Motif ID: LMX1B_MNX1_RAX2
Z-value: 1.176
Transcription factors associated with LMX1B_MNX1_RAX2:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
LMX1B | ENSG00000136944.13 | LMX1B |
MNX1 | ENSG00000130675.10 | MNX1 |
RAX2 | ENSG00000173976.11 | RAX2 |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.6 | 6.2 | GO:0060649 | nipple development(GO:0060618) mammary gland bud elongation(GO:0060649) nipple morphogenesis(GO:0060658) nipple sheath formation(GO:0060659) |
0.6 | 1.9 | GO:0035987 | endodermal cell fate commitment(GO:0001711) endodermal cell differentiation(GO:0035987) |
0.4 | 3.1 | GO:0034392 | negative regulation of smooth muscle cell apoptotic process(GO:0034392) |
0.3 | 1.0 | GO:0021836 | chemorepulsion involved in postnatal olfactory bulb interneuron migration(GO:0021836) regulation of negative chemotaxis(GO:0050923) |
0.2 | 0.6 | GO:0055005 | optic placode formation involved in camera-type eye formation(GO:0046619) ventricular cardiac myofibril assembly(GO:0055005) embryonic retina morphogenesis in camera-type eye(GO:0060059) regulation of bile acid biosynthetic process(GO:0070857) regulation of bile acid metabolic process(GO:1904251) |
0.2 | 0.6 | GO:0045715 | negative regulation of low-density lipoprotein particle receptor biosynthetic process(GO:0045715) |
0.1 | 0.9 | GO:0071392 | cellular response to estradiol stimulus(GO:0071392) |
0.1 | 0.4 | GO:0046621 | negative regulation of organ growth(GO:0046621) |
0.1 | 1.6 | GO:0034446 | substrate adhesion-dependent cell spreading(GO:0034446) |
0.1 | 0.5 | GO:0050955 | thermoception(GO:0050955) |
0.1 | 0.5 | GO:0006651 | diacylglycerol biosynthetic process(GO:0006651) |
0.1 | 0.5 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
0.1 | 0.5 | GO:0042693 | muscle cell fate commitment(GO:0042693) |
0.1 | 0.3 | GO:0060743 | epithelial cell maturation involved in prostate gland development(GO:0060743) |
0.1 | 0.5 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
0.0 | 0.3 | GO:0010739 | positive regulation of protein kinase A signaling(GO:0010739) |
0.0 | 0.1 | GO:0021529 | spinal cord oligodendrocyte cell differentiation(GO:0021529) spinal cord oligodendrocyte cell fate specification(GO:0021530) oligodendrocyte cell fate specification(GO:0021778) glial cell fate specification(GO:0021780) |
0.0 | 0.1 | GO:1904037 | positive regulation of epithelial cell apoptotic process(GO:1904037) positive regulation of endothelial cell apoptotic process(GO:2000353) |
0.0 | 0.2 | GO:0018345 | protein palmitoylation(GO:0018345) |
0.0 | 0.1 | GO:0021797 | forebrain anterior/posterior pattern specification(GO:0021797) |
0.0 | 0.6 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
0.0 | 0.1 | GO:0002384 | hepatic immune response(GO:0002384) |
0.0 | 0.1 | GO:0010957 | negative regulation of calcidiol 1-monooxygenase activity(GO:0010956) negative regulation of vitamin D biosynthetic process(GO:0010957) negative regulation of vitamin metabolic process(GO:0046137) |
0.0 | 0.6 | GO:0071479 | cellular response to ionizing radiation(GO:0071479) |
0.0 | 0.1 | GO:0043049 | otic placode formation(GO:0043049) |
0.0 | 0.1 | GO:0070561 | vitamin D receptor signaling pathway(GO:0070561) |
0.0 | 0.1 | GO:0014889 | muscle atrophy(GO:0014889) regulation of skeletal muscle tissue growth(GO:0048631) |
0.0 | 0.3 | GO:0007603 | phototransduction, visible light(GO:0007603) |
0.0 | 0.1 | GO:0032472 | cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) Golgi calcium ion transport(GO:0032472) manganese ion homeostasis(GO:0055071) |
0.0 | 0.7 | GO:0051881 | regulation of mitochondrial membrane potential(GO:0051881) |
0.0 | 0.3 | GO:0019228 | neuronal action potential(GO:0019228) |
0.0 | 0.1 | GO:0021615 | glossopharyngeal nerve development(GO:0021563) glossopharyngeal nerve morphogenesis(GO:0021615) |
0.0 | 0.1 | GO:0046520 | diol biosynthetic process(GO:0034312) sphingosine biosynthetic process(GO:0046512) sphingoid biosynthetic process(GO:0046520) |
0.0 | 0.2 | GO:0008272 | sulfate transport(GO:0008272) |
0.0 | 0.1 | GO:0006562 | proline catabolic process(GO:0006562) |
0.0 | 0.6 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
0.0 | 0.1 | GO:0035335 | peptidyl-tyrosine dephosphorylation(GO:0035335) |
0.0 | 0.3 | GO:0071577 | zinc II ion transmembrane transport(GO:0071577) |
0.0 | 0.0 | GO:0006540 | glutamate decarboxylation to succinate(GO:0006540) |
0.0 | 0.4 | GO:0031532 | actin cytoskeleton reorganization(GO:0031532) |
0.0 | 0.5 | GO:0048813 | dendrite morphogenesis(GO:0048813) |
0.0 | 0.4 | GO:0090263 | positive regulation of canonical Wnt signaling pathway(GO:0090263) |
0.0 | 0.1 | GO:0042354 | fucose catabolic process(GO:0019317) L-fucose metabolic process(GO:0042354) L-fucose catabolic process(GO:0042355) |
0.0 | 0.1 | GO:0048387 | protein maturation by protein folding(GO:0022417) negative regulation of retinoic acid receptor signaling pathway(GO:0048387) |
0.0 | 0.1 | GO:0045197 | establishment or maintenance of epithelial cell apical/basal polarity(GO:0045197) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.5 | 1.6 | GO:0005607 | laminin-2 complex(GO:0005607) |
0.1 | 3.1 | GO:0042627 | chylomicron(GO:0042627) |
0.1 | 0.3 | GO:0036452 | ESCRT III complex(GO:0000815) ESCRT complex(GO:0036452) |
0.1 | 4.9 | GO:0005884 | actin filament(GO:0005884) |
0.1 | 0.6 | GO:0046581 | intercellular canaliculus(GO:0046581) |
0.1 | 2.9 | GO:0045095 | keratin filament(GO:0045095) |
0.1 | 0.5 | GO:0032311 | angiogenin-PRI complex(GO:0032311) |
0.0 | 0.1 | GO:0005726 | perichromatin fibrils(GO:0005726) |
0.0 | 2.0 | GO:0043197 | dendritic spine(GO:0043197) |
0.0 | 0.7 | GO:0042612 | MHC class I protein complex(GO:0042612) |
0.0 | 0.7 | GO:0030057 | desmosome(GO:0030057) |
0.0 | 4.8 | GO:0005925 | focal adhesion(GO:0005925) |
0.0 | 0.1 | GO:0005896 | interleukin-6 receptor complex(GO:0005896) |
0.0 | 0.3 | GO:0031258 | lamellipodium membrane(GO:0031258) |
0.0 | 0.5 | GO:0034364 | high-density lipoprotein particle(GO:0034364) |
0.0 | 0.6 | GO:0098636 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
0.0 | 0.8 | GO:0030964 | mitochondrial respiratory chain complex I(GO:0005747) NADH dehydrogenase complex(GO:0030964) respiratory chain complex I(GO:0045271) |
0.0 | 0.6 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
0.0 | 0.5 | GO:0030018 | Z disc(GO:0030018) |
0.0 | 0.1 | GO:0042824 | MHC class I peptide loading complex(GO:0042824) |
0.0 | 0.6 | GO:0042734 | presynaptic membrane(GO:0042734) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.2 | 7.1 | GO:0051371 | muscle alpha-actinin binding(GO:0051371) |
0.6 | 3.1 | GO:0060230 | lipoprotein lipase activator activity(GO:0060230) |
0.3 | 1.7 | GO:0034597 | phosphatidylinositol-3,4-bisphosphate 4-phosphatase activity(GO:0016316) phosphatidylinositol phosphate 4-phosphatase activity(GO:0034596) phosphatidylinositol-4,5-bisphosphate 4-phosphatase activity(GO:0034597) |
0.2 | 0.6 | GO:0050692 | DBD domain binding(GO:0050692) |
0.2 | 0.7 | GO:0030881 | beta-2-microglobulin binding(GO:0030881) |
0.2 | 0.6 | GO:0042910 | xenobiotic-transporting ATPase activity(GO:0008559) xenobiotic transporter activity(GO:0042910) |
0.1 | 1.0 | GO:0008046 | axon guidance receptor activity(GO:0008046) |
0.1 | 4.3 | GO:0005523 | tropomyosin binding(GO:0005523) |
0.1 | 2.0 | GO:0017017 | MAP kinase tyrosine/serine/threonine phosphatase activity(GO:0017017) |
0.1 | 2.4 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
0.1 | 0.4 | GO:0030280 | structural constituent of epidermis(GO:0030280) |
0.1 | 0.5 | GO:0004522 | ribonuclease A activity(GO:0004522) |
0.1 | 0.2 | GO:0019166 | trans-2-enoyl-CoA reductase (NADPH) activity(GO:0019166) |
0.0 | 6.2 | GO:0005179 | hormone activity(GO:0005179) |
0.0 | 0.3 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
0.0 | 0.1 | GO:0004607 | phosphatidylcholine-sterol O-acyltransferase activity(GO:0004607) |
0.0 | 0.7 | GO:0051537 | 2 iron, 2 sulfur cluster binding(GO:0051537) |
0.0 | 0.1 | GO:0005174 | CD40 receptor binding(GO:0005174) |
0.0 | 0.3 | GO:0008179 | adenylate cyclase binding(GO:0008179) |
0.0 | 0.4 | GO:0004904 | interferon receptor activity(GO:0004904) |
0.0 | 0.1 | GO:0008502 | melatonin receptor activity(GO:0008502) |
0.0 | 0.2 | GO:0008271 | secondary active sulfate transmembrane transporter activity(GO:0008271) |
0.0 | 0.1 | GO:0044183 | protein binding involved in protein folding(GO:0044183) |
0.0 | 0.2 | GO:0030021 | extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345) |
0.0 | 0.1 | GO:0019981 | interleukin-6 receptor activity(GO:0004915) interleukin-6 binding(GO:0019981) |
0.0 | 0.6 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
0.0 | 0.3 | GO:0001228 | transcription factor activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0000982) transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding(GO:0001077) transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific binding(GO:0001228) |
0.0 | 0.1 | GO:0004657 | proline dehydrogenase activity(GO:0004657) |
0.0 | 0.1 | GO:0017060 | 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity(GO:0017060) |
0.0 | 0.1 | GO:0015410 | manganese-transporting ATPase activity(GO:0015410) |
0.0 | 0.2 | GO:0034185 | apolipoprotein binding(GO:0034185) |
0.0 | 0.5 | GO:0070888 | E-box binding(GO:0070888) |
0.0 | 0.2 | GO:0008527 | taste receptor activity(GO:0008527) |
0.0 | 1.8 | GO:0005201 | extracellular matrix structural constituent(GO:0005201) |
0.0 | 0.2 | GO:0016409 | palmitoyltransferase activity(GO:0016409) |
0.0 | 0.1 | GO:0008454 | alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity(GO:0008454) |
0.0 | 0.1 | GO:0008158 | hedgehog receptor activity(GO:0008158) |
0.0 | 0.1 | GO:0034056 | estrogen response element binding(GO:0034056) |
0.0 | 5.3 | GO:0005096 | GTPase activator activity(GO:0005096) |
0.0 | 0.3 | GO:0004012 | phospholipid-translocating ATPase activity(GO:0004012) |
0.0 | 0.1 | GO:0004167 | dopachrome isomerase activity(GO:0004167) |
0.0 | 0.3 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
0.0 | 0.1 | GO:0016018 | cyclosporin A binding(GO:0016018) |
0.0 | 0.5 | GO:0008093 | cytoskeletal adaptor activity(GO:0008093) |
0.0 | 0.3 | GO:0005385 | zinc ion transmembrane transporter activity(GO:0005385) |
0.0 | 2.2 | GO:0004252 | serine-type endopeptidase activity(GO:0004252) |
0.0 | 0.1 | GO:0000099 | sulfur amino acid transmembrane transporter activity(GO:0000099) |
0.0 | 0.1 | GO:0016812 | hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides(GO:0016812) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 1.9 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |