Motif ID: MEF2B

Z-value: 1.534


Transcription factors associated with MEF2B:

Gene SymbolEntrez IDGene Name
MEF2B ENSG00000213999.11 MEF2B



Activity profile for motif MEF2B.

activity profile for motif MEF2B


Sorted Z-values histogram for motif MEF2B

Sorted Z-values for motif MEF2B



Network of associatons between targets according to the STRING database.



First level regulatory network of MEF2B

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr5_-_111091948 3.965 ENST00000447165.2
 NREP
neuronal regeneration related protein
chr2_+_170366203 3.015 ENST00000284669.1
 KLHL41
kelch-like family member 41
chr5_+_53751445 2.732 ENST00000302005.1
 HSPB3
heat shock 27kDa protein 3
chr5_-_150521192 2.723 ENST00000523714.1
ENST00000521749.1
 ANXA6

annexin A6

chr12_+_119616447 2.401 ENST00000281938.2
 HSPB8
heat shock 22kDa protein 8
chr1_-_116311402 2.366 ENST00000261448.5
 CASQ2
calsequestrin 2 (cardiac muscle)
chr2_-_211168332 2.264 ENST00000341685.4
 MYL1
myosin, light chain 1, alkali; skeletal, fast
chr3_-_52486841 2.088 ENST00000496590.1
 TNNC1
troponin C type 1 (slow)
chr1_-_201391149 2.044 ENST00000555948.1
ENST00000556362.1
 TNNI1

troponin I type 1 (skeletal, slow)

chr9_+_100263912 1.924 ENST00000259365.4
 TMOD1
tropomodulin 1
chr3_+_138067521 1.867 ENST00000494949.1
 MRAS
muscle RAS oncogene homolog
chr10_-_75415825 1.550 ENST00000394810.2
 SYNPO2L
synaptopodin 2-like
chr3_+_138067666 1.530 ENST00000475711.1
ENST00000464896.1
 MRAS

muscle RAS oncogene homolog

chr3_+_138067314 1.517 ENST00000423968.2
 MRAS
muscle RAS oncogene homolog
chr2_-_86564776 1.487 ENST00000165698.5
ENST00000541910.1
ENST00000535845.1
 REEP1


receptor accessory protein 1


chr16_-_88717423 1.452 ENST00000568278.1
ENST00000569359.1
ENST00000567174.1
 CYBA


cytochrome b-245, alpha polypeptide


chr3_+_8543393 1.415 ENST00000157600.3
ENST00000415597.1
ENST00000535732.1
 LMCD1


LIM and cysteine-rich domains 1


chr3_+_8543561 1.375 ENST00000397386.3
 LMCD1
LIM and cysteine-rich domains 1
chr16_-_88717482 1.312 ENST00000261623.3
 CYBA
cytochrome b-245, alpha polypeptide
chrX_-_11284095 1.170 ENST00000303025.6
ENST00000534860.1
 ARHGAP6

Rho GTPase activating protein 6

chr2_+_33661382 1.157 ENST00000402538.3
 RASGRP3
RAS guanyl releasing protein 3 (calcium and DAG-regulated)
chr3_+_8543533 1.147 ENST00000454244.1
 LMCD1
LIM and cysteine-rich domains 1
chr4_+_41362796 1.141 ENST00000508501.1
ENST00000512946.1
ENST00000313860.7
ENST00000512632.1
ENST00000512820.1
 LIMCH1




LIM and calponin homology domains 1




chr1_+_212782012 1.133 ENST00000341491.4
ENST00000366985.1
 ATF3

activating transcription factor 3

chr16_+_12058961 1.108 ENST00000053243.1
 TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr12_+_25205568 1.096 ENST00000548766.1
ENST00000556887.1
 LRMP

lymphoid-restricted membrane protein

chr16_+_12059050 1.086 ENST00000396495.3
 TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr17_-_34417479 1.085 ENST00000225245.5
 CCL3
chemokine (C-C motif) ligand 3
chr12_-_111358372 1.076 ENST00000548438.1
ENST00000228841.8
 MYL2

myosin, light chain 2, regulatory, cardiac, slow

chr2_-_190044480 1.054 ENST00000374866.3
 COL5A2
collagen, type V, alpha 2
chr8_+_11351876 1.020 ENST00000529894.1
 BLK
B lymphoid tyrosine kinase
chr8_+_11351494 1.020 ENST00000259089.4
 BLK
B lymphoid tyrosine kinase
chr12_+_25205666 1.013 ENST00000547044.1
 LRMP
lymphoid-restricted membrane protein
chr11_+_7597639 0.993 ENST00000533792.1
 PPFIBP2
PTPRF interacting protein, binding protein 2 (liprin beta 2)
chr4_+_120056939 0.966 ENST00000307128.5
 MYOZ2
myozenin 2
chr3_+_179370517 0.937 ENST00000263966.3
 USP13
ubiquitin specific peptidase 13 (isopeptidase T-3)
chr2_+_233497931 0.930 ENST00000264059.3
 EFHD1
EF-hand domain family, member D1
chr1_+_145524891 0.831 ENST00000369304.3
 ITGA10
integrin, alpha 10
chr12_+_25205446 0.787 ENST00000557489.1
ENST00000354454.3
ENST00000536173.1
 LRMP


lymphoid-restricted membrane protein


chr16_+_84328429 0.760 ENST00000568638.1
 WFDC1
WAP four-disulfide core domain 1
chr16_+_84328252 0.743 ENST00000219454.5
 WFDC1
WAP four-disulfide core domain 1
chr16_+_12059091 0.727 ENST00000562385.1
 TNFRSF17
tumor necrosis factor receptor superfamily, member 17
chr5_+_155753745 0.674 ENST00000435422.3
ENST00000337851.4
ENST00000447401.1
 SGCD


sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)


chr14_-_22005343 0.611 ENST00000327430.3
 SALL2
spalt-like transcription factor 2
chr15_+_100106155 0.568 ENST00000557785.1
ENST00000558049.1
ENST00000449277.2
 MEF2A


myocyte enhancer factor 2A


chr5_-_42811986 0.562 ENST00000511224.1
ENST00000507920.1
ENST00000510965.1
 SEPP1


selenoprotein P, plasma, 1


chrX_+_70521584 0.556 ENST00000373829.3
ENST00000538820.1
 ITGB1BP2

integrin beta 1 binding protein (melusin) 2

chr15_+_100106126 0.534 ENST00000558812.1
ENST00000338042.6
 MEF2A

myocyte enhancer factor 2A

chr8_+_1993152 0.531 ENST00000262113.4
 MYOM2
myomesin 2
chr15_+_100106244 0.528 ENST00000557942.1
 MEF2A
myocyte enhancer factor 2A
chr7_-_37488834 0.528 ENST00000310758.4
 ELMO1
engulfment and cell motility 1
chr5_-_42812143 0.490 ENST00000514985.1
 SEPP1
selenoprotein P, plasma, 1
chr8_+_107282389 0.488 ENST00000445937.1
ENST00000577661.1
 OXR1
RP11-395G23.3
oxidation resistance 1
RP11-395G23.3
chr8_+_1993173 0.475 ENST00000523438.1
 MYOM2
myomesin 2
chr7_+_120629653 0.464 ENST00000450913.2
ENST00000340646.5
 CPED1

cadherin-like and PC-esterase domain containing 1

chr17_-_5322786 0.407 ENST00000225696.4
 NUP88
nucleoporin 88kDa
chr22_-_30642782 0.404 ENST00000249075.3
 LIF
leukemia inhibitory factor
chr17_+_80186908 0.365 ENST00000582743.1
ENST00000578684.1
ENST00000577650.1
ENST00000582715.1
 SLC16A3



solute carrier family 16 (monocarboxylate transporter), member 3



chr14_-_102704783 0.360 ENST00000522534.1
 MOK
MOK protein kinase
chr5_+_138609782 0.343 ENST00000361059.2
ENST00000514694.1
ENST00000504203.1
ENST00000502929.1
ENST00000394800.2
ENST00000509644.1
ENST00000505016.1
 MATR3






matrin 3






chr4_-_25865159 0.342 ENST00000502949.1
ENST00000264868.5
ENST00000513691.1
ENST00000514872.1
 SEL1L3



sel-1 suppressor of lin-12-like 3 (C. elegans)



chr6_+_139094657 0.340 ENST00000332797.6
 CCDC28A
coiled-coil domain containing 28A
chr8_-_70745575 0.334 ENST00000524945.1
 SLCO5A1
solute carrier organic anion transporter family, member 5A1
chr15_+_68346501 0.331 ENST00000249636.6
 PIAS1
protein inhibitor of activated STAT, 1
chr1_-_204329013 0.317 ENST00000272203.3
ENST00000414478.1
 PLEKHA6

pleckstrin homology domain containing, family A member 6

chr6_+_42984723 0.273 ENST00000332245.8
 KLHDC3
kelch domain containing 3
chr3_+_186739636 0.250 ENST00000440338.1
ENST00000448044.1
 ST6GAL1

ST6 beta-galactosamide alpha-2,6-sialyltranferase 1

chr10_+_118350522 0.243 ENST00000530319.1
ENST00000527980.1
ENST00000471549.1
ENST00000534537.1
 PNLIPRP1



pancreatic lipase-related protein 1



chr3_-_176914238 0.229 ENST00000430069.1
ENST00000428970.1
 TBL1XR1

transducin (beta)-like 1 X-linked receptor 1

chr3_+_127634312 0.224 ENST00000407609.3
 KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr6_+_44194762 0.223 ENST00000371708.1
 SLC29A1
solute carrier family 29 (equilibrative nucleoside transporter), member 1
chr16_-_31439735 0.207 ENST00000287490.4
 COX6A2
cytochrome c oxidase subunit VIa polypeptide 2
chr19_-_40324767 0.204 ENST00000601972.1
ENST00000430012.2
ENST00000323039.5
ENST00000348817.3
 DYRK1B



dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B



chr10_+_118350468 0.202 ENST00000358834.4
ENST00000528052.1
ENST00000442761.1
 PNLIPRP1


pancreatic lipase-related protein 1


chr9_-_74980113 0.184 ENST00000376962.5
ENST00000376960.4
ENST00000237937.3
 ZFAND5


zinc finger, AN1-type domain 5


chr7_+_143013198 0.175 ENST00000343257.2
 CLCN1
chloride channel, voltage-sensitive 1
chr3_+_54157480 0.175 ENST00000490478.1
 CACNA2D3
calcium channel, voltage-dependent, alpha 2/delta subunit 3
chr19_+_56713670 0.172 ENST00000534327.1
 ZSCAN5C
zinc finger and SCAN domain containing 5C
chr2_-_157198860 0.140 ENST00000409572.1
 NR4A2
nuclear receptor subfamily 4, group A, member 2
chr1_+_170633047 0.135 ENST00000239461.6
ENST00000497230.2
 PRRX1

paired related homeobox 1

chr17_-_42200996 0.128 ENST00000587135.1
ENST00000225983.6
ENST00000393622.2
ENST00000588703.1
 HDAC5



histone deacetylase 5



chr8_-_27115903 0.101 ENST00000350889.4
ENST00000519997.1
ENST00000519614.1
ENST00000522908.1
ENST00000265770.7
 STMN4




stathmin-like 4




chr3_+_127634069 0.093 ENST00000405109.1
 KBTBD12
kelch repeat and BTB (POZ) domain containing 12
chr5_-_66492562 0.088 ENST00000256447.4
 CD180
CD180 molecule
chr9_+_116327326 0.074 ENST00000342620.5
 RGS3
regulator of G-protein signaling 3
chr7_+_30951461 0.068 ENST00000311813.4
 AQP1
aquaporin 1 (Colton blood group)
chr4_+_44680429 0.064 ENST00000281543.5
 GUF1
GUF1 GTPase homolog (S. cerevisiae)
chr3_+_46924829 0.044 ENST00000313049.5
 PTH1R
parathyroid hormone 1 receptor
chr19_-_40324255 0.040 ENST00000593685.1
ENST00000600611.1
 DYRK1B

dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1B

chr17_-_42200958 0.035 ENST00000336057.5
 HDAC5
histone deacetylase 5
chr7_+_86781847 0.027 ENST00000432366.2
ENST00000423590.2
ENST00000394703.5
 DMTF1


cyclin D binding myb-like transcription factor 1


chr8_-_27115931 0.023 ENST00000523048.1
 STMN4
stathmin-like 4
chr8_+_95565947 0.014 ENST00000523011.1
 RP11-267M23.4
RP11-267M23.4
chr11_-_47400078 0.011 ENST00000378538.3
 SPI1
spleen focus forming virus (SFFV) proviral integration oncogene
chr12_+_15699286 0.000 ENST00000442921.2
ENST00000542557.1
ENST00000445537.2
ENST00000544244.1
 PTPRO



protein tyrosine phosphatase, receptor type, O




Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.3 3.9 GO:0070886 positive regulation of calcineurin-NFAT signaling cascade(GO:0070886)
0.6 2.8 GO:0003093 regulation of glomerular filtration(GO:0003093) glomerular filtration(GO:0003094) renal filtration(GO:0097205) regulation of renal system process(GO:0098801)
0.5 1.6 GO:1903115 regulation of muscle filament sliding(GO:0032971) regulation of actin filament-based movement(GO:1903115)
0.2 2.9 GO:0006906 vesicle fusion(GO:0006906)
0.1 1.5 GO:0051205 protein insertion into membrane(GO:0051205)
0.1 1.2 GO:0051895 negative regulation of focal adhesion assembly(GO:0051895) negative regulation of cell junction assembly(GO:1901889) negative regulation of adherens junction organization(GO:1903392)
0.1 0.4 GO:0048861 serine phosphorylation of STAT protein(GO:0042501) leukemia inhibitory factor signaling pathway(GO:0048861)
0.1 1.1 GO:0042693 muscle cell fate commitment(GO:0042693)
0.1 1.0 GO:0015074 DNA integration(GO:0015074)
0.1 2.9 GO:0033209 tumor necrosis factor-mediated signaling pathway(GO:0033209)
0.1 5.3 GO:0030049 muscle filament sliding(GO:0030049) actin-myosin filament sliding(GO:0033275)
0.1 0.5 GO:0016998 cell wall macromolecule catabolic process(GO:0016998)
0.1 4.9 GO:0009408 response to heat(GO:0009408)
0.0 0.2 GO:0010761 fibroblast migration(GO:0010761)
0.0 1.1 GO:0045069 regulation of viral genome replication(GO:0045069)
0.0 0.2 GO:0051154 negative regulation of myotube differentiation(GO:0010832) negative regulation of striated muscle cell differentiation(GO:0051154)
0.0 1.4 GO:0032024 positive regulation of insulin secretion(GO:0032024)
0.0 2.4 GO:0006941 striated muscle contraction(GO:0006941)
0.0 0.2 GO:0019227 neuronal action potential propagation(GO:0019227) action potential propagation(GO:0098870)
0.0 0.5 GO:0016601 Rac protein signal transduction(GO:0016601)
0.0 0.7 GO:0030199 collagen fibril organization(GO:0030199)
0.0 0.2 GO:0015862 uridine transport(GO:0015862)
0.0 1.6 GO:0051149 positive regulation of muscle cell differentiation(GO:0051149)
0.0 0.6 GO:0007517 muscle organ development(GO:0007517)
0.0 0.3 GO:0033235 positive regulation of protein sumoylation(GO:0033235)
0.0 0.1 GO:0042416 dopamine biosynthetic process(GO:0042416)
0.0 4.9 GO:0006184 obsolete GTP catabolic process(GO:0006184)
0.0 0.1 GO:0030185 nitric oxide transport(GO:0030185) epithelial fluid transport(GO:0042045) cellular response to copper ion(GO:0071280)
0.0 0.1 GO:0045880 positive regulation of smoothened signaling pathway(GO:0045880)
0.0 1.5 GO:0050680 negative regulation of epithelial cell proliferation(GO:0050680)
0.0 0.2 GO:0006091 generation of precursor metabolites and energy(GO:0006091)
0.0 0.2 GO:0007520 myoblast fusion(GO:0007520)
0.0 1.0 GO:0006094 gluconeogenesis(GO:0006094)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.4 1.1 GO:0005588 collagen type V trimer(GO:0005588)
0.3 2.4 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.3 2.8 GO:0043020 NADPH oxidase complex(GO:0043020)
0.1 3.2 GO:0005861 troponin complex(GO:0005861)
0.1 1.0 GO:0032982 myosin filament(GO:0032982)
0.1 0.7 GO:0016012 sarcoglycan complex(GO:0016012)
0.1 1.7 GO:0005859 muscle myosin complex(GO:0005859)
0.0 1.9 GO:0030863 cortical cytoskeleton(GO:0030863)
0.0 0.2 GO:0070069 cytochrome complex(GO:0070069)
0.0 0.1 GO:0033655 host(GO:0018995) host cell cytoplasm(GO:0030430) host cell part(GO:0033643) host intracellular part(GO:0033646) host cell cytoplasm part(GO:0033655) intracellular region of host(GO:0043656) host cell(GO:0043657) other organism(GO:0044215) other organism cell(GO:0044216) other organism part(GO:0044217)
0.0 1.0 GO:0030018 Z disc(GO:0030018)
0.0 1.0 GO:0005884 actin filament(GO:0005884)
0.0 0.8 GO:0098636 integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636)
0.0 0.9 GO:0016459 myosin complex(GO:0016459)
0.0 2.7 GO:0042470 melanosome(GO:0042470) pigment granule(GO:0048770)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 1.0 GO:0008907 integrase activity(GO:0008907)
0.2 4.9 GO:0030742 GTP-dependent protein binding(GO:0030742)
0.2 2.8 GO:0016175 superoxide-generating NADPH oxidase activity(GO:0016175)
0.2 2.9 GO:0005031 tumor necrosis factor-activated receptor activity(GO:0005031)
0.2 1.8 GO:0031013 troponin I binding(GO:0031013)
0.2 4.0 GO:0005523 tropomyosin binding(GO:0005523)
0.1 1.2 GO:0016004 phospholipase activator activity(GO:0016004)
0.1 0.6 GO:0032036 myosin heavy chain binding(GO:0032036)
0.1 0.3 GO:0003835 beta-galactoside alpha-2,6-sialyltransferase activity(GO:0003835)
0.1 2.7 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.1 0.9 GO:0008242 omega peptidase activity(GO:0008242)
0.1 1.0 GO:0030346 protein phosphatase 2B binding(GO:0030346)
0.1 1.2 GO:0019992 diacylglycerol binding(GO:0019992)
0.0 1.1 GO:0008430 selenium binding(GO:0008430)
0.0 1.1 GO:0042056 chemoattractant activity(GO:0042056)
0.0 0.3 GO:0019789 SUMO transferase activity(GO:0019789)
0.0 0.4 GO:0015355 secondary active monocarboxylate transmembrane transporter activity(GO:0015355)
0.0 2.5 GO:0008307 structural constituent of muscle(GO:0008307)
0.0 2.0 GO:0004715 non-membrane spanning protein tyrosine kinase activity(GO:0004715)
0.0 0.1 GO:0005223 intracellular cGMP activated cation channel activity(GO:0005223)
0.0 4.8 GO:0003714 transcription corepressor activity(GO:0003714)
0.0 0.4 GO:0004806 triglyceride lipase activity(GO:0004806)
0.0 0.2 GO:0031078 histone deacetylase activity (H3-K14 specific)(GO:0031078) NAD-dependent histone deacetylase activity (H3-K14 specific)(GO:0032041) histone deacetylase activity (H4-K16 specific)(GO:0034739) NAD-dependent histone deacetylase activity (H4-K16 specific)(GO:0046970)
0.0 1.5 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 0.8 GO:0005518 collagen binding(GO:0005518)
0.0 0.2 GO:0005337 nucleoside transmembrane transporter activity(GO:0005337)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 4.7 ST_INTEGRIN_SIGNALING_PATHWAY Integrin Signaling Pathway
0.0 0.3 ST_JAK_STAT_PATHWAY Jak-STAT Pathway
0.0 1.2 ST_T_CELL_SIGNAL_TRANSDUCTION T Cell Signal Transduction