Motif ID: KLF15
Z-value: 1.119
Transcription factors associated with KLF15:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| KLF15 | ENSG00000163884.3 | KLF15 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.2 | GO:0048627 | myoblast development(GO:0048627) |
| 0.7 | 2.8 | GO:0033602 | negative regulation of gamma-aminobutyric acid secretion(GO:0014053) negative regulation of dopamine secretion(GO:0033602) |
| 0.4 | 1.6 | GO:0001705 | ectoderm formation(GO:0001705) central nervous system myelination(GO:0022010) axon ensheathment in central nervous system(GO:0032291) |
| 0.3 | 0.3 | GO:0019884 | antigen processing and presentation of exogenous peptide antigen(GO:0002478) antigen processing and presentation of exogenous antigen(GO:0019884) |
| 0.2 | 0.5 | GO:0032223 | negative regulation of synaptic transmission, cholinergic(GO:0032223) neurotransmitter receptor biosynthetic process(GO:0045212) |
| 0.2 | 0.5 | GO:0010881 | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion(GO:0010881) |
| 0.2 | 0.5 | GO:1901419 | regulation of response to alcohol(GO:1901419) |
| 0.1 | 0.6 | GO:0032929 | negative regulation of superoxide anion generation(GO:0032929) |
| 0.1 | 0.3 | GO:0031999 | negative regulation of fatty acid beta-oxidation(GO:0031999) |
| 0.1 | 0.7 | GO:0051045 | negative regulation of membrane protein ectodomain proteolysis(GO:0051045) |
| 0.1 | 0.9 | GO:0002726 | positive regulation of T cell cytokine production(GO:0002726) |
| 0.1 | 0.5 | GO:0048619 | embryonic hindgut morphogenesis(GO:0048619) |
| 0.1 | 0.4 | GO:0021919 | BMP signaling pathway involved in spinal cord dorsal/ventral patterning(GO:0021919) |
| 0.1 | 0.6 | GO:0006290 | pyrimidine dimer repair(GO:0006290) |
| 0.1 | 0.5 | GO:0046952 | ketone body catabolic process(GO:0046952) |
| 0.1 | 0.4 | GO:0071894 | histone H2B conserved C-terminal lysine ubiquitination(GO:0071894) |
| 0.1 | 0.6 | GO:0006562 | proline catabolic process(GO:0006562) |
| 0.1 | 0.3 | GO:0070734 | histone H3-K27 methylation(GO:0070734) |
| 0.1 | 1.1 | GO:0034447 | very-low-density lipoprotein particle clearance(GO:0034447) |
| 0.1 | 0.3 | GO:0006478 | peptidyl-tyrosine sulfation(GO:0006478) |
| 0.1 | 0.3 | GO:0032927 | positive regulation of activin receptor signaling pathway(GO:0032927) |
| 0.1 | 0.3 | GO:0002268 | follicular dendritic cell activation(GO:0002266) follicular dendritic cell differentiation(GO:0002268) |
| 0.1 | 0.4 | GO:2001259 | positive regulation of calcium ion transmembrane transporter activity(GO:1901021) positive regulation of cation channel activity(GO:2001259) |
| 0.1 | 0.8 | GO:0060716 | labyrinthine layer blood vessel development(GO:0060716) |
| 0.1 | 0.4 | GO:0048845 | venous blood vessel morphogenesis(GO:0048845) |
| 0.1 | 0.3 | GO:0001672 | regulation of chromatin assembly or disassembly(GO:0001672) |
| 0.1 | 0.2 | GO:0046015 | carbon catabolite regulation of transcription(GO:0045990) regulation of transcription by glucose(GO:0046015) positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus(GO:1901522) |
| 0.1 | 0.3 | GO:0002036 | regulation of L-glutamate transport(GO:0002036) |
| 0.1 | 0.7 | GO:0002021 | response to dietary excess(GO:0002021) |
| 0.1 | 0.2 | GO:0045299 | otolith mineralization(GO:0045299) |
| 0.1 | 0.3 | GO:0046642 | negative regulation of alpha-beta T cell proliferation(GO:0046642) |
| 0.1 | 0.6 | GO:0043508 | negative regulation of JUN kinase activity(GO:0043508) |
| 0.0 | 0.3 | GO:0005981 | regulation of glycogen catabolic process(GO:0005981) |
| 0.0 | 0.3 | GO:0009450 | gamma-aminobutyric acid catabolic process(GO:0009450) |
| 0.0 | 0.4 | GO:0045793 | positive regulation of cell size(GO:0045793) |
| 0.0 | 0.3 | GO:0006610 | ribosomal protein import into nucleus(GO:0006610) |
| 0.0 | 0.4 | GO:0007217 | tachykinin receptor signaling pathway(GO:0007217) |
| 0.0 | 0.6 | GO:0051319 | mitotic G2 phase(GO:0000085) G2 phase(GO:0051319) |
| 0.0 | 0.2 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
| 0.0 | 1.3 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.0 | 0.2 | GO:0043249 | erythrocyte maturation(GO:0043249) |
| 0.0 | 0.2 | GO:0016584 | nucleosome positioning(GO:0016584) |
| 0.0 | 0.4 | GO:0060762 | regulation of branching involved in mammary gland duct morphogenesis(GO:0060762) |
| 0.0 | 0.5 | GO:0008634 | obsolete negative regulation of survival gene product expression(GO:0008634) |
| 0.0 | 0.7 | GO:0031648 | protein destabilization(GO:0031648) |
| 0.0 | 4.6 | GO:0007266 | Rho protein signal transduction(GO:0007266) |
| 0.0 | 0.2 | GO:0043045 | DNA methylation involved in embryo development(GO:0043045) changes to DNA methylation involved in embryo development(GO:1901538) |
| 0.0 | 0.3 | GO:0016180 | snRNA processing(GO:0016180) |
| 0.0 | 0.6 | GO:0001578 | microtubule bundle formation(GO:0001578) |
| 0.0 | 0.1 | GO:0000114 | obsolete regulation of transcription involved in G1 phase of mitotic cell cycle(GO:0000114) |
| 0.0 | 0.3 | GO:0045540 | regulation of cholesterol biosynthetic process(GO:0045540) |
| 0.0 | 0.1 | GO:0045060 | negative T cell selection(GO:0043383) negative thymic T cell selection(GO:0045060) |
| 0.0 | 0.1 | GO:0048295 | positive regulation of isotype switching to IgE isotypes(GO:0048295) |
| 0.0 | 0.2 | GO:0043923 | positive regulation by host of viral transcription(GO:0043923) |
| 0.0 | 0.9 | GO:0042246 | tissue regeneration(GO:0042246) |
| 0.0 | 1.0 | GO:0006958 | complement activation, classical pathway(GO:0006958) |
| 0.0 | 0.3 | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846) |
| 0.0 | 0.1 | GO:0043982 | histone H4-K5 acetylation(GO:0043981) histone H4-K8 acetylation(GO:0043982) |
| 0.0 | 0.3 | GO:0007520 | myoblast fusion(GO:0007520) |
| 0.0 | 0.2 | GO:0006198 | cAMP catabolic process(GO:0006198) |
| 0.0 | 0.0 | GO:0019056 | modulation by virus of host transcription(GO:0019056) regulation of sprouting of injured axon(GO:0048686) positive regulation of sprouting of injured axon(GO:0048687) regulation of axon extension involved in regeneration(GO:0048690) positive regulation of axon extension involved in regeneration(GO:0048691) modulation by symbiont of host transcription(GO:0052026) |
| 0.0 | 0.5 | GO:0045646 | regulation of erythrocyte differentiation(GO:0045646) |
| 0.0 | 0.1 | GO:0060707 | trophoblast giant cell differentiation(GO:0060707) |
| 0.0 | 0.7 | GO:0007224 | smoothened signaling pathway(GO:0007224) |
| 0.0 | 0.3 | GO:0046627 | negative regulation of insulin receptor signaling pathway(GO:0046627) negative regulation of cellular response to insulin stimulus(GO:1900077) |
| 0.0 | 0.1 | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway(GO:0043568) |
| 0.0 | 0.1 | GO:0060390 | regulation of SMAD protein import into nucleus(GO:0060390) |
| 0.0 | 0.0 | GO:0051151 | negative regulation of smooth muscle cell differentiation(GO:0051151) |
| 0.0 | 0.3 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.0 | 0.2 | GO:0006750 | glutathione biosynthetic process(GO:0006750) |
| 0.0 | 0.2 | GO:0048260 | positive regulation of receptor-mediated endocytosis(GO:0048260) |
| 0.0 | 0.1 | GO:0051926 | negative regulation of calcium ion transport(GO:0051926) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 2.2 | GO:0016012 | sarcoglycan complex(GO:0016012) |
| 0.3 | 3.2 | GO:0031254 | uropod(GO:0001931) cell trailing edge(GO:0031254) |
| 0.2 | 2.8 | GO:0030673 | axolemma(GO:0030673) |
| 0.2 | 0.9 | GO:0032449 | CBM complex(GO:0032449) |
| 0.2 | 0.5 | GO:0005726 | perichromatin fibrils(GO:0005726) |
| 0.1 | 0.3 | GO:0033257 | Bcl3/NF-kappaB2 complex(GO:0033257) |
| 0.1 | 0.3 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.1 | 0.5 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) beta-catenin-TCF complex(GO:1990907) |
| 0.1 | 0.2 | GO:0031213 | RSF complex(GO:0031213) |
| 0.1 | 0.2 | GO:0016600 | flotillin complex(GO:0016600) |
| 0.1 | 1.0 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
| 0.0 | 0.5 | GO:0030061 | mitochondrial crista(GO:0030061) |
| 0.0 | 0.5 | GO:0031307 | integral component of mitochondrial outer membrane(GO:0031307) |
| 0.0 | 0.2 | GO:0016589 | NURF complex(GO:0016589) |
| 0.0 | 1.1 | GO:0034361 | very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385) |
| 0.0 | 0.3 | GO:0016327 | apicolateral plasma membrane(GO:0016327) |
| 0.0 | 0.3 | GO:0016602 | CCAAT-binding factor complex(GO:0016602) |
| 0.0 | 0.3 | GO:0032039 | integrator complex(GO:0032039) |
| 0.0 | 0.2 | GO:0000791 | euchromatin(GO:0000791) |
| 0.0 | 0.5 | GO:0005605 | basal lamina(GO:0005605) |
| 0.0 | 0.3 | GO:0031105 | septin complex(GO:0031105) septin cytoskeleton(GO:0032156) |
| 0.0 | 0.5 | GO:0005839 | proteasome core complex(GO:0005839) |
| 0.0 | 0.2 | GO:0001673 | male germ cell nucleus(GO:0001673) |
| 0.0 | 0.4 | GO:0043005 | neuron projection(GO:0043005) |
| 0.0 | 0.6 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 0.3 | GO:0033017 | sarcoplasmic reticulum membrane(GO:0033017) |
| 0.0 | 0.9 | GO:0016363 | nuclear matrix(GO:0016363) |
| 0.0 | 0.8 | GO:0035097 | methyltransferase complex(GO:0034708) histone methyltransferase complex(GO:0035097) |
| 0.0 | 0.3 | GO:0005640 | nuclear outer membrane(GO:0005640) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.9 | 2.8 | GO:0004965 | G-protein coupled GABA receptor activity(GO:0004965) |
| 0.6 | 2.8 | GO:0034711 | inhibin binding(GO:0034711) |
| 0.2 | 0.5 | GO:0003858 | 3-hydroxybutyrate dehydrogenase activity(GO:0003858) |
| 0.2 | 1.1 | GO:0030229 | very-low-density lipoprotein particle receptor activity(GO:0030229) |
| 0.2 | 0.8 | GO:0042156 | obsolete zinc-mediated transcriptional activator activity(GO:0042156) |
| 0.2 | 0.3 | GO:0016362 | activin receptor activity, type II(GO:0016362) |
| 0.1 | 0.5 | GO:0003990 | acetylcholinesterase activity(GO:0003990) |
| 0.1 | 0.9 | GO:0008158 | hedgehog receptor activity(GO:0008158) |
| 0.1 | 0.7 | GO:0001784 | phosphotyrosine binding(GO:0001784) |
| 0.1 | 1.3 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
| 0.1 | 0.3 | GO:0046976 | histone methyltransferase activity (H3-K27 specific)(GO:0046976) |
| 0.1 | 0.3 | GO:0008476 | protein-tyrosine sulfotransferase activity(GO:0008476) |
| 0.1 | 1.6 | GO:0000978 | RNA polymerase II core promoter proximal region sequence-specific DNA binding(GO:0000978) core promoter proximal region sequence-specific DNA binding(GO:0000987) core promoter proximal region DNA binding(GO:0001159) |
| 0.1 | 0.4 | GO:0001098 | RNA polymerase II core binding(GO:0000993) basal transcription machinery binding(GO:0001098) basal RNA polymerase II transcription machinery binding(GO:0001099) |
| 0.1 | 0.4 | GO:0050321 | tau-protein kinase activity(GO:0050321) |
| 0.1 | 1.5 | GO:0008143 | poly(A) binding(GO:0008143) |
| 0.1 | 0.4 | GO:0008327 | methyl-CpG binding(GO:0008327) |
| 0.1 | 0.4 | GO:0004674 | protein serine/threonine kinase activity(GO:0004674) |
| 0.1 | 0.6 | GO:0015379 | potassium:chloride symporter activity(GO:0015379) |
| 0.1 | 0.5 | GO:0005219 | ryanodine-sensitive calcium-release channel activity(GO:0005219) |
| 0.1 | 2.7 | GO:0042169 | SH2 domain binding(GO:0042169) |
| 0.1 | 0.4 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.1 | 0.4 | GO:0004703 | G-protein coupled receptor kinase activity(GO:0004703) |
| 0.1 | 0.5 | GO:0034056 | estrogen response element binding(GO:0034056) |
| 0.1 | 1.1 | GO:0017153 | sodium:dicarboxylate symporter activity(GO:0017153) |
| 0.1 | 0.8 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 0.9 | GO:0043621 | protein self-association(GO:0043621) |
| 0.0 | 0.6 | GO:0003993 | acid phosphatase activity(GO:0003993) |
| 0.0 | 0.6 | GO:0008242 | omega peptidase activity(GO:0008242) |
| 0.0 | 0.5 | GO:0004571 | mannosyl-oligosaccharide 1,2-alpha-mannosidase activity(GO:0004571) |
| 0.0 | 0.4 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.0 | 0.6 | GO:0004029 | aldehyde dehydrogenase (NAD) activity(GO:0004029) |
| 0.0 | 0.8 | GO:0046965 | retinoid X receptor binding(GO:0046965) |
| 0.0 | 0.6 | GO:0070742 | C2H2 zinc finger domain binding(GO:0070742) |
| 0.0 | 0.2 | GO:0004306 | ethanolamine-phosphate cytidylyltransferase activity(GO:0004306) |
| 0.0 | 0.3 | GO:0015355 | secondary active monocarboxylate transmembrane transporter activity(GO:0015355) |
| 0.0 | 2.2 | GO:0001948 | glycoprotein binding(GO:0001948) |
| 0.0 | 0.3 | GO:0030235 | nitric-oxide synthase regulator activity(GO:0030235) |
| 0.0 | 0.1 | GO:0016531 | copper chaperone activity(GO:0016531) |
| 0.0 | 0.2 | GO:0004835 | tubulin-tyrosine ligase activity(GO:0004835) |
| 0.0 | 0.2 | GO:0003886 | DNA (cytosine-5-)-methyltransferase activity(GO:0003886) |
| 0.0 | 0.7 | GO:0003887 | DNA-directed DNA polymerase activity(GO:0003887) |
| 0.0 | 2.1 | GO:0005089 | Rho guanyl-nucleotide exchange factor activity(GO:0005089) |
| 0.0 | 0.1 | GO:0010485 | H4 histone acetyltransferase activity(GO:0010485) |
| 0.0 | 0.2 | GO:0030899 | calcium-dependent ATPase activity(GO:0030899) |
| 0.0 | 0.1 | GO:0031877 | somatostatin receptor binding(GO:0031877) |
| 0.0 | 0.1 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.0 | 0.5 | GO:0004129 | cytochrome-c oxidase activity(GO:0004129) heme-copper terminal oxidase activity(GO:0015002) oxidoreductase activity, acting on a heme group of donors(GO:0016675) oxidoreductase activity, acting on a heme group of donors, oxygen as acceptor(GO:0016676) |
| 0.0 | 0.5 | GO:0005546 | phosphatidylinositol-4,5-bisphosphate binding(GO:0005546) |
| 0.0 | 1.1 | GO:0004722 | protein serine/threonine phosphatase activity(GO:0004722) |
| 0.0 | 0.1 | GO:0031821 | G-protein coupled serotonin receptor binding(GO:0031821) |
| 0.0 | 0.3 | GO:0004683 | calmodulin-dependent protein kinase activity(GO:0004683) |
| 0.0 | 0.3 | GO:0008536 | Ran GTPase binding(GO:0008536) |
| 0.0 | 0.4 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.0 | 0.5 | GO:0004298 | threonine-type endopeptidase activity(GO:0004298) threonine-type peptidase activity(GO:0070003) |
| 0.0 | 0.2 | GO:0043425 | bHLH transcription factor binding(GO:0043425) |
| 0.0 | 2.7 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
| 0.0 | 0.1 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.0 | 1.3 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 0.6 | GO:0017048 | Rho GTPase binding(GO:0017048) |
| 0.0 | 0.1 | GO:0016802 | adenosylhomocysteinase activity(GO:0004013) trialkylsulfonium hydrolase activity(GO:0016802) |
| 0.0 | 0.2 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.7 | GO:0008301 | DNA binding, bending(GO:0008301) |
| 0.0 | 0.2 | GO:0003840 | gamma-glutamyltransferase activity(GO:0003840) |
| 0.0 | 0.1 | GO:0005087 | Ran guanyl-nucleotide exchange factor activity(GO:0005087) |
| 0.0 | 0.2 | GO:0035035 | histone acetyltransferase binding(GO:0035035) |
| 0.0 | 0.3 | GO:0016628 | oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor(GO:0016628) |
| 0.0 | 0.3 | GO:0005001 | transmembrane receptor protein tyrosine phosphatase activity(GO:0005001) transmembrane receptor protein phosphatase activity(GO:0019198) |
| 0.0 | 0.3 | GO:0016620 | oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor(GO:0016620) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 1.7 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 0.6 | SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES | Genes related to regulation of the actin cytoskeleton |
