Motif ID: NFATC4
Z-value: 1.702
Transcription factors associated with NFATC4:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| NFATC4 | ENSG00000100968.9 | NFATC4 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.9 | GO:0009609 | response to symbiont(GO:0009608) response to symbiotic bacterium(GO:0009609) |
| 0.9 | 2.6 | GO:0007412 | axon target recognition(GO:0007412) |
| 0.7 | 2.0 | GO:0019482 | beta-alanine metabolic process(GO:0019482) |
| 0.6 | 1.7 | GO:2000064 | regulation of cortisol biosynthetic process(GO:2000064) |
| 0.4 | 1.2 | GO:0006348 | chromatin silencing at telomere(GO:0006348) |
| 0.4 | 2.4 | GO:2000172 | regulation of branching morphogenesis of a nerve(GO:2000172) |
| 0.3 | 1.9 | GO:0060242 | contact inhibition(GO:0060242) |
| 0.3 | 2.8 | GO:0008354 | germ cell migration(GO:0008354) |
| 0.3 | 1.5 | GO:0006651 | diacylglycerol biosynthetic process(GO:0006651) |
| 0.3 | 0.8 | GO:2000121 | regulation of removal of superoxide radicals(GO:2000121) |
| 0.3 | 1.3 | GO:0007221 | positive regulation of transcription of Notch receptor target(GO:0007221) |
| 0.2 | 5.5 | GO:0030199 | collagen fibril organization(GO:0030199) |
| 0.2 | 1.4 | GO:0022614 | membrane to membrane docking(GO:0022614) chorio-allantoic fusion(GO:0060710) |
| 0.2 | 0.7 | GO:0014063 | regulation of serotonin secretion(GO:0014062) negative regulation of serotonin secretion(GO:0014063) |
| 0.2 | 0.9 | GO:0050653 | UDP-N-acetylgalactosamine metabolic process(GO:0019276) chondroitin sulfate proteoglycan biosynthetic process, polysaccharide chain biosynthetic process(GO:0050653) |
| 0.2 | 1.3 | GO:0045916 | negative regulation of complement activation(GO:0045916) negative regulation of protein activation cascade(GO:2000258) |
| 0.2 | 0.6 | GO:0060596 | mammary placode formation(GO:0060596) |
| 0.2 | 1.6 | GO:0040037 | negative regulation of fibroblast growth factor receptor signaling pathway(GO:0040037) |
| 0.2 | 1.6 | GO:0060666 | dichotomous subdivision of terminal units involved in salivary gland branching(GO:0060666) |
| 0.2 | 1.0 | GO:0007499 | ectoderm and mesoderm interaction(GO:0007499) |
| 0.2 | 0.5 | GO:0010836 | negative regulation of protein ADP-ribosylation(GO:0010836) negative regulation of protein glycosylation(GO:0060051) |
| 0.2 | 1.1 | GO:0035162 | embryonic hemopoiesis(GO:0035162) |
| 0.2 | 0.8 | GO:0007386 | compartment pattern specification(GO:0007386) |
| 0.1 | 4.3 | GO:0030224 | monocyte differentiation(GO:0030224) |
| 0.1 | 1.5 | GO:0050872 | white fat cell differentiation(GO:0050872) |
| 0.1 | 0.5 | GO:0072180 | mesonephric duct morphogenesis(GO:0072180) |
| 0.1 | 1.3 | GO:0090292 | nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292) |
| 0.1 | 0.7 | GO:0035414 | negative regulation of catenin import into nucleus(GO:0035414) |
| 0.1 | 1.1 | GO:0034638 | phosphatidylcholine catabolic process(GO:0034638) |
| 0.1 | 0.7 | GO:0032527 | retrograde protein transport, ER to cytosol(GO:0030970) protein exit from endoplasmic reticulum(GO:0032527) |
| 0.1 | 0.4 | GO:0042118 | endothelial cell activation(GO:0042118) |
| 0.1 | 0.9 | GO:0003065 | regulation of heart rate by chemical signal(GO:0003062) positive regulation of heart rate by epinephrine(GO:0003065) |
| 0.1 | 0.1 | GO:0032672 | regulation of interleukin-3 production(GO:0032672) positive regulation of interleukin-3 production(GO:0032752) interleukin-3 biosynthetic process(GO:0042223) regulation of interleukin-3 biosynthetic process(GO:0045399) positive regulation of interleukin-3 biosynthetic process(GO:0045401) |
| 0.1 | 0.4 | GO:0048619 | embryonic hindgut morphogenesis(GO:0048619) |
| 0.1 | 0.5 | GO:0061003 | positive regulation of dendritic spine morphogenesis(GO:0061003) |
| 0.1 | 1.8 | GO:0032012 | regulation of ARF protein signal transduction(GO:0032012) |
| 0.1 | 0.7 | GO:0060363 | cranial suture morphogenesis(GO:0060363) craniofacial suture morphogenesis(GO:0097094) |
| 0.1 | 0.5 | GO:0010842 | retina layer formation(GO:0010842) |
| 0.1 | 0.2 | GO:0007500 | mesodermal cell fate determination(GO:0007500) |
| 0.1 | 0.7 | GO:0009249 | protein lipoylation(GO:0009249) |
| 0.1 | 0.7 | GO:0030048 | actin filament-based movement(GO:0030048) |
| 0.1 | 0.4 | GO:0046069 | cGMP catabolic process(GO:0046069) |
| 0.1 | 0.6 | GO:0030206 | chondroitin sulfate biosynthetic process(GO:0030206) |
| 0.1 | 2.5 | GO:0030866 | cortical actin cytoskeleton organization(GO:0030866) |
| 0.1 | 1.1 | GO:0051319 | mitotic G2 phase(GO:0000085) G2 phase(GO:0051319) |
| 0.1 | 1.0 | GO:0008347 | glial cell migration(GO:0008347) |
| 0.1 | 0.5 | GO:0040032 | post-embryonic body morphogenesis(GO:0040032) |
| 0.1 | 2.7 | GO:0030520 | intracellular estrogen receptor signaling pathway(GO:0030520) |
| 0.1 | 1.0 | GO:0045749 | obsolete negative regulation of S phase of mitotic cell cycle(GO:0045749) |
| 0.1 | 0.3 | GO:0003416 | endochondral bone growth(GO:0003416) growth plate cartilage development(GO:0003417) bone growth(GO:0098868) |
| 0.1 | 0.5 | GO:0001510 | RNA methylation(GO:0001510) |
| 0.0 | 0.4 | GO:0000185 | activation of MAPKKK activity(GO:0000185) |
| 0.0 | 1.4 | GO:0016486 | peptide hormone processing(GO:0016486) |
| 0.0 | 0.3 | GO:0051708 | intracellular transport of viral protein in host cell(GO:0019060) symbiont intracellular protein transport in host(GO:0030581) regulation by virus of viral protein levels in host cell(GO:0046719) intracellular protein transport in other organism involved in symbiotic interaction(GO:0051708) |
| 0.0 | 0.3 | GO:0042448 | progesterone metabolic process(GO:0042448) |
| 0.0 | 1.1 | GO:0007263 | nitric oxide mediated signal transduction(GO:0007263) |
| 0.0 | 3.5 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
| 0.0 | 0.3 | GO:0009396 | folic acid-containing compound biosynthetic process(GO:0009396) |
| 0.0 | 0.1 | GO:0019521 | aldonic acid metabolic process(GO:0019520) D-gluconate metabolic process(GO:0019521) |
| 0.0 | 1.3 | GO:0000188 | inactivation of MAPK activity(GO:0000188) |
| 0.0 | 1.3 | GO:0030837 | negative regulation of actin filament polymerization(GO:0030837) |
| 0.0 | 0.7 | GO:0007528 | neuromuscular junction development(GO:0007528) |
| 0.0 | 2.4 | GO:0006665 | sphingolipid metabolic process(GO:0006665) |
| 0.0 | 1.7 | GO:0030282 | bone mineralization(GO:0030282) |
| 0.0 | 0.4 | GO:0050812 | acetyl-CoA biosynthetic process from pyruvate(GO:0006086) regulation of acetyl-CoA biosynthetic process from pyruvate(GO:0010510) regulation of acyl-CoA biosynthetic process(GO:0050812) |
| 0.0 | 0.1 | GO:0033590 | response to cobalamin(GO:0033590) |
| 0.0 | 0.2 | GO:0007016 | cytoskeletal anchoring at plasma membrane(GO:0007016) |
| 0.0 | 0.1 | GO:0045898 | regulation of RNA polymerase II transcriptional preinitiation complex assembly(GO:0045898) |
| 0.0 | 0.2 | GO:0006942 | regulation of striated muscle contraction(GO:0006942) |
| 0.0 | 0.2 | GO:0006084 | acetyl-CoA metabolic process(GO:0006084) |
| 0.0 | 0.0 | GO:0071635 | negative regulation of transforming growth factor beta production(GO:0071635) |
| 0.0 | 1.3 | GO:0008154 | actin polymerization or depolymerization(GO:0008154) |
| 0.0 | 0.1 | GO:0009642 | response to light intensity(GO:0009642) |
| 0.0 | 1.0 | GO:0007585 | respiratory gaseous exchange(GO:0007585) |
| 0.0 | 2.6 | GO:0043281 | regulation of cysteine-type endopeptidase activity involved in apoptotic process(GO:0043281) |
| 0.0 | 0.5 | GO:0060048 | cardiac muscle contraction(GO:0060048) |
| 0.0 | 4.5 | GO:0007517 | muscle organ development(GO:0007517) |
| 0.0 | 0.6 | GO:0090263 | positive regulation of canonical Wnt signaling pathway(GO:0090263) |
| 0.0 | 5.5 | GO:0051056 | regulation of small GTPase mediated signal transduction(GO:0051056) |
| 0.0 | 1.3 | GO:0006986 | response to unfolded protein(GO:0006986) |
| 0.0 | 0.5 | GO:0007368 | determination of left/right symmetry(GO:0007368) |
| 0.0 | 0.4 | GO:0006305 | DNA alkylation(GO:0006305) DNA methylation(GO:0006306) |
| 0.0 | 0.0 | GO:0032621 | interleukin-18 production(GO:0032621) regulation of interleukin-18 production(GO:0032661) |
| 0.0 | 0.3 | GO:0009615 | response to virus(GO:0009615) |
| 0.0 | 1.4 | GO:0034138 | toll-like receptor 3 signaling pathway(GO:0034138) |
| 0.0 | 0.1 | GO:0035329 | hippo signaling(GO:0035329) |
| 0.0 | 0.2 | GO:0051925 | obsolete regulation of calcium ion transport via voltage-gated calcium channel activity(GO:0051925) |
| 0.0 | 0.1 | GO:0010447 | response to acidic pH(GO:0010447) |
| 0.0 | 0.2 | GO:0042403 | thyroid hormone metabolic process(GO:0042403) |
| 0.0 | 0.5 | GO:0006888 | ER to Golgi vesicle-mediated transport(GO:0006888) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.1 | 3.4 | GO:0005588 | collagen type V trimer(GO:0005588) |
| 0.5 | 1.4 | GO:0071065 | alpha9-beta1 integrin-vascular cell adhesion molecule-1 complex(GO:0071065) |
| 0.4 | 5.9 | GO:0098647 | collagen type VI trimer(GO:0005589) collagen beaded filament(GO:0098647) |
| 0.3 | 0.8 | GO:0071953 | elastic fiber(GO:0071953) |
| 0.2 | 1.5 | GO:0032311 | angiogenin-PRI complex(GO:0032311) |
| 0.2 | 0.7 | GO:0031594 | neuromuscular junction(GO:0031594) |
| 0.2 | 2.1 | GO:0098643 | fibrillar collagen trimer(GO:0005583) banded collagen fibril(GO:0098643) |
| 0.2 | 0.5 | GO:0010370 | perinucleolar chromocenter(GO:0010370) |
| 0.2 | 2.4 | GO:0008091 | spectrin(GO:0008091) |
| 0.1 | 1.2 | GO:0005677 | chromatin silencing complex(GO:0005677) |
| 0.1 | 1.1 | GO:0008074 | guanylate cyclase complex, soluble(GO:0008074) |
| 0.1 | 3.2 | GO:0016010 | dystrophin-associated glycoprotein complex(GO:0016010) glycoprotein complex(GO:0090665) |
| 0.1 | 1.3 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.1 | 0.4 | GO:0033270 | paranode region of axon(GO:0033270) |
| 0.1 | 3.5 | GO:0098636 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.1 | 0.9 | GO:0032059 | bleb(GO:0032059) |
| 0.1 | 0.4 | GO:0070369 | beta-catenin-TCF7L2 complex(GO:0070369) beta-catenin-TCF complex(GO:1990907) |
| 0.0 | 0.5 | GO:0032588 | trans-Golgi network membrane(GO:0032588) |
| 0.0 | 0.2 | GO:0031362 | anchored component of external side of plasma membrane(GO:0031362) |
| 0.0 | 1.5 | GO:0005913 | cell-cell adherens junction(GO:0005913) |
| 0.0 | 0.9 | GO:0005811 | lipid particle(GO:0005811) |
| 0.0 | 1.5 | GO:0030173 | integral component of Golgi membrane(GO:0030173) |
| 0.0 | 0.4 | GO:0031265 | CD95 death-inducing signaling complex(GO:0031265) |
| 0.0 | 2.6 | GO:0030426 | growth cone(GO:0030426) |
| 0.0 | 1.9 | GO:0030176 | integral component of endoplasmic reticulum membrane(GO:0030176) |
| 0.0 | 0.5 | GO:0031201 | SNARE complex(GO:0031201) |
| 0.0 | 0.2 | GO:0030992 | intraciliary transport particle B(GO:0030992) |
| 0.0 | 0.3 | GO:0005868 | cytoplasmic dynein complex(GO:0005868) |
| 0.0 | 0.2 | GO:0046658 | anchored component of plasma membrane(GO:0046658) |
| 0.0 | 1.3 | GO:0031093 | platelet alpha granule lumen(GO:0031093) |
| 0.0 | 0.4 | GO:0005720 | nuclear heterochromatin(GO:0005720) |
| 0.0 | 0.4 | GO:0030134 | ER to Golgi transport vesicle(GO:0030134) |
| 0.0 | 1.6 | GO:0005795 | Golgi stack(GO:0005795) |
| 0.0 | 2.5 | GO:0043025 | neuronal cell body(GO:0043025) |
| 0.0 | 2.3 | GO:0005912 | adherens junction(GO:0005912) |
| 0.0 | 0.1 | GO:0044665 | MLL1/2 complex(GO:0044665) MLL1 complex(GO:0071339) |
| 0.0 | 1.3 | GO:0014069 | postsynaptic density(GO:0014069) postsynaptic specialization(GO:0099572) |
| 0.0 | 0.0 | GO:0032009 | early phagosome(GO:0032009) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.8 | GO:0016312 | inositol bisphosphate phosphatase activity(GO:0016312) |
| 0.5 | 2.6 | GO:0031694 | alpha-2A adrenergic receptor binding(GO:0031694) |
| 0.5 | 2.8 | GO:0042577 | lipid phosphatase activity(GO:0042577) |
| 0.4 | 1.3 | GO:0019958 | C-X-C chemokine binding(GO:0019958) interleukin-8 binding(GO:0019959) |
| 0.4 | 1.3 | GO:0000150 | recombinase activity(GO:0000150) |
| 0.4 | 1.2 | GO:0005017 | platelet-derived growth factor-activated receptor activity(GO:0005017) |
| 0.4 | 1.1 | GO:0047391 | alkylglycerophosphoethanolamine phosphodiesterase activity(GO:0047391) |
| 0.3 | 2.4 | GO:0042731 | PH domain binding(GO:0042731) |
| 0.3 | 1.2 | GO:0042903 | tubulin deacetylase activity(GO:0042903) |
| 0.3 | 0.9 | GO:0008955 | peptidoglycan glycosyltransferase activity(GO:0008955) |
| 0.3 | 0.8 | GO:0016524 | latrotoxin receptor activity(GO:0016524) |
| 0.2 | 1.7 | GO:0030021 | extracellular matrix structural constituent conferring compression resistance(GO:0030021) structural constituent of tooth enamel(GO:0030345) |
| 0.2 | 2.1 | GO:0048407 | platelet-derived growth factor binding(GO:0048407) |
| 0.2 | 1.3 | GO:0097493 | extracellular matrix constituent conferring elasticity(GO:0030023) structural molecule activity conferring elasticity(GO:0097493) |
| 0.2 | 3.0 | GO:0004065 | arylsulfatase activity(GO:0004065) |
| 0.2 | 3.9 | GO:0004602 | glutathione peroxidase activity(GO:0004602) |
| 0.2 | 1.5 | GO:0004522 | ribonuclease A activity(GO:0004522) |
| 0.2 | 1.6 | GO:0017154 | semaphorin receptor activity(GO:0017154) |
| 0.2 | 3.0 | GO:0008430 | selenium binding(GO:0008430) |
| 0.2 | 3.9 | GO:0004697 | protein kinase C activity(GO:0004697) |
| 0.2 | 0.5 | GO:0008174 | mRNA methyltransferase activity(GO:0008174) |
| 0.1 | 0.6 | GO:0034481 | chondroitin sulfotransferase activity(GO:0034481) |
| 0.1 | 3.1 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.1 | 0.5 | GO:0060422 | peptidyl-dipeptidase inhibitor activity(GO:0060422) |
| 0.1 | 0.6 | GO:0008131 | primary amine oxidase activity(GO:0008131) |
| 0.1 | 2.0 | GO:0000062 | fatty-acyl-CoA binding(GO:0000062) |
| 0.1 | 1.8 | GO:0005086 | ARF guanyl-nucleotide exchange factor activity(GO:0005086) |
| 0.1 | 0.4 | GO:0004741 | magnesium-dependent protein serine/threonine phosphatase activity(GO:0004724) [pyruvate dehydrogenase (lipoamide)] phosphatase activity(GO:0004741) |
| 0.1 | 1.3 | GO:0005521 | lamin binding(GO:0005521) |
| 0.1 | 0.3 | GO:0016882 | cyclo-ligase activity(GO:0016882) |
| 0.1 | 0.4 | GO:0070087 | chromo shadow domain binding(GO:0070087) |
| 0.1 | 0.4 | GO:0048101 | calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity(GO:0048101) |
| 0.1 | 0.2 | GO:0047708 | biotinidase activity(GO:0047708) |
| 0.1 | 5.9 | GO:0004867 | serine-type endopeptidase inhibitor activity(GO:0004867) |
| 0.1 | 1.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.1 | 0.3 | GO:0004692 | cGMP-dependent protein kinase activity(GO:0004692) |
| 0.1 | 1.1 | GO:0004383 | guanylate cyclase activity(GO:0004383) |
| 0.1 | 0.5 | GO:0031852 | mu-type opioid receptor binding(GO:0031852) |
| 0.0 | 3.4 | GO:0046332 | SMAD binding(GO:0046332) |
| 0.0 | 1.0 | GO:0001540 | beta-amyloid binding(GO:0001540) |
| 0.0 | 0.2 | GO:0003989 | acetyl-CoA carboxylase activity(GO:0003989) |
| 0.0 | 5.0 | GO:0035091 | phosphatidylinositol binding(GO:0035091) |
| 0.0 | 0.1 | GO:0019763 | immunoglobulin receptor activity(GO:0019763) |
| 0.0 | 1.4 | GO:0005518 | collagen binding(GO:0005518) |
| 0.0 | 0.8 | GO:0005388 | calcium-transporting ATPase activity(GO:0005388) |
| 0.0 | 0.2 | GO:0008331 | high voltage-gated calcium channel activity(GO:0008331) |
| 0.0 | 0.2 | GO:0008599 | protein phosphatase type 1 regulator activity(GO:0008599) |
| 0.0 | 0.4 | GO:0070016 | armadillo repeat domain binding(GO:0070016) |
| 0.0 | 1.6 | GO:0043028 | cysteine-type endopeptidase regulator activity involved in apoptotic process(GO:0043028) |
| 0.0 | 0.5 | GO:0005537 | mannose binding(GO:0005537) |
| 0.0 | 0.5 | GO:0042813 | Wnt-activated receptor activity(GO:0042813) |
| 0.0 | 2.9 | GO:0005070 | SH3/SH2 adaptor activity(GO:0005070) |
| 0.0 | 0.1 | GO:0033867 | Fas-activated serine/threonine kinase activity(GO:0033867) |
| 0.0 | 0.1 | GO:0043184 | vascular endothelial growth factor receptor 2 binding(GO:0043184) |
| 0.0 | 0.7 | GO:0008373 | sialyltransferase activity(GO:0008373) |
| 0.0 | 0.7 | GO:0070888 | E-box binding(GO:0070888) |
| 0.0 | 0.5 | GO:0042162 | telomeric DNA binding(GO:0042162) |
| 0.0 | 4.9 | GO:0003714 | transcription corepressor activity(GO:0003714) |
| 0.0 | 0.3 | GO:0008140 | cAMP response element binding protein binding(GO:0008140) |
| 0.0 | 0.2 | GO:0030172 | troponin C binding(GO:0030172) |
| 0.0 | 5.2 | GO:0016564 | obsolete transcription repressor activity(GO:0016564) |
| 0.0 | 2.0 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 2.8 | GO:0051082 | unfolded protein binding(GO:0051082) |
| 0.0 | 0.1 | GO:0004616 | phosphogluconate dehydrogenase (decarboxylating) activity(GO:0004616) |
| 0.0 | 1.6 | GO:0004197 | cysteine-type endopeptidase activity(GO:0004197) |
| 0.0 | 0.5 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.0 | 0.4 | GO:0005520 | insulin-like growth factor binding(GO:0005520) |
| 0.0 | 0.1 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
| 0.0 | 0.1 | GO:0008273 | calcium, potassium:sodium antiporter activity(GO:0008273) |
| 0.0 | 0.2 | GO:0004190 | aspartic-type endopeptidase activity(GO:0004190) aspartic-type peptidase activity(GO:0070001) |
| 0.0 | 0.2 | GO:0004062 | aryl sulfotransferase activity(GO:0004062) |
| 0.0 | 0.1 | GO:0046980 | oligopeptide-transporting ATPase activity(GO:0015421) tapasin binding(GO:0046980) |
| 0.0 | 0.1 | GO:0017034 | Rap guanyl-nucleotide exchange factor activity(GO:0017034) |
| 0.0 | 1.9 | GO:0003774 | motor activity(GO:0003774) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.0 | 2.4 | ST_ERK1_ERK2_MAPK_PATHWAY | ERK1/ERK2 MAPK Pathway |
| 0.0 | 1.4 | ST_WNT_BETA_CATENIN_PATHWAY | Wnt/beta-catenin Pathway |
| 0.0 | 1.0 | ST_GAQ_PATHWAY | G alpha q Pathway |
| 0.0 | 0.6 | SIG_PIP3_SIGNALING_IN_CARDIAC_MYOCTES | Genes related to PIP3 signaling in cardiac myocytes |
| 0.0 | 0.4 | ST_TUMOR_NECROSIS_FACTOR_PATHWAY | Tumor Necrosis Factor Pathway. |
