Motif ID: MECOM

Z-value: 0.996


Transcription factors associated with MECOM:

Gene SymbolEntrez IDGene Name
MECOM ENSG00000085276.13 MECOM



Activity profile for motif MECOM.

activity profile for motif MECOM


Sorted Z-values histogram for motif MECOM

Sorted Z-values for motif MECOM



Network of associatons between targets according to the STRING database.



First level regulatory network of MECOM

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr4_+_74275057 2.080 ENST00000511370.1
ALB
albumin
chr3_-_145968923 1.912 ENST00000493382.1
ENST00000354952.2
ENST00000383083.2
PLSCR4


phospholipid scramblase 4


chr8_-_6420777 1.739 ENST00000415216.1
ANGPT2
angiopoietin 2
chr3_-_145968857 1.726 ENST00000433593.2
ENST00000476202.1
ENST00000460885.1
PLSCR4


phospholipid scramblase 4


chr17_+_53344945 1.696 ENST00000575345.1
HLF
hepatic leukemia factor
chr1_-_161193349 1.647 ENST00000469730.2
ENST00000463273.1
ENST00000464492.1
ENST00000367990.3
ENST00000470459.2
ENST00000468465.1
ENST00000463812.1
APOA2






apolipoprotein A-II






chr5_+_92919043 1.602 ENST00000327111.3
NR2F1
nuclear receptor subfamily 2, group F, member 1
chr5_+_102201722 1.292 ENST00000274392.9
ENST00000455264.2
PAM

peptidylglycine alpha-amidating monooxygenase

chr5_+_102201509 1.196 ENST00000348126.2
ENST00000379787.4
PAM

peptidylglycine alpha-amidating monooxygenase

chr12_-_15038779 1.176 ENST00000228938.5
ENST00000539261.1
MGP

matrix Gla protein

chr7_+_17338239 1.176 ENST00000242057.4
AHR
aryl hydrocarbon receptor
chr8_-_6420930 1.146 ENST00000325203.5
ANGPT2
angiopoietin 2
chr4_+_74301880 1.135 ENST00000395792.2
ENST00000226359.2
AFP

alpha-fetoprotein

chr6_-_52860171 1.105 ENST00000370963.4
GSTA4
glutathione S-transferase alpha 4
chr3_-_149093499 1.078 ENST00000472441.1
TM4SF1
transmembrane 4 L six family member 1
chr8_-_6420565 1.065 ENST00000338312.6
ANGPT2
angiopoietin 2
chr2_-_56150910 1.001 ENST00000424836.2
ENST00000438672.1
ENST00000440439.1
ENST00000429909.1
ENST00000424207.1
ENST00000452337.1
ENST00000355426.3
ENST00000439193.1
ENST00000421664.1
EFEMP1








EGF containing fibulin-like extracellular matrix protein 1








chr3_+_148583043 0.990 ENST00000296046.3
CPA3
carboxypeptidase A3 (mast cell)
chr8_-_6420759 0.911 ENST00000523120.1
ANGPT2
angiopoietin 2
chr4_+_155484155 0.847 ENST00000509493.1
FGB
fibrinogen beta chain
chr1_-_146696901 0.821 ENST00000369272.3
ENST00000441068.2
FMO5

flavin containing monooxygenase 5

chr5_+_102201430 0.815 ENST00000438793.3
ENST00000346918.2
PAM

peptidylglycine alpha-amidating monooxygenase

chrX_+_15525426 0.690 ENST00000342014.6
BMX
BMX non-receptor tyrosine kinase
chr1_+_82266053 0.680 ENST00000370715.1
ENST00000370713.1
ENST00000319517.6
ENST00000370717.2
ENST00000394879.1
ENST00000271029.4
ENST00000335786.5
LPHN2






latrophilin 2






chr9_-_13175823 0.675 ENST00000545857.1
MPDZ
multiple PDZ domain protein
chrX_-_106243451 0.637 ENST00000355610.4
ENST00000535534.1
MORC4

MORC family CW-type zinc finger 4

chr2_+_242289502 0.622 ENST00000451310.1
SEPT2
septin 2
chr4_+_155484103 0.606 ENST00000302068.4
FGB
fibrinogen beta chain
chr6_-_52859968 0.560 ENST00000370959.1
GSTA4
glutathione S-transferase alpha 4
chr13_+_76334567 0.542 ENST00000321797.8
LMO7
LIM domain 7
chr8_-_93029865 0.525 ENST00000422361.2
RUNX1T1
runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
chr9_-_107690420 0.517 ENST00000423487.2
ENST00000374733.1
ENST00000374736.3
ABCA1


ATP-binding cassette, sub-family A (ABC1), member 1


chrX_-_43741594 0.510 ENST00000536181.1
ENST00000378069.4
MAOB

monoamine oxidase B

chr11_+_17316870 0.455 ENST00000458064.2
NUCB2
nucleobindin 2
chr2_+_37571717 0.453 ENST00000338415.3
ENST00000404976.1
QPCT

glutaminyl-peptide cyclotransferase

chrX_-_10588459 0.448 ENST00000380782.2
MID1
midline 1 (Opitz/BBB syndrome)
chr1_+_171060018 0.443 ENST00000367755.4
ENST00000392085.2
ENST00000542847.1
ENST00000538429.1
ENST00000479749.1
FMO3




flavin containing monooxygenase 3




chr13_+_102142296 0.420 ENST00000376162.3
ITGBL1
integrin, beta-like 1 (with EGF-like repeat domains)
chr6_+_153019069 0.419 ENST00000532295.1
MYCT1
myc target 1
chr14_+_22458631 0.419 ENST00000390444.1
TRAV16
T cell receptor alpha variable 16
chr3_-_178984759 0.415 ENST00000349697.2
ENST00000497599.1
KCNMB3

potassium large conductance calcium-activated channel, subfamily M beta member 3

chr6_+_153019023 0.412 ENST00000367245.5
ENST00000529453.1
MYCT1

myc target 1

chr7_-_100844193 0.410 ENST00000440203.2
ENST00000379423.3
ENST00000223114.4
MOGAT3


monoacylglycerol O-acyltransferase 3


chr19_-_47735918 0.402 ENST00000449228.1
ENST00000300880.7
ENST00000341983.4
BBC3


BCL2 binding component 3


chrX_+_67718863 0.390 ENST00000374622.2
YIPF6
Yip1 domain family, member 6
chrX_-_10588595 0.386 ENST00000423614.1
ENST00000317552.4
MID1

midline 1 (Opitz/BBB syndrome)

chr20_+_36012051 0.383 ENST00000373567.2
SRC
v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
chr14_-_25479811 0.366 ENST00000550887.1
STXBP6
syntaxin binding protein 6 (amisyn)
chr11_+_22696314 0.365 ENST00000532398.1
ENST00000433790.1
GAS2

growth arrest-specific 2

chr16_-_73093597 0.358 ENST00000397992.5
ZFHX3
zinc finger homeobox 3
chr1_-_98386543 0.355 ENST00000423006.2
ENST00000370192.3
ENST00000306031.5
DPYD


dihydropyrimidine dehydrogenase


chr14_+_64680854 0.355 ENST00000458046.2
SYNE2
spectrin repeat containing, nuclear envelope 2
chr4_-_40859132 0.337 ENST00000543538.1
ENST00000502841.1
ENST00000504305.1
ENST00000513516.1
ENST00000510670.1
APBB2




amyloid beta (A4) precursor protein-binding, family B, member 2




chr3_+_99357319 0.328 ENST00000452013.1
ENST00000261037.3
ENST00000273342.4
COL8A1


collagen, type VIII, alpha 1


chr17_-_56494882 0.318 ENST00000584437.1
RNF43
ring finger protein 43
chrX_+_66764375 0.297 ENST00000374690.3
AR
androgen receptor
chr17_-_56494908 0.296 ENST00000577716.1
RNF43
ring finger protein 43
chr9_+_134378289 0.294 ENST00000423007.1
ENST00000404875.2
ENST00000441334.1
ENST00000341012.7
ENST00000372228.3
ENST00000402686.3
ENST00000419118.2
ENST00000541219.1
ENST00000354713.4
ENST00000418774.1
ENST00000415075.1
ENST00000448212.1
ENST00000430619.1
POMT1












protein-O-mannosyltransferase 1












chr17_-_56494713 0.284 ENST00000407977.2
RNF43
ring finger protein 43
chrX_+_102883620 0.283 ENST00000372626.3
TCEAL1
transcription elongation factor A (SII)-like 1
chr12_+_57522258 0.280 ENST00000553277.1
ENST00000243077.3
LRP1

low density lipoprotein receptor-related protein 1

chr2_+_172544294 0.270 ENST00000358002.6
ENST00000435234.1
ENST00000443458.1
ENST00000412370.1
DYNC1I2



dynein, cytoplasmic 1, intermediate chain 2



chr2_+_172543967 0.270 ENST00000534253.2
ENST00000263811.4
ENST00000397119.3
ENST00000410079.3
ENST00000438879.1
DYNC1I2




dynein, cytoplasmic 1, intermediate chain 2




chr2_+_172544011 0.267 ENST00000508530.1
DYNC1I2
dynein, cytoplasmic 1, intermediate chain 2
chr2_-_1629176 0.261 ENST00000366424.2
AC144450.2
AC144450.2
chr2_+_189839046 0.257 ENST00000304636.3
ENST00000317840.5
COL3A1

collagen, type III, alpha 1

chr2_+_172544182 0.254 ENST00000409197.1
ENST00000456808.1
ENST00000409317.1
ENST00000409773.1
ENST00000411953.1
ENST00000409453.1
DYNC1I2





dynein, cytoplasmic 1, intermediate chain 2





chr19_-_48894762 0.253 ENST00000600980.1
ENST00000330720.2
KDELR1

KDEL (Lys-Asp-Glu-Leu) endoplasmic reticulum protein retention receptor 1

chr14_+_24584508 0.245 ENST00000559354.1
ENST00000560459.1
ENST00000559593.1
ENST00000396941.4
ENST00000396936.1
DCAF11




DDB1 and CUL4 associated factor 11




chrX_+_2959512 0.245 ENST00000381127.1
ARSF
arylsulfatase F
chr14_-_24584138 0.245 ENST00000558280.1
ENST00000561028.1
NRL

neural retina leucine zipper

chr5_+_140739537 0.244 ENST00000522605.1
PCDHGB2
protocadherin gamma subfamily B, 2
chr11_-_18656028 0.242 ENST00000336349.5
SPTY2D1
SPT2, Suppressor of Ty, domain containing 1 (S. cerevisiae)
chr1_-_208084729 0.239 ENST00000310833.7
ENST00000356522.4
CD34

CD34 molecule

chr22_+_29138013 0.232 ENST00000216027.3
ENST00000398941.2
HSCB

HscB mitochondrial iron-sulfur cluster co-chaperone

chrX_+_86772787 0.215 ENST00000373114.4
KLHL4
kelch-like family member 4
chr20_-_45985464 0.199 ENST00000458360.2
ENST00000262975.4
ZMYND8

zinc finger, MYND-type containing 8

chr2_+_55746746 0.197 ENST00000406691.3
ENST00000349456.4
ENST00000407816.3
ENST00000403007.3
CCDC104



coiled-coil domain containing 104



chr20_-_45984401 0.196 ENST00000311275.7
ZMYND8
zinc finger, MYND-type containing 8
chr2_+_172543919 0.176 ENST00000452242.1
ENST00000340296.4
DYNC1I2

dynein, cytoplasmic 1, intermediate chain 2

chr16_-_71758602 0.175 ENST00000568954.1
PHLPP2
PH domain and leucine rich repeat protein phosphatase 2
chr3_-_45883558 0.172 ENST00000445698.1
ENST00000296135.6
LZTFL1

leucine zipper transcription factor-like 1

chr7_-_115670804 0.168 ENST00000320239.7
TFEC
transcription factor EC
chr12_+_72080253 0.157 ENST00000549735.1
TMEM19
transmembrane protein 19
chr6_+_31515337 0.154 ENST00000376148.4
ENST00000376145.4
NFKBIL1

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1

chr3_-_27498235 0.151 ENST00000295736.5
ENST00000428386.1
ENST00000428179.1
SLC4A7


solute carrier family 4, sodium bicarbonate cotransporter, member 7


chr20_-_45985414 0.149 ENST00000461685.1
ENST00000372023.3
ENST00000540497.1
ENST00000435836.1
ENST00000471951.2
ENST00000352431.2
ENST00000396281.4
ENST00000355972.4
ENST00000360911.3
ZMYND8








zinc finger, MYND-type containing 8








chr9_+_82186682 0.147 ENST00000376552.2
TLE4
transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)
chr20_-_45985172 0.145 ENST00000536340.1
ZMYND8
zinc finger, MYND-type containing 8
chr16_-_3930724 0.142 ENST00000262367.5
CREBBP
CREB binding protein
chr2_-_231989808 0.139 ENST00000258400.3
HTR2B
5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled
chr19_-_46366392 0.138 ENST00000598059.1
ENST00000594293.1
ENST00000245934.7
SYMPK


symplekin


chr5_-_115910091 0.134 ENST00000257414.8
SEMA6A
sema domain, transmembrane domain (TM), and cytoplasmic domain, (semaphorin) 6A
chr16_-_50402836 0.133 ENST00000394688.3
BRD7
bromodomain containing 7
chr13_-_46626847 0.116 ENST00000242848.4
ENST00000282007.3
ZC3H13

zinc finger CCCH-type containing 13

chr10_-_29923893 0.112 ENST00000355867.4
SVIL
supervillin
chr10_+_57358750 0.111 ENST00000512524.2
MTRNR2L5
MT-RNR2-like 5
chr12_-_81763127 0.111 ENST00000541017.1
PPFIA2
protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2
chr8_-_133637624 0.110 ENST00000522789.1
LRRC6
leucine rich repeat containing 6
chr2_+_97779233 0.106 ENST00000461153.2
ENST00000420699.2
ANKRD36

ankyrin repeat domain 36

chr5_+_74807886 0.095 ENST00000514296.1
POLK
polymerase (DNA directed) kappa
chr6_+_29624898 0.095 ENST00000396704.3
ENST00000483013.1
ENST00000490427.1
ENST00000416766.2
ENST00000376891.4
ENST00000376898.3
ENST00000396701.2
ENST00000494692.1
ENST00000431798.2
MOG








myelin oligodendrocyte glycoprotein








chr2_+_108145913 0.092 ENST00000443205.1
AC096669.3
AC096669.3
chr3_+_39448180 0.091 ENST00000301821.6
ENST00000458478.1
ENST00000443003.1
RPSA


ribosomal protein SA


chr7_+_97361388 0.089 ENST00000350485.4
ENST00000346867.4
TAC1

tachykinin, precursor 1

chr11_+_61008514 0.088 ENST00000312403.5
PGA5
pepsinogen 5, group I (pepsinogen A)
chr19_+_36630454 0.087 ENST00000246533.3
CAPNS1
calpain, small subunit 1
chr15_-_48470558 0.085 ENST00000324324.7
MYEF2
myelin expression factor 2
chrX_-_85302531 0.084 ENST00000537751.1
ENST00000358786.4
ENST00000357749.2
CHM


choroideremia (Rab escort protein 1)


chr16_-_50402690 0.084 ENST00000394689.2
BRD7
bromodomain containing 7
chr5_+_54320078 0.083 ENST00000231009.2
GZMK
granzyme K (granzyme 3; tryptase II)
chr12_+_15699286 0.082 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
PTPRO



protein tyrosine phosphatase, receptor type, O



chr17_-_37308824 0.080 ENST00000415163.1
ENST00000441877.1
ENST00000444911.2
PLXDC1


plexin domain containing 1


chr8_-_39695719 0.079 ENST00000347580.4
ENST00000379853.2
ENST00000521880.1
ADAM2


ADAM metallopeptidase domain 2


chr9_+_82186872 0.078 ENST00000376544.3
ENST00000376520.4
TLE4

transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila)

chr14_-_102701740 0.078 ENST00000561150.1
ENST00000522867.1
MOK

MOK protein kinase

chr11_+_60989688 0.078 ENST00000378149.3
ENST00000422676.2
PGA4

pepsinogen 4, group I (pepsinogen A)

chr12_+_72079842 0.077 ENST00000266673.5
ENST00000550524.1
TMEM19

transmembrane protein 19

chr3_-_38992052 0.077 ENST00000302328.3
ENST00000450244.1
ENST00000444237.2
SCN11A


sodium channel, voltage-gated, type XI, alpha subunit


chr16_+_10837643 0.077 ENST00000574334.1
ENST00000283027.5
ENST00000433392.2
NUBP1


nucleotide binding protein 1


chr8_-_39695764 0.073 ENST00000265708.4
ADAM2
ADAM metallopeptidase domain 2
chr12_+_96588279 0.073 ENST00000552142.1
ELK3
ELK3, ETS-domain protein (SRF accessory protein 2)
chr15_+_71185148 0.072 ENST00000443425.2
ENST00000560755.1
LRRC49

leucine rich repeat containing 49

chr1_+_15802594 0.068 ENST00000375910.3
CELA2B
chymotrypsin-like elastase family, member 2B
chr12_+_21207503 0.068 ENST00000545916.1
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr12_-_81763184 0.063 ENST00000548670.1
ENST00000541570.2
ENST00000553058.1
PPFIA2


protein tyrosine phosphatase, receptor type, f polypeptide (PTPRF), interacting protein (liprin), alpha 2


chr1_+_160160283 0.058 ENST00000368079.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr1_+_172422026 0.056 ENST00000367725.4
C1orf105
chromosome 1 open reading frame 105
chr1_+_160160346 0.055 ENST00000368078.3
CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chrX_+_155227246 0.055 ENST00000244174.5
ENST00000424344.3
IL9R

interleukin 9 receptor

chr16_-_90096309 0.052 ENST00000408886.2
C16orf3
chromosome 16 open reading frame 3
chr6_-_10882174 0.050 ENST00000379491.4
GCM2
glial cells missing homolog 2 (Drosophila)
chr20_+_36932521 0.045 ENST00000262865.4
BPI
bactericidal/permeability-increasing protein
chr2_+_27435734 0.043 ENST00000419744.1
ATRAID
all-trans retinoic acid-induced differentiation factor
chr6_-_154831779 0.042 ENST00000607772.1
CNKSR3
CNKSR family member 3
chr16_+_9449445 0.041 ENST00000564305.1
RP11-243A14.1
RP11-243A14.1
chr9_+_33240157 0.040 ENST00000379721.3
SPINK4
serine peptidase inhibitor, Kazal type 4
chr4_-_74847800 0.040 ENST00000296029.3
PF4
platelet factor 4
chr6_-_31514516 0.039 ENST00000303892.5
ENST00000483251.1
ATP6V1G2

ATPase, H+ transporting, lysosomal 13kDa, V1 subunit G2

chr13_-_113242439 0.037 ENST00000375669.3
ENST00000261965.3
TUBGCP3

tubulin, gamma complex associated protein 3

chr3_+_147127142 0.037 ENST00000282928.4
ZIC1
Zic family member 1
chr12_+_21168630 0.035 ENST00000421593.2
SLCO1B7
solute carrier organic anion transporter family, member 1B7 (non-functional)
chr3_-_184971853 0.033 ENST00000231887.3
EHHADH
enoyl-CoA, hydratase/3-hydroxyacyl CoA dehydrogenase
chr7_-_15601595 0.031 ENST00000342526.3
AGMO
alkylglycerol monooxygenase
chr22_+_36113919 0.031 ENST00000249044.2
APOL5
apolipoprotein L, 5
chr13_+_49280951 0.031 ENST00000282018.3
CYSLTR2
cysteinyl leukotriene receptor 2
chr22_-_31688431 0.026 ENST00000402249.3
ENST00000443175.1
ENST00000215912.5
ENST00000441972.1
PIK3IP1



phosphoinositide-3-kinase interacting protein 1



chr14_-_24551195 0.025 ENST00000560550.1
NRL
neural retina leucine zipper
chr19_+_48497962 0.022 ENST00000596043.1
ENST00000597519.1
ELSPBP1

epididymal sperm binding protein 1

chr4_-_77997126 0.021 ENST00000537948.1
ENST00000507788.1
ENST00000237654.4
CCNI


cyclin I


chr4_-_88450244 0.020 ENST00000503414.1
SPARCL1
SPARC-like 1 (hevin)
chr8_+_134203303 0.019 ENST00000519433.1
ENST00000517423.1
ENST00000377863.2
ENST00000220856.6
WISP1



WNT1 inducible signaling pathway protein 1



chr19_-_10614386 0.019 ENST00000171111.5
KEAP1
kelch-like ECH-associated protein 1
chr17_-_43138357 0.018 ENST00000342350.5
DCAKD
dephospho-CoA kinase domain containing
chr19_-_9785743 0.014 ENST00000537617.1
ENST00000589542.1
ENST00000590155.1
ENST00000541032.1
ENST00000588653.1
ENST00000448622.1
ENST00000453792.2
ZNF562






zinc finger protein 562






chr1_-_92949505 0.014 ENST00000370332.1
GFI1
growth factor independent 1 transcription repressor
chr17_-_10276319 0.014 ENST00000252172.4
ENST00000418404.3
MYH13

myosin, heavy chain 13, skeletal muscle

chr14_-_75179774 0.014 ENST00000555249.1
ENST00000556202.1
ENST00000356357.4
ENST00000338772.5
AREL1


AC007956.1
apoptosis resistant E3 ubiquitin protein ligase 1


Full-length cDNA 5-PRIME end of clone CS0CAP004YO05 of Thymus of Homo sapiens (human); Uncharacterized protein
chr1_+_25664408 0.013 ENST00000374358.4
TMEM50A
transmembrane protein 50A
chr5_-_147162078 0.006 ENST00000507386.1
JAKMIP2
janus kinase and microtubule interacting protein 2
chr6_+_31514622 0.006 ENST00000376146.4
NFKBIL1
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1
chr19_+_47538560 0.003 ENST00000439365.2
ENST00000594670.1
NPAS1

neuronal PAS domain protein 1

chr8_+_134203273 0.003 ENST00000250160.6
WISP1
WNT1 inducible signaling pathway protein 1
chr5_+_140165876 0.001 ENST00000504120.2
ENST00000394633.3
ENST00000378133.3
PCDHA1


protocadherin alpha 1


chr3_+_121311966 0.001 ENST00000338040.4
FBXO40
F-box protein 40

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.2 4.9 GO:0050928 negative regulation of positive chemotaxis(GO:0050928)
0.7 2.1 GO:0001907 cytolysis by symbiont of host cells(GO:0001897) killing by symbiont of host cells(GO:0001907) hemolysis by symbiont of host erythrocytes(GO:0019836) disruption by symbiont of host cell(GO:0044004) hemolysis in other organism(GO:0044179) positive regulation of circadian sleep/wake cycle, non-REM sleep(GO:0046010) cytolysis in other organism(GO:0051715) cytolysis in other organism involved in symbiotic interaction(GO:0051801) hemolysis in other organism involved in symbiotic interaction(GO:0052331)
0.5 1.6 GO:2000910 regulation of cholesterol import(GO:0060620) negative regulation of cholesterol import(GO:0060621) regulation of sterol import(GO:2000909) negative regulation of sterol import(GO:2000910)
0.4 3.6 GO:0017121 phospholipid scrambling(GO:0017121)
0.2 0.5 GO:0032488 Cdc42 protein signal transduction(GO:0032488)
0.2 0.5 GO:0014063 regulation of serotonin secretion(GO:0014062) negative regulation of serotonin secretion(GO:0014063)
0.1 1.2 GO:0060261 positive regulation of transcription initiation from RNA polymerase II promoter(GO:0060261) positive regulation of DNA-templated transcription, initiation(GO:2000144)
0.1 1.1 GO:0042448 progesterone metabolic process(GO:0042448)
0.1 0.4 GO:0009174 UMP biosynthetic process(GO:0006222) pyrimidine ribonucleoside monophosphate metabolic process(GO:0009173) pyrimidine ribonucleoside monophosphate biosynthetic process(GO:0009174) UMP metabolic process(GO:0046049)
0.1 0.6 GO:0002036 regulation of L-glutamate transport(GO:0002036)
0.1 0.3 GO:0090598 male genitalia morphogenesis(GO:0048808) lateral sprouting involved in mammary gland duct morphogenesis(GO:0060599) male anatomical structure morphogenesis(GO:0090598)
0.1 0.4 GO:0033622 integrin activation(GO:0033622) regulation of integrin activation(GO:0033623) positive regulation of integrin activation(GO:0033625)
0.1 0.4 GO:0045662 negative regulation of myoblast differentiation(GO:0045662)
0.1 0.4 GO:0070245 positive regulation of thymocyte apoptotic process(GO:0070245)
0.1 1.0 GO:0032331 negative regulation of chondrocyte differentiation(GO:0032331)
0.1 0.2 GO:0045872 positive regulation of rhodopsin gene expression(GO:0045872)
0.1 0.4 GO:0099515 nuclear migration along microfilament(GO:0031022) actin filament-based transport(GO:0099515)
0.1 1.0 GO:0001502 cartilage condensation(GO:0001502) cell aggregation(GO:0098743)
0.0 0.1 GO:0018076 N-terminal peptidyl-lysine acetylation(GO:0018076)
0.0 0.1 GO:0014831 intestine smooth muscle contraction(GO:0014827) gastro-intestinal system smooth muscle contraction(GO:0014831)
0.0 0.1 GO:0034126 regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034124) positive regulation of MyD88-dependent toll-like receptor signaling pathway(GO:0034126)
0.0 0.1 GO:0043628 ncRNA 3'-end processing(GO:0043628)
0.0 0.4 GO:0019228 neuronal action potential(GO:0019228)
0.0 1.7 GO:0006749 glutathione metabolic process(GO:0006749)
0.0 0.2 GO:1901985 positive regulation of histone acetylation(GO:0035066) positive regulation of protein acetylation(GO:1901985) positive regulation of peptidyl-lysine acetylation(GO:2000758)
0.0 0.3 GO:0097435 extracellular fibril organization(GO:0043206) fibril organization(GO:0097435)
0.0 0.3 GO:0010875 positive regulation of cholesterol efflux(GO:0010875)
0.0 0.4 GO:0006071 glycerol metabolic process(GO:0006071)
0.0 0.3 GO:0006621 protein retention in ER lumen(GO:0006621) maintenance of protein localization in endoplasmic reticulum(GO:0035437)
0.0 0.8 GO:0007026 negative regulation of microtubule depolymerization(GO:0007026)
0.0 0.3 GO:0045749 obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749)
0.0 0.1 GO:0018344 protein geranylgeranylation(GO:0018344)
0.0 1.1 GO:0001764 neuron migration(GO:0001764)
0.0 0.4 GO:0017144 drug metabolic process(GO:0017144)
0.0 0.0 GO:0042268 regulation of cytolysis(GO:0042268)
0.0 1.1 GO:0051592 response to calcium ion(GO:0051592)
0.0 0.1 GO:0030643 cellular phosphate ion homeostasis(GO:0030643) cellular divalent inorganic anion homeostasis(GO:0072501) cellular trivalent inorganic anion homeostasis(GO:0072502)
0.0 0.3 GO:0006493 protein O-linked glycosylation(GO:0006493)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 1.5 GO:0005577 fibrinogen complex(GO:0005577)
0.1 1.6 GO:0034366 spherical high-density lipoprotein particle(GO:0034366)
0.1 0.6 GO:0000145 exocyst(GO:0000145)
0.1 0.5 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.3 GO:0098645 network-forming collagen trimer(GO:0098642) collagen network(GO:0098645)
0.0 0.4 GO:0034993 microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993)
0.0 1.2 GO:0030286 dynein complex(GO:0030286)
0.0 0.3 GO:0098643 fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643)
0.0 2.1 GO:0005604 basement membrane(GO:0005604)
0.0 0.5 GO:0045335 phagocytic vesicle(GO:0045335)
0.0 0.8 GO:0005881 cytoplasmic microtubule(GO:0005881)
0.0 0.1 GO:0002102 podosome(GO:0002102)
0.0 0.1 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 1.3 GO:0031227 intrinsic component of endoplasmic reticulum membrane(GO:0031227)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.8 3.3 GO:0004504 peptidylglycine monooxygenase activity(GO:0004504) peptidylamidoglycolate lyase activity(GO:0004598)
0.4 1.6 GO:0034190 apolipoprotein receptor binding(GO:0034190) high-density lipoprotein particle receptor binding(GO:0070653)
0.4 3.6 GO:0017128 phospholipid scramblase activity(GO:0017128)
0.3 0.7 GO:0016524 latrotoxin receptor activity(GO:0016524)
0.2 1.8 GO:0015643 toxic substance binding(GO:0015643)
0.1 1.3 GO:0004499 N,N-dimethylaniline monooxygenase activity(GO:0004499)
0.1 0.4 GO:0003846 2-acylglycerol O-acyltransferase activity(GO:0003846)
0.1 1.9 GO:0003706 obsolete ligand-regulated transcription factor activity(GO:0003706)
0.1 0.5 GO:0034186 apolipoprotein A-I binding(GO:0034186)
0.1 1.0 GO:0005006 epidermal growth factor-activated receptor activity(GO:0005006)
0.1 0.5 GO:0008131 primary amine oxidase activity(GO:0008131)
0.1 4.5 GO:1990782 receptor tyrosine kinase binding(GO:0030971) protein tyrosine kinase binding(GO:1990782)
0.1 0.4 GO:0016635 oxidoreductase activity, acting on the CH-CH group of donors, quinone or related compound as acceptor(GO:0016635)
0.1 0.2 GO:0043199 sulfate binding(GO:0043199)
0.1 1.2 GO:0051879 Hsp90 protein binding(GO:0051879)
0.1 0.3 GO:0005046 KDEL sequence binding(GO:0005046)
0.1 1.5 GO:0043499 obsolete eukaryotic cell surface binding(GO:0043499)
0.1 0.3 GO:0004169 dolichyl-phosphate-mannose-protein mannosyltransferase activity(GO:0004169)
0.0 0.1 GO:0043426 MRF binding(GO:0043426)
0.0 1.6 GO:0004364 glutathione transferase activity(GO:0004364)
0.0 0.3 GO:0034187 obsolete apolipoprotein E binding(GO:0034187)
0.0 1.0 GO:0004181 metallocarboxypeptidase activity(GO:0004181)
0.0 0.3 GO:0048407 platelet-derived growth factor binding(GO:0048407)
0.0 0.1 GO:0032422 purine-rich negative regulatory element binding(GO:0032422)
0.0 0.1 GO:0001965 G-protein alpha-subunit binding(GO:0001965)
0.0 0.1 GO:0004663 Rab geranylgeranyltransferase activity(GO:0004663)
0.0 0.4 GO:0015269 calcium-activated potassium channel activity(GO:0015269)
0.0 0.9 GO:0048306 calcium-dependent protein binding(GO:0048306)
0.0 0.2 GO:0008510 sodium:bicarbonate symporter activity(GO:0008510) bicarbonate transmembrane transporter activity(GO:0015106)
0.0 0.2 GO:0004065 arylsulfatase activity(GO:0004065)
0.0 0.4 GO:0016755 transferase activity, transferring amino-acyl groups(GO:0016755)
0.0 1.2 GO:0003777 microtubule motor activity(GO:0003777)
0.0 0.3 GO:0001540 beta-amyloid binding(GO:0001540)
0.0 0.2 GO:0070577 lysine-acetylated histone binding(GO:0070577)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.4 ST_STAT3_PATHWAY STAT3 Pathway