Motif ID: MSX1

Z-value: 1.395


Transcription factors associated with MSX1:

Gene SymbolEntrez IDGene Name
MSX1 ENSG00000163132.6 MSX1



Activity profile for motif MSX1.

activity profile for motif MSX1


Sorted Z-values histogram for motif MSX1

Sorted Z-values for motif MSX1



Network of associatons between targets according to the STRING database.



First level regulatory network of MSX1

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr13_-_38172863 8.494 ENST00000541481.1
ENST00000379743.4
ENST00000379742.4
ENST00000379749.4
ENST00000541179.1
ENST00000379747.4
 POSTN





periostin, osteoblast specific factor





chr1_+_158985457 3.568 ENST00000567661.1
ENST00000474473.1
 IFI16

interferon, gamma-inducible protein 16

chr14_+_55595762 3.374 ENST00000254301.9
 LGALS3
lectin, galactoside-binding, soluble, 3
chr8_+_30244580 2.897 ENST00000523115.1
ENST00000519647.1
 RBPMS

RNA binding protein with multiple splicing

chr14_+_55595960 2.725 ENST00000554715.1
 LGALS3
lectin, galactoside-binding, soluble, 3
chr3_-_123339418 2.583 ENST00000583087.1
 MYLK
myosin light chain kinase
chr3_-_123339343 2.524 ENST00000578202.1
 MYLK
myosin light chain kinase
chr3_-_123512688 2.299 ENST00000475616.1
 MYLK
myosin light chain kinase
chr18_+_61637159 1.613 ENST00000397985.2
ENST00000353706.2
ENST00000542677.1
ENST00000397988.3
ENST00000448851.1
 SERPINB8




serpin peptidase inhibitor, clade B (ovalbumin), member 8




chr21_+_30502806 1.544 ENST00000399928.1
ENST00000399926.1
 MAP3K7CL

MAP3K7 C-terminal like

chr12_-_52911718 1.507 ENST00000548409.1
 KRT5
keratin 5
chr9_+_79074068 1.413 ENST00000444201.2
ENST00000376730.4
 GCNT1

glucosaminyl (N-acetyl) transferase 1, core 2

chr2_-_31361543 1.357 ENST00000349752.5
 GALNT14
UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14 (GalNAc-T14)
chr5_+_82767487 1.351 ENST00000343200.5
ENST00000342785.4
 VCAN

versican

chr5_+_82767284 1.094 ENST00000265077.3
 VCAN
versican
chr10_+_13141585 1.053 ENST00000378764.2
 OPTN
optineurin
chr9_+_115913222 1.050 ENST00000259392.3
 SLC31A2
solute carrier family 31 (copper transporter), member 2
chr5_+_82767583 0.989 ENST00000512590.2
ENST00000513960.1
ENST00000513984.1
ENST00000502527.2
 VCAN



versican



chr11_+_12766583 0.989 ENST00000361985.2
 TEAD1
TEA domain family member 1 (SV40 transcriptional enhancer factor)
chr10_+_13142225 0.982 ENST00000378747.3
 OPTN
optineurin
chr5_+_140762268 0.940 ENST00000518325.1
 PCDHGA7
protocadherin gamma subfamily A, 7
chr10_+_17270214 0.895 ENST00000544301.1
 VIM
vimentin
chr16_-_66584059 0.889 ENST00000417693.3
ENST00000544898.1
ENST00000569718.1
ENST00000527284.1
ENST00000299697.7
ENST00000451102.2
 TK2





thymidine kinase 2, mitochondrial





chr12_+_56324756 0.816 ENST00000331886.5
ENST00000555090.1
 DGKA

diacylglycerol kinase, alpha 80kDa

chr6_-_109777128 0.731 ENST00000358807.3
ENST00000358577.3
 MICAL1

microtubule associated monooxygenase, calponin and LIM domain containing 1

chr4_-_57547454 0.730 ENST00000556376.2
 HOPX
HOP homeobox
chr1_-_149908217 0.661 ENST00000369140.3
 MTMR11
myotubularin related protein 11
chr11_+_12132117 0.650 ENST00000256194.4
 MICAL2
microtubule associated monooxygenase, calponin and LIM domain containing 2
chr1_+_84630645 0.616 ENST00000394839.2
 PRKACB
protein kinase, cAMP-dependent, catalytic, beta
chr1_+_224370873 0.609 ENST00000323699.4
ENST00000391877.3
 DEGS1

delta(4)-desaturase, sphingolipid 1

chr10_-_101380121 0.586 ENST00000370495.4
 SLC25A28
solute carrier family 25 (mitochondrial iron transporter), member 28
chr7_-_32338917 0.514 ENST00000396193.1
 PDE1C
phosphodiesterase 1C, calmodulin-dependent 70kDa
chr1_-_35450897 0.475 ENST00000373337.3
 ZMYM6NB
ZMYM6 neighbor
chr22_+_51176624 0.465 ENST00000216139.5
ENST00000529621.1
 ACR

acrosin

chr14_-_64194745 0.464 ENST00000247225.6
 SGPP1
sphingosine-1-phosphate phosphatase 1
chr5_+_67586465 0.453 ENST00000336483.5
 PIK3R1
phosphoinositide-3-kinase, regulatory subunit 1 (alpha)
chr14_+_22964877 0.438 ENST00000390494.1
 TRAJ43
T cell receptor alpha joining 43
chr4_+_169013666 0.413 ENST00000359299.3
 ANXA10
annexin A10
chr16_-_66583701 0.385 ENST00000527800.1
ENST00000525974.1
ENST00000563369.2
 TK2


thymidine kinase 2, mitochondrial


chrX_+_1710484 0.373 ENST00000313871.3
ENST00000381261.3
 AKAP17A

A kinase (PRKA) anchor protein 17A

chr6_-_32557610 0.371 ENST00000360004.5
 HLA-DRB1
major histocompatibility complex, class II, DR beta 1
chr5_+_150404904 0.362 ENST00000521632.1
 GPX3
glutathione peroxidase 3 (plasma)
chr5_+_175490540 0.346 ENST00000515817.1
 FAM153B
family with sequence similarity 153, member B
chr12_+_54422142 0.344 ENST00000243108.4
 HOXC6
homeobox C6
chr12_+_56324933 0.339 ENST00000549629.1
ENST00000555218.1
 DGKA

diacylglycerol kinase, alpha 80kDa

chr3_+_93781728 0.318 ENST00000314622.4
 NSUN3
NOP2/Sun domain family, member 3
chr1_+_210501589 0.301 ENST00000413764.2
ENST00000541565.1
 HHAT

hedgehog acyltransferase

chr10_+_135204338 0.301 ENST00000468317.2
 RP11-108K14.8
Mitochondrial GTPase 1
chr11_-_85376121 0.299 ENST00000527447.1
 CREBZF
CREB/ATF bZIP transcription factor
chr22_-_32766972 0.283 ENST00000382084.4
ENST00000382086.2
 RFPL3S

RFPL3 antisense

chr6_-_32784687 0.276 ENST00000447394.1
ENST00000438763.2
 HLA-DOB

major histocompatibility complex, class II, DO beta

chr5_-_177207634 0.262 ENST00000513554.1
ENST00000440605.3
 FAM153A

family with sequence similarity 153, member A

chr2_-_136288113 0.256 ENST00000401392.1
 ZRANB3
zinc finger, RAN-binding domain containing 3
chr20_+_34129770 0.249 ENST00000348547.2
ENST00000357394.4
ENST00000447986.1
ENST00000279052.6
ENST00000416206.1
ENST00000411577.1
ENST00000413587.1
 ERGIC3






ERGIC and golgi 3






chr6_+_6588316 0.245 ENST00000379953.2
 LY86
lymphocyte antigen 86
chr6_-_32095968 0.240 ENST00000375203.3
ENST00000375201.4
 ATF6B

activating transcription factor 6 beta

chr7_-_16840820 0.231 ENST00000450569.1
 AGR2
anterior gradient 2
chr18_+_29598335 0.228 ENST00000217740.3
 RNF125
ring finger protein 125, E3 ubiquitin protein ligase
chr8_+_97597148 0.228 ENST00000521590.1
 SDC2
syndecan 2
chrX_+_73164149 0.222 ENST00000602938.1
ENST00000602294.1
ENST00000602920.1
ENST00000602737.1
ENST00000602772.1
 JPX




JPX transcript, XIST activator (non-protein coding)




chr5_-_137475071 0.212 ENST00000265191.2
 NME5
NME/NM23 family member 5
chr6_-_52705641 0.210 ENST00000370989.2
 GSTA5
glutathione S-transferase alpha 5
chr3_+_108308513 0.195 ENST00000361582.3
 DZIP3
DAZ interacting zinc finger protein 3
chr8_-_99057742 0.192 ENST00000521291.1
ENST00000396070.2
ENST00000523172.1
ENST00000287038.3
 RPL30



ribosomal protein L30



chr15_-_77712477 0.186 ENST00000560626.2
 PEAK1
pseudopodium-enriched atypical kinase 1
chr15_-_42500351 0.185 ENST00000348544.4
ENST00000318006.5
 VPS39

vacuolar protein sorting 39 homolog (S. cerevisiae)

chr13_+_50570019 0.178 ENST00000442421.1
 TRIM13
tripartite motif containing 13
chr15_+_79166065 0.176 ENST00000559690.1
ENST00000559158.1
 MORF4L1

mortality factor 4 like 1

chr1_+_160160283 0.169 ENST00000368079.3
 CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr5_+_140220769 0.163 ENST00000531613.1
ENST00000378123.3
 PCDHA8

protocadherin alpha 8

chrX_+_11311533 0.156 ENST00000380714.3
ENST00000380712.3
ENST00000348912.4
 AMELX


amelogenin, X-linked


chr4_-_120243545 0.147 ENST00000274024.3
 FABP2
fatty acid binding protein 2, intestinal
chr14_+_22293618 0.147 ENST00000390432.2
 TRAV10
T cell receptor alpha variable 10
chr1_+_160160346 0.130 ENST00000368078.3
 CASQ1
calsequestrin 1 (fast-twitch, skeletal muscle)
chr13_+_49551020 0.123 ENST00000541916.1
 FNDC3A
fibronectin type III domain containing 3A
chr22_-_32767017 0.123 ENST00000400234.1
 RFPL3S
RFPL3 antisense
chr8_+_24241789 0.116 ENST00000256412.4
ENST00000538205.1
 ADAMDEC1

ADAM-like, decysin 1

chr1_-_167487758 0.108 ENST00000362089.5
 CD247
CD247 molecule
chr8_-_17555164 0.099 ENST00000297488.6
 MTUS1
microtubule associated tumor suppressor 1
chr11_-_128894053 0.096 ENST00000392657.3
 ARHGAP32
Rho GTPase activating protein 32
chr6_+_29141311 0.094 ENST00000377167.2
 OR2J2
olfactory receptor, family 2, subfamily J, member 2
chr19_-_53758094 0.092 ENST00000601828.1
ENST00000598513.1
ENST00000599012.1
ENST00000333952.4
ENST00000598806.1
 ZNF677




zinc finger protein 677




chr11_-_66964638 0.089 ENST00000444002.2
 AP001885.1
AP001885.1
chr8_-_121824374 0.088 ENST00000517992.1
 SNTB1
syntrophin, beta 1 (dystrophin-associated protein A1, 59kDa, basic component 1)
chr21_+_43619796 0.083 ENST00000398457.2
 ABCG1
ATP-binding cassette, sub-family G (WHITE), member 1
chr1_+_158815588 0.064 ENST00000438394.1
 MNDA
myeloid cell nuclear differentiation antigen
chr7_+_2636522 0.062 ENST00000423196.1
 IQCE
IQ motif containing E
chr1_-_167487808 0.058 ENST00000392122.3
 CD247
CD247 molecule
chr19_-_20150014 0.050 ENST00000358523.5
ENST00000397162.1
ENST00000601100.1
 ZNF682


zinc finger protein 682


chr10_+_135050908 0.044 ENST00000325980.9
 VENTX
VENT homeobox
chr19_+_55043977 0.040 ENST00000335056.3
 KIR3DX1
killer cell immunoglobulin-like receptor, three domains, X1
chr2_-_219031709 0.040 ENST00000295683.2
 CXCR1
chemokine (C-X-C motif) receptor 1
chr1_+_202091980 0.040 ENST00000367282.5
 GPR37L1
G protein-coupled receptor 37 like 1
chr17_-_37934466 0.026 ENST00000583368.1
 IKZF3
IKAROS family zinc finger 3 (Aiolos)
chr3_-_190040223 0.025 ENST00000295522.3
 CLDN1
claudin 1
chr8_+_24241969 0.024 ENST00000522298.1
 ADAMDEC1
ADAM-like, decysin 1
chr2_-_158345462 0.023 ENST00000439355.1
ENST00000540637.1
 CYTIP

cytohesin 1 interacting protein

chr11_+_45825616 0.019 ENST00000442528.2
ENST00000456334.1
ENST00000526817.1
 SLC35C1


solute carrier family 35 (GDP-fucose transporter), member C1


chr14_-_75389975 0.012 ENST00000555647.1
ENST00000557413.1
 RPS6KL1

ribosomal protein S6 kinase-like 1

chr6_-_84419101 0.005 ENST00000520302.1
ENST00000520213.1
ENST00000439399.2
ENST00000428679.2
ENST00000437520.1
 SNAP91




synaptosomal-associated protein, 91kDa





Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
1.1 7.4 GO:0060414 aorta development(GO:0035904) aorta morphogenesis(GO:0035909) aorta smooth muscle tissue morphogenesis(GO:0060414)
0.5 2.0 GO:0090161 Golgi ribbon formation(GO:0090161)
0.2 2.9 GO:0060391 positive regulation of SMAD protein import into nucleus(GO:0060391)
0.2 1.3 GO:0006264 mitochondrial DNA replication(GO:0006264)
0.1 3.4 GO:0008347 glial cell migration(GO:0008347)
0.1 3.6 GO:0030224 monocyte differentiation(GO:0030224)
0.1 14.6 GO:0030198 extracellular matrix organization(GO:0030198) extracellular structure organization(GO:0043062)
0.1 0.4 GO:0006982 response to lipid hydroperoxide(GO:0006982)
0.1 1.0 GO:0035434 copper ion transmembrane transport(GO:0035434)
0.1 0.5 GO:0006668 sphinganine-1-phosphate metabolic process(GO:0006668)
0.1 0.7 GO:0043415 positive regulation of skeletal muscle tissue regeneration(GO:0043415) regulation of skeletal muscle tissue regeneration(GO:0043416)
0.1 0.5 GO:0046069 cGMP catabolic process(GO:0046069)
0.1 0.5 GO:0007341 penetration of zona pellucida(GO:0007341)
0.1 0.5 GO:0010459 negative regulation of heart rate(GO:0010459)
0.1 1.4 GO:0006493 protein O-linked glycosylation(GO:0006493)
0.1 1.5 GO:0031581 hemidesmosome assembly(GO:0031581)
0.0 1.0 GO:0035329 hippo signaling(GO:0035329)
0.0 0.3 GO:0018345 protein palmitoylation(GO:0018345)
0.0 0.9 GO:0045103 intermediate filament-based process(GO:0045103)
0.0 0.2 GO:0070254 mucus secretion(GO:0070254)
0.0 0.2 GO:0070172 positive regulation of tooth mineralization(GO:0070172)
0.0 1.2 GO:0007205 protein kinase C-activating G-protein coupled receptor signaling pathway(GO:0007205)
0.0 0.6 GO:0034199 activation of protein kinase A activity(GO:0034199)
0.0 0.6 GO:0002504 antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504)
0.0 0.2 GO:0046051 GTP biosynthetic process(GO:0006183) UTP biosynthetic process(GO:0006228) CTP biosynthetic process(GO:0006241) pyrimidine ribonucleoside triphosphate metabolic process(GO:0009208) pyrimidine ribonucleoside triphosphate biosynthetic process(GO:0009209) CTP metabolic process(GO:0046036) UTP metabolic process(GO:0046051)
0.0 0.1 GO:0060009 Sertoli cell development(GO:0060009)
0.0 0.2 GO:0031000 response to caffeine(GO:0031000)
0.0 1.6 GO:0010951 negative regulation of endopeptidase activity(GO:0010951)
0.0 0.6 GO:0006636 unsaturated fatty acid biosynthetic process(GO:0006636)
0.0 0.1 GO:0045542 positive regulation of cholesterol biosynthetic process(GO:0045542)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.2 0.5 GO:0043159 acrosomal matrix(GO:0043159)
0.1 0.5 GO:0097651 phosphatidylinositol 3-kinase complex, class IA(GO:0005943) phosphatidylinositol 3-kinase complex, class I(GO:0097651)
0.0 18.0 GO:0005578 proteinaceous extracellular matrix(GO:0005578)
0.0 1.5 GO:0045095 keratin filament(GO:0045095)
0.0 0.3 GO:0033018 sarcoplasmic reticulum lumen(GO:0033018)
0.0 1.6 GO:0005882 intermediate filament(GO:0005882)
0.0 0.6 GO:0042613 MHC class II protein complex(GO:0042613)
0.0 0.1 GO:0045179 apical cortex(GO:0045179)
0.0 0.2 GO:0042105 alpha-beta T cell receptor complex(GO:0042105)
0.0 2.0 GO:0005802 trans-Golgi network(GO:0005802)
0.0 0.6 GO:0005952 cAMP-dependent protein kinase complex(GO:0005952)
0.0 0.2 GO:0030897 HOPS complex(GO:0030897)
0.0 0.1 GO:0042598 obsolete vesicular fraction(GO:0042598)
0.0 0.2 GO:0033116 endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
1.5 7.4 GO:0004687 myosin light chain kinase activity(GO:0004687)
1.0 6.1 GO:0019863 IgE binding(GO:0019863)
0.5 1.4 GO:0003829 beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase activity(GO:0003829)
0.4 1.3 GO:0004797 thymidine kinase activity(GO:0004797)
0.2 0.5 GO:0042806 fucose binding(GO:0042806)
0.1 2.9 GO:0008143 poly(A) binding(GO:0008143)
0.1 3.4 GO:0005540 hyaluronic acid binding(GO:0005540)
0.1 1.0 GO:0005375 copper ion transmembrane transporter activity(GO:0005375)
0.1 0.5 GO:0048101 calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101)
0.1 1.4 GO:0004653 polypeptide N-acetylgalactosaminyltransferase activity(GO:0004653)
0.1 0.5 GO:0043559 insulin binding(GO:0043559)
0.1 0.5 GO:0042392 sphingosine-1-phosphate phosphatase activity(GO:0042392)
0.1 8.5 GO:0008201 heparin binding(GO:0008201)
0.1 0.2 GO:0046848 hydroxyapatite binding(GO:0046848)
0.0 0.6 GO:0032395 MHC class II receptor activity(GO:0032395)
0.0 1.2 GO:0004143 diacylglycerol kinase activity(GO:0004143)
0.0 0.6 GO:0004691 cAMP-dependent protein kinase activity(GO:0004691)
0.0 0.1 GO:0005324 long-chain fatty acid transporter activity(GO:0005324)
0.0 0.4 GO:1900750 glutathione binding(GO:0043295) oligopeptide binding(GO:1900750)
0.0 0.3 GO:0016409 palmitoyltransferase activity(GO:0016409)
0.0 0.2 GO:0004550 nucleoside diphosphate kinase activity(GO:0004550)
0.0 0.0 GO:0019958 C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959)
0.0 1.6 GO:0004867 serine-type endopeptidase inhibitor activity(GO:0004867)
0.0 1.9 GO:0005200 structural constituent of cytoskeleton(GO:0005200)
0.0 3.4 GO:0003690 double-stranded DNA binding(GO:0003690)
0.0 1.3 GO:0004497 monooxygenase activity(GO:0004497)
0.0 0.4 GO:0005544 calcium-dependent phospholipid binding(GO:0005544)
0.0 0.6 GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen(GO:0016705)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 7.4 SIG_REGULATION_OF_THE_ACTIN_CYTOSKELETON_BY_RHO_GTPASES Genes related to regulation of the actin cytoskeleton
0.0 0.5 SIG_CHEMOTAXIS Genes related to chemotaxis