Motif ID: IRX6_IRX4

Z-value: 0.575

Transcription factors associated with IRX6_IRX4:

Gene SymbolEntrez IDGene Name
IRX4 ENSG00000113430.5 IRX4
IRX6 ENSG00000159387.7 IRX6






Network of associatons between targets according to the STRING database.



First level regulatory network of IRX6_IRX4

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_46716969 2.453 ENST00000435666.2
LCP1
lymphocyte cytosolic protein 1 (L-plastin)
chrX_+_49294472 2.298 ENST00000361446.5
GAGE12B
G antigen 12B
chr1_+_26644441 0.763 ENST00000374213.2
CD52
CD52 molecule
chr2_+_58655461 0.596 ENST00000429095.1
ENST00000429664.1
ENST00000452840.1
AC007092.1


long intergenic non-protein coding RNA 1122


chr12_+_32655048 0.495 ENST00000427716.2
ENST00000266482.3
FGD4

FYVE, RhoGEF and PH domain containing 4

chr15_+_41057818 0.425 ENST00000558467.1
GCHFR
GTP cyclohydrolase I feedback regulator
chr21_-_34185944 0.361 ENST00000479548.1
C21orf62
chromosome 21 open reading frame 62
chr21_-_34186006 0.339 ENST00000490358.1
C21orf62
chromosome 21 open reading frame 62
chr17_-_29641104 0.321 ENST00000577894.1
ENST00000330927.4
EVI2B

ecotropic viral integration site 2B

chr17_-_42327236 0.318 ENST00000399246.2
AC003102.1
AC003102.1
chr14_-_23623577 0.317 ENST00000422941.2
ENST00000453702.1
SLC7A8

solute carrier family 7 (amino acid transporter light chain, L system), member 8

chr21_-_34185989 0.271 ENST00000487113.1
ENST00000382373.4
C21orf62

chromosome 21 open reading frame 62

chr14_-_21737551 0.270 ENST00000554891.1
ENST00000555883.1
ENST00000553753.1
ENST00000555914.1
ENST00000557336.1
ENST00000555215.1
ENST00000556628.1
ENST00000555137.1
ENST00000556226.1
ENST00000555309.1
ENST00000556142.1
ENST00000554969.1
ENST00000554455.1
ENST00000556513.1
ENST00000557201.1
ENST00000420743.2
ENST00000557768.1
ENST00000553300.1
ENST00000554383.1
ENST00000554539.1
HNRNPC



















heterogeneous nuclear ribonucleoprotein C (C1/C2)



















chr15_+_66585879 0.268 ENST00000319212.4
DIS3L
DIS3 mitotic control homolog (S. cerevisiae)-like
chr17_-_29641084 0.254 ENST00000544462.1
EVI2B
ecotropic viral integration site 2B
chr17_-_47723943 0.236 ENST00000510476.1
ENST00000503676.1
SPOP

speckle-type POZ protein

chr15_+_66585555 0.196 ENST00000319194.5
ENST00000525134.2
ENST00000441424.2
DIS3L


DIS3 mitotic control homolog (S. cerevisiae)-like


chr3_-_9994021 0.192 ENST00000411976.2
ENST00000412055.1
PRRT3

proline-rich transmembrane protein 3

chr12_-_10282742 0.190 ENST00000298523.5
ENST00000396484.2
ENST00000310002.4
CLEC7A


C-type lectin domain family 7, member A


chr2_-_183106641 0.176 ENST00000346717.4
PDE1A
phosphodiesterase 1A, calmodulin-dependent
chr8_+_12803176 0.167 ENST00000524591.2
KIAA1456
KIAA1456
chr14_-_106845789 0.157 ENST00000390617.2
IGHV3-35
immunoglobulin heavy variable 3-35 (non-functional)
chr4_-_153303658 0.156 ENST00000296555.5
FBXW7
F-box and WD repeat domain containing 7, E3 ubiquitin protein ligase
chr4_+_158142750 0.155 ENST00000505888.1
ENST00000449365.1
GRIA2

glutamate receptor, ionotropic, AMPA 2

chr8_+_67976593 0.154 ENST00000262210.5
ENST00000412460.1
CSPP1

centrosome and spindle pole associated protein 1

chr1_+_220267429 0.138 ENST00000366922.1
ENST00000302637.5
IARS2

isoleucyl-tRNA synthetase 2, mitochondrial

chr2_+_160590469 0.131 ENST00000409591.1
MARCH7
membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase
chr15_-_64665911 0.121 ENST00000606793.1
ENST00000561349.1
ENST00000560278.1
CTD-2116N17.1


Uncharacterized protein


chr4_-_104119528 0.117 ENST00000380026.3
ENST00000503705.1
ENST00000265148.3
CENPE


centromere protein E, 312kDa


chr8_-_67976509 0.108 ENST00000518747.1
COPS5
COP9 signalosome subunit 5
chrX_+_15767971 0.096 ENST00000479740.1
ENST00000454127.2
CA5B

carbonic anhydrase VB, mitochondrial

chr12_-_10282836 0.090 ENST00000304084.8
ENST00000353231.5
ENST00000525605.1
CLEC7A


C-type lectin domain family 7, member A


chr4_+_158141899 0.090 ENST00000264426.9
ENST00000506284.1
GRIA2

glutamate receptor, ionotropic, AMPA 2

chr22_-_24096562 0.089 ENST00000398465.3
VPREB3
pre-B lymphocyte 3
chr7_-_80141328 0.088 ENST00000398291.3
GNAT3
guanine nucleotide binding protein, alpha transducing 3
chr8_+_84824920 0.085 ENST00000523678.1
RP11-120I21.2
RP11-120I21.2
chr5_+_54320078 0.085 ENST00000231009.2
GZMK
granzyme K (granzyme 3; tryptase II)
chr10_-_115904361 0.079 ENST00000428953.1
ENST00000543782.1
C10orf118

chromosome 10 open reading frame 118

chr3_-_168865522 0.068 ENST00000464456.1
MECOM
MDS1 and EVI1 complex locus
chr1_-_3566590 0.066 ENST00000424367.1
ENST00000378322.3
WRAP73

WD repeat containing, antisense to TP73

chrX_-_19988382 0.060 ENST00000356980.3
ENST00000379687.3
ENST00000379682.4
CXorf23


chromosome X open reading frame 23


chr3_+_171561127 0.056 ENST00000334567.5
ENST00000450693.1
TMEM212

transmembrane protein 212

chr1_+_53308398 0.048 ENST00000371528.1
ZYG11A
zyg-11 family member A, cell cycle regulator
chr19_-_22379753 0.045 ENST00000397121.2
ZNF676
zinc finger protein 676
chr1_-_152086556 0.040 ENST00000368804.1
TCHH
trichohyalin
chr12_-_76462713 0.039 ENST00000552056.1
NAP1L1
nucleosome assembly protein 1-like 1
chr10_+_118350522 0.035 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
PNLIPRP1



pancreatic lipase-related protein 1



chr10_+_118350468 0.034 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
PNLIPRP1


pancreatic lipase-related protein 1


chr3_+_53528659 0.032 ENST00000350061.5
CACNA1D
calcium channel, voltage-dependent, L type, alpha 1D subunit
chrX_-_15333736 0.026 ENST00000380470.3
ASB11
ankyrin repeat and SOCS box containing 11
chr1_+_67673297 0.020 ENST00000425614.1
ENST00000395227.1
IL23R

interleukin 23 receptor

chr6_-_49834209 0.020 ENST00000507853.1
CRISP1
cysteine-rich secretory protein 1
chr11_+_61891445 0.016 ENST00000394818.3
ENST00000533896.1
ENST00000278849.4
INCENP


inner centromere protein antigens 135/155kDa


chr15_-_51630772 0.015 ENST00000557858.1
ENST00000558328.1
ENST00000396404.4
ENST00000561075.1
ENST00000405011.2
ENST00000559980.1
ENST00000453807.2
ENST00000396402.1
CYP19A1







cytochrome P450, family 19, subfamily A, polypeptide 1







chr19_+_50691437 0.014 ENST00000598205.1
MYH14
myosin, heavy chain 14, non-muscle
chr12_+_5541267 0.013 ENST00000423158.3
NTF3
neurotrophin 3
chr6_-_49834240 0.007 ENST00000335847.4
CRISP1
cysteine-rich secretory protein 1
chr12_+_53848549 0.006 ENST00000439930.3
ENST00000548933.1
ENST00000562264.1
PCBP2


poly(rC) binding protein 2


chr7_-_16844611 0.006 ENST00000401412.1
ENST00000419304.2
AGR2

anterior gradient 2


Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0043095 regulation of GTP cyclohydrolase I activity(GO:0043095) negative regulation of GTP cyclohydrolase I activity(GO:0043105)
0.1 0.3 GO:0002752 cell surface pattern recognition receptor signaling pathway(GO:0002752)
0.1 0.5 GO:0016075 rRNA catabolic process(GO:0016075)
0.1 2.5 GO:0002286 T cell activation involved in immune response(GO:0002286)
0.0 0.1 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 0.1 GO:0007079 mitotic chromosome movement towards spindle pole(GO:0007079) chromosome movement towards spindle pole(GO:0051305)
0.0 0.8 GO:0045730 respiratory burst(GO:0045730)
0.0 0.1 GO:0000338 protein deneddylation(GO:0000338)
0.0 0.1 GO:0050917 sensory perception of umami taste(GO:0050917)
0.0 0.1 GO:0001780 neutrophil homeostasis(GO:0001780)
0.0 0.5 GO:0030032 lamellipodium assembly(GO:0030032)
0.0 0.3 GO:0015695 organic cation transport(GO:0015695)
0.0 0.2 GO:0032876 regulation of DNA endoreduplication(GO:0032875) negative regulation of DNA endoreduplication(GO:0032876) DNA endoreduplication(GO:0042023)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 2.5 GO:0001891 phagocytic cup(GO:0001891)
0.0 0.5 GO:0000178 exosome (RNase complex)(GO:0000178)
0.0 0.3 GO:0045120 pronucleus(GO:0045120)
0.0 0.1 GO:0000940 condensed chromosome outer kinetochore(GO:0000940)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.4 GO:0044549 GTP cyclohydrolase binding(GO:0044549)
0.0 0.1 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.2 GO:0004971 AMPA glutamate receptor activity(GO:0004971)
0.0 0.3 GO:0001846 opsonin binding(GO:0001846)
0.0 0.1 GO:0043515 kinetochore binding(GO:0043515)
0.0 2.9 GO:0051015 actin filament binding(GO:0051015)
0.0 0.3 GO:0015101 organic cation transmembrane transporter activity(GO:0015101)
0.0 0.2 GO:0004117 calmodulin-dependent cyclic-nucleotide phosphodiesterase activity(GO:0004117)