Motif ID: LHX6
Z-value: 1.619
Transcription factors associated with LHX6:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| LHX6 | ENSG00000106852.11 | LHX6 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 2.3 | 7.0 | GO:0008218 | bioluminescence(GO:0008218) |
| 1.1 | 4.4 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.8 | 2.3 | GO:0090086 | negative regulation of protein deubiquitination(GO:0090086) |
| 0.3 | 2.9 | GO:0008354 | germ cell migration(GO:0008354) |
| 0.3 | 3.3 | GO:0007141 | male meiosis I(GO:0007141) |
| 0.3 | 1.3 | GO:0046642 | negative regulation of alpha-beta T cell proliferation(GO:0046642) |
| 0.2 | 1.0 | GO:0000733 | DNA strand renaturation(GO:0000733) |
| 0.2 | 6.3 | GO:0030574 | collagen catabolic process(GO:0030574) |
| 0.2 | 1.3 | GO:0006552 | leucine catabolic process(GO:0006552) |
| 0.2 | 1.4 | GO:0006264 | mitochondrial DNA replication(GO:0006264) |
| 0.2 | 3.7 | GO:0070206 | protein trimerization(GO:0070206) |
| 0.2 | 0.9 | GO:0015712 | hexose phosphate transport(GO:0015712) glucose-6-phosphate transport(GO:0015760) |
| 0.2 | 1.9 | GO:0019800 | peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan(GO:0019800) |
| 0.1 | 0.4 | GO:0001907 | cytolysis by symbiont of host cells(GO:0001897) killing by symbiont of host cells(GO:0001907) hemolysis by symbiont of host erythrocytes(GO:0019836) disruption by symbiont of host cell(GO:0044004) hemolysis in other organism(GO:0044179) positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010) cytolysis in other organism(GO:0051715) cytolysis in other organism involved in symbiotic interaction(GO:0051801) hemolysis in other organism involved in symbiotic interaction(GO:0052331) |
| 0.1 | 3.4 | GO:0002474 | antigen processing and presentation of peptide antigen via MHC class I(GO:0002474) |
| 0.1 | 0.4 | GO:0009822 | alkaloid catabolic process(GO:0009822) |
| 0.1 | 0.8 | GO:0006553 | lysine metabolic process(GO:0006553) lysine catabolic process(GO:0006554) |
| 0.1 | 0.3 | GO:0070544 | histone H3-K36 demethylation(GO:0070544) |
| 0.1 | 1.1 | GO:0048488 | synaptic vesicle recycling(GO:0036465) synaptic vesicle endocytosis(GO:0048488) clathrin-mediated endocytosis(GO:0072583) |
| 0.1 | 1.0 | GO:0051497 | negative regulation of stress fiber assembly(GO:0051497) |
| 0.1 | 0.3 | GO:0019367 | fatty acid elongation, saturated fatty acid(GO:0019367) fatty acid elongation, monounsaturated fatty acid(GO:0034625) |
| 0.1 | 0.5 | GO:2000172 | regulation of branching morphogenesis of a nerve(GO:2000172) |
| 0.1 | 0.5 | GO:0071392 | cellular response to estradiol stimulus(GO:0071392) |
| 0.1 | 0.7 | GO:0032528 | microvillus assembly(GO:0030033) microvillus organization(GO:0032528) |
| 0.1 | 0.5 | GO:0099515 | nuclear migration along microfilament(GO:0031022) actin filament-based transport(GO:0099515) |
| 0.1 | 0.6 | GO:0019388 | galactose catabolic process(GO:0019388) |
| 0.1 | 1.3 | GO:0009312 | oligosaccharide biosynthetic process(GO:0009312) |
| 0.1 | 1.2 | GO:0000038 | very long-chain fatty acid metabolic process(GO:0000038) |
| 0.1 | 0.3 | GO:0061099 | negative regulation of protein tyrosine kinase activity(GO:0061099) |
| 0.1 | 0.3 | GO:0043162 | ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway(GO:0043162) |
| 0.1 | 0.2 | GO:1904358 | positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358) |
| 0.0 | 0.2 | GO:0032486 | Rap protein signal transduction(GO:0032486) |
| 0.0 | 0.3 | GO:0018027 | peptidyl-lysine dimethylation(GO:0018027) |
| 0.0 | 0.2 | GO:0006436 | tryptophanyl-tRNA aminoacylation(GO:0006436) |
| 0.0 | 0.3 | GO:0008653 | lipopolysaccharide metabolic process(GO:0008653) |
| 0.0 | 1.3 | GO:0036075 | endochondral ossification(GO:0001958) replacement ossification(GO:0036075) |
| 0.0 | 0.2 | GO:0051567 | histone H3-K9 methylation(GO:0051567) histone H3-K9 modification(GO:0061647) |
| 0.0 | 0.6 | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway(GO:0030511) positive regulation of cellular response to transforming growth factor beta stimulus(GO:1903846) |
| 0.0 | 2.7 | GO:0034138 | MyD88-independent toll-like receptor signaling pathway(GO:0002756) toll-like receptor 3 signaling pathway(GO:0034138) |
| 0.0 | 0.9 | GO:0060512 | prostate gland morphogenesis(GO:0060512) |
| 0.0 | 0.2 | GO:0071542 | dopaminergic neuron differentiation(GO:0071542) |
| 0.0 | 0.2 | GO:0006379 | mRNA cleavage(GO:0006379) |
| 0.0 | 0.0 | GO:0034126 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) positive regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034126) |
| 0.0 | 0.1 | GO:0050667 | homocysteine metabolic process(GO:0050667) |
| 0.0 | 0.5 | GO:0046847 | filopodium assembly(GO:0046847) |
| 0.0 | 0.4 | GO:0016338 | calcium-independent cell-cell adhesion via plasma membrane cell-adhesion molecules(GO:0016338) |
| 0.0 | 0.2 | GO:0042273 | ribosomal large subunit biogenesis(GO:0042273) |
| 0.0 | 0.2 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.0 | 0.1 | GO:0009396 | folic acid-containing compound biosynthetic process(GO:0009396) |
| 0.0 | 0.8 | GO:0016126 | sterol biosynthetic process(GO:0016126) |
| 0.0 | 0.3 | GO:0016236 | macroautophagy(GO:0016236) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.3 | 1.3 | GO:0030936 | collagen type XIII trimer(GO:0005600) transmembrane collagen trimer(GO:0030936) |
| 0.2 | 2.8 | GO:0071203 | WASH complex(GO:0071203) |
| 0.2 | 0.5 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.1 | 1.9 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.1 | 3.4 | GO:0042612 | MHC class I protein complex(GO:0042612) |
| 0.1 | 7.4 | GO:0005604 | basement membrane(GO:0005604) |
| 0.1 | 2.3 | GO:0016234 | inclusion body(GO:0016234) |
| 0.1 | 4.7 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.1 | 0.5 | GO:0008250 | oligosaccharyltransferase complex(GO:0008250) |
| 0.1 | 3.0 | GO:0015030 | Cajal body(GO:0015030) |
| 0.0 | 0.4 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
| 0.0 | 0.5 | GO:0034993 | axonemal dynein complex(GO:0005858) microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) axoneme part(GO:0044447) |
| 0.0 | 0.5 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 0.1 | GO:0030904 | retromer complex(GO:0030904) |
| 0.0 | 2.5 | GO:0016459 | myosin complex(GO:0016459) |
| 0.0 | 0.9 | GO:0036064 | ciliary basal body(GO:0036064) |
| 0.0 | 0.7 | GO:0030286 | dynein complex(GO:0030286) |
| 0.0 | 6.1 | GO:0005578 | proteinaceous extracellular matrix(GO:0005578) |
| 0.0 | 1.0 | GO:0005884 | actin filament(GO:0005884) |
| 0.0 | 0.1 | GO:0000164 | protein phosphatase type 1 complex(GO:0000164) |
| 0.0 | 3.1 | GO:0005925 | focal adhesion(GO:0005925) |
| 0.0 | 0.5 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 1.9 | GO:0030027 | lamellipodium(GO:0030027) |
| 0.0 | 0.3 | GO:0005771 | multivesicular body(GO:0005771) |
| 0.0 | 0.4 | GO:0016328 | lateral plasma membrane(GO:0016328) |
| 0.0 | 0.2 | GO:0000242 | pericentriolar material(GO:0000242) |
| 0.0 | 0.1 | GO:0000275 | mitochondrial proton-transporting ATP synthase complex, catalytic core F(1)(GO:0000275) |
| 0.0 | 0.9 | GO:0032580 | Golgi cisterna membrane(GO:0032580) |
| 0.0 | 0.3 | GO:0005776 | autophagosome(GO:0005776) |
| 0.0 | 0.8 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 3.8 | GO:0017112 | Rab guanyl-nucleotide exchange factor activity(GO:0017112) |
| 0.5 | 1.4 | GO:0004797 | thymidine kinase activity(GO:0004797) |
| 0.5 | 1.4 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.4 | 1.3 | GO:0047273 | galactosylgalactosylglucosylceramide beta-D-acetylgalactosaminyltransferase activity(GO:0047273) |
| 0.4 | 2.9 | GO:0042392 | sphingosine-1-phosphate phosphatase activity(GO:0042392) |
| 0.3 | 0.9 | GO:0050510 | N-acetylgalactosaminyl-proteoglycan 3-beta-glucuronosyltransferase activity(GO:0050510) |
| 0.2 | 1.0 | GO:0043140 | obsolete DNA strand annealing activity(GO:0000739) ATP-dependent 3'-5' DNA helicase activity(GO:0043140) |
| 0.2 | 0.9 | GO:0004346 | glucose-6-phosphatase activity(GO:0004346) sugar-terminal-phosphatase activity(GO:0050309) |
| 0.2 | 3.4 | GO:0032393 | MHC class I receptor activity(GO:0032393) |
| 0.2 | 2.3 | GO:0070628 | proteasome binding(GO:0070628) |
| 0.1 | 1.2 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.1 | 6.7 | GO:0005518 | collagen binding(GO:0005518) |
| 0.1 | 0.5 | GO:0008599 | protein phosphatase type 1 regulator activity(GO:0008599) |
| 0.1 | 0.9 | GO:0004835 | tubulin-tyrosine ligase activity(GO:0004835) |
| 0.1 | 0.3 | GO:0050528 | acyloxyacyl hydrolase activity(GO:0050528) |
| 0.1 | 0.3 | GO:0030292 | protein tyrosine kinase inhibitor activity(GO:0030292) |
| 0.1 | 1.3 | GO:0003995 | acyl-CoA dehydrogenase activity(GO:0003995) |
| 0.1 | 1.0 | GO:0043274 | phospholipase binding(GO:0043274) |
| 0.1 | 0.6 | GO:0070569 | uridylyltransferase activity(GO:0070569) |
| 0.1 | 6.3 | GO:0004222 | metalloendopeptidase activity(GO:0004222) |
| 0.1 | 0.4 | GO:0008073 | ornithine decarboxylase inhibitor activity(GO:0008073) |
| 0.1 | 0.3 | GO:0046975 | histone methyltransferase activity (H3-K36 specific)(GO:0046975) |
| 0.1 | 1.1 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 0.3 | GO:0009922 | fatty acid elongase activity(GO:0009922) |
| 0.1 | 0.5 | GO:0004579 | dolichyl-diphosphooligosaccharide-protein glycotransferase activity(GO:0004579) |
| 0.0 | 0.3 | GO:0051864 | histone demethylase activity (H3-K36 specific)(GO:0051864) |
| 0.0 | 0.4 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.0 | 0.2 | GO:0004830 | tryptophan-tRNA ligase activity(GO:0004830) |
| 0.0 | 0.1 | GO:0008898 | S-adenosylmethionine-homocysteine S-methyltransferase activity(GO:0008898) |
| 0.0 | 0.8 | GO:0016646 | oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor(GO:0016646) |
| 0.0 | 0.6 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 0.4 | GO:0070330 | aromatase activity(GO:0070330) |
| 0.0 | 4.9 | GO:0008022 | protein C-terminus binding(GO:0008022) |
| 0.0 | 3.8 | GO:0000287 | magnesium ion binding(GO:0000287) |
| 0.0 | 0.6 | GO:0017022 | myosin binding(GO:0017022) |
| 0.0 | 3.4 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 0.2 | GO:0070410 | co-SMAD binding(GO:0070410) |
| 0.0 | 0.1 | GO:0042910 | xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910) |
| 0.0 | 0.5 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
| 0.0 | 0.1 | GO:0003747 | translation release factor activity(GO:0003747) translation termination factor activity(GO:0008079) |
| 0.0 | 1.2 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.1 | 3.3 | SA_REG_CASCADE_OF_CYCLIN_EXPR | Expression of cyclins regulates progression through the cell cycle by activating cyclin-dependent kinases. |
| 0.1 | 3.3 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 0.2 | ST_TYPE_I_INTERFERON_PATHWAY | Type I Interferon (alpha/beta IFN) Pathway |
