Motif ID: MECOM
Z-value: 0.996
Transcription factors associated with MECOM:
Gene Symbol | Entrez ID | Gene Name |
---|---|---|
MECOM | ENSG00000085276.13 | MECOM |
Top targets:
Gene overrepresentation in biological_process category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
1.2 | 4.9 | GO:0050928 | negative regulation of positive chemotaxis(GO:0050928) |
0.7 | 2.1 | GO:0001907 | cytolysis by symbiont of host cells(GO:0001897) killing by symbiont of host cells(GO:0001907) hemolysis by symbiont of host erythrocytes(GO:0019836) disruption by symbiont of host cell(GO:0044004) hemolysis in other organism(GO:0044179) positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010) cytolysis in other organism(GO:0051715) cytolysis in other organism involved in symbiotic interaction(GO:0051801) hemolysis in other organism involved in symbiotic interaction(GO:0052331) |
0.5 | 1.6 | GO:2000910 | regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910) |
0.4 | 3.6 | GO:0017121 | phospholipid scrambling(GO:0017121) |
0.2 | 0.5 | GO:0032488 | Cdc42 protein signal transduction(GO:0032488) |
0.2 | 0.5 | GO:0014063 | regulation of serotonin secretion(GO:0014062) negative regulation of serotonin secretion(GO:0014063) |
0.1 | 1.2 | GO:0060261 | positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144) |
0.1 | 1.1 | GO:0042448 | progesterone metabolic process(GO:0042448) |
0.1 | 0.4 | GO:0009174 | UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049) |
0.1 | 0.6 | GO:0002036 | regulation of L-glutamate transport(GO:0002036) |
0.1 | 0.3 | GO:0090598 | male genitalia morphogenesis(GO:0048808) lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) male anatomical structure morphogenesis(GO:0090598) |
0.1 | 0.4 | GO:0033622 | integrin activation(GO:0033622) regulation of integrin activation(GO:0033623) positive regulation of integrin activation(GO:0033625) |
0.1 | 0.4 | GO:0045662 | negative regulation of myoblast differentiation(GO:0045662) |
0.1 | 0.4 | GO:0070245 | positive regulation of thymocyte apoptotic process(GO:0070245) |
0.1 | 1.0 | GO:0032331 | negative regulation of chondrocyte differentiation(GO:0032331) |
0.1 | 0.2 | GO:0045872 | positive regulation of rhodopsin gene expression(GO:0045872) |
0.1 | 0.4 | GO:0099515 | nuclear migration along microfilament(GO:0031022) actin filament-based transport(GO:0099515) |
0.1 | 1.0 | GO:0001502 | cartilage condensation(GO:0001502) cell aggregation(GO:0098743) |
0.0 | 0.1 | GO:0018076 | N-terminal peptidyl-lysine acetylation(GO:0018076) |
0.0 | 0.1 | GO:0014831 | intestine smooth muscle contraction(GO:0014827) gastro-intestinal system smooth muscle contraction(GO:0014831) |
0.0 | 0.1 | GO:0034126 | regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) positive regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034126) |
0.0 | 0.1 | GO:0043628 | ncRNA 3'-end processing(GO:0043628) |
0.0 | 0.4 | GO:0019228 | neuronal action potential(GO:0019228) |
0.0 | 1.7 | GO:0006749 | glutathione metabolic process(GO:0006749) |
0.0 | 0.2 | GO:1901985 | positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758) |
0.0 | 0.3 | GO:0097435 | extracellular fibril organization(GO:0043206) fibril organization(GO:0097435) |
0.0 | 0.3 | GO:0010875 | positive regulation of cholesterol efflux(GO:0010875) |
0.0 | 0.4 | GO:0006071 | glycerol metabolic process(GO:0006071) |
0.0 | 0.3 | GO:0006621 | protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437) |
0.0 | 0.8 | GO:0007026 | negative regulation of microtubule depolymerization(GO:0007026) |
0.0 | 0.3 | GO:0045749 | obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749) |
0.0 | 0.1 | GO:0018344 | protein geranylgeranylation(GO:0018344) |
0.0 | 1.1 | GO:0001764 | neuron migration(GO:0001764) |
0.0 | 0.4 | GO:0017144 | drug metabolic process(GO:0017144) |
0.0 | 0.0 | GO:0042268 | regulation of cytolysis(GO:0042268) |
0.0 | 1.1 | GO:0051592 | response to calcium ion(GO:0051592) |
0.0 | 0.1 | GO:0030643 | cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502) |
0.0 | 0.3 | GO:0006493 | protein O-linked glycosylation(GO:0006493) |
Gene overrepresentation in cellular_component category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.1 | 1.5 | GO:0005577 | fibrinogen complex(GO:0005577) |
0.1 | 1.6 | GO:0034366 | spherical high-density lipoprotein particle(GO:0034366) |
0.1 | 0.6 | GO:0000145 | exocyst(GO:0000145) |
0.1 | 0.5 | GO:0005797 | Golgi medial cisterna(GO:0005797) |
0.0 | 0.3 | GO:0098645 | network-forming collagen trimer(GO:0098642) collagen network(GO:0098645) |
0.0 | 0.4 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
0.0 | 1.2 | GO:0030286 | dynein complex(GO:0030286) |
0.0 | 0.3 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
0.0 | 2.1 | GO:0005604 | basement membrane(GO:0005604) |
0.0 | 0.5 | GO:0045335 | phagocytic vesicle(GO:0045335) |
0.0 | 0.8 | GO:0005881 | cytoplasmic microtubule(GO:0005881) |
0.0 | 0.1 | GO:0002102 | podosome(GO:0002102) |
0.0 | 0.1 | GO:0033018 | sarcoplasmic reticulum lumen(GO:0033018) |
0.0 | 1.3 | GO:0031227 | intrinsic component of endoplasmic reticulum membrane(GO:0031227) |
Gene overrepresentation in molecular_function category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.8 | 3.3 | GO:0004504 | peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598) |
0.4 | 1.6 | GO:0034190 | apolipoprotein receptor binding(GO:0034190) high-density lipoprotein particle receptor binding(GO:0070653) |
0.4 | 3.6 | GO:0017128 | phospholipid scramblase activity(GO:0017128) |
0.3 | 0.7 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
0.2 | 1.8 | GO:0015643 | toxic substance binding(GO:0015643) |
0.1 | 1.3 | GO:0004499 | N,N-dimethylaniline monooxygenase activity(GO:0004499) |
0.1 | 0.4 | GO:0003846 | 2-acylglycerol O-acyltransferase activity(GO:0003846) |
0.1 | 1.9 | GO:0003706 | obsolete ligand-regulated transcription factor activity(GO:0003706) |
0.1 | 0.5 | GO:0034186 | apolipoprotein A-I binding(GO:0034186) |
0.1 | 1.0 | GO:0005006 | epidermal growth factor-activated receptor activity(GO:0005006) |
0.1 | 0.5 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
0.1 | 4.5 | GO:1990782 | receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782) |
0.1 | 0.4 | GO:0016635 | oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635) |
0.1 | 0.2 | GO:0043199 | sulfate binding(GO:0043199) |
0.1 | 1.2 | GO:0051879 | Hsp90 protein binding(GO:0051879) |
0.1 | 0.3 | GO:0005046 | KDEL sequence binding(GO:0005046) |
0.1 | 1.5 | GO:0043499 | obsolete eukaryotic cell surface binding(GO:0043499) |
0.1 | 0.3 | GO:0004169 | dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169) |
0.0 | 0.1 | GO:0043426 | MRF binding(GO:0043426) |
0.0 | 1.6 | GO:0004364 | glutathione transferase activity(GO:0004364) |
0.0 | 0.3 | GO:0034187 | obsolete apolipoprotein E binding(GO:0034187) |
0.0 | 1.0 | GO:0004181 | metallocarboxypeptidase activity(GO:0004181) |
0.0 | 0.3 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
0.0 | 0.1 | GO:0032422 | purine-rich negative regulatory element binding(GO:0032422) |
0.0 | 0.1 | GO:0001965 | G-protein alpha-subunit binding(GO:0001965) |
0.0 | 0.1 | GO:0004663 | Rab geranylgeranyltransferase activity(GO:0004663) |
0.0 | 0.4 | GO:0015269 | calcium-activated potassium channel activity(GO:0015269) |
0.0 | 0.9 | GO:0048306 | calcium-dependent protein binding(GO:0048306) |
0.0 | 0.2 | GO:0008510 | sodium:bicarbonate symporter activity(GO:0008510) bicarbonate transmembrane transporter activity(GO:0015106) |
0.0 | 0.2 | GO:0004065 | arylsulfatase activity(GO:0004065) |
0.0 | 0.4 | GO:0016755 | transferase activity, transferring amino-acyl groups(GO:0016755) |
0.0 | 1.2 | GO:0003777 | microtubule motor activity(GO:0003777) |
0.0 | 0.3 | GO:0001540 | beta-amyloid binding(GO:0001540) |
0.0 | 0.2 | GO:0070577 | lysine-acetylated histone binding(GO:0070577) |
Gene overrepresentation in C2:CP category:
Log-likelihood per target | Total log-likelihood | Term | Description |
---|---|---|---|
0.0 | 0.4 | ST_STAT3_PATHWAY | STAT3 Pathway |