Motif ID: LHX3
Z-value: 1.525
Transcription factors associated with LHX3:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| LHX3 | ENSG00000107187.11 | LHX3 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.7 | GO:0007206 | phospholipase C-activating G-protein coupled glutamate receptor signaling pathway(GO:0007206) |
| 0.4 | 1.2 | GO:0002752 | cell surface pattern recognition receptor signaling pathway(GO:0002752) |
| 0.3 | 1.4 | GO:0007614 | short-term memory(GO:0007614) |
| 0.3 | 2.5 | GO:0042448 | progesterone metabolic process(GO:0042448) |
| 0.2 | 2.0 | GO:0034392 | negative regulation of smooth muscle cell apoptotic process(GO:0034392) |
| 0.2 | 0.7 | GO:0090206 | negative regulation of cholesterol biosynthetic process(GO:0045541) negative regulation of cholesterol metabolic process(GO:0090206) |
| 0.2 | 1.1 | GO:0045722 | response to muscle activity(GO:0014850) positive regulation of gluconeogenesis(GO:0045722) |
| 0.2 | 1.5 | GO:0042541 | hemoglobin biosynthetic process(GO:0042541) |
| 0.1 | 1.2 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 0.1 | 0.7 | GO:0071168 | protein localization to chromatin(GO:0071168) |
| 0.1 | 0.6 | GO:0010957 | negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137) |
| 0.1 | 0.6 | GO:0050955 | thermoception(GO:0050955) |
| 0.1 | 0.3 | GO:0048865 | stem cell fate commitment(GO:0048865) stem cell fate determination(GO:0048867) |
| 0.1 | 1.8 | GO:0009812 | flavonoid metabolic process(GO:0009812) |
| 0.1 | 0.3 | GO:0021759 | globus pallidus development(GO:0021759) menarche(GO:0042696) |
| 0.1 | 0.2 | GO:0035461 | vitamin transmembrane transport(GO:0035461) |
| 0.0 | 0.8 | GO:0016601 | Rac protein signal transduction(GO:0016601) |
| 0.0 | 0.8 | GO:0000380 | alternative mRNA splicing, via spliceosome(GO:0000380) |
| 0.0 | 0.6 | GO:0006491 | N-glycan processing(GO:0006491) |
| 0.0 | 0.3 | GO:0010459 | negative regulation of heart rate(GO:0010459) |
| 0.0 | 0.8 | GO:0016578 | histone deubiquitination(GO:0016578) |
| 0.0 | 2.7 | GO:0051592 | response to calcium ion(GO:0051592) |
| 0.0 | 0.4 | GO:0060736 | prostate gland growth(GO:0060736) |
| 0.0 | 0.1 | GO:0060025 | regulation of synaptic activity(GO:0060025) |
| 0.0 | 0.2 | GO:0007217 | tachykinin receptor signaling pathway(GO:0007217) |
| 0.0 | 0.4 | GO:1904031 | positive regulation of cyclin-dependent protein serine/threonine kinase activity(GO:0045737) positive regulation of cyclin-dependent protein kinase activity(GO:1904031) |
| 0.0 | 0.6 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation(GO:0033138) |
| 0.0 | 0.1 | GO:0042354 | fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355) |
| 0.0 | 0.3 | GO:0006607 | NLS-bearing protein import into nucleus(GO:0006607) |
| 0.0 | 0.5 | GO:0050931 | melanocyte differentiation(GO:0030318) pigment cell differentiation(GO:0050931) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 3.0 | GO:0005577 | fibrinogen complex(GO:0005577) |
| 0.2 | 1.7 | GO:0046581 | intercellular canaliculus(GO:0046581) |
| 0.1 | 2.0 | GO:0042627 | chylomicron(GO:0042627) |
| 0.1 | 1.1 | GO:0001518 | voltage-gated sodium channel complex(GO:0001518) |
| 0.1 | 1.7 | GO:0043034 | costamere(GO:0043034) |
| 0.1 | 0.3 | GO:0097651 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) phosphatidylinositol 3-kinase complex, class I(GO:0097651) |
| 0.0 | 1.1 | GO:0005665 | DNA-directed RNA polymerase II, core complex(GO:0005665) |
| 0.0 | 0.7 | GO:0005671 | Ada2/Gcn5/Ada3 transcription activator complex(GO:0005671) |
| 0.0 | 2.8 | GO:0005882 | intermediate filament(GO:0005882) |
| 0.0 | 0.7 | GO:0012507 | ER to Golgi transport vesicle membrane(GO:0012507) |
| 0.0 | 0.7 | GO:0016592 | mediator complex(GO:0016592) |
| 0.0 | 1.5 | GO:0005778 | peroxisomal membrane(GO:0005778) microbody membrane(GO:0031903) |
| 0.0 | 0.5 | GO:0032982 | myosin filament(GO:0032982) |
| 0.0 | 0.4 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 1.4 | GO:0030666 | endocytic vesicle membrane(GO:0030666) |
| 0.0 | 0.1 | GO:0045179 | apical cortex(GO:0045179) |
| 0.0 | 2.2 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 0.7 | GO:0005876 | spindle microtubule(GO:0005876) |
| 0.0 | 1.3 | GO:0034399 | nuclear periphery(GO:0034399) |
| 0.0 | 0.4 | GO:0000307 | cyclin-dependent protein kinase holoenzyme complex(GO:0000307) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 1.5 | GO:0003870 | 5-aminolevulinate synthase activity(GO:0003870) N-succinyltransferase activity(GO:0016749) |
| 0.4 | 1.7 | GO:0042910 | xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910) |
| 0.4 | 2.0 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
| 0.4 | 1.2 | GO:0003978 | UDP-glucose 4-epimerase activity(GO:0003978) |
| 0.3 | 1.8 | GO:0047894 | flavonol 3-sulfotransferase activity(GO:0047894) |
| 0.2 | 1.4 | GO:0004971 | AMPA glutamate receptor activity(GO:0004971) |
| 0.2 | 1.8 | GO:0004969 | histamine receptor activity(GO:0004969) |
| 0.2 | 1.2 | GO:0001846 | opsonin binding(GO:0001846) |
| 0.2 | 1.1 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
| 0.1 | 3.0 | GO:0043499 | obsolete eukaryotic cell surface binding(GO:0043499) |
| 0.1 | 0.5 | GO:0034701 | tripeptidase activity(GO:0034701) |
| 0.1 | 4.3 | GO:0019212 | phosphatase inhibitor activity(GO:0019212) |
| 0.1 | 0.6 | GO:0031434 | mitogen-activated protein kinase kinase binding(GO:0031434) |
| 0.1 | 1.8 | GO:0001104 | RNA polymerase II transcription cofactor activity(GO:0001104) |
| 0.1 | 1.1 | GO:1905030 | voltage-gated sodium channel activity(GO:0005248) voltage-gated ion channel activity involved in regulation of postsynaptic membrane potential(GO:1905030) |
| 0.0 | 0.3 | GO:0043559 | insulin binding(GO:0043559) |
| 0.0 | 0.2 | GO:0090482 | vitamin transmembrane transporter activity(GO:0090482) |
| 0.0 | 0.7 | GO:0000049 | tRNA binding(GO:0000049) |
| 0.0 | 0.4 | GO:0043236 | laminin binding(GO:0043236) |
| 0.0 | 0.1 | GO:0005324 | long-chain fatty acid transporter activity(GO:0005324) |
| 0.0 | 0.7 | GO:0035064 | methylated histone binding(GO:0035064) |
| 0.0 | 0.1 | GO:0008107 | galactoside 2-alpha-L-fucosyltransferase activity(GO:0008107) alpha-(1,2)-fucosyltransferase activity(GO:0031127) |
| 0.0 | 0.5 | GO:0000146 | microfilament motor activity(GO:0000146) |
| 0.0 | 0.3 | GO:0004089 | carbonate dehydratase activity(GO:0004089) |
| 0.0 | 0.1 | GO:0008379 | thioredoxin peroxidase activity(GO:0008379) |
| 0.0 | 1.5 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.0 | 1.5 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 0.7 | GO:0008013 | beta-catenin binding(GO:0008013) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 0.7 | SA_CASPASE_CASCADE | Apoptosis is mediated by caspases, cysteine proteases arranged in a proteolytic cascade. |
| 0.0 | 0.6 | ST_G_ALPHA_S_PATHWAY | G alpha s Pathway |
