GO:0014724) fast-twitch skeletal muscle fiber contraction(GO:0031443) regulation of fast-twitch skeletal muscle fiber contraction(GO:0031446) positive regulation of fast-twitch skeletal muscle fiber contraction(GO:0031448) positive regulation of endoplasmic reticulum calcium ion concentration(GO:0032470) mitochondrial calcium ion homeostasis(GO:0051560) positive regulation of mitochondrial calcium ion concentration(GO:0051561) relaxation of skeletal muscle(GO:0090076) |
| 0.1 | 0.1 | GO:0097435 | extracellular fibril organization(GO:0043206) fibril organization(GO:0097435) |
| 0.1 | 0.3 | GO:0001973 | adenosine receptor signaling pathway(GO:0001973) G-protein coupled purinergic receptor signaling pathway(GO:0035588) |
| 0.1 | 1.0 | GO:0043330 | response to exogenous dsRNA(GO:0043330) |
| 0.1 | 1.1 | GO:0031000 | response to caffeine(GO:0031000) |
| 0.1 | 4.0 | GO:0007519 | skeletal muscle tissue development(GO:0007519) |
| 0.1 | 0.5 | GO:0048387 | negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
| 0.1 | 0.4 | GO:0071731 | response to nitric oxide(GO:0071731) |
| 0.1 | 4.9 | GO:0009408 | response to heat(GO:0009408) |
| 0.1 | 0.1 | GO:0006344 | maintenance of chromatin silencing(GO:0006344) |
| 0.1 | 0.7 | GO:0010390 | histone monoubiquitination(GO:0010390) |
| 0.1 | 0.5 | GO:0060216 | definitive hemopoiesis(GO:0060216) |
| 0.1 | 0.5 | GO:0016322 | neuron remodeling(GO:0016322) |
| 0.1 | 0.2 | GO:0046541 | saliva secretion(GO:0046541) |
| 0.1 | 1.6 | GO:0031532 | actin cytoskeleton reorganization(GO:0031532) |
| 0.0 | 1.4 | GO:0060048 | cardiac muscle contraction(GO:0060048) |
| 0.0 | 0.1 | GO:0006663 | platelet activating factor biosynthetic process(GO:0006663) |
| 0.0 | 0.7 | GO:0070536 | protein K63-linked deubiquitination(GO:0070536) |
| 0.0 | 0.2 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
| 0.0 | 0.3 | GO:0010759 | complement receptor mediated signaling pathway(GO:0002430) positive regulation of macrophage chemotaxis(GO:0010759) |
| 0.0 | 0.1 | GO:0031167 | rRNA methylation(GO:0031167) |
| 0.0 | 0.5 | GO:1901797 | negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797) |
| 0.0 | 0.2 | GO:0019885 | antigen processing and presentation of endogenous peptide antigen(GO:0002483) antigen processing and presentation of endogenous peptide antigen via MHC class I(GO:0019885) |
| 0.0 | 0.4 | GO:0045329 | amino-acid betaine biosynthetic process(GO:0006578) carnitine biosynthetic process(GO:0045329) |
| 0.0 | 0.3 | GO:0097061 | dendritic spine morphogenesis(GO:0060997) regulation of dendritic spine morphogenesis(GO:0061001) dendritic spine organization(GO:0097061) |
| 0.0 | 0.8 | GO:0010811 | positive regulation of cell-substrate adhesion(GO:0010811) |
| 0.0 | 0.1 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.0 | 0.9 | GO:0018208 | peptidyl-proline modification(GO:0018208) |
| 0.0 | 0.3 | GO:0043248 | proteasome assembly(GO:0043248) |
| 0.0 | 0.5 | GO:1902749 | regulation of G2/M transition of mitotic cell cycle(GO:0010389) regulation of cell cycle G2/M phase transition(GO:1902749) |
| 0.0 | 0.3 | GO:0031017 | exocrine pancreas development(GO:0031017) |
| 0.0 | 0.2 | GO:0018345 | protein palmitoylation(GO:0018345) |
| 0.0 | 1.0 | GO:0060338 | regulation of type I interferon-mediated signaling pathway(GO:0060338) |
| 0.0 | 0.2 | GO:0002282 | microglial cell activation involved in immune response(GO:0002282) |
| 0.0 | 0.5 | GO:0043984 | histone H4-K16 acetylation(GO:0043984) |
| 0.0 | 0.2 | GO:0050912 | detection of chemical stimulus involved in sensory perception of bitter taste(GO:0001580) detection of chemical stimulus involved in sensory perception of taste(GO:0050912) |
| 0.0 | 0.6 | GO:0009058 | biosynthetic process(GO:0009058) |
| 0.0 | 0.6 | GO:0060765 | regulation of androgen receptor signaling pathway(GO:0060765) |
| 0.0 | 1.3 | GO:0007045 | cell-substrate adherens junction assembly(GO:0007045) focal adhesion assembly(GO:0048041) |
| 0.0 | 0.1 | GO:0016081 | synaptic vesicle docking(GO:0016081) |
| 0.0 | 1.6 | GO:0031032 | actomyosin structure organization(GO:0031032) |
| 0.0 | 0.8 | GO:0030866 | cortical cytoskeleton organization(GO:0030865) cortical actin cytoskeleton organization(GO:0030866) |
| 0.0 | 0.2 | GO:0006999 | nuclear pore organization(GO:0006999) |
| 0.0 | 2.4 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
| 0.0 | 0.2 | GO:0051168 | nuclear export(GO:0051168) |
| 0.0 | 0.5 | GO:0008635 | activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c(GO:0008635) |
| 0.0 | 0.1 | GO:0072385 | minus-end-directed organelle transport along microtubule(GO:0072385) microtubule anchoring at microtubule organizing center(GO:0072393) |
| 0.0 | 0.3 | GO:1904031 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031) |
| 0.0 | 0.1 | GO:0050942 | positive regulation of melanocyte differentiation(GO:0045636) positive regulation of pigment cell differentiation(GO:0050942) |
| 0.0 | 0.2 | GO:0001782 | B cell homeostasis(GO:0001782) |
| 0.0 | 0.0 | GO:0045343 | MHC class I biosynthetic process(GO:0045341) regulation of MHC class I biosynthetic process(GO:0045343) |
| 0.0 | 0.7 | GO:0015949 | nucleobase-containing small molecule interconversion(GO:0015949) |
| 0.0 | 0.1 | GO:0048172 | regulation of short-term neuronal synaptic plasticity(GO:0048172) |
| 0.0 | 0.2 | GO:0032228 | regulation of synaptic transmission, GABAergic(GO:0032228) |
| 0.0 | 0.7 | GO:0050771 | negative regulation of axonogenesis(GO:0050771) |
| 0.0 | 1.2 | GO:0006914 | autophagy(GO:0006914) |
| 0.0 | 0.2 | GO:0009396 | folic acid-containing compound biosynthetic process(GO:0009396) |
| 0.0 | 1.0 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 0.3 | GO:0048821 | erythrocyte development(GO:0048821) myeloid cell development(GO:0061515) |
| 0.0 | 0.2 | GO:0008272 | sulfate transport(GO:0008272) |
| 0.0 | 1.4 | GO:0008360 | regulation of cell shape(GO:0008360) |
| 0.0 | 0.3 | GO:0048207 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114) |
| 0.0 | 1.0 | GO:0043407 | negative regulation of MAP kinase activity(GO:0043407) |
| 0.0 | 3.4 | GO:0006184 | obsolete GTP catabolic process(GO:0006184) |
| 0.0 | 0.3 | GO:0007628 | adult walking behavior(GO:0007628) walking behavior(GO:0090659) |
| 0.0 | 0.7 | GO:0009060 | aerobic respiration(GO:0009060) |
| 0.0 | 3.8 | GO:0006936 | muscle contraction(GO:0006936) |
| 0.0 | 0.6 | GO:0042542 | response to hydrogen peroxide(GO:0042542) |
| 0.0 | 0.1 | GO:0033962 | cytoplasmic mRNA processing body assembly(GO:0033962) |
| 0.0 | 0.1 | GO:0043545 | Mo-molybdopterin cofactor biosynthetic process(GO:0006777) Mo-molybdopterin cofactor metabolic process(GO:0019720) molybdopterin cofactor biosynthetic process(GO:0032324) molybdopterin cofactor metabolic process(GO:0043545) prosthetic group metabolic process(GO:0051189) |
| 0.0 | 0.1 | GO:0002675 | positive regulation of acute inflammatory response(GO:0002675) |
| 0.0 | 0.5 | GO:0034968 | histone lysine methylation(GO:0034968) |
| 0.0 | 0.3 | GO:0042130 | negative regulation of T cell proliferation(GO:0042130) |
| 0.0 | 0.2 | GO:0008333 | endosome to lysosome transport(GO:0008333) |
| 0.0 | 0.2 | GO:0035036 | binding of sperm to zona pellucida(GO:0007339) sperm-egg recognition(GO:0035036) |
| 0.0 | 0.2 | GO:0017158 | regulation of calcium ion-dependent exocytosis(GO:0017158) |
| 0.0 | 0.4 | GO:0001501 | skeletal system development(GO:0001501) |
| 0.0 | 0.2 | GO:0033209 | tumor necrosis factor-mediated signaling pathway(GO:0033209) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.5 | 21.2 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 1.1 | 3.2 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.5 | 3.1 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.3 | 0.9 | GO:0071065 | alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065) |
| 0.3 | 2.6 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.2 | 1.1 | GO:0032807 | DNA ligase IV complex(GO:0032807) |
| 0.2 | 1.9 | GO:0032059 | bleb(GO:0032059) |
| 0.1 | 0.7 | GO:0005614 | interstitial matrix(GO:0005614) |
| 0.1 | 0.7 | GO:0070552 | BRISC complex(GO:0070552) |
| 0.1 | 1.6 | GO:0034451 | centriolar satellite(GO:0034451) |
| 0.1 | 2.7 | GO:0005892 | acetylcholine-gated channel complex(GO:0005892) |
| 0.1 | 1.6 | GO:0031143 | pseudopodium(GO:0031143) |
| 0.1 | 0.4 | GO:0000124 | SAGA complex(GO:0000124) |
| 0.1 | 6.0 | GO:0030863 | cortical cytoskeleton(GO:0030863) |
| 0.1 | 2.9 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.1 | 2.6 | GO:0005859 | muscle myosin complex(GO:0005859) |
| 0.1 | 1.0 | GO:0070688 | MLL5-L complex(GO:0070688) |
| 0.1 | 0.5 | GO:0000138 | Golgi trans cisterna(GO:0000138) |
| 0.1 | 0.5 | GO:0072487 | MSL complex(GO:0072487) |
| 0.1 | 2.0 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 0.2 | GO:0031673 | H zone(GO:0031673) |
| 0.1 | 2.0 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.1 | 3.0 | GO:0098636 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.1 | 0.9 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.1 | 0.7 | GO:0032839 | dendrite cytoplasm(GO:0032839) |
| 0.1 | 0.7 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.1 | 0.4 | GO:0000145 | exocyst(GO:0000145) |
| 0.1 | 0.7 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.1 | 0.2 | GO:0005900 | oncostatin-M receptor complex(GO:0005900) |
| 0.1 | 0.2 | GO:0031045 | dense core granule(GO:0031045) |
| 0.1 | 4.3 | GO:0044853 | caveola(GO:0005901) plasma membrane raft(GO:0044853) |
| 0.1 | 3.2 | GO:0031674 | I band(GO:0031674) |
| 0.0 | 1.5 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
| 0.0 | 0.2 | GO:0008385 | IkappaB kinase complex(GO:0008385) |
| 0.0 | 4.0 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 0.2 | GO:0030936 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.0 | 1.8 | GO:0001725 | stress fiber(GO:0001725) contractile actin filament bundle(GO:0097517) |
| 0.0 | 0.9 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 3.3 | GO:0030016 | myofibril(GO:0030016) |
| 0.0 | 0.4 | GO:0032391 | photoreceptor connecting cilium(GO:0032391) |
| 0.0 | 0.7 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 1.3 | GO:0030175 | filopodium(GO:0030175) |
| 0.0 | 0.2 | GO:0030121 | AP-1 adaptor complex(GO:0030121) |
| 0.0 | 1.4 | GO:0030672 | synaptic vesicle membrane(GO:0030672) exocytic vesicle membrane(GO:0099501) |
| 0.0 | 3.1 | GO:0005765 | lysosomal membrane(GO:0005765) lytic vacuole membrane(GO:0098852) |
| 0.0 | 0.1 | GO:0051233 | spindle midzone(GO:0051233) |
| 0.0 | 0.3 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 0.1 | GO:0001741 | XY body(GO:0001741) |
| 0.0 | 2.1 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.0 | 0.2 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 0.1 | GO:0005947 | mitochondrial alpha-ketoglutarate dehydrogenase complex(GO:0005947) |
| 0.0 | 7.2 | GO:0000139 | Golgi membrane(GO:0000139) |
| 0.0 | 0.2 | GO:0035631 | CD40 receptor complex(GO:0035631) |
| 0.0 | 0.3 | GO:0005581 | collagen trimer(GO:0005581) |
| 0.0 | 1.3 | GO:0098857 | membrane raft(GO:0045121) membrane microdomain(GO:0098857) |
| 0.0 | 0.1 | GO:0017071 | intracellular cyclic nucleotide activated cation channel complex(GO:0017071) |
| 0.0 | 1.6 | GO:0031252 | cell leading edge(GO:0031252) |
| 0.0 | 0.1 | GO:0045261 | proton-transporting ATP synthase complex, catalytic core F(1)(GO:0045261) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.7 | 0.7 | GO:0070052 | collagen V binding(GO:0070052) |
| 0.6 | 1.8 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
| 0.6 | 23.8 | GO:0050840 | extracellular matrix binding(GO:0050840) |
| 0.5 | 2.6 | GO:0034235 | GPI anchor binding(GO:0034235) |
| 0.4 | 4.4 | GO:0008499 | UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity(GO:0008499) |
| 0.3 | 2.0 | GO:0017162 | aryl hydrocarbon receptor binding(GO:0017162) |
| 0.3 | 1.5 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 0.2 | 1.2 | GO:0005157 | macrophage colony-stimulating factor receptor binding(GO:0005157) |
| 0.2 | 1.7 | GO:0031435 | mitogen-activated protein kinase kinase kinase binding(GO:0031435) |
| 0.2 | 2.7 | GO:0042166 | acetylcholine binding(GO:0042166) |
| 0.2 | 1.2 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
| 0.2 | 1.6 | GO:0005497 | androgen binding(GO:0005497) |
| 0.2 | 1.6 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
| 0.2 | 1.1 | GO:0016941 | natriuretic peptide receptor activity(GO:0016941) |
| 0.2 | 2.6 | GO:0003706 | obsolete ligand-regulated transcription factor activity(GO:0003706) |
| 0.2 | 1.2 | GO:0031994 | insulin-like growth factor I binding(GO:0031994) |
| 0.2 | 0.5 | GO:0004833 | tryptophan 2,3-dioxygenase activity(GO:0004833) |
| 0.2 | 2.9 | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity(GO:0004861) |
| 0.1 | 2.5 | GO:0003785 | actin monomer binding(GO:0003785) |
| 0.1 | 1.0 | GO:0005132 | type I interferon receptor binding(GO:0005132) |
| 0.1 | 1.0 | GO:0016538 | cyclin-dependent protein serine/threonine kinase regulator activity(GO:0016538) |
| 0.1 | 0.8 | GO:0070892 | lipoteichoic acid receptor activity(GO:0070892) |
| 0.1 | 0.5 | GO:0004083 | bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619) |
| 0.1 | 0.9 | GO:0080025 | phosphatidylinositol-3,5-bisphosphate binding(GO:0080025) |
| 0.1 | 0.8 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.1 | 0.6 | GO:0045499 | chemorepellent activity(GO:0045499) |
| 0.1 | 0.4 | GO:0016531 | copper chaperone activity(GO:0016531) |
| 0.1 | 1.4 | GO:0001011 | transcription factor activity, sequence-specific DNA binding, RNA polymerase recruiting(GO:0001011) transcription factor activity, RNA polymerase II basal transcription factor binding(GO:0001083) transcription factor activity, TFIIB-class binding(GO:0001087) RNA polymerase II basal transcription factor binding(GO:0001091) TFIIB-class transcription factor binding(GO:0001093) |
| 0.1 | 0.4 | GO:0004909 | interleukin-1, Type I, activating receptor activity(GO:0004909) |
| 0.1 | 0.4 | GO:0008336 | gamma-butyrobetaine dioxygenase activity(GO:0008336) |
| 0.1 | 0.7 | GO:0015038 | glutathione disulfide oxidoreductase activity(GO:0015038) |
| 0.1 | 2.5 | GO:0005212 | structural constituent of eye lens(GO:0005212) |
| 0.1 | 0.9 | GO:0005041 | low-density lipoprotein receptor activity(GO:0005041) |
| 0.1 | 1.1 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.1 | 6.1 | GO:0046332 | SMAD binding(GO:0046332) |
| 0.1 | 2.8 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 1.4 | GO:0017166 | vinculin binding(GO:0017166) |
| 0.1 | 0.3 | GO:0005111 | type 2 fibroblast growth factor receptor binding(GO:0005111) |
| 0.1 | 0.2 | GO:0046848 | hydroxyapatite binding(GO:0046848) |
| 0.1 | 1.9 | GO:0005523 | tropomyosin binding(GO:0005523) |
| 0.1 | 0.9 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.1 | 0.5 | GO:0004862 | cAMP-dependent protein kinase inhibitor activity(GO:0004862) |
| 0.1 | 4.7 | GO:0008307 | structural constituent of muscle(GO:0008307) |
| 0.1 | 1.5 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.1 | 0.6 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.1 | 0.2 | GO:0004924 | oncostatin-M receptor activity(GO:0004924) |
| 0.0 | 1.0 | GO:0008519 | ammonium transmembrane transporter activity(GO:0008519) |
| 0.0 | 0.3 | GO:0003696 | satellite DNA binding(GO:0003696) |
| 0.0 | 0.4 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.0 | 0.4 | GO:0005143 | interleukin-12 receptor binding(GO:0005143) |
| 0.0 | 0.3 | GO:0004875 | complement receptor activity(GO:0004875) |
| 0.0 | 0.6 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.2 | GO:0004766 | spermidine synthase activity(GO:0004766) |
| 0.0 | 0.1 | GO:0030151 | molybdenum ion binding(GO:0030151) |
| 0.0 | 0.2 | GO:0016882 | cyclo-ligase activity(GO:0016882) |
| 0.0 | 0.9 | GO:0005528 | macrolide binding(GO:0005527) FK506 binding(GO:0005528) |
| 0.0 | 1.1 | GO:0030552 | cAMP binding(GO:0030552) |
| 0.0 | 0.2 | GO:0008271 | secondary active sulfate transmembrane transporter activity(GO:0008271) |
| 0.0 | 1.1 | GO:0005544 | calcium-dependent phospholipid binding(GO:0005544) |
| 0.0 | 0.3 | GO:0042805 | actinin binding(GO:0042805) |
| 0.0 | 0.3 | GO:0030169 | low-density lipoprotein particle binding(GO:0030169) |
| 0.0 | 0.9 | GO:0005158 | insulin receptor binding(GO:0005158) |
| 0.0 | 0.1 | GO:0008508 | bile acid:sodium symporter activity(GO:0008508) |
| 0.0 | 2.6 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.0 | 0.2 | GO:0090599 | alpha-glucosidase activity(GO:0090599) |
| 0.0 | 6.7 | GO:0003924 | GTPase activity(GO:0003924) |
| 0.0 | 0.1 | GO:0016423 | tRNA (guanine) methyltransferase activity(GO:0016423) |
| 0.0 | 4.7 | GO:0008083 | growth factor activity(GO:0008083) |
| 0.0 | 0.1 | GO:0030551 | cyclic nucleotide binding(GO:0030551) |
| 0.0 | 4.1 | GO:0005543 | phospholipid binding(GO:0005543) |
| 0.0 | 0.1 | GO:0031624 | ubiquitin conjugating enzyme binding(GO:0031624) ubiquitin-like protein conjugating enzyme binding(GO:0044390) |
| 0.0 | 0.2 | GO:0004428 | obsolete inositol or phosphatidylinositol kinase activity(GO:0004428) |
| 0.0 | 0.1 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
| 0.0 | 0.8 | GO:0018024 | histone-lysine N-methyltransferase activity(GO:0018024) |
| 0.0 | 0.3 | GO:0046527 | glucosyltransferase activity(GO:0046527) |
| 0.0 | 2.0 | GO:0031072 | heat shock protein binding(GO:0031072) |
| 0.0 | 0.6 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 0.1 | GO:0034452 | dynactin binding(GO:0034452) |
| 0.0 | 0.1 | GO:0033130 | acetylcholine receptor binding(GO:0033130) |
| 0.0 | 0.0 | GO:0008035 | high-density lipoprotein particle binding(GO:0008035) |
| 0.0 | 0.1 | GO:0097493 | extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493) |
| 0.0 | 0.1 | GO:0004995 | tachykinin receptor activity(GO:0004995) |
| 0.0 | 1.1 | GO:0030165 | PDZ domain binding(GO:0030165) |
| 0.0 | 0.5 | GO:0001637 | G-protein coupled chemoattractant receptor activity(GO:0001637) chemokine receptor activity(GO:0004950) |
| 0.0 | 0.2 | GO:0016409 | palmitoyltransferase activity(GO:0016409) |
| 0.0 | 2.6 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.1 | GO:0004647 | phosphoserine phosphatase activity(GO:0004647) |
| 0.0 | 0.3 | GO:0042974 | retinoic acid receptor binding(GO:0042974) |
| 0.0 | 0.3 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
| 0.0 | 1.2 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 0.1 | GO:0032454 | histone demethylase activity (H3-K9 specific)(GO:0032454) |
| 0.0 | 0.1 | GO:0015277 | kainate selective glutamate receptor activity(GO:0015277) |
| 0.0 | 0.3 | GO:0005044 | scavenger receptor activity(GO:0005044) |
| 0.0 | 0.2 | GO:0005031 | tumor necrosis factor-activated receptor activity(GO:0005031) |
| 0.0 | 0.0 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.0 | 0.4 | GO:0030374 | ligand-dependent nuclear receptor transcription coactivator activity(GO:0030374) |
| 0.0 | 0.9 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 2.3 | GO:0003690 | double-stranded DNA binding(GO:0003690) |
| 0.0 | 0.2 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.0 | 2.4 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 0.2 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 0.1 | GO:0005243 | gap junction channel activity(GO:0005243) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 2.0 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 1.0 | ST_TYPE_I_INTERFERON_PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
| 0.1 | 0.3 | SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES | Genes related to PIP3 signaling in B lymphocytes |
| 0.1 | 1.9 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 2.7 | ST_P38_MAPK_PATHWAY | p38 MAPK Pathway |
| 0.0 | 0.5 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.5 | SA_FAS_SIGNALING | The TNF-type receptor Fas induces apoptosis on ligand binding. |
| 0.0 | 0.6 | SIG_CD40PATHWAYMAP | Genes related to CD40 signaling |
| 0.0 | 1.6 | SIG_BCR_SIGNALING_PATHWAY | Members of the BCR signaling pathway |
| 0.0 | 0.5 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.2 | ST_INTEGRIN_SIGNALING_PATHWAY | Integrin Signaling Pathway |
