Motif ID: NFE2L1
Z-value: 1.754
Transcription factors associated with NFE2L1:
| Gene Symbol | Entrez ID | Gene Name |
|---|---|---|
| NFE2L1 | ENSG00000082641.11 | NFE2L1 |
Top targets:
Gene overrepresentation in biological_process category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 1.0 | 3.0 | GO:0071639 | positive regulation of vitamin metabolic process(GO:0046136) positive regulation of vitamin D biosynthetic process(GO:0060557) positive regulation of calcidiol 1-monooxygenase activity(GO:0060559) positive regulation of monocyte chemotactic protein-1 production(GO:0071639) |
| 1.0 | 13.9 | GO:1901797 | negative regulation of DNA damage response, signal transduction by p53 class mediator(GO:0043518) negative regulation of signal transduction by p53 class mediator(GO:1901797) |
| 0.8 | 7.3 | GO:0051552 | flavone metabolic process(GO:0051552) |
| 0.6 | 1.9 | GO:0000738 | DNA catabolic process, exonucleolytic(GO:0000738) |
| 0.6 | 1.7 | GO:0046586 | regulation of calcium-dependent cell-cell adhesion(GO:0046586) |
| 0.5 | 1.4 | GO:0021769 | orbitofrontal cortex development(GO:0021769) ventricular zone neuroblast division(GO:0021847) fibroblast growth factor receptor signaling pathway involved in negative regulation of apoptotic process in bone marrow(GO:0035602) fibroblast growth factor receptor signaling pathway involved in hemopoiesis(GO:0035603) fibroblast growth factor receptor signaling pathway involved in positive regulation of cell proliferation in bone marrow(GO:0035604) fibroblast growth factor receptor signaling pathway involved in orbitofrontal cortex development(GO:0035607) fibroblast growth factor receptor signaling pathway involved in mammary gland specification(GO:0060595) mammary gland bud formation(GO:0060615) branch elongation involved in salivary gland morphogenesis(GO:0060667) mesenchymal cell differentiation involved in lung development(GO:0060915) |
| 0.4 | 1.5 | GO:0060708 | spongiotrophoblast differentiation(GO:0060708) |
| 0.3 | 1.3 | GO:0090161 | Golgi ribbon formation(GO:0090161) |
| 0.3 | 1.9 | GO:2000124 | cannabinoid signaling pathway(GO:0038171) endocannabinoid signaling pathway(GO:0071926) regulation of endocannabinoid signaling pathway(GO:2000124) |
| 0.3 | 1.1 | GO:0031223 | auditory behavior(GO:0031223) malate-aspartate shuttle(GO:0043490) |
| 0.2 | 0.7 | GO:0060279 | progesterone secretion(GO:0042701) regulation of ovulation(GO:0060278) positive regulation of ovulation(GO:0060279) |
| 0.2 | 6.9 | GO:0007398 | ectoderm development(GO:0007398) |
| 0.2 | 2.2 | GO:0051654 | establishment of mitochondrion localization(GO:0051654) |
| 0.2 | 1.1 | GO:0016255 | attachment of GPI anchor to protein(GO:0016255) |
| 0.2 | 0.5 | GO:0046931 | pore complex assembly(GO:0046931) |
| 0.2 | 0.9 | GO:0042159 | lipoprotein catabolic process(GO:0042159) |
| 0.1 | 0.6 | GO:0006931 | substrate-dependent cell migration, cell attachment to substrate(GO:0006931) |
| 0.1 | 2.1 | GO:0060638 | mesenchymal-epithelial cell signaling(GO:0060638) |
| 0.1 | 0.8 | GO:0045176 | apical protein localization(GO:0045176) |
| 0.1 | 0.3 | GO:0019441 | tryptophan catabolic process to kynurenine(GO:0019441) |
| 0.1 | 0.6 | GO:0099515 | nuclear migration along microfilament(GO:0031022) actin filament-based transport(GO:0099515) |
| 0.1 | 0.6 | GO:0002313 | mature B cell differentiation involved in immune response(GO:0002313) |
| 0.1 | 0.6 | GO:0060242 | contact inhibition(GO:0060242) |
| 0.1 | 1.3 | GO:0051016 | barbed-end actin filament capping(GO:0051016) |
| 0.1 | 0.3 | GO:0045091 | regulation of single stranded viral RNA replication via double stranded DNA intermediate(GO:0045091) |
| 0.1 | 0.3 | GO:0070171 | negative regulation of tooth mineralization(GO:0070171) |
| 0.1 | 0.8 | GO:0045741 | positive regulation of epidermal growth factor-activated receptor activity(GO:0045741) |
| 0.1 | 0.2 | GO:0016476 | regulation of embryonic cell shape(GO:0016476) |
| 0.1 | 0.5 | GO:0035313 | wound healing, spreading of epidermal cells(GO:0035313) wound healing, spreading of cells(GO:0044319) epiboly(GO:0090504) epiboly involved in wound healing(GO:0090505) |
| 0.1 | 0.4 | GO:0032472 | cellular manganese ion homeostasis(GO:0030026) Golgi calcium ion homeostasis(GO:0032468) Golgi calcium ion transport(GO:0032472) manganese ion homeostasis(GO:0055071) |
| 0.1 | 0.4 | GO:0000098 | sulfur amino acid catabolic process(GO:0000098) |
| 0.1 | 1.5 | GO:0045104 | intermediate filament cytoskeleton organization(GO:0045104) |
| 0.1 | 1.6 | GO:0002504 | antigen processing and presentation of peptide or polysaccharide antigen via MHC class II(GO:0002504) |
| 0.1 | 0.7 | GO:0030155 | regulation of cell adhesion(GO:0030155) |
| 0.1 | 0.2 | GO:0017014 | protein nitrosylation(GO:0017014) peptidyl-cysteine S-nitrosylation(GO:0018119) |
| 0.1 | 0.3 | GO:0042769 | DNA damage response, detection of DNA damage(GO:0042769) |
| 0.1 | 0.9 | GO:0006700 | C21-steroid hormone biosynthetic process(GO:0006700) |
| 0.0 | 0.1 | GO:2000001 | regulation of DNA damage checkpoint(GO:2000001) |
| 0.0 | 0.2 | GO:0035520 | monoubiquitinated protein deubiquitination(GO:0035520) |
| 0.0 | 0.2 | GO:0060122 | auditory receptor cell morphogenesis(GO:0002093) auditory receptor cell stereocilium organization(GO:0060088) inner ear receptor stereocilium organization(GO:0060122) |
| 0.0 | 0.9 | GO:0030838 | positive regulation of actin filament polymerization(GO:0030838) |
| 0.0 | 0.2 | GO:0090005 | negative regulation of establishment of protein localization to plasma membrane(GO:0090005) negative regulation of protein localization to plasma membrane(GO:1903077) negative regulation of protein localization to cell periphery(GO:1904376) |
| 0.0 | 4.1 | GO:0007162 | negative regulation of cell adhesion(GO:0007162) |
| 0.0 | 0.1 | GO:0006531 | aspartate metabolic process(GO:0006531) aspartate catabolic process(GO:0006533) |
| 0.0 | 0.4 | GO:0033523 | histone monoubiquitination(GO:0010390) histone H2B ubiquitination(GO:0033523) |
| 0.0 | 0.1 | GO:0045065 | cytotoxic T cell differentiation(GO:0045065) |
| 0.0 | 0.2 | GO:0051973 | positive regulation of telomerase activity(GO:0051973) |
| 0.0 | 0.1 | GO:0090292 | nuclear matrix organization(GO:0043578) nuclear matrix anchoring at nuclear membrane(GO:0090292) |
| 0.0 | 1.7 | GO:0006892 | post-Golgi vesicle-mediated transport(GO:0006892) |
| 0.0 | 0.4 | GO:0007220 | Notch receptor processing(GO:0007220) membrane protein intracellular domain proteolysis(GO:0031293) |
| 0.0 | 0.2 | GO:0015781 | pyrimidine nucleotide-sugar transport(GO:0015781) |
| 0.0 | 0.6 | GO:0034199 | activation of protein kinase A activity(GO:0034199) |
| 0.0 | 0.7 | GO:0031424 | keratinization(GO:0031424) |
| 0.0 | 0.5 | GO:0001516 | prostaglandin biosynthetic process(GO:0001516) prostanoid biosynthetic process(GO:0046457) |
| 0.0 | 0.1 | GO:0007210 | serotonin receptor signaling pathway(GO:0007210) |
| 0.0 | 0.2 | GO:0008054 | negative regulation of cyclin-dependent protein serine/threonine kinase by cyclin degradation(GO:0008054) |
| 0.0 | 0.5 | GO:0042113 | B cell activation(GO:0042113) |
| 0.0 | 0.1 | GO:0035630 | glycolate metabolic process(GO:0009441) skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration(GO:0014834) bone mineralization involved in bone maturation(GO:0035630) |
| 0.0 | 0.1 | GO:0042905 | progesterone metabolic process(GO:0042448) 9-cis-retinoic acid biosynthetic process(GO:0042904) 9-cis-retinoic acid metabolic process(GO:0042905) |
| 0.0 | 0.1 | GO:0006547 | histidine metabolic process(GO:0006547) |
| 0.0 | 0.1 | GO:0018874 | benzoate metabolic process(GO:0018874) |
| 0.0 | 0.9 | GO:0060271 | cilium morphogenesis(GO:0060271) |
| 0.0 | 1.0 | GO:0051084 | 'de novo' posttranslational protein folding(GO:0051084) |
| 0.0 | 0.1 | GO:0045007 | depurination(GO:0045007) |
| 0.0 | 1.4 | GO:0007229 | integrin-mediated signaling pathway(GO:0007229) |
| 0.0 | 0.2 | GO:0048207 | vesicle targeting, rough ER to cis-Golgi(GO:0048207) COPII vesicle coating(GO:0048208) COPII-coated vesicle budding(GO:0090114) |
| 0.0 | 1.2 | GO:0045454 | cell redox homeostasis(GO:0045454) |
| 0.0 | 0.1 | GO:0014820 | tonic smooth muscle contraction(GO:0014820) artery smooth muscle contraction(GO:0014824) |
| 0.0 | 0.0 | GO:0014831 | intestine smooth muscle contraction(GO:0014827) gastro-intestinal system smooth muscle contraction(GO:0014831) |
| 0.0 | 0.3 | GO:0016339 | calcium-dependent cell-cell adhesion via plasma membrane cell adhesion molecules(GO:0016339) |
| 0.0 | 0.1 | GO:0035024 | negative regulation of Rho protein signal transduction(GO:0035024) |
| 0.0 | 0.1 | GO:0021759 | globus pallidus development(GO:0021759) forebrain dorsal/ventral pattern formation(GO:0021798) menarche(GO:0042696) |
| 0.0 | 0.1 | GO:0003085 | negative regulation of systemic arterial blood pressure(GO:0003085) |
| 0.0 | 0.4 | GO:0014047 | glutamate secretion(GO:0014047) |
| 0.0 | 0.2 | GO:0006000 | fructose metabolic process(GO:0006000) |
| 0.0 | 0.7 | GO:0019233 | sensory perception of pain(GO:0019233) |
| 0.0 | 0.1 | GO:0002281 | macrophage activation involved in immune response(GO:0002281) |
| 0.0 | 0.2 | GO:0015701 | bicarbonate transport(GO:0015701) |
Gene overrepresentation in cellular_component category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.2 | 0.7 | GO:0043512 | inhibin complex(GO:0043511) inhibin A complex(GO:0043512) |
| 0.2 | 1.5 | GO:1990752 | microtubule plus-end(GO:0035371) microtubule end(GO:1990752) |
| 0.2 | 6.6 | GO:0045095 | keratin filament(GO:0045095) |
| 0.1 | 0.6 | GO:0016939 | kinesin II complex(GO:0016939) |
| 0.1 | 0.5 | GO:0071062 | alphav-beta3 integrin-vitronectin complex(GO:0071062) |
| 0.1 | 1.4 | GO:0001950 | obsolete plasma membrane enriched fraction(GO:0001950) |
| 0.1 | 0.4 | GO:0016593 | Cdc73/Paf1 complex(GO:0016593) |
| 0.1 | 1.5 | GO:0005922 | connexon complex(GO:0005922) |
| 0.1 | 0.8 | GO:0031430 | M band(GO:0031430) |
| 0.1 | 1.6 | GO:0042613 | MHC class II protein complex(GO:0042613) |
| 0.1 | 0.9 | GO:0005885 | Arp2/3 protein complex(GO:0005885) |
| 0.1 | 1.3 | GO:0033116 | endoplasmic reticulum-Golgi intermediate compartment membrane(GO:0033116) |
| 0.1 | 0.8 | GO:0034993 | microtubule organizing center attachment site(GO:0034992) LINC complex(GO:0034993) |
| 0.1 | 0.9 | GO:0031463 | Cul3-RING ubiquitin ligase complex(GO:0031463) |
| 0.1 | 0.2 | GO:0097651 | phosphatidylinositol 3-kinase complex, class IA(GO:0005943) phosphatidylinositol 3-kinase complex, class I(GO:0097651) |
| 0.0 | 1.1 | GO:0043205 | fibril(GO:0043205) |
| 0.0 | 0.1 | GO:0070044 | synaptobrevin 2-SNAP-25-syntaxin-1a complex(GO:0070044) |
| 0.0 | 0.7 | GO:0031941 | filamentous actin(GO:0031941) |
| 0.0 | 1.7 | GO:0098636 | integrin complex(GO:0008305) protein complex involved in cell adhesion(GO:0098636) |
| 0.0 | 0.8 | GO:0005801 | cis-Golgi network(GO:0005801) |
| 0.0 | 0.7 | GO:0001533 | cornified envelope(GO:0001533) |
| 0.0 | 0.2 | GO:0005869 | dynactin complex(GO:0005869) |
| 0.0 | 12.8 | GO:0009986 | cell surface(GO:0009986) |
| 0.0 | 1.7 | GO:0005604 | basement membrane(GO:0005604) |
| 0.0 | 0.4 | GO:0030057 | desmosome(GO:0030057) |
| 0.0 | 1.3 | GO:0042734 | presynaptic membrane(GO:0042734) |
| 0.0 | 0.1 | GO:0070937 | CRD-mediated mRNA stability complex(GO:0070937) |
| 0.0 | 6.0 | GO:0005792 | obsolete microsome(GO:0005792) |
| 0.0 | 0.3 | GO:0043198 | dendritic shaft(GO:0043198) |
| 0.0 | 0.2 | GO:0030127 | COPII vesicle coat(GO:0030127) |
| 0.0 | 0.3 | GO:0005833 | hemoglobin complex(GO:0005833) |
| 0.0 | 0.4 | GO:0009925 | basal plasma membrane(GO:0009925) |
| 0.0 | 1.6 | GO:0016605 | PML body(GO:0016605) |
| 0.0 | 0.2 | GO:0032420 | stereocilium(GO:0032420) |
| 0.0 | 0.5 | GO:0005952 | cAMP-dependent protein kinase complex(GO:0005952) |
| 0.0 | 0.1 | GO:0016942 | insulin-like growth factor binding protein complex(GO:0016942) growth factor complex(GO:0036454) |
| 0.0 | 1.1 | GO:0005802 | trans-Golgi network(GO:0005802) |
| 0.0 | 0.2 | GO:0019773 | proteasome core complex, alpha-subunit complex(GO:0019773) |
| 0.0 | 0.0 | GO:0070081 | clathrin-sculpted monoamine transport vesicle(GO:0070081) clathrin-sculpted monoamine transport vesicle membrane(GO:0070083) |
| 0.0 | 0.6 | GO:0000781 | chromosome, telomeric region(GO:0000781) |
| 0.0 | 2.3 | GO:0030425 | dendrite(GO:0030425) |
| 0.0 | 1.2 | GO:0042470 | melanosome(GO:0042470) pigment granule(GO:0048770) |
| 0.0 | 2.2 | GO:0030141 | secretory granule(GO:0030141) |
| 0.0 | 4.2 | GO:0016023 | cytoplasmic, membrane-bounded vesicle(GO:0016023) |
Gene overrepresentation in molecular_function category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.6 | 1.9 | GO:0008310 | single-stranded DNA 3'-5' exodeoxyribonuclease activity(GO:0008310) exoribonuclease II activity(GO:0008859) |
| 0.5 | 13.6 | GO:0005540 | hyaluronic acid binding(GO:0005540) |
| 0.4 | 4.5 | GO:0005094 | Rho GDP-dissociation inhibitor activity(GO:0005094) |
| 0.4 | 1.1 | GO:0030377 | urokinase plasminogen activator receptor activity(GO:0030377) |
| 0.4 | 2.1 | GO:0045545 | syndecan binding(GO:0045545) |
| 0.3 | 3.0 | GO:0005149 | interleukin-1 receptor binding(GO:0005149) |
| 0.2 | 7.4 | GO:0001972 | retinoic acid binding(GO:0001972) |
| 0.2 | 0.7 | GO:0048184 | obsolete follistatin binding(GO:0048184) |
| 0.2 | 1.3 | GO:0045159 | myosin II binding(GO:0045159) |
| 0.2 | 2.2 | GO:0043015 | gamma-tubulin binding(GO:0043015) |
| 0.2 | 0.6 | GO:0004677 | DNA-dependent protein kinase activity(GO:0004677) |
| 0.2 | 1.5 | GO:0008113 | peptide-methionine (S)-S-oxide reductase activity(GO:0008113) |
| 0.1 | 1.9 | GO:0047372 | acylglycerol lipase activity(GO:0047372) |
| 0.1 | 1.4 | GO:0005007 | fibroblast growth factor-activated receptor activity(GO:0005007) |
| 0.1 | 1.3 | GO:0005314 | high-affinity glutamate transmembrane transporter activity(GO:0005314) |
| 0.1 | 0.5 | GO:0050220 | prostaglandin-E synthase activity(GO:0050220) |
| 0.1 | 0.4 | GO:0004348 | glucosylceramidase activity(GO:0004348) |
| 0.1 | 0.9 | GO:0017049 | GTP-Rho binding(GO:0017049) |
| 0.1 | 0.5 | GO:0043184 | vascular endothelial growth factor receptor 2 binding(GO:0043184) |
| 0.1 | 0.3 | GO:0046403 | polynucleotide 3'-phosphatase activity(GO:0046403) |
| 0.1 | 1.2 | GO:0032395 | MHC class II receptor activity(GO:0032395) |
| 0.1 | 0.3 | GO:0045236 | CXCR chemokine receptor binding(GO:0045236) |
| 0.1 | 0.7 | GO:0015280 | ligand-gated sodium channel activity(GO:0015280) |
| 0.1 | 0.3 | GO:0003985 | acetyl-CoA C-acetyltransferase activity(GO:0003985) |
| 0.1 | 0.4 | GO:0015410 | manganese-transporting ATPase activity(GO:0015410) |
| 0.1 | 0.4 | GO:0016670 | oxidoreductase activity, acting on a sulfur group of donors, oxygen as acceptor(GO:0016670) |
| 0.1 | 0.2 | GO:0008502 | melatonin receptor activity(GO:0008502) |
| 0.1 | 0.2 | GO:0043891 | glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity(GO:0004365) glyceraldehyde-3-phosphate dehydrogenase (NAD(P)+) (phosphorylating) activity(GO:0043891) |
| 0.1 | 1.5 | GO:0051010 | microtubule plus-end binding(GO:0051010) |
| 0.1 | 6.6 | GO:0005200 | structural constituent of cytoskeleton(GO:0005200) |
| 0.1 | 0.4 | GO:0030229 | very-low-density lipoprotein particle receptor activity(GO:0030229) |
| 0.1 | 1.5 | GO:0005484 | SNAP receptor activity(GO:0005484) |
| 0.1 | 0.2 | GO:0042132 | fructose 1,6-bisphosphate 1-phosphatase activity(GO:0042132) |
| 0.0 | 0.4 | GO:0016290 | palmitoyl-CoA hydrolase activity(GO:0016290) |
| 0.0 | 0.2 | GO:0003827 | alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity(GO:0003827) |
| 0.0 | 0.1 | GO:0004477 | methenyltetrahydrofolate cyclohydrolase activity(GO:0004477) |
| 0.0 | 1.2 | GO:0045296 | cadherin binding(GO:0045296) |
| 0.0 | 0.1 | GO:0004937 | alpha1-adrenergic receptor activity(GO:0004937) |
| 0.0 | 1.2 | GO:0015035 | protein disulfide oxidoreductase activity(GO:0015035) |
| 0.0 | 0.1 | GO:0004045 | aminoacyl-tRNA hydrolase activity(GO:0004045) |
| 0.0 | 0.8 | GO:0005154 | epidermal growth factor receptor binding(GO:0005154) |
| 0.0 | 0.6 | GO:0004691 | cAMP-dependent protein kinase activity(GO:0004691) |
| 0.0 | 0.2 | GO:0043559 | insulin binding(GO:0043559) |
| 0.0 | 0.4 | GO:0015643 | toxic substance binding(GO:0015643) |
| 0.0 | 1.3 | GO:0017137 | Rab GTPase binding(GO:0017137) |
| 0.0 | 0.1 | GO:0032408 | MutLbeta complex binding(GO:0032406) MutSbeta complex binding(GO:0032408) |
| 0.0 | 0.6 | GO:0045028 | G-protein coupled nucleotide receptor activity(GO:0001608) G-protein coupled purinergic nucleotide receptor activity(GO:0045028) |
| 0.0 | 0.6 | GO:0070064 | proline-rich region binding(GO:0070064) |
| 0.0 | 0.6 | GO:0019894 | kinesin binding(GO:0019894) |
| 0.0 | 0.2 | GO:0015165 | pyrimidine nucleotide-sugar transmembrane transporter activity(GO:0015165) |
| 0.0 | 0.1 | GO:0047035 | testosterone dehydrogenase (NAD+) activity(GO:0047035) |
| 0.0 | 0.1 | GO:0005412 | glucose:sodium symporter activity(GO:0005412) |
| 0.0 | 0.1 | GO:0004652 | polynucleotide adenylyltransferase activity(GO:0004652) |
| 0.0 | 0.3 | GO:0016174 | NAD(P)H oxidase activity(GO:0016174) |
| 0.0 | 0.2 | GO:0008527 | taste receptor activity(GO:0008527) |
| 0.0 | 0.5 | GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process(GO:0008656) |
| 0.0 | 1.8 | GO:0005178 | integrin binding(GO:0005178) |
| 0.0 | 0.1 | GO:0003996 | acyl-CoA ligase activity(GO:0003996) |
| 0.0 | 0.1 | GO:0003998 | acylphosphatase activity(GO:0003998) |
| 0.0 | 0.0 | GO:0004946 | bombesin receptor activity(GO:0004946) |
| 0.0 | 0.2 | GO:0005522 | profilin binding(GO:0005522) |
| 0.0 | 0.1 | GO:0004994 | somatostatin receptor activity(GO:0004994) |
| 0.0 | 0.1 | GO:0004046 | aminoacylase activity(GO:0004046) |
| 0.0 | 0.1 | GO:0031708 | bombesin receptor binding(GO:0031705) endothelin B receptor binding(GO:0031708) |
| 0.0 | 0.3 | GO:0004303 | estradiol 17-beta-dehydrogenase activity(GO:0004303) |
| 0.0 | 0.1 | GO:0016918 | retinal binding(GO:0016918) |
| 0.0 | 0.1 | GO:0005123 | death receptor binding(GO:0005123) |
Gene overrepresentation in C2:CP category:
| Log-likelihood per target | Total log-likelihood | Term | Description |
|---|---|---|---|
| 0.5 | 17.1 | SA_MMP_CYTOKINE_CONNECTION | Cytokines can induce activation of matrix metalloproteinases, which degrade extracellular matrix. |
| 0.0 | 0.5 | SA_PROGRAMMED_CELL_DEATH | Programmed cell death, or apoptosis, eliminates damaged or unneeded cells. |
