Motif ID: MSX2

Z-value: 0.597


Transcription factors associated with MSX2:

Gene SymbolEntrez IDGene Name
MSX2 ENSG00000120149.7 MSX2



Activity profile for motif MSX2.

activity profile for motif MSX2


Sorted Z-values histogram for motif MSX2

Sorted Z-values for motif MSX2



Network of associatons between targets according to the STRING database.



First level regulatory network of MSX2

PNG image of the network

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Top targets:


Promoter Score Refseq Gene Symbol Gene Name
chr1_-_151965048 1.785 ENST00000368809.1
 S100A10
S100 calcium binding protein A10
chr1_-_68698222 1.119 ENST00000370976.3
ENST00000354777.2
ENST00000262348.4
ENST00000540432.1
 WLS



wntless Wnt ligand secretion mediator



chr6_-_167040731 1.017 ENST00000265678.4
 RPS6KA2
ribosomal protein S6 kinase, 90kDa, polypeptide 2
chr1_-_94050668 0.891 ENST00000539242.1
 BCAR3
breast cancer anti-estrogen resistance 3
chr3_-_151034734 0.776 ENST00000260843.4
 GPR87
G protein-coupled receptor 87
chr1_-_68698197 0.662 ENST00000370973.2
ENST00000370971.1
 WLS

wntless Wnt ligand secretion mediator

chr12_-_10022735 0.599 ENST00000228438.2
 CLEC2B
C-type lectin domain family 2, member B
chrX_-_48931648 0.482 ENST00000376386.3
ENST00000376390.4
 PRAF2

PRA1 domain family, member 2

chr12_+_9102632 0.469 ENST00000539240.1
 KLRG1
killer cell lectin-like receptor subfamily G, member 1
chr3_-_112127981 0.468 ENST00000486726.2
 RP11-231E6.1
RP11-231E6.1
chr5_+_95997918 0.466 ENST00000395812.2
ENST00000395813.1
ENST00000359176.4
ENST00000325674.7
 CAST



calpastatin



chr7_+_134331550 0.447 ENST00000344924.3
ENST00000418040.1
ENST00000393132.2
 BPGM


2,3-bisphosphoglycerate mutase


chr6_-_111927449 0.398 ENST00000368761.5
ENST00000392556.4
ENST00000340026.6
 TRAF3IP2


TRAF3 interacting protein 2


chr5_+_66254698 0.378 ENST00000405643.1
ENST00000407621.1
ENST00000432426.1
 MAST4


microtubule associated serine/threonine kinase family member 4


chr5_+_95998070 0.367 ENST00000421689.2
ENST00000510756.1
ENST00000512620.1
 CAST


calpastatin


chr5_+_140797296 0.352 ENST00000398594.2
 PCDHGB7
protocadherin gamma subfamily B, 7
chr10_-_99447024 0.351 ENST00000370626.3
 AVPI1
arginine vasopressin-induced 1
chr15_+_41245160 0.347 ENST00000444189.2
ENST00000446533.3
 CHAC1

ChaC, cation transport regulator homolog 1 (E. coli)

chr7_-_2883928 0.330 ENST00000275364.3
 GNA12
guanine nucleotide binding protein (G protein) alpha 12
chr6_-_111927062 0.326 ENST00000359831.4
 TRAF3IP2
TRAF3 interacting protein 2
chr7_+_100210133 0.309 ENST00000393950.2
ENST00000424091.2
 MOSPD3

motile sperm domain containing 3

chr7_+_100209725 0.290 ENST00000223054.4
 MOSPD3
motile sperm domain containing 3
chr7_+_100209979 0.286 ENST00000493970.1
ENST00000379527.2
 MOSPD3

motile sperm domain containing 3

chr1_+_44115814 0.210 ENST00000372396.3
 KDM4A
lysine (K)-specific demethylase 4A
chr12_+_54718904 0.206 ENST00000262061.2
ENST00000549043.1
ENST00000552218.1
ENST00000553231.1
ENST00000552362.1
ENST00000455864.2
ENST00000416254.2
ENST00000549116.1
ENST00000551779.1
 COPZ1








coatomer protein complex, subunit zeta 1








chr12_-_9102549 0.196 ENST00000000412.3
 M6PR
mannose-6-phosphate receptor (cation dependent)
chr1_-_21377383 0.195 ENST00000374935.3
 EIF4G3
eukaryotic translation initiation factor 4 gamma, 3
chr4_-_69536346 0.185 ENST00000338206.5
 UGT2B15
UDP glucuronosyltransferase 2 family, polypeptide B15
chr1_-_151762943 0.181 ENST00000368825.3
ENST00000368823.1
ENST00000458431.2
ENST00000368827.6
ENST00000368824.3
 TDRKH




tudor and KH domain containing




chr9_+_34646651 0.179 ENST00000378842.3
 GALT
galactose-1-phosphate uridylyltransferase
chr1_+_151735431 0.172 ENST00000321531.5
ENST00000315067.8
 OAZ3

ornithine decarboxylase antizyme 3

chr9_+_34646624 0.166 ENST00000450095.2
ENST00000556278.1
 GALT
GALT
galactose-1-phosphate uridylyltransferase
Uncharacterized protein
chr4_+_71587669 0.156 ENST00000381006.3
ENST00000226328.4
 RUFY3

RUN and FYVE domain containing 3

chr7_-_100183742 0.156 ENST00000310300.6
 LRCH4
leucine-rich repeats and calponin homology (CH) domain containing 4
chr10_-_28571015 0.136 ENST00000375719.3
ENST00000375732.1
 MPP7

membrane protein, palmitoylated 7 (MAGUK p55 subfamily member 7)

chr8_+_9413410 0.124 ENST00000520408.1
ENST00000310430.6
ENST00000522110.1
 TNKS


tankyrase, TRF1-interacting ankyrin-related ADP-ribose polymerase


chr20_+_54967409 0.115 ENST00000415828.1
ENST00000217109.4
ENST00000428552.1
 CSTF1


cleavage stimulation factor, 3' pre-RNA, subunit 1, 50kDa


chrX_-_139587225 0.102 ENST00000370536.2
 SOX3
SRY (sex determining region Y)-box 3
chr7_+_100183927 0.099 ENST00000241071.6
ENST00000360609.2
 FBXO24

F-box protein 24

chr11_-_71823266 0.098 ENST00000538919.1
ENST00000539395.1
ENST00000542531.1
 ANAPC15


anaphase promoting complex subunit 15


chr4_-_69434245 0.095 ENST00000317746.2
 UGT2B17
UDP glucuronosyltransferase 2 family, polypeptide B17
chr20_+_56964169 0.093 ENST00000475243.1
 VAPB
VAMP (vesicle-associated membrane protein)-associated protein B and C
chr19_+_17378278 0.089 ENST00000596335.1
ENST00000601436.1
ENST00000595632.1
 BABAM1


BRISC and BRCA1 A complex member 1


chr5_-_132200477 0.087 ENST00000296875.2
 GDF9
growth differentiation factor 9
chr7_-_99716952 0.087 ENST00000523306.1
ENST00000344095.4
ENST00000417349.1
ENST00000493322.1
ENST00000520135.1
ENST00000418432.2
ENST00000460673.2
ENST00000452041.1
ENST00000452438.2
ENST00000451699.1
ENST00000453269.2
 TAF6










TAF6 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 80kDa










chr1_+_202317815 0.085 ENST00000608999.1
ENST00000336894.4
ENST00000480184.1
 PPP1R12B


protein phosphatase 1, regulatory subunit 12B


chr9_-_95056010 0.085 ENST00000443024.2
 IARS
isoleucyl-tRNA synthetase
chr14_-_23504337 0.079 ENST00000361611.6
 PSMB5
proteasome (prosome, macropain) subunit, beta type, 5
chr17_-_43045439 0.079 ENST00000253407.3
 C1QL1
complement component 1, q subcomponent-like 1
chr5_+_150639360 0.079 ENST00000523004.1
 GM2A
GM2 ganglioside activator
chr3_-_114866084 0.073 ENST00000357258.3
 ZBTB20
zinc finger and BTB domain containing 20
chr11_+_17298297 0.072 ENST00000529010.1
 NUCB2
nucleobindin 2
chr3_-_11685345 0.070 ENST00000430365.2
 VGLL4
vestigial like 4 (Drosophila)
chr19_+_17378159 0.060 ENST00000598188.1
ENST00000359435.4
ENST00000599474.1
ENST00000599057.1
ENST00000601043.1
ENST00000447614.2
 BABAM1





BRISC and BRCA1 A complex member 1





chr11_-_71823796 0.060 ENST00000545680.1
ENST00000543587.1
ENST00000538393.1
ENST00000535234.1
ENST00000227618.4
ENST00000535503.1
 ANAPC15





anaphase promoting complex subunit 15





chr11_-_71823715 0.059 ENST00000545944.1
ENST00000502597.2
 ANAPC15

anaphase promoting complex subunit 15

chr14_-_23504432 0.053 ENST00000425762.2
 PSMB5
proteasome (prosome, macropain) subunit, beta type, 5
chr11_-_13517565 0.053 ENST00000282091.1
ENST00000529816.1
 PTH

parathyroid hormone

chr12_-_10955226 0.051 ENST00000240687.2
 TAS2R7
taste receptor, type 2, member 7
chr12_-_57039739 0.051 ENST00000552959.1
ENST00000551020.1
ENST00000553007.2
ENST00000552919.1
ENST00000552104.1
ENST00000262030.3
 ATP5B





ATP synthase, H+ transporting, mitochondrial F1 complex, beta polypeptide





chr2_-_98280383 0.048 ENST00000289228.5
 ACTR1B
ARP1 actin-related protein 1 homolog B, centractin beta (yeast)
chr11_+_17298255 0.031 ENST00000531172.1
ENST00000533738.2
ENST00000323688.6
 NUCB2


nucleobindin 2


chrX_+_113818545 0.031 ENST00000371951.1
ENST00000276198.1
ENST00000371950.3
 HTR2C


5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled


chr19_-_10121144 0.030 ENST00000264828.3
 COL5A3
collagen, type V, alpha 3
chr4_-_46996424 0.030 ENST00000264318.3
 GABRA4
gamma-aminobutyric acid (GABA) A receptor, alpha 4
chr8_+_1993173 0.019 ENST00000523438.1
 MYOM2
myomesin 2
chr9_-_5339873 0.016 ENST00000223862.1
ENST00000223858.4
 RLN1

relaxin 1

chr1_-_228613026 0.014 ENST00000366696.1
 HIST3H3
histone cluster 3, H3
chr8_+_1993152 0.011 ENST00000262113.4
 MYOM2
myomesin 2
chr16_+_69345243 0.009 ENST00000254950.11
 VPS4A
vacuolar protein sorting 4 homolog A (S. cerevisiae)
chr3_+_129247479 0.009 ENST00000296271.3
 RHO
rhodopsin
chr18_+_39535152 0.001 ENST00000262039.4
ENST00000398870.3
ENST00000586545.1
 PIK3C3


phosphatidylinositol 3-kinase, catalytic subunit type 3


chr19_+_42817527 0.000 ENST00000598766.1
 TMEM145
transmembrane protein 145

Gene Ontology Analysis

Gene overrepresentation in biological_process category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.2 GO:0070544 histone H3-K36 demethylation(GO:0070544)
0.0 0.3 GO:0019388 galactose catabolic process(GO:0019388)
0.0 0.8 GO:0007520 myoblast fusion(GO:0007520)
0.0 0.1 GO:1904358 positive regulation of telomere maintenance via telomerase(GO:0032212) positive regulation of telomere maintenance via telomere lengthening(GO:1904358)
0.0 1.8 GO:0090263 positive regulation of canonical Wnt signaling pathway(GO:0090263)
0.0 0.1 GO:1902414 protein localization to adherens junction(GO:0071896) protein localization to cell junction(GO:1902414)
0.0 0.1 GO:0006428 isoleucyl-tRNA aminoacylation(GO:0006428)
0.0 0.4 GO:0048821 erythrocyte development(GO:0048821) myeloid cell development(GO:0061515)
0.0 0.3 GO:0070059 intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress(GO:0070059)
0.0 0.2 GO:0035964 COPI-coated vesicle budding(GO:0035964) Golgi vesicle budding(GO:0048194) Golgi transport vesicle coating(GO:0048200) COPI coating of Golgi vesicle(GO:0048205)
0.0 0.5 GO:0015813 L-glutamate transport(GO:0015813)
0.0 0.2 GO:0007128 meiotic prophase I(GO:0007128)
0.0 0.1 GO:0009313 oligosaccharide catabolic process(GO:0009313)
0.0 0.1 GO:0008628 hormone-mediated apoptotic signaling pathway(GO:0008628)
0.0 0.1 GO:0006379 mRNA cleavage(GO:0006379)

Gene overrepresentation in cellular_component category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 0.1 GO:0070552 BRISC complex(GO:0070552)
0.0 0.2 GO:0030126 COPI vesicle coat(GO:0030126)
0.0 0.1 GO:0005889 hydrogen:potassium-exchanging ATPase complex(GO:0005889)
0.0 0.1 GO:0005797 Golgi medial cisterna(GO:0005797)
0.0 0.0 GO:0005588 collagen type V trimer(GO:0005588)

Gene overrepresentation in molecular_function category:

Log-likelihood per target  Total log-likelihood Term Description
0.1 0.8 GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity(GO:0010859)
0.1 0.4 GO:0004083 bisphosphoglycerate mutase activity(GO:0004082) bisphosphoglycerate 2-phosphatase activity(GO:0004083) phosphoglycerate mutase activity(GO:0004619)
0.0 0.2 GO:0051864 histone demethylase activity (H3-K36 specific)(GO:0051864)
0.0 0.3 GO:0070569 uridylyltransferase activity(GO:0070569)
0.0 0.8 GO:0045028 G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028)
0.0 0.1 GO:0004822 isoleucine-tRNA ligase activity(GO:0004822)
0.0 0.3 GO:0050780 dopamine receptor binding(GO:0050780)
0.0 0.2 GO:0008073 ornithine decarboxylase inhibitor activity(GO:0008073)
0.0 0.2 GO:0000339 RNA cap binding(GO:0000339)
0.0 0.2 GO:0005537 mannose binding(GO:0005537)

Gene overrepresentation in C2:CP category:

Log-likelihood per target  Total log-likelihood Term Description
0.0 1.0 ST_ERK1_ERK2_MAPK_PATHWAY ERK1/ERK2 MAPK Pathway