Motif ID: MAFA

Z-value: 1.137


Transcription factors associated with MAFA:

Gene SymbolEntrez IDGene Name
MAFA ENSG00000182759.3 MAFA



Activity profile for motif MAFA.

activity profile for motif MAFA


Sorted Z-values histogram for motif MAFA

Sorted Z-values for motif MAFA



Network of associatons between targets according to the STRING database.



First level regulatory network of MAFA

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr10_+_124221036 2.519 ENST00000368984.3
 HTRA1
HtrA serine peptidase 1
chr11_-_104817919 2.176 ENST00000533252.1
 CASP4
caspase 4, apoptosis-related cysteine peptidase
chr2_+_85811525 2.146 ENST00000306384.4
 VAMP5
vesicle-associated membrane protein 5
chr1_-_153517473 1.990 ENST00000368715.1
 S100A4
S100 calcium binding protein A4
chr17_-_10325261 1.739 ENST00000403437.2
 MYH8
myosin, heavy chain 8, skeletal muscle, perinatal
chr10_-_79397391 1.466 ENST00000286628.8
ENST00000406533.3
ENST00000354353.5
ENST00000404857.1
 KCNMA1



potassium large conductance calcium-activated channel, subfamily M, alpha member 1



chr1_-_57045228 1.408 ENST00000371250.3
 PPAP2B
phosphatidic acid phosphatase type 2B
chr7_-_151433342 1.348 ENST00000433631.2
 PRKAG2
protein kinase, AMP-activated, gamma 2 non-catalytic subunit
chr7_-_30029574 1.339 ENST00000426154.1
ENST00000421434.1
ENST00000434476.2
 SCRN1


secernin 1


chr16_+_56598961 1.329 ENST00000219162.3
 MT4
metallothionein 4
chr10_+_120967072 1.241 ENST00000392870.2
 GRK5
G protein-coupled receptor kinase 5
chr7_-_30029367 1.228 ENST00000242059.5
 SCRN1
secernin 1
chr6_+_116692102 1.226 ENST00000359564.2
 DSE
dermatan sulfate epimerase
chr6_+_89791507 1.206 ENST00000354922.3
 PNRC1
proline-rich nuclear receptor coactivator 1
chr9_+_97488939 1.191 ENST00000277198.2
ENST00000297979.5
 C9orf3

chromosome 9 open reading frame 3

chr12_-_21654479 1.108 ENST00000421138.2
ENST00000444129.2
ENST00000539672.1
ENST00000542432.1
ENST00000536964.1
ENST00000536240.1
ENST00000396093.3
ENST00000314748.6
 RECQL







RecQ protein-like (DNA helicase Q1-like)







chr4_-_22517620 1.046 ENST00000502482.1
ENST00000334304.5
 GPR125

G protein-coupled receptor 125

chr12_+_79258444 0.888 ENST00000261205.4
 SYT1
synaptotagmin I
chr1_+_163039143 0.867 ENST00000531057.1
ENST00000527809.1
ENST00000367908.4
 RGS4


regulator of G-protein signaling 4


chr12_+_21654714 0.865 ENST00000542038.1
ENST00000540141.1
ENST00000229314.5
 GOLT1B


golgi transport 1B


chr1_-_203144941 0.826 ENST00000255416.4
 MYBPH
myosin binding protein H
chr7_-_86849883 0.793 ENST00000433078.1
 TMEM243
transmembrane protein 243, mitochondrial
chr2_+_191745535 0.736 ENST00000320717.3
 GLS
glutaminase
chr3_+_107241783 0.720 ENST00000415149.2
ENST00000402543.1
ENST00000325805.8
ENST00000427402.1
 BBX



bobby sox homolog (Drosophila)



chr15_+_80696666 0.712 ENST00000303329.4
 ARNT2
aryl-hydrocarbon receptor nuclear translocator 2
chr12_+_79258547 0.621 ENST00000457153.2
 SYT1
synaptotagmin I
chr16_-_29517141 0.616 ENST00000550665.1
 RP11-231C14.4
Uncharacterized protein
chr5_-_94620239 0.612 ENST00000515393.1
 MCTP1
multiple C2 domains, transmembrane 1
chr2_+_118846008 0.553 ENST00000245787.4
 INSIG2
insulin induced gene 2
chr12_+_56546363 0.532 ENST00000551834.1
ENST00000552568.1
 MYL6B

myosin, light chain 6B, alkali, smooth muscle and non-muscle

chrX_-_153141302 0.527 ENST00000361699.4
ENST00000543994.1
ENST00000370057.3
ENST00000538883.1
ENST00000361981.3
 L1CAM




L1 cell adhesion molecule




chrX_-_92928557 0.519 ENST00000373079.3
ENST00000475430.2
 NAP1L3

nucleosome assembly protein 1-like 3

chr4_-_10118348 0.472 ENST00000502702.1
 WDR1
WD repeat domain 1
chr16_-_21436459 0.417 ENST00000448012.2
ENST00000504841.2
ENST00000419180.2
 NPIPB3


nuclear pore complex interacting protein family, member B3


chr6_+_7727030 0.385 ENST00000283147.6
 BMP6
bone morphogenetic protein 6
chr10_-_79397479 0.384 ENST00000404771.3
 KCNMA1
potassium large conductance calcium-activated channel, subfamily M, alpha member 1
chrX_-_106959631 0.361 ENST00000486554.1
ENST00000372390.4
 TSC22D3

TSC22 domain family, member 3

chr11_-_66103867 0.359 ENST00000424433.2
 RIN1
Ras and Rab interactor 1
chr14_+_24605389 0.338 ENST00000382708.3
ENST00000561435.1
 PSME1

proteasome (prosome, macropain) activator subunit 1 (PA28 alpha)

chr16_+_22524844 0.302 ENST00000538606.1
ENST00000424340.1
ENST00000517539.1
ENST00000528249.1
 NPIPB5



nuclear pore complex interacting protein family, member B5



chr16_-_21868739 0.297 ENST00000415645.2
 NPIPB4
nuclear pore complex interacting protein family, member B4
chr2_+_191745560 0.291 ENST00000338435.4
 GLS
glutaminase
chr7_-_100860851 0.280 ENST00000223127.3
 PLOD3
procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3
chr11_-_2182388 0.280 ENST00000397270.1
ENST00000421783.1
ENST00000397262.1
ENST00000250971.3
ENST00000381330.4
 INS-IGF2
INS



INS-IGF2 readthrough
insulin



chr10_-_29811456 0.267 ENST00000535393.1
 SVIL
supervillin
chr20_-_23066953 0.262 ENST00000246006.4
 CD93
CD93 molecule
chr9_+_2622085 0.247 ENST00000382099.2
 VLDLR
very low density lipoprotein receptor
chr3_-_48754599 0.234 ENST00000413654.1
ENST00000454335.1
ENST00000440424.1
ENST00000449610.1
ENST00000443964.1
ENST00000417896.1
ENST00000413298.1
ENST00000449563.1
ENST00000443853.1
ENST00000437427.1
ENST00000446860.1
ENST00000412850.1
ENST00000424035.1
ENST00000340879.4
ENST00000431721.2
ENST00000434860.1
ENST00000328631.5
ENST00000432678.2
 IP6K2

















inositol hexakisphosphate kinase 2

















chr16_-_29415350 0.234 ENST00000524087.1
 NPIPB11
nuclear pore complex interacting protein family, member B11
chr22_-_28197486 0.227 ENST00000302326.4
 MN1
meningioma (disrupted in balanced translocation) 1
chr1_+_90286562 0.224 ENST00000525774.1
ENST00000337338.5
 LRRC8D

leucine rich repeat containing 8 family, member D

chr5_-_114505624 0.223 ENST00000513154.1
 TRIM36
tripartite motif containing 36
chr2_+_33172221 0.219 ENST00000354476.3
 LTBP1
latent transforming growth factor beta binding protein 1
chr2_+_102624977 0.187 ENST00000441002.1
 IL1R2
interleukin 1 receptor, type II
chr4_+_2470664 0.180 ENST00000314289.8
ENST00000541204.1
ENST00000502316.1
ENST00000507247.1
ENST00000509258.1
ENST00000511859.1
 RNF4





ring finger protein 4





chrY_-_1461617 0.166 ENSTR0000381401.5
 SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr11_+_33563821 0.161 ENST00000321505.4
ENST00000265654.5
ENST00000389726.3
 KIAA1549L


KIAA1549-like


chr5_-_118324200 0.157 ENST00000515439.3
ENST00000510708.1
 DTWD2

DTW domain containing 2

chr10_-_102289611 0.154 ENST00000535773.1
ENST00000299166.4
ENST00000370320.4
ENST00000531258.1
ENST00000370322.1
 SEC31B
NDUFB8



SEC31 homolog B (S. cerevisiae)
NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 8, 19kDa



chr4_+_74606223 0.153 ENST00000307407.3
ENST00000401931.1
 IL8

interleukin 8

chrX_-_43741594 0.153 ENST00000536181.1
ENST00000378069.4
 MAOB

monoamine oxidase B

chr8_+_85095553 0.146 ENST00000521268.1
 RALYL
RALY RNA binding protein-like
chr5_+_138629389 0.119 ENST00000504045.1
ENST00000504311.1
ENST00000502499.1
 MATR3


matrin 3


chr9_+_2621798 0.110 ENST00000382100.3
 VLDLR
very low density lipoprotein receptor
chr11_+_72929319 0.109 ENST00000393597.2
ENST00000311131.2
 P2RY2

purinergic receptor P2Y, G-protein coupled, 2

chr5_+_138629337 0.107 ENST00000394805.3
ENST00000512876.1
ENST00000513678.1
 MATR3


matrin 3


chr19_+_12949251 0.105 ENST00000251472.4
 MAST1
microtubule associated serine/threonine kinase 1
chr8_+_85095497 0.105 ENST00000522455.1
ENST00000521695.1
 RALYL

RALY RNA binding protein-like

chr7_-_73133959 0.098 ENST00000395155.3
ENST00000395154.3
ENST00000222812.3
ENST00000395156.3
 STX1A



syntaxin 1A (brain)



chr8_+_85095769 0.094 ENST00000518566.1
 RALYL
RALY RNA binding protein-like
chr22_+_23161491 0.093 ENST00000390316.2
 IGLV3-9
immunoglobulin lambda variable 3-9 (gene/pseudogene)
chr17_-_42019836 0.085 ENST00000225992.3
 PPY
pancreatic polypeptide
chr11_-_66103932 0.081 ENST00000311320.4
 RIN1
Ras and Rab interactor 1
chr18_+_77623668 0.081 ENST00000316249.3
 KCNG2
potassium voltage-gated channel, subfamily G, member 2
chrX_-_65859096 0.080 ENST00000456230.2
 EDA2R
ectodysplasin A2 receptor
chr10_-_49701686 0.077 ENST00000417247.2
 ARHGAP22
Rho GTPase activating protein 22
chrX_-_1511617 0.067 ENST00000381401.5
 SLC25A6
solute carrier family 25 (mitochondrial carrier; adenine nucleotide translocator), member 6
chr11_+_72929402 0.067 ENST00000393596.2
 P2RY2
purinergic receptor P2Y, G-protein coupled, 2
chr19_-_43099070 0.056 ENST00000244336.5
 CEACAM8
carcinoembryonic antigen-related cell adhesion molecule 8
chr5_-_179285848 0.056 ENST00000403396.2
ENST00000292586.6
 C5orf45

chromosome 5 open reading frame 45

chr4_+_72052964 0.051 ENST00000264485.5
ENST00000425175.1
 SLC4A4

solute carrier family 4 (sodium bicarbonate cotransporter), member 4

chr19_+_33182823 0.042 ENST00000397061.3
 NUDT19
nudix (nucleoside diphosphate linked moiety X)-type motif 19
chr1_-_216978709 0.042 ENST00000360012.3
 ESRRG
estrogen-related receptor gamma
chr5_-_179285785 0.038 ENST00000520698.1
ENST00000518235.1
ENST00000376931.2
ENST00000518219.1
ENST00000521333.1
ENST00000523084.1
 C5orf45





chromosome 5 open reading frame 45





chr1_+_66458072 0.036 ENST00000423207.2
 PDE4B
phosphodiesterase 4B, cAMP-specific
chrX_-_65858865 0.036 ENST00000374719.3
ENST00000450752.1
ENST00000451436.2
 EDA2R


ectodysplasin A2 receptor


chr3_-_196439065 0.033 ENST00000399942.4
ENST00000409690.3
 CEP19

centrosomal protein 19kDa

chr21_+_19617140 0.027 ENST00000299295.2
ENST00000338326.3
 CHODL

chondrolectin

chr1_+_156124162 0.026 ENST00000368282.1
 SEMA4A
sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4A
chr21_+_41239243 0.019 ENST00000328619.5
 PCP4
Purkinje cell protein 4
chr17_+_25936862 0.014 ENST00000582410.1
 KSR1
kinase suppressor of ras 1
chr20_+_306177 0.010 ENST00000544632.1
 SOX12
SRY (sex determining region Y)-box 12
chr12_-_123215306 0.005 ENST00000356987.2
ENST00000436083.2
 HCAR1

hydroxycarboxylic acid receptor 1

chr11_-_62783276 0.004 ENST00000535878.1
ENST00000545207.1
 SLC22A8

solute carrier family 22 (organic anion transporter), member 8


Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.2 GO:0030205 dermatan sulfate metabolic process(GO:0030205) dermatan sulfate biosynthetic process(GO:0030208)
0.3 1.0 GO:0006543 glutamine catabolic process(GO:0006543)
0.3 1.1 GO:0000733 DNA strand renaturation(GO:0000733)
0.3 1.9 GO:0030007 cellular potassium ion homeostasis(GO:0030007) negative regulation of cell volume(GO:0045794)
0.2 1.4 GO:0008354 germ cell migration(GO:0008354)
0.1 1.3 GO:0010799 regulation of peptidyl-threonine phosphorylation(GO:0010799) positive regulation of peptidyl-threonine phosphorylation(GO:0010800)
0.1 1.2 GO:0007217 tachykinin receptor signaling pathway(GO:0007217)
0.1 0.2 GO:0046732 induction by symbiont of host defense response(GO:0044416) induction of host immune response by virus(GO:0046730) active induction of host immune response by virus(GO:0046732) modulation by virus of host immune response(GO:0075528)
0.1 0.6 GO:0032933 SREBP signaling pathway(GO:0032933) cellular response to sterol depletion(GO:0071501)
0.1 0.4 GO:0010566 regulation of ketone biosynthetic process(GO:0010566) regulation of aldosterone metabolic process(GO:0032344) regulation of aldosterone biosynthetic process(GO:0032347)
0.1 0.3 GO:0060267 respiratory burst involved in defense response(GO:0002679) negative regulation of vasodilation(GO:0045908) positive regulation of respiratory burst(GO:0060267)
0.1 2.5 GO:0030514 negative regulation of BMP signaling pathway(GO:0030514)
0.1 0.2 GO:0036072 intramembranous ossification(GO:0001957) direct ossification(GO:0036072)
0.1 1.5 GO:0005513 detection of calcium ion(GO:0005513)
0.1 0.2 GO:0014063 regulation of serotonin secretion(GO:0014062) negative regulation of serotonin secretion(GO:0014063)
0.0 0.5 GO:0033631 cell-cell adhesion mediated by integrin(GO:0033631)
0.0 0.2 GO:0045091 regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091)
0.0 0.8 GO:0006942 regulation of striated muscle contraction(GO:0006942)
0.0 0.2 GO:0090224 regulation of spindle organization(GO:0090224)
0.0 0.1 GO:0016081 synaptic vesicle docking(GO:0016081)
0.0 0.2 GO:0071692 sequestering of extracellular ligand from receptor(GO:0035581) sequestering of TGFbeta in extracellular matrix(GO:0035583) protein localization to extracellular region(GO:0071692) maintenance of protein location in extracellular region(GO:0071694) extracellular regulation of signal transduction(GO:1900115) extracellular negative regulation of signal transduction(GO:1900116)
0.0 2.0 GO:0001837 epithelial to mesenchymal transition(GO:0001837)
0.0 0.2 GO:0071415 positive regulation of penile erection(GO:0060406) cellular response to purine-containing compound(GO:0071415)
0.0 0.4 GO:0034447 very-low-density lipoprotein particle clearance(GO:0034447)
0.0 2.3 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.0 0.9 GO:0000188 inactivation of MAPK activity(GO:0000188)
0.0 1.2 GO:0007519 skeletal muscle tissue development(GO:0007519)
0.0 0.2 GO:0007340 acrosome reaction(GO:0007340)
0.0 1.0 GO:0007218 neuropeptide signaling pathway(GO:0007218)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.5 GO:0060201 clathrin-sculpted acetylcholine transport vesicle(GO:0060200) clathrin-sculpted acetylcholine transport vesicle membrane(GO:0060201)
0.1 2.6 GO:0032982 myosin filament(GO:0032982)
0.1 1.3 GO:0031588 nucleotide-activated protein kinase complex(GO:0031588)
0.1 0.3 GO:0031904 endosome lumen(GO:0031904)
0.1 0.3 GO:0008537 proteasome activator complex(GO:0008537)
0.0 0.5 GO:0005678 obsolete chromatin assembly complex(GO:0005678)
0.0 0.5 GO:0016461 unconventional myosin complex(GO:0016461)
0.0 0.1 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044)
0.0 0.3 GO:0071437 podosome(GO:0002102) invadopodium(GO:0071437)
0.0 2.1 GO:0005802 trans-Golgi network(GO:0005802)
0.0 1.9 GO:0044853 caveola(GO:0005901) plasma membrane raft(GO:0044853)
0.0 0.2 GO:0005744 mitochondrial inner membrane presequence translocase complex(GO:0005744)
0.0 0.3 GO:0030867 rough endoplasmic reticulum membrane(GO:0030867)
0.0 0.5 GO:0043195 terminal bouton(GO:0043195)
0.0 0.4 GO:0034361 very-low-density lipoprotein particle(GO:0034361) triglyceride-rich lipoprotein particle(GO:0034385)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.3 1.1 GO:0043140 obsolete DNA strand annealing activity(GO:0000739) ATP-dependent 3'-5' DNA helicase activity(GO:0043140)
0.3 1.9 GO:0060072 large conductance calcium-activated potassium channel activity(GO:0060072)
0.3 1.0 GO:0004359 glutaminase activity(GO:0004359)
0.2 1.4 GO:0042577 lipid phosphatase activity(GO:0042577)
0.1 1.3 GO:0008607 phosphorylase kinase regulator activity(GO:0008607)
0.1 2.0 GO:0050786 RAGE receptor binding(GO:0050786)
0.1 2.6 GO:0016805 dipeptidase activity(GO:0016805)
0.1 0.7 GO:0017162 aryl hydrocarbon receptor binding(GO:0017162)
0.1 1.5 GO:0050750 low-density lipoprotein particle receptor binding(GO:0050750)
0.1 0.8 GO:0004703 G-protein coupled receptor kinase activity(GO:0004703)
0.1 1.2 GO:0016857 racemase and epimerase activity, acting on carbohydrates and derivatives(GO:0016857)
0.1 0.5 GO:0033691 sialic acid binding(GO:0033691)
0.1 0.1 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 0.3 GO:0008475 procollagen-lysine 5-dioxygenase activity(GO:0008475)
0.1 2.5 GO:0005520 insulin-like growth factor binding(GO:0005520)
0.1 0.2 GO:0015217 purine ribonucleotide transmembrane transporter activity(GO:0005346) ATP transmembrane transporter activity(GO:0005347) ATP:ADP antiporter activity(GO:0005471) ADP transmembrane transporter activity(GO:0015217)
0.1 0.3 GO:0001849 complement component C1q binding(GO:0001849)
0.1 0.2 GO:0045030 A1 adenosine receptor binding(GO:0031686) UTP-activated nucleotide receptor activity(GO:0045030)
0.1 0.4 GO:0030229 very-low-density lipoprotein particle receptor activity(GO:0030229)
0.0 0.4 GO:0070700 BMP receptor binding(GO:0070700)
0.0 0.2 GO:0032183 SUMO binding(GO:0032183)
0.0 0.2 GO:0045236 CXCR chemokine receptor binding(GO:0045236)
0.0 0.2 GO:0004910 interleukin-1, Type II, blocking receptor activity(GO:0004910)
0.0 3.1 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 0.2 GO:0051766 inositol-1,4,5-trisphosphate 3-kinase activity(GO:0008440) inositol trisphosphate kinase activity(GO:0051766)
0.0 0.2 GO:0008131 primary amine oxidase activity(GO:0008131)
0.0 2.2 GO:0004197 cysteine-type endopeptidase activity(GO:0004197)
0.0 1.3 GO:0005507 copper ion binding(GO:0005507)
0.0 0.6 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.5 SIG_CD40PATHWAYMAP Genes related to CD40 signaling